메뉴 건너뛰기




Volumn 17, Issue 5, 2016, Pages 305-312

GWAS analysis implicates NF-κB-mediated induction of inflammatory T cells in multiple sclerosis

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 12P40; STROMAL INTERACTION MOLECULE 2; TRANSCRIPTION FACTOR RELA; TRANSCRIPTION FACTOR SOX8;

EID: 84973325720     PISSN: 14664879     EISSN: 14765470     Source Type: Journal    
DOI: 10.1038/gene.2016.23     Document Type: Article
Times cited : (60)

References (82)
  • 1
    • 84856910444 scopus 로고    scopus 로고
    • Neuropsychological, medical and rehabilitative management of persons with multiple sclerosis
    • De Luca J, Nocentini U. Neuropsychological, medical and rehabilitative management of persons with multiple sclerosis. Neuro Rehabilitation 2011; 29: 197-219.
    • (2011) Neuro Rehabilitation , vol.29 , pp. 197-219
    • De Luca, J.1    Nocentini, U.2
  • 2
    • 15844368830 scopus 로고    scopus 로고
    • A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22
    • Sawcer S, Jones HB, Feakes R, Gray J, Smaldon N, Chataway J et al. A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22. Nat Genet 1996; 13: 464-476.
    • (1996) Nat Genet , vol.13 , pp. 464-476
    • Sawcer, S.1    Jones, H.B.2    Feakes, R.3    Gray, J.4    Smaldon, N.5    Chataway, J.6
  • 3
    • 0025767289 scopus 로고
    • HLA class II-associated genetic susceptibility in multiple sclerosis: A critical evaluation
    • Olerup O, Hillert J. HLA class II-associated genetic susceptibility in multiple sclerosis: a critical evaluation. Tissue Antigens 1991; 38: 1-15.
    • (1991) Tissue Antigens , vol.38 , pp. 1-15
    • Olerup, O.1    Hillert, J.2
  • 5
    • 84255194782 scopus 로고    scopus 로고
    • Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci
    • Patsopoulos NA, the Bayer Pharma MS Genetics Working Group, the Steering Committees of Studies Evaluating IFNbeta-1b and a CCR1-Antagonist, ANZgene Consortium, Gene MSA, International Multiple Sclerosis Genetics Consortium et al. Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci. Ann Neurol 2011; 70: 897-912.
    • (2011) Ann Neurol , vol.70 , pp. 897-912
  • 6
    • 34548299105 scopus 로고    scopus 로고
    • Risk alleles for multiple sclerosis identified by a genomewide study
    • International Multiple Sclerosis Genetics Consortium, Hafler DA, Compston A, Sawcer S, Lander ES, Daly MJ et al. Risk alleles for multiple sclerosis identified by a genomewide study. N Engl J Med 2007; 357: 851-862.
    • (2007) N Engl J Med , vol.357 , pp. 851-862
    • Hafler, D.A.1    Compston, A.2    Sawcer, S.3    Lander, E.S.4    Daly, M.J.5
  • 7
    • 34548351247 scopus 로고    scopus 로고
    • Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis
    • Gregory SG, Schmidt S, Seth P, Oksenberg JR, Hart J, Prokop A et al. Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis. Nat Genet 2007; 39: 1083-1091.
    • (2007) Nat Genet , vol.39 , pp. 1083-1091
    • Gregory, S.G.1    Schmidt, S.2    Seth, P.3    Oksenberg, J.R.4    Hart, J.5    Prokop, A.6
  • 8
    • 77950544633 scopus 로고    scopus 로고
    • Comprehensive follow-up of the first genome-wide association study of multiple sclerosis identifies KIF21B and TMEM39A as susceptibility loci
    • International Multiple Sclerosis Genetics Consortium (IMSGC). Comprehensive follow-up of the first genome-wide association study of multiple sclerosis identifies KIF21B and TMEM39A as susceptibility loci. Hum Mol Genet 2010; 19: 953-962.
    • (2010) Hum Mol Genet , vol.19 , pp. 953-962
  • 9
    • 67649876123 scopus 로고    scopus 로고
    • Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci
    • De Jager PL, Jia X, Wang J, de Bakker PI, Ottoboni L, Aggarwal NT et al. Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. Nat Genet 2009; 41: 776-782.
    • (2009) Nat Genet , vol.41 , pp. 776-782
    • De Jager, P.L.1    Jia, X.2    Wang, J.3    De Bakker, P.I.4    Ottoboni, L.5    Aggarwal, N.T.6
  • 10
    • 80051684615 scopus 로고    scopus 로고
    • Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
    • International Multiple Sclerosis Genetics Consortium, Wellcome Trust Case Control Consortium 2, Sawcer S, Hellenthal G, Pirinen M, Spencer CC et al. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature 2011; 476: 214-219.
    • (2011) Nature , vol.476 , pp. 214-219
    • Sawcer, S.1    Hellenthal, G.2    Pirinen, M.3    Spencer, C.C.4
  • 11
    • 84878863691 scopus 로고    scopus 로고
    • MANBA, CXCR5, SOX8, RPS6KB1 and ZBTB46 are genetic risk loci for multiple sclerosis
    • International Multiple Sclerosis Genetics Consortium, Lill CM, Schjeide BM, Graetz C, Ban M, Alcina A et al. MANBA, CXCR5, SOX8, RPS6KB1 and ZBTB46 are genetic risk loci for multiple sclerosis. Brain 2013; 136: 1778-1782.
    • (2013) Brain , vol.136 , pp. 1778-1782
    • Lill, C.M.1    Schjeide, B.M.2    Graetz, C.3    Ban, M.4    Alcina, A.5
  • 12
    • 84887058596 scopus 로고    scopus 로고
    • Analysis of immunerelated loci identifies 48 new susceptibility variants for multiple sclerosis
    • International Multiple Sclerosis Genetics Consortium (IMSGC), Beecham AH, Patsopoulos NA, Xifara DK, Davis MF, Kemppinen A et al. Analysis of immunerelated loci identifies 48 new susceptibility variants for multiple sclerosis. Nat Genet 2013; 45: 1353-1360.
    • (2013) Nat Genet , vol.45 , pp. 1353-1360
    • Beecham, A.H.1    Patsopoulos, N.A.2    Xifara, D.K.3    Davis, M.F.4    Kemppinen, A.5
  • 13
    • 84895891926 scopus 로고    scopus 로고
    • A gene pathway analysis highlights the role of cellular adhesion molecules in multiple sclerosis susceptibility
    • Damotte V, Guillot-Noel L, Patsopoulos NA, Madireddy L, El Behi M, International Multiple Sclerosis Genetics Consortium et al. A gene pathway analysis highlights the role of cellular adhesion molecules in multiple sclerosis susceptibility. Genes Immun 2014; 15: 126-132.
    • (2014) Genes Immun , vol.15 , pp. 126-132
    • Damotte, V.1    Guillot-Noel, L.2    Patsopoulos, N.A.3    Madireddy, L.4    El Behi, M.5
  • 14
    • 84878883338 scopus 로고    scopus 로고
    • Network-based multiple sclerosis pathway analysis with GWAS data from 15, 000 cases and 30,000 controls
    • International Multiple Sclerosis Genetics Consortium. Network-based multiple sclerosis pathway analysis with GWAS data from 15, 000 cases and 30,000 controls. Am J Hum Genet 2013; 92: 854-865.
    • (2013) Am J Hum Genet , vol.92 , pp. 854-865
  • 15
    • 79960938123 scopus 로고    scopus 로고
    • A noise-reduction GWAS analysis implicates altered regulation of neurite outgrowth and guidance in autism
    • Hussman JP, Chung RH, Griswold AJ, Jaworkski JM, Salyakina D, Ma D et al. A noise-reduction GWAS analysis implicates altered regulation of neurite outgrowth and guidance in autism. Mol Autism 2011; 2: 1.
    • (2011) Mol Autism , vol.2 , pp. 1
    • Hussman, J.P.1    Chung, R.H.2    Griswold, A.J.3    Jaworkski, J.M.4    Salyakina, D.5    Ma, D.6
  • 16
    • 84863295500 scopus 로고    scopus 로고
    • Once phosphorylated, tyrosines in carboxyl terminus of protein-tyrosine kinase Syk interact with signaling proteins, including TULA-2, a negative regulator of mast cell degranulation
    • de Castro RO, Zhang J, Groves JR, Barbu EA, Siraganian RP. Once phosphorylated, tyrosines in carboxyl terminus of protein-tyrosine kinase Syk interact with signaling proteins, including TULA-2, a negative regulator of mast cell degranulation. J Biol Chem 2012; 287: 8194-8204.
    • (2012) J Biol Chem , vol.287 , pp. 8194-8204
    • De Castro, R.O.1    Zhang, J.2    Groves, J.R.3    Barbu, E.A.4    Siraganian, R.P.5
  • 17
    • 4444256335 scopus 로고    scopus 로고
    • Different enzymatic activities recruitment by specific domains of TIF2 are involved in NF-kappaB transactivation
    • Nojek IM, Werbajh SE, Colo GP, Rubio FM, Franco LD, Nahmod VE et al. Different enzymatic activities recruitment by specific domains of TIF2 are involved in NF-kappaB transactivation. Medicina (B Aires) 2004; 64: 135-138.
    • (2004) Medicina (B Aires) , vol.64 , pp. 135-138
    • Nojek, I.M.1    Werbajh, S.E.2    Colo, G.P.3    Rubio, F.M.4    Franco, L.D.5    Nahmod, V.E.6
  • 18
    • 84878547634 scopus 로고    scopus 로고
    • Regulation of nuclear factor-kappaB in autoimmunity
    • Sun SC, Chang JH, Jin J. Regulation of nuclear factor-kappaB in autoimmunity. Trends Immunol 2013; 34: 282-289.
    • (2013) Trends Immunol , vol.34 , pp. 282-289
    • Sun, S.C.1    Chang, J.H.2    Jin, J.3
  • 19
    • 84892448752 scopus 로고    scopus 로고
    • S6K1 negatively regulates TAK1 activity in the toll-like receptor signaling pathway
    • Kim SY, Baik KH, Baek KH, Chah KH, Kim KA, Moon G et al. S6K1 negatively regulates TAK1 activity in the toll-like receptor signaling pathway. Mol Cell Biol 2014; 34: 510-521.
    • (2014) Mol Cell Biol , vol.34 , pp. 510-521
    • Kim, S.Y.1    Baik, K.H.2    Baek, K.H.3    Chah, K.H.4    Kim, K.A.5    Moon, G.6
  • 20
    • 0038644520 scopus 로고    scopus 로고
    • GMCSF activates NF-kappaB via direct interaction of the GMCSF receptor with IkappaB kinase beta
    • Ebner K, Bandion A, Binder BR, de Martin R, Schmid JA. GMCSF activates NF-kappaB via direct interaction of the GMCSF receptor with IkappaB kinase beta. Blood 2003; 102: 192-199.
    • (2003) Blood , vol.102 , pp. 192-199
    • Ebner, K.1    Bandion, A.2    Binder, B.R.3    De Martin, R.4    Schmid, J.A.5
  • 21
    • 78650643147 scopus 로고    scopus 로고
    • T-cell-specific deletion of STIM1 and STIM2 protects mice from EAE by impairing the effector functions of Th1 and Th17 cells
    • Ma J, McCarl CA, Khalil S, Luthy K, Feske S. T-cell-specific deletion of STIM1 and STIM2 protects mice from EAE by impairing the effector functions of Th1 and Th17 cells. Eur J Immunol 2010; 40: 3028-3042.
    • (2010) Eur J Immunol , vol.40 , pp. 3028-3042
    • Ma, J.1    McCarl, C.A.2    Khalil, S.3    Luthy, K.4    Feske, S.5
  • 22
    • 0036498563 scopus 로고    scopus 로고
    • Txk, a member of nonreceptor tyrosine kinase of Tec family, acts as a Th1 cell-specific transcription factor and regulates IFN-gamma gene transcription
    • Takeba Y, Nagafuchi H, Takeno M, Kashiwakura J, Suzuki N. Txk, a member of nonreceptor tyrosine kinase of Tec family, acts as a Th1 cell-specific transcription factor and regulates IFN-gamma gene transcription. J Immunol 2002; 168: 2365-2370.
    • (2002) J Immunol , vol.168 , pp. 2365-2370
    • Takeba, Y.1    Nagafuchi, H.2    Takeno, M.3    Kashiwakura, J.4    Suzuki, N.5
  • 23
    • 84862067258 scopus 로고    scopus 로고
    • Human th17 cells express high levels of enzymatically active dipeptidylpeptidase IV (CD26)
    • Bengsch B, Seigel B, Flecken T, Wolanski J, Blum HE, Thimme R. Human Th17 cells express high levels of enzymatically active dipeptidylpeptidase IV (CD26). J Immunol 2012; 188: 5438-5447.
    • (2012) J Immunol , vol.188 , pp. 5438-5447
    • Bengsch, B.1    Seigel, B.2    Flecken, T.3    Wolanski, J.4    Blum, H.E.5    Thimme, R.6
  • 24
    • 23044445246 scopus 로고    scopus 로고
    • The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8+ T-cell responses through the cell-surface receptor CRTAM
    • Boles KS, Barchet W, Diacovo T, Cella M, Colonna M. The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8+ T-cell responses through the cell-surface receptor CRTAM. Blood 2005; 106: 779-786.
    • (2005) Blood , vol.106 , pp. 779-786
    • Boles, K.S.1    Barchet, W.2    Diacovo, T.3    Cella, M.4    Colonna, M.5
  • 25
    • 0028830922 scopus 로고
    • Assignment of DAP1 and DAPK-genes that positively mediate programmed cell death triggered by IFN-gamma-to chromosome regions 5p12.2 and 9q34.1, respectively
    • Feinstein E, Druck T, Kastury K, Berissi H, Goodart SA, Overhauser J et al. Assignment of DAP1 and DAPK-genes that positively mediate programmed cell death triggered by IFN-gamma-to chromosome regions 5p12.2 and 9q34.1, respectively. Genomics 1995; 29: 305-307.
    • (1995) Genomics , vol.29 , pp. 305-307
    • Feinstein, E.1    Druck, T.2    Kastury, K.3    Berissi, H.4    Goodart, S.A.5    Overhauser, J.6
  • 27
    • 77951877914 scopus 로고    scopus 로고
    • Ikappa bzeta regulates T(H)17 development by cooperating with ROR nuclear receptors
    • Okamoto K, Iwai Y, Oh-Hora M, Yamamoto M, Morio T, Aoki K et al. Ikappa Bzeta regulates T(H)17 development by cooperating with ROR nuclear receptors. Nature 2010; 464: 1381-1385.
    • (2010) Nature , vol.464 , pp. 1381-1385
    • Okamoto, K.1    Iwai, Y.2    Oh-Hora, M.3    Yamamoto, M.4    Morio, T.5    Aoki, K.6
  • 29
    • 84863995539 scopus 로고    scopus 로고
    • The inositol phosphatase SHIP-1 inhibits NOD2-induced NF-kappaB activation by disturbing the interaction of XIAP with RIP2
    • Conde C, Rambout X, Lebrun M, Lecat A, Di Valentin E, Dequiedt F et al. The inositol phosphatase SHIP-1 inhibits NOD2-induced NF-kappaB activation by disturbing the interaction of XIAP with RIP2. PLoS One 2012; 7: e41005.
    • (2012) PLoS One , vol.7 , pp. e41005
    • Conde, C.1    Rambout, X.2    Lebrun, M.3    Lecat, A.4    Di Valentin, E.5    Dequiedt, F.6
  • 30
    • 84874566776 scopus 로고    scopus 로고
    • Identification of shared genes and pathways: A comparative study of multiple sclerosis susceptibility, severity and response to interferon beta treatment
    • Mahurkar S, Moldovan M, Suppiah V, O'Doherty C. Identification of shared genes and pathways: a comparative study of multiple sclerosis susceptibility, severity and response to interferon beta treatment. PLoS One 2013; 8: e57655.
    • (2013) PLoS One , vol.8 , pp. e57655
    • Mahurkar, S.1    Moldovan, M.2    Suppiah, V.3    O'Doherty, C.4
  • 31
    • 84865363457 scopus 로고    scopus 로고
    • Myeloid cell-specific expression of Ship1 regulates IL-12 production and immunity to helminth infection
    • Hadidi S, Antignano F, Hughes MR, Wang SK, Snyder K, Sammis GM et al. Myeloid cell-specific expression of Ship1 regulates IL-12 production and immunity to helminth infection. Mucosal Immunol 2012; 5: 535-543.
    • (2012) Mucosal Immunol , vol.5 , pp. 535-543
    • Hadidi, S.1    Antignano, F.2    Hughes, M.R.3    Wang, S.K.4    Snyder, K.5    Sammis, G.M.6
  • 32
    • 67349125150 scopus 로고    scopus 로고
    • Tec kinases regulate actin assembly and cytokine expression in LPS-stimulated human neutrophils via JNK activation
    • Zemans RL, Arndt PG. Tec kinases regulate actin assembly and cytokine expression in LPS-stimulated human neutrophils via JNK activation. Cell Immunol 2009; 258: 90-97.
    • (2009) Cell Immunol , vol.258 , pp. 90-97
    • Zemans, R.L.1    Arndt, P.G.2
  • 33
    • 84861951340 scopus 로고    scopus 로고
    • Inhibiting mer receptor tyrosine kinase suppresses STAT1, SOCS1/3, and NF-kappaB activation and enhances inflammatory responses in lipopolysaccharide-induced acute lung injury
    • Lee YJ, Han JY, Byun J, Park HJ, Park EM, Chong YH et al. Inhibiting Mer receptor tyrosine kinase suppresses STAT1, SOCS1/3, and NF-kappaB activation and enhances inflammatory responses in lipopolysaccharide-induced acute lung injury. J Leukoc Biol 2012; 91: 921-932.
    • (2012) J Leukoc Biol , vol.91 , pp. 921-932
    • Lee, Y.J.1    Han, J.Y.2    Byun, J.3    Park, H.J.4    Park, E.M.5    Chong, Y.H.6
  • 34
    • 79951563979 scopus 로고    scopus 로고
    • Polymorphisms in the receptor tyrosine kinase MERTK gene are associated with multiple sclerosis susceptibility
    • Ma GZ, Stankovich JAustralia and New Zealand Multiple Sclerosis Genetics Consortium (ANZgene), Kilpatrick TJ, Binder MD, Field J. Polymorphisms in the receptor tyrosine kinase MERTK gene are associated with multiple sclerosis susceptibility. PLoS One 2011; 6: e16964.
    • (2011) PLoS One , vol.6 , pp. e16964
    • Ma, G.Z.1    Kilpatrick, T.J.2    Binder, M.D.3    Field, J.4
  • 36
    • 84863199471 scopus 로고    scopus 로고
    • Replication study of 10 genes showing evidence for association with multiple sclerosis: Validation of TMEM39A, IL12B and CBLB [correction of CLBL] genes
    • Varade J, Comabella M, Ortiz MA, Arroyo R, Fernandez O, Pinto-Medel MJ et al. Replication study of 10 genes showing evidence for association with multiple sclerosis: validation of TMEM39A, IL12B and CBLB [correction of CLBL] genes. Mult Scler 2012; 18: 959-965.
    • (2012) Mult Scler , vol.18 , pp. 959-965
    • Varade, J.1    Comabella, M.2    Ortiz, M.A.3    Arroyo, R.4    Fernandez, O.5    Pinto-Medel, M.J.6
  • 37
    • 84875340407 scopus 로고    scopus 로고
    • BATF regulates the development and function of IL-17 producing iNKT cells
    • Jordan-Williams KL, Poston S, Taparowsky EJ. BATF regulates the development and function of IL-17 producing iNKT cells. BMC Immunol 2013; 14: 16.
    • (2013) BMC Immunol , vol.14 , pp. 16
    • Jordan-Williams, K.L.1    Poston, S.2    Taparowsky, E.J.3
  • 38
    • 84931562423 scopus 로고    scopus 로고
    • Multiple sclerosis risk loci correlate with cervical cord atrophy and may explain the course of disability
    • Akkad DA, Bellenberg B, Esser S, Weiler F, Epplen JT, Gold R et al. Multiple sclerosis risk loci correlate with cervical cord atrophy and may explain the course of disability. Neurogenetics 2015; 16: 161-168.
    • (2015) Neurogenetics , vol.16 , pp. 161-168
    • Akkad, D.A.1    Bellenberg, B.2    Esser, S.3    Weiler, F.4    Epplen, J.T.5    Gold, R.6
  • 40
    • 79952303794 scopus 로고    scopus 로고
    • Paris (ZNF746) repression of PGC-1alpha contributes to neurodegeneration in Parkinson's disease
    • Shin JH, Ko HS, Kang H, Lee Y, Lee YI, Pletinkova O et al. Paris (ZNF746) repression of PGC-1alpha contributes to neurodegeneration in Parkinson's disease. Cell 2011; 144: 689-702.
    • (2011) Cell , vol.144 , pp. 689-702
    • Shin, J.H.1    Ko, H.S.2    Kang, H.3    Lee, Y.4    Lee, Y.I.5    Pletinkova, O.6
  • 41
    • 61449172037 scopus 로고    scopus 로고
    • Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
    • Huang da W, Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 2009; 4: 44-57.
    • (2009) Nat Protoc , vol.4 , pp. 44-57
    • Huang Da, W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 42
    • 58549112996 scopus 로고    scopus 로고
    • Bioinformatics enrichment tools: Paths toward the comprehensive functional analysis of large gene lists
    • Huang da W, Sherman BT, Lempicki RA. Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res 2009; 37: 1-13.
    • (2009) Nucleic Acids Res , vol.37 , pp. 1-13
    • Huang Da, W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 43
    • 84930809027 scopus 로고    scopus 로고
    • Genetic variants associated with autoimmunity drive NFκB signaling and responses to inflammatory stimuli
    • Housley W, Fernandez S, Vera K, Murikinati S, Grutzendler J, Cuerdon N et al. Genetic variants associated with autoimmunity drive NFκB signaling and responses to inflammatory stimuli. Sci Transl Med 2015; 7: 291ra93.
    • (2015) Sci Transl Med , vol.7 , pp. 291ra93
    • Housley, W.1    Fernandez, S.2    Vera, K.3    Murikinati, S.4    Grutzendler, J.5    Cuerdon, N.6
  • 45
    • 84904039019 scopus 로고    scopus 로고
    • Regulation of NF-kappaB by TNF family cytokines
    • Hayden MS, Ghosh S. Regulation of NF-kappaB by TNF family cytokines. Semin Immunol 2014; 26: 253-266.
    • (2014) Semin Immunol , vol.26 , pp. 253-266
    • Hayden, M.S.1    Ghosh, S.2
  • 46
    • 80555126026 scopus 로고    scopus 로고
    • Nuclear factor-kappab in immunity and inflammation: The treg and th17 connection
    • Ruan Q, Chen YH. Nuclear factor-kappaB in immunity and inflammation: the Treg and Th17 connection. Adv Exp Med Biol 2012; 946: 207-221.
    • (2012) Adv Exp Med Biol , vol.946 , pp. 207-221
    • Ruan, Q.1    Chen, Y.H.2
  • 48
    • 0029101772 scopus 로고
    • Transcriptional regulation of endothelial cell adhesion molecules: NF-kappa B and cytokineinducible enhancers
    • Collins T, Read MA, Neish AS, Whitley MZ, Thanos D, Maniatis T. Transcriptional regulation of endothelial cell adhesion molecules: NF-kappa B and cytokineinducible enhancers. FASEB J 1995; 9: 899-909.
    • (1995) FASEB J , vol.9 , pp. 899-909
    • Collins, T.1    Read, M.A.2    Neish, A.S.3    Whitley, M.Z.4    Thanos, D.5    Maniatis, T.6
  • 49
    • 78651227754 scopus 로고    scopus 로고
    • Therapeutic effect of PEGylated TNFR1-selective antagonistic mutant TNF in experimental autoimmune encephalomyelitis mice
    • Nomura T, Abe Y, Kamada H, Shibata H, Kayamuro H, Inoue M et al. Therapeutic effect of PEGylated TNFR1-selective antagonistic mutant TNF in experimental autoimmune encephalomyelitis mice. J Control Release 2011; 149: 8-14.
    • (2011) J Control Release , vol.149 , pp. 8-14
    • Nomura, T.1    Abe, Y.2    Kamada, H.3    Shibata, H.4    Kayamuro, H.5    Inoue, M.6
  • 50
    • 84877625422 scopus 로고    scopus 로고
    • Autophagy contributes to inflammation in patients with TNFR-associated periodic syndrome (TRAPS)
    • Bachetti T, Chiesa S, Castagnola P, Bani D, Di Zanni E, Omenetti A et al. Autophagy contributes to inflammation in patients with TNFR-associated periodic syndrome (TRAPS). Ann Rheum Dis 2013; 72: 1044-1052.
    • (2013) Ann Rheum Dis , vol.72 , pp. 1044-1052
    • Bachetti, T.1    Chiesa, S.2    Castagnola, P.3    Bani, D.4    Di Zanni, E.5    Omenetti, A.6
  • 51
    • 84862224791 scopus 로고    scopus 로고
    • Regional susceptibility to TNF-alpha induction of murine brain inflammation via classical IKK/NF-kappaB signalling
    • Young AM, Campbell EC, Lynch S, Dunn MH, Powis SJ, Suckling J. Regional susceptibility to TNF-alpha induction of murine brain inflammation via classical IKK/NF-kappaB signalling. PLoS One 2012; 7: e39049.
    • (2012) PLoS One , vol.7 , pp. e39049
    • Young, A.M.1    Campbell, E.C.2    Lynch, S.3    Dunn, M.H.4    Powis, S.J.5    Suckling, J.6
  • 52
    • 84885089440 scopus 로고    scopus 로고
    • Suppression of IL-12 production by tristetraprolin through blocking NF-kcyB nuclear translocation
    • Gu L, Ning H, Qian X, Huang Q, Hou R, Almourani R et al. Suppression of IL-12 production by tristetraprolin through blocking NF-kcyB nuclear translocation. J Immunol 2013; 191: 3922-3930.
    • (2013) J Immunol , vol.191 , pp. 3922-3930
    • Gu, L.1    Ning, H.2    Qian, X.3    Huang, Q.4    Hou, R.5    Almourani, R.6
  • 53
    • 33645991527 scopus 로고    scopus 로고
    • Controlling NF-kappaB activation in T cells by costimulatory receptors
    • Schmitz ML, Krappmann D. Controlling NF-kappaB activation in T cells by costimulatory receptors. Cell Death Differ 2006; 13: 834-842.
    • (2006) Cell Death Differ , vol.13 , pp. 834-842
    • Schmitz, M.L.1    Krappmann, D.2
  • 54
    • 80054837244 scopus 로고    scopus 로고
    • NIK signaling in dendritic cells but not in T cells is required for the development of effector T cells and cell-mediated immune responses
    • Hofmann J, Mair F, Greter M, Schmidt-Supprian M, Becher B. NIK signaling in dendritic cells but not in T cells is required for the development of effector T cells and cell-mediated immune responses. J Exp Med 2011; 208: 1917-1929.
    • (2011) J Exp Med , vol.208 , pp. 1917-1929
    • Hofmann, J.1    Mair, F.2    Greter, M.3    Schmidt-Supprian, M.4    Becher, B.5
  • 55
    • 69249223474 scopus 로고    scopus 로고
    • Regulation of Th17 cell differentiation and EAE induction by MAP3K NIK
    • Jin W, Zhou XF, Yu J, Cheng X, Sun SC. Regulation of Th17 cell differentiation and EAE induction by MAP3K NIK. Blood 2009; 113: 6603-6610.
    • (2009) Blood , vol.113 , pp. 6603-6610
    • Jin, W.1    Zhou, X.F.2    Yu, J.3    Cheng, X.4    Sun, S.C.5
  • 56
    • 58849155087 scopus 로고    scopus 로고
    • T-bet and eomesodermin play critical roles in directing T cell differentiation to Th1 versus Th17
    • Yang Y, Xu J, Niu Y, Bromberg JS, Ding Y. T-bet and eomesodermin play critical roles in directing T cell differentiation to Th1 versus Th17. J Immunol 2008; 181: 8700-8710.
    • (2008) J Immunol , vol.181 , pp. 8700-8710
    • Yang, Y.1    Xu, J.2    Niu, Y.3    Bromberg, J.S.4    Ding, Y.5
  • 58
    • 77951674573 scopus 로고    scopus 로고
    • The nuclear factor-kappaB-interleukin-6 signalling pathway mediating vascular inflammation
    • Brasier AR. The nuclear factor-kappaB-interleukin-6 signalling pathway mediating vascular inflammation. Cardiovasc Res 2010; 86: 211-218.
    • (2010) Cardiovasc Res , vol.86 , pp. 211-218
    • Brasier, A.R.1
  • 59
    • 80052259648 scopus 로고    scopus 로고
    • Making sense of regulatory T cell suppressive function
    • Shalev I, Schmelzle M, Robson SC, Levy G. Making sense of regulatory T cell suppressive function. Semin Immunol 2011; 23: 282-292.
    • (2011) Semin Immunol , vol.23 , pp. 282-292
    • Shalev, I.1    Schmelzle, M.2    Robson, S.C.3    Levy, G.4
  • 60
    • 0035102242 scopus 로고    scopus 로고
    • Contrasting roles of IL-2 and IL-15 in the life and death of lymphocytes: Implications for immunotherapy
    • Waldmann TA, Dubois S, Tagaya Y. Contrasting roles of IL-2 and IL-15 in the life and death of lymphocytes: implications for immunotherapy. Immunity 2001; 14: 105-110.
    • (2001) Immunity , vol.14 , pp. 105-110
    • Waldmann, T.A.1    Dubois, S.2    Tagaya, Y.3
  • 61
    • 84871152858 scopus 로고    scopus 로고
    • IL-7 abrogates suppressive activity of human CD4+CD25+FOXP3+ regulatory T cells and allows expansion of alloreactive and autoreactive T cells
    • Heninger AK, Theil A, Wilhelm C, Petzold C, Huebel N, Kretschmer K et al. IL-7 abrogates suppressive activity of human CD4+CD25+FOXP3+ regulatory T cells and allows expansion of alloreactive and autoreactive T cells. J Immunol 2012; 189: 5649-5658.
    • (2012) J Immunol , vol.189 , pp. 5649-5658
    • Heninger, A.K.1    Theil, A.2    Wilhelm, C.3    Petzold, C.4    Huebel, N.5    Kretschmer, K.6
  • 63
    • 58249090536 scopus 로고    scopus 로고
    • JAM-L-mediated leukocyte adhesion to endothelial cells is regulated in cis by alpha4-beta1 integrin activation
    • Luissint AC, Lutz PG, Calderwood DA, Couraud PO, Bourdoulous S. JAM-L-mediated leukocyte adhesion to endothelial cells is regulated in cis by alpha4-beta1 integrin activation. J Cell Biol 2008; 183: 1159-1173.
    • (2008) J Cell Biol , vol.183 , pp. 1159-1173
    • Luissint, A.C.1    Lutz, P.G.2    Calderwood, D.A.3    Couraud, P.O.4    Bourdoulous, S.5
  • 64
    • 84911976822 scopus 로고    scopus 로고
    • Endogenous interleukin-6 amplifies interleukin-17 production and corticoidresistance in peripheral T cells from patients with multiple sclerosis
    • Ferreira TB, Hygino J, Barros PO, Teixeira B, Kasahara TM, Linhares UC et al. Endogenous interleukin-6 amplifies interleukin-17 production and corticoidresistance in peripheral T cells from patients with multiple sclerosis. Immunology 2014; 143: 560-568.
    • (2014) Immunology , vol.143 , pp. 560-568
    • Ferreira, T.B.1    Hygino, J.2    Barros, P.O.3    Teixeira, B.4    Kasahara, T.M.5    Linhares, U.C.6
  • 65
    • 83555178479 scopus 로고    scopus 로고
    • Th17 expansion in MS patients is counterbalanced by an expanded CD39+ regulatory T cell population during remission but not during relapse
    • Peelen E, Damoiseaux J, Smolders J, Knippenberg S, Menheere P, Tervaert JW et al. Th17 expansion in MS patients is counterbalanced by an expanded CD39+ regulatory T cell population during remission but not during relapse. J Neuroimmunol 2011; 240-241: 97-103.
    • (2011) J Neuroimmunol , vol.240-241 , pp. 97-103
    • Peelen, E.1    Damoiseaux, J.2    Smolders, J.3    Knippenberg, S.4    Menheere, P.5    Tervaert, J.W.6
  • 66
    • 72649089874 scopus 로고    scopus 로고
    • Phenotypical and functional characterization of T helper 17 cells in multiple sclerosis
    • Brucklacher-Waldert V, Stuerner K, Kolster M, Wolthausen J, Tolosa E. Phenotypical and functional characterization of T helper 17 cells in multiple sclerosis. Brain 2009; 132: 3329-3341.
    • (2009) Brain , vol.132 , pp. 3329-3341
    • Brucklacher-Waldert, V.1    Stuerner, K.2    Kolster, M.3    Wolthausen, J.4    Tolosa, E.5
  • 67
    • 52949094997 scopus 로고    scopus 로고
    • IL17 and IFNgamma production by peripheral blood mononuclear cells from clinically isolated syndrome to secondary progressive multiple sclerosis
    • Frisullo G, Nociti V, Iorio R, Patanella AK, Marti A, Caggiula M et al. IL17 and IFNgamma production by peripheral blood mononuclear cells from clinically isolated syndrome to secondary progressive multiple sclerosis. Cytokine 2008; 44: 22-25.
    • (2008) Cytokine , vol.44 , pp. 22-25
    • Frisullo, G.1    Nociti, V.2    Iorio, R.3    Patanella, A.K.4    Marti, A.5    Caggiula, M.6
  • 68
    • 50249125248 scopus 로고    scopus 로고
    • Molecular network analysis of T-cell transcriptome suggests aberrant regulation of gene expression by NF-kappaB as a biomarker for relapse of multiple sclerosis
    • Satoh J, Misawa T, Tabunoki H, Yamamura T. Molecular network analysis of T-cell transcriptome suggests aberrant regulation of gene expression by NF-kappaB as a biomarker for relapse of multiple sclerosis. Dis Markers 2008; 25: 27-35.
    • (2008) Dis Markers , vol.25 , pp. 27-35
    • Satoh, J.1    Misawa, T.2    Tabunoki, H.3    Yamamura, T.4
  • 69
    • 0032589563 scopus 로고    scopus 로고
    • Activation of NF-kappaB and c-jun transcription factors in multiple sclerosis lesions. Implications for oligodendrocyte pathology
    • Bonetti B, Stegagno C, Cannella B, Rizzuto N, Moretto G, Raine CS. Activation of NF-kappaB and c-jun transcription factors in multiple sclerosis lesions. Implications for oligodendrocyte pathology. Am J Pathol 1999; 155: 1433-1438.
    • (1999) Am J Pathol , vol.155 , pp. 1433-1438
    • Bonetti, B.1    Stegagno, C.2    Cannella, B.3    Rizzuto, N.4    Moretto, G.5    Raine, C.S.6
  • 70
  • 71
  • 73
    • 84861012357 scopus 로고    scopus 로고
    • Evolutionary dynamics of co-segregating gene clusters associated with complex diseases
    • Preuss C, Riemenschneider M, Wiedmann D, Stoll M. Evolutionary dynamics of co-segregating gene clusters associated with complex diseases. PLoS One 2012; 7: e36205.
    • (2012) PLoS One , vol.7 , pp. e36205
    • Preuss, C.1    Riemenschneider, M.2    Wiedmann, D.3    Stoll, M.4
  • 76
    • 79954577277 scopus 로고    scopus 로고
    • TLR-signaling networks: An integration of adaptor molecules, kinases, and cross-talk
    • Brown J, Wang H, Hajishengallis GN, Martin M. TLR-signaling networks: an integration of adaptor molecules, kinases, and cross-talk. J Dent Res 2011; 90: 417-427.
    • (2011) J Dent Res , vol.90 , pp. 417-427
    • Brown, J.1    Wang, H.2    Hajishengallis, G.N.3    Martin, M.4
  • 78
    • 84893853003 scopus 로고    scopus 로고
    • L-CBM signaling in lymphocyte development and function
    • Hara H, Iizasa E, Nakaya M, Yoshida H. L-CBM signaling in lymphocyte development and function. J Blood Med 2010; 1: 93-104.
    • (2010) J Blood Med , vol.1 , pp. 93-104
    • Hara, H.1    Iizasa, E.2    Nakaya, M.3    Yoshida, H.4
  • 79
    • 80051971631 scopus 로고    scopus 로고
    • IKKα takes control of canonical NF-κB activation
    • Pelzer C, Thome M. IKKα takes control of canonical NF-κB activation. Nat Immunol 2011; 12: 815-816.
    • (2011) Nat Immunol , vol.12 , pp. 815-816
    • Pelzer, C.1    Thome, M.2
  • 80
    • 56349164232 scopus 로고    scopus 로고
    • Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling
    • Vallabhapurapu S, Matsuzawa A, Zhang W, Tseng PH, Keats JJ, Wang H et al. Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling. Nat Immunol 2008; 9: 1364-1370.
    • (2008) Nat Immunol , vol.9 , pp. 1364-1370
    • Vallabhapurapu, S.1    Matsuzawa, A.2    Zhang, W.3    Tseng, P.H.4    Keats, J.J.5    Wang, H.6
  • 81
    • 84873695281 scopus 로고    scopus 로고
    • NF-kappaB: Roles and regulation in different CD4(+) T-cell subsets
    • Oh H, Ghosh S. NF-kappaB: roles and regulation in different CD4(+) T-cell subsets. Immunol Rev 2013; 252: 41-51.
    • (2013) Immunol Rev , vol.252 , pp. 41-51
    • Oh, H.1    Ghosh, S.2
  • 82
    • 0029157292 scopus 로고
    • Follicular dendritic cells in malignant lymphomas
    • Petrasch S. Follicular dendritic cells in malignant lymphomas. Curr Top Microbiol Immunol 1995; 201: 189-203.
    • (1995) Curr Top Microbiol Immunol , vol.201 , pp. 189-203
    • Petrasch, S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.