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Volumn 47, Issue 5, 2008, Pages 584-590

Signalling, inflammation and arthritis: NF-κB and its relevance to arthritis and inflammation

Author keywords

NF B; Review; Signalling pathways

Indexed keywords

CHEMOKINE; HETERODIMER; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; I KAPPA B KINASE EPSILON; I KAPPA B KINASE GAMMA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MATRIX METALLOPROTEINASE; PROTEIN P50; SYNAPTOTAGMIN I; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

EID: 42949171833     PISSN: 14620324     EISSN: 14620332     Source Type: Journal    
DOI: 10.1093/rheumatology/kem298     Document Type: Article
Times cited : (293)

References (92)
  • 1
    • 1642553460 scopus 로고    scopus 로고
    • To be, or not to be: NF-kappaB is the answer-role of Rel/NF-kappaB in the regulation of apoptosis
    • Kucharczak J, Simmons MJ, Fan Y, Gelinas C. To be, or not to be: NF-kappaB is the answer-role of Rel/NF-kappaB in the regulation of apoptosis. Oncogene 2003;22:8961-82.
    • (2003) Oncogene , vol.22 , pp. 8961-8982
    • Kucharczak, J.1    Simmons, M.J.2    Fan, Y.3    Gelinas, C.4
  • 2
    • 33747594754 scopus 로고    scopus 로고
    • At once harmful and beneficial: The dual properties of NF-kappaB
    • Yousset S, Steinman L. At once harmful and beneficial: The dual properties of NF-kappaB. Nat Immunol 2006;7:901-2.
    • (2006) Nat Immunol , vol.7 , pp. 901-902
    • Yousset, S.1    Steinman, L.2
  • 3
    • 2342522110 scopus 로고    scopus 로고
    • Shaping the nuclear action of NF-kappaB
    • Chen LF, Greene WC. Shaping the nuclear action of NF-kappaB. Nat Rev Mol Cell Biol 2004;5:392-401.
    • (2004) Nat Rev Mol Cell Biol , vol.5 , pp. 392-401
    • Chen, L.F.1    Greene, W.C.2
  • 4
    • 0031906550 scopus 로고    scopus 로고
    • Signal transduction through NF-kappa B
    • May MJ, Ghosh S. Signal transduction through NF-kappa B. Immunol Today 1998;19:80-8.
    • (1998) Immunol Today , vol.19 , pp. 80-88
    • May, M.J.1    Ghosh, S.2
  • 5
    • 24644433852 scopus 로고    scopus 로고
    • Enhanced NF-kappaB activation and cellular function in macrophages lackng IkappaB kinase 1 (IKK1)
    • Li, Lu Q, Bottero V et al. Enhanced NF-kappaB activation and cellular function in macrophages lackng IkappaB kinase 1 (IKK1). Proc Nat Acad Sci USA 2005;102:12425-30.
    • (2005) Proc Nat Acad Sci USA , vol.102 , pp. 12425-12430
    • Li1    Lu, Q.2    Bottero, V.3
  • 6
    • 0035983756 scopus 로고    scopus 로고
    • TNFalpha-induced macrophage chemokine secretion is more dependent on NF-kappaB expression than lipopolysaccharides-induced macrophage chemokine secretion
    • Ciesielski CJ, Andreakos E, Foxwell BM, Feldmann M. TNFalpha-induced macrophage chemokine secretion is more dependent on NF-kappaB expression than lipopolysaccharides-induced macrophage chemokine secretion. Eur J Immunol 2002;32:2037-45.
    • (2002) Eur J Immunol , vol.32 , pp. 2037-2045
    • Ciesielski, C.J.1    Andreakos, E.2    Foxwell, B.M.3    Feldmann, M.4
  • 7
    • 33749023888 scopus 로고    scopus 로고
    • Mechanisms of disease: The molecular and cellular basis of joint destruction in rheumatoid arthritis
    • Muller-Ladner U, Pap T, Gay RE, Neidhart M, Gay S. Mechanisms of disease: The molecular and cellular basis of joint destruction in rheumatoid arthritis. Nat Clin Pract Rheumatol 2005;1:102-10.
    • (2005) Nat Clin Pract Rheumatol , vol.1 , pp. 102-110
    • Muller-Ladner, U.1    Pap, T.2    Gay, R.E.3    Neidhart, M.4    Gay, S.5
  • 8
    • 0035056003 scopus 로고    scopus 로고
    • Anti-TNF alpha therapy of rheumatoid arthritis: What have we learned?
    • Feldmann M, Maini RN. Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned? Annu Rev Immunol 2001;19:163-96.
    • (2001) Annu Rev Immunol , vol.19 , pp. 163-196
    • Feldmann, M.1    Maini, R.N.2
  • 9
    • 0030044619 scopus 로고    scopus 로고
    • Activation of transcription factor NF-kappa B in human synovial cells in response to tumor necrosis factor alpha
    • Fujisawa K, Aono H, Hasunuma T, Yamamoto K, Mita S, Nishioka K. Activation of transcription factor NF-kappa B in human synovial cells in response to tumor necrosis factor alpha. Arthritis Rheum 1996;39:197-203.
    • (1996) Arthritis Rheum , vol.39 , pp. 197-203
    • Fujisawa, K.1    Aono, H.2    Hasunuma, T.3    Yamamoto, K.4    Mita, S.5    Nishioka, K.6
  • 10
    • 0029658494 scopus 로고    scopus 로고
    • Manipulation of distinct NFkappaB proteins alters interleukin-1beta-induced human rheumatoid synovial fibroblast prostaglandin E2 formation
    • Roshak AK, Jackson JR, McGough K, Chabot-Fletcher M, Mochan E, Marshall LA. Manipulation of distinct NFkappaB proteins alters interleukin-1beta-induced human rheumatoid synovial fibroblast prostaglandin E2 formation. J Biol Chem 1996;271:31496-501.
    • (1996) J Biol Chem , vol.271 , pp. 31496-31501
    • Roshak, A.K.1    Jackson, J.R.2    McGough, K.3    Chabot-Fletcher, M.4    Mochan, E.5    Marshall, L.A.6
  • 11
    • 0034743429 scopus 로고    scopus 로고
    • Importance of NF-kappaB in rheumatoid synovial tissues: In situ NF-kappaB expression and in vitro study using cultured synovial cells
    • Yamasaki S, Kawakami A, Nakashima T et al. Importance of NF-kappaB in rheumatoid synovial tissues: In situ NF-kappaB expression and in vitro study using cultured synovial cells. Ann Rheum Dis 2001;60:678-84.
    • (2001) Ann Rheum Dis , vol.60 , pp. 678-684
    • Yamasaki, S.1    Kawakami, A.2    Nakashima, T.3
  • 13
    • 0031744967 scopus 로고    scopus 로고
    • Analysis of the NF-kappa B p65 subunit, Fas antigen, Fas ligand and Bcl-2-related proteins in the synovium of RA and polyarticular JRA
    • Sioud M, Mellbye O, Forre O. Analysis of the NF-kappa B p65 subunit, Fas antigen, Fas ligand and Bcl-2-related proteins in the synovium of RA and polyarticular JRA. Clin Exp Rheumatol 1998;16:125-34.
    • (1998) Clin Exp Rheumatol , vol.16 , pp. 125-134
    • Sioud, M.1    Mellbye, O.2    Forre, O.3
  • 14
    • 15844384253 scopus 로고    scopus 로고
    • Activation of the transcription factor nuclear factor-kappaB in human inflamed synovial tissue
    • Marok R, Winyard PG, Coumbe A et al. Activation of the transcription factor nuclear factor-kappaB in human inflamed synovial tissue. Arthritis Rheum 1996;39:583-91.
    • (1996) Arthritis Rheum , vol.39 , pp. 583-591
    • Marok, R.1    Winyard, P.G.2    Coumbe, A.3
  • 15
    • 0029563524 scopus 로고
    • Nuclear factor-kappa B in rheumatoid synovium. Localization of p50 and p65
    • Handel ML, McMorrow LB, Gravallese EM. Nuclear factor-kappa B in rheumatoid synovium. Localization of p50 and p65. Arthritis Rheum 1995;38:1762-70.
    • (1995) Arthritis Rheum , vol.38 , pp. 1762-1770
    • Handel, M.L.1    McMorrow, L.B.2    Gravallese, E.M.3
  • 16
    • 2642517290 scopus 로고    scopus 로고
    • Increased syncMal tissue NF-kappa B1 expression at sites adjacent to the cartilage-pannus junction in rheumatoid arthritis
    • Benito MJ, Murphy E, Murphy EP, van den Berg WB, FitzGerald O, Bresnihan B. Increased syncMal tissue NF-kappa B1 expression at sites adjacent to the cartilage-pannus junction in rheumatoid arthritis. Arthritis Rheum 2004;50:1781-7.
    • (2004) Arthritis Rheum , vol.50 , pp. 1781-1787
    • Benito, M.J.1    Murphy, E.2    Murphy, E.P.3    van den Berg, W.B.4    FitzGerald, O.5    Bresnihan, B.6
  • 17
    • 0034086893 scopus 로고    scopus 로고
    • Macrophage-derived cytokine, and nuclear factor kappaB p65 expression in synovial membrane and skin of patients with psoriatic arthritis
    • Danning CL, Illei GG, Hitchon C, Greer MR, Boumpas DT, McInnes JB. Macrophage-derived cytokine, and nuclear factor kappaB p65 expression in synovial membrane and skin of patients with psoriatic arthritis. Arthritis Rheum 2000;43:1244-56.
    • (2000) Arthritis Rheum , vol.43 , pp. 1244-1256
    • Danning, C.L.1    Illei, G.G.2    Hitchon, C.3    Greer, M.R.4    Boumpas, D.T.5    McInnes, J.B.6
  • 18
    • 0030907182 scopus 로고    scopus 로고
    • The effect of dexamethasone on the expression of activated NF-kappa B in adjuvant arthritis
    • Tsao PW, Suzuki T, Totsuka R et al. The effect of dexamethasone on the expression of activated NF-kappa B in adjuvant arthritis. Clin Immunol. Immunopathol 1997;83:173-8.
    • (1997) Clin Immunol. Immunopathol , vol.83 , pp. 173-178
    • Tsao, P.W.1    Suzuki, T.2    Totsuka, R.3
  • 19
    • 0032428729 scopus 로고    scopus 로고
    • AP-1 and NF-kappaB regulation in rheumatoid arthritis and murine collagen-induced arthritis
    • Han Z, Boyle DL, Manning AM, Firestein GS, AP-1 and NF-kappaB regulation in rheumatoid arthritis and murine collagen-induced arthritis. Autoimmunity 1998;28:197-208.
    • (1998) Autoimmunity , vol.28 , pp. 197-208
    • Han, Z.1    Boyle, D.L.2    Manning, A.M.3    Firestein, G.S.4
  • 20
    • 0033917674 scopus 로고    scopus 로고
    • Distinct roles for the NF-kappaB1 (p50) and c-Rel transcription factors in inflammatory arthritis
    • Campbell IK, Gerondakis S, O'Donnell K, Wicks IP. Distinct roles for the NF-kappaB1 (p50) and c-Rel transcription factors in inflammatory arthritis. J Clin Invest 2000;105:1799-806.
    • (2000) J Clin Invest , vol.105 , pp. 1799-1806
    • Campbell, I.K.1    Gerondakis, S.2    O'Donnell, K.3    Wicks, I.P.4
  • 21
    • 17844386319 scopus 로고    scopus 로고
    • IKKalpha limits macrophage NF-kappaB activation and contributes to the resolution of inflammation
    • Lawrence T, Bebien M, Liu GY, Nizet V, Karin M. IKKalpha limits macrophage NF-kappaB activation and contributes to the resolution of inflammation. Nature 2005,434:1138-43.
    • (2005) Nature , vol.434 , pp. 1138-1143
    • Lawrence, T.1    Bebien, M.2    Liu, G.Y.3    Nizet, V.4    Karin, M.5
  • 22
    • 0032568792 scopus 로고    scopus 로고
    • Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation
    • Yamaoka S, Courtois G, Bessie C et al. Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation. Cell 1998;93:1231-40.
    • (1998) Cell , vol.93 , pp. 1231-1240
    • Yamaoka, S.1    Courtois, G.2    Bessie, C.3
  • 23
    • 0032541657 scopus 로고    scopus 로고
    • IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex
    • Rothwarf DM, Zandi E, Natoli G, Karin M. IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex. Nature 1998;395:297-300.
    • (1998) Nature , vol.395 , pp. 297-300
    • Rothwarf, D.M.1    Zandi, E.2    Natoli, G.3    Karin, M.4
  • 24
    • 24944586285 scopus 로고    scopus 로고
    • Achieving stability of lipopolysaccharide-induced NF-kappaB activation
    • Covert MW, Leung TH, Gaston JE, Baltimore D. Achieving stability of lipopolysaccharide-induced NF-kappaB activation. Science 2005;309:1854-7.
    • (2005) Science , vol.309 , pp. 1854-1857
    • Covert, M.W.1    Leung, T.H.2    Gaston, J.E.3    Baltimore, D.4
  • 25
    • 33747388013 scopus 로고    scopus 로고
    • IkappaBepsilon provides negative feedback to control NF-kpppaB oscillations, signaling dynamics, and inflammatory gene expression
    • Kearns JD, Basak S, Werner SL, Huang CS, Hoffmann A. IkappaBepsilon provides negative feedback to control NF-kpppaB oscillations, signaling dynamics, and inflammatory gene expression, J Cell Biol 2006;173:659-64.
    • (2006) J Cell Biol , vol.173 , pp. 659-664
    • Kearns, J.D.1    Basak, S.2    Werner, S.L.3    Huang, C.S.4    Hoffmann, A.5
  • 26
    • 33749152085 scopus 로고    scopus 로고
    • Toll-like receptors: From the discovery of NFkappaB to new insights into transcriptional regulations in innate immunity
    • Doyle SL, O'Neill LA. Toll-like receptors: From the discovery of NFkappaB to new insights into transcriptional regulations in innate immunity. Biochem Pharmacol 2006;72:1102-13.
    • (2006) Biochem Pharmacol , vol.72 , pp. 1102-1113
    • Doyle, S.L.1    O'Neill, L.A.2
  • 27
    • 0034459681 scopus 로고    scopus 로고
    • Functional, consequences of a polymorphism affecting NF-kappaB p50-p50 binding to the TNF promoter region
    • Udalova IA, Richardson A, Denys A et al. Functional, consequences of a polymorphism affecting NF-kappaB p50-p50 binding to the TNF promoter region. Mol Cell Biol 2000;20:9113-9.
    • (2000) Mol Cell Biol , vol.20 , pp. 9113-9119
    • Udalova, I.A.1    Richardson, A.2    Denys, A.3
  • 28
    • 0036312203 scopus 로고    scopus 로고
    • Association of accelerated erosive rheumatoid arthritis with a polymorphism that alters NF-kappaB binding to the TNF promoter region
    • Udalova IA, Richardson A, Ackerman H, Wordsworth P, Kwiatkowski D. Association of accelerated erosive rheumatoid arthritis with a polymorphism that alters NF-kappaB binding to the TNF promoter region. Rheumatology 2002;41:830-1.
    • (2002) Rheumatology , vol.41 , pp. 830-831
    • Udalova, I.A.1    Richardson, A.2    Ackerman, H.3    Wordsworth, P.4    Kwiatkowski, D.5
  • 30
    • 0033596123 scopus 로고    scopus 로고
    • Genetic approaches in mice to understand Rel/NF-kappaB and IkappaB function: Transgenics and knockouts
    • Gerondakis S, Grossmann M, Nakamura Y, Pohl T, Grumont R. Genetic approaches in mice to understand Rel/NF-kappaB and IkappaB function: transgenics and knockouts. Oncogene 1999;18:6888-95.
    • (1999) Oncogene , vol.18 , pp. 6888-6895
    • Gerondakis, S.1    Grossmann, M.2    Nakamura, Y.3    Pohl, T.4    Grumont, R.5
  • 31
    • 33750467991 scopus 로고    scopus 로고
    • Unravelling the complexities of the NF-kappaB signalling pathway using mouse knockout and transgenic models
    • Gerondakis S, Grumont R, Gugasyan R et al. Unravelling the complexities of the NF-kappaB signalling pathway using mouse knockout and transgenic models. Oncogene 2006;25:6781-99.
    • (2006) Oncogene , vol.25 , pp. 6781-6799
    • Gerondakis, S.1    Grumont, R.2    Gugasyan, R.3
  • 32
    • 33646001448 scopus 로고    scopus 로고
    • Dissection of the NF-kappaB signalling cascade in transgenic and knockout mice
    • Pasparakis M, Luedde T, Schmidt-Supprian M. Dissection of the NF-kappaB signalling cascade in transgenic and knockout mice. Cell Death Differ 2006;13:861-72.
    • (2006) Cell Death Differ , vol.13 , pp. 861-872
    • Pasparakis, M.1    Luedde, T.2    Schmidt-Supprian, M.3
  • 33
    • 0032555927 scopus 로고    scopus 로고
    • Functional redundancy of the nuclear factor kappa B inhibitors I kappa B alpha and I kappa B beta
    • Cheng JD, Ryseck RP, Attar RM, Dambach D, Bravo R. Functional redundancy of the nuclear factor kappa B inhibitors I kappa B alpha and I kappa B beta. J Exp Med 1998;188:1055-62.
    • (1998) J Exp Med , vol.188 , pp. 1055-1062
    • Cheng, J.D.1    Ryseck, R.P.2    Attar, R.M.3    Dambach, D.4    Bravo, R.5
  • 34
    • 0036826910 scopus 로고    scopus 로고
    • Functions of IkappaB proteins in inflammatory responses to Escherichia coli LPS in mouse lungs
    • Mizgerd JP, Scott ML, Spieker MR, Doerschuk CM. Functions of IkappaB proteins in inflammatory responses to Escherichia coli LPS in mouse lungs. Am J Respir Cell Mol Biol 2002;27:575-82.
    • (2002) Am J Respir Cell Mol Biol , vol.27 , pp. 575-582
    • Mizgerd, J.P.1    Scott, M.L.2    Spieker, M.R.3    Doerschuk, C.M.4
  • 35
    • 0035424999 scopus 로고    scopus 로고
    • Targeted mutation of TNF receptor I rescues the RelA-deficient mouse and reveals a critical role for NF-kappa B in leukocyte recruitment
    • Alcamo E, Mizgerd JP, Horwitz BH et al. Targeted mutation of TNF receptor I rescues the RelA-deficient mouse and reveals a critical role for NF-kappa B in leukocyte recruitment. J Immunol 2001;167:1592-600.
    • (2001) J Immunol , vol.167 , pp. 1592-1600
    • Alcamo, E.1    Mizgerd, J.P.2    Horwitz, B.H.3
  • 37
    • 0033537739 scopus 로고    scopus 로고
    • Severe liver degeneration in mice lacking the IkappaB kinase-2 gene
    • Li Q, Van Antwerp D, Mercurio F, Lee KF, Verma IM. Severe liver degeneration in mice lacking the IkappaB kinase-2 gene. Science 1999;284:321-5.
    • (1999) Science , vol.284 , pp. 321-325
    • Li, Q.1    Van Antwerp, D.2    Mercurio, F.3    Lee, K.F.4    Verma, I.M.5
  • 38
    • 33746760161 scopus 로고    scopus 로고
    • Pathogenic role for skin macrophages in a mouse model of keratinocyte-induced psoriasis-like skin inflammation
    • Stratis A, Pasparakis M, Rupec RA et al. Pathogenic role for skin macrophages in a mouse model of keratinocyte-induced psoriasis-like skin inflammation, J Clin Invest 2006;116:2094-104.
    • (2006) J Clin Invest , vol.116 , pp. 2094-2104
    • Stratis, A.1    Pasparakis, M.2    Rupec, R.A.3
  • 39
    • 0037142027 scopus 로고    scopus 로고
    • TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2
    • Pasparakis M, Courtois G, Hafner M et al. TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2. Nature 2002;417:861-6.
    • (2002) Nature , vol.417 , pp. 861-866
    • Pasparakis, M.1    Courtois, G.2    Hafner, M.3
  • 40
    • 33947573767 scopus 로고    scopus 로고
    • Epithelial-cell-intrinsic IKK-beta expression regulates intestinal immune homeostasis
    • Zaph C, Troy AE, Taylor BC et al. Epithelial-cell-intrinsic IKK-beta expression regulates intestinal immune homeostasis. Nature 2007;446:552-6.
    • (2007) Nature , vol.446 , pp. 552-556
    • Zaph, C.1    Troy, A.E.2    Taylor, B.C.3
  • 41
    • 34047173496 scopus 로고    scopus 로고
    • Epithelial NEMO links innate immunity to chronic intestinal inflammation
    • Nenci A, Becker C, Wullaert A et al. Epithelial NEMO links innate immunity to chronic intestinal inflammation. Nature 2007;446:557-61.
    • (2007) Nature , vol.446 , pp. 557-561
    • Nenci, A.1    Becker, C.2    Wullaert, A.3
  • 42
    • 0038575364 scopus 로고    scopus 로고
    • Heterogeneous requirement of IkappaB kinase 2 for inflammatory cytokine and matrix metalloproteinase production in rheumatoid arthritis: Implications for therapy
    • Andreakos E, Smith C, Kiriakidis S et al. Heterogeneous requirement of IkappaB kinase 2 for inflammatory cytokine and matrix metalloproteinase production in rheumatoid arthritis: Implications for therapy. Arthritis Rheum 2003;48:1901-12.
    • (2003) Arthritis Rheum , vol.48 , pp. 1901-1912
    • Andreakos, E.1    Smith, C.2    Kiriakidis, S.3
  • 43
    • 0033104615 scopus 로고    scopus 로고
    • Selective regulation of cytokine induction by adenoviral gene transfer of IkappaBalpha into human macrophages: Lipopolysaccharide-induced, but not zymosan-induced, proinflammatory cytokines are inhibited, but IL-10 is nuclear factor-kappaB independent
    • Bondeson J, Browne KA, Brennan FM, Foxwell BM, Feldmann M. Selective regulation of cytokine induction by adenoviral gene transfer of IkappaBalpha into human macrophages: Lipopolysaccharide-induced, but not zymosan-induced, proinflammatory cytokines are inhibited, but IL-10 is nuclear factor-kappaB independent. J Immunol 1999;162:2939-45.
    • (1999) J Immunol , vol.162 , pp. 2939-2945
    • Bondeson, J.1    Browne, K.A.2    Brennan, F.M.3    Foxwell, B.M.4    Feldmann, M.5
  • 44
    • 33745852665 scopus 로고    scopus 로고
    • Alternative pathways of NF-kappaB activation: A double-edged sword in health and disease
    • Xiao G, Rabson AB, Young W, Qing G, Qu Z. Alternative pathways of NF-kappaB activation: A double-edged sword in health and disease. Cytokine Growth Factor Rev 2006;17:281-93.
    • (2006) Cytokine Growth Factor Rev , vol.17 , pp. 281-293
    • Xiao, G.1    Rabson, A.B.2    Young, W.3    Qing, G.4    Qu, Z.5
  • 45
    • 33846323310 scopus 로고    scopus 로고
    • A fourth IkappaB protein within the NF-kappaB signaling module
    • Basak S, Kim H, Kearns JD et al. A fourth IkappaB protein within the NF-kappaB signaling module. Cell 2007;128:369-81.
    • (2007) Cell , vol.128 , pp. 369-381
    • Basak, S.1    Kim, H.2    Kearns, J.D.3
  • 46
    • 0035889229 scopus 로고    scopus 로고
    • NF-kappaB-inducing kinase is dispensable for activation of NF-kappaB in inflammatory settings but essential for lymphotoxin beta receptor activation of NF-kappaB in primary human fibroblasts
    • Smith C, Andreakos E, Crawley JB, Brennan FM, Feldmann M, Foxwell BM. NF-kappaB-inducing kinase is dispensable for activation of NF-kappaB in inflammatory settings but essential for lymphotoxin beta receptor activation of NF-kappaB in primary human fibroblasts. J Immunol 2001;167:5895-903.
    • (2001) J Immunol , vol.167 , pp. 5895-5903
    • Smith, C.1    Andreakos, E.2    Crawley, J.B.3    Brennan, F.M.4    Feldmann, M.5    Foxwell, B.M.6
  • 47
    • 0027446955 scopus 로고
    • The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers
    • Bours V, Franzoso G, Azarenko V et al. The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers. Cell 1993;72:729-39.
    • (1993) Cell , vol.72 , pp. 729-739
    • Bours, V.1    Franzoso, G.2    Azarenko, V.3
  • 48
    • 14844293877 scopus 로고    scopus 로고
    • Positive and negative regulation of nuclear factor-kappaB-mediated transcription by IkappaB-zeta, an inducible nuclear protein
    • Motoyama M, Yamazaki S, Eto-Kimura A, Takeshige K, Muta T. Positive and negative regulation of nuclear factor-kappaB-mediated transcription by IkappaB-zeta, an inducible nuclear protein. J Biol Chem 2005;280:7444-51.
    • (2005) J Biol Chem , vol.280 , pp. 7444-7451
    • Motoyama, M.1    Yamazaki, S.2    Eto-Kimura, A.3    Takeshige, K.4    Muta, T.5
  • 49
    • 12544255812 scopus 로고    scopus 로고
    • Stimulus-specific induction of a novel nuclear factor-kappaB regulator, IkappaB-zeta, via Toll/ Interleukin-1 receptor is mediated by mRNA stabilization
    • Yamazaki S, Muta T, Matsuo S, Takeshige K. Stimulus-specific induction of a novel nuclear factor-kappaB regulator, IkappaB-zeta, via Toll/ Interleukin-1 receptor is mediated by mRNA stabilization. J Biol Chem 2005;280:1678-87.
    • (2005) J Biol Chem , vol.280 , pp. 1678-1687
    • Yamazaki, S.1    Muta, T.2    Matsuo, S.3    Takeshige, K.4
  • 50
    • 14844344042 scopus 로고    scopus 로고
    • The nuclear IkappaB protein IkappaBNS selectively inhibits lipopolysaccharide-induced IL-6 production in macrophages of the colonic lamina propria
    • Hirotani T, Lee PY, Kuwata H et al. The nuclear IkappaB protein IkappaBNS selectively inhibits lipopolysaccharide-induced IL-6 production in macrophages of the colonic lamina propria. J Immunol 2005;174:3650-7.
    • (2005) J Immunol , vol.174 , pp. 3650-3657
    • Hirotani, T.1    Lee, P.Y.2    Kuwata, H.3
  • 51
    • 30444456370 scopus 로고    scopus 로고
    • IkappaBNS inhibits induction of a subset of Toll-like receptor-dependent genes and limits inflammation
    • Kuwata H, Matsumoto M, Atarashi K et al. IkappaBNS inhibits induction of a subset of Toll-like receptor-dependent genes and limits inflammation. Immunity 2006;24:41-51.
    • (2006) Immunity , vol.24 , pp. 41-51
    • Kuwata, H.1    Matsumoto, M.2    Atarashi, K.3
  • 52
    • 9644268197 scopus 로고    scopus 로고
    • BCL-3 and NF-kappaB p50 attenuate lipopolysaccharide-induced inflammatory responses in macrophages
    • Wessells J, Baer M, Young HA et al. BCL-3 and NF-kappaB p50 attenuate lipopolysaccharide-induced inflammatory responses in macrophages. J Biol Chem 2004;279:49995-50003.
    • (2004) J Biol Chem , vol.279 , pp. 49995-50003
    • Wessells, J.1    Baer, M.2    Young, H.A.3
  • 53
    • 0242433137 scopus 로고    scopus 로고
    • IL-10-inducible Bcl-3 negatively regulates LPS-induced TNF-alpha production in macrophages
    • Kuwata H, Watanabe Y, Miyoshi H et al. IL-10-inducible Bcl-3 negatively regulates LPS-induced TNF-alpha production in macrophages. Blood 2003;102:4123-9.
    • (2003) Blood , vol.102 , pp. 4123-4129
    • Kuwata, H.1    Watanabe, Y.2    Miyoshi, H.3
  • 54
    • 0027175501 scopus 로고
    • The bcl-3 proto-oncogene encodes a nuclear I kappa B-like molecule that preferentially interacts with NF-kappa B p50 and p52 in a phosphorylation-dependent manner
    • Nolan GP, Fujita T, Bhatia K et al. The bcl-3 proto-oncogene encodes a nuclear I kappa B-like molecule that preferentially interacts with NF-kappa B p50 and p52 in a phosphorylation-dependent manner. Mol Cell Biol 1993;13:3557-66.
    • (1993) Mol Cell Biol , vol.13 , pp. 3557-3566
    • Nolan, G.P.1    Fujita, T.2    Bhatia, K.3
  • 55
    • 0027222103 scopus 로고
    • The oncoprotein Bcl-3 can facilitate NF-kappa B-mediated transactivation by removing inhibiting p50 homodimers from select kappa B sites
    • Franzoso G, Bours V, Azarenko V et al. The oncoprotein Bcl-3 can facilitate NF-kappa B-mediated transactivation by removing inhibiting p50 homodimers from select kappa B sites. EMBO J 1993;12:3893-901.
    • (1993) EMBO J , vol.12 , pp. 3893-3901
    • Franzoso, G.1    Bours, V.2    Azarenko, V.3
  • 56
    • 0028216491 scopus 로고
    • BCL3 encodes a nuclear protein which can alter the subcellular location of NF-kappa B proteins
    • Zhang Q, Didonato JA, Karin M, McKeithan TW. BCL3 encodes a nuclear protein which can alter the subcellular location of NF-kappa B proteins. Mol Cell Biol 1994;14:3915-26.
    • (1994) Mol Cell Biol , vol.14 , pp. 3915-3926
    • Zhang, Q.1    Didonato, J.A.2    Karin, M.3    McKeithan, T.W.4
  • 57
    • 3142581432 scopus 로고    scopus 로고
    • Regulation of Toll/ IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta
    • Yamamoto M, Yamazaki S, Uematsu S et al. Regulation of Toll/ IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta. Nature 2004;430:218-22.
    • (2004) Nature , vol.430 , pp. 218-222
    • Yamamoto, M.1    Yamazaki, S.2    Uematsu, S.3
  • 58
    • 33845768987 scopus 로고    scopus 로고
    • Integrating cell-signalling pathways with NF-kappaB and IKK function
    • Perkins ND. Integrating cell-signalling pathways with NF-kappaB and IKK function. Nat Rev Mol Cell Biol 2007;8:49-62.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 49-62
    • Perkins, N.D.1
  • 59
    • 33745077384 scopus 로고    scopus 로고
    • Immunobiology of toll-like receptors: Emerging trends
    • Pandey S, Agrawal DK. Immunobiology of toll-like receptors: Emerging trends. Immunol Cell Biol 2006;84:333-41.
    • (2006) Immunol Cell Biol , vol.84 , pp. 333-341
    • Pandey, S.1    Agrawal, D.K.2
  • 60
    • 1542373649 scopus 로고    scopus 로고
    • Distinct pathways of LPS-induced NF-kappa B activation and cytokine production in human myeloid and nonmyeloid cells defined by selective utilization of MyD88 and Mal/TIRAP
    • Andreakos E, Sacre SM, Smith C et al. Distinct pathways of LPS-induced NF-kappa B activation and cytokine production in human myeloid and nonmyeloid cells defined by selective utilization of MyD88 and Mal/TIRAP. Blood 2004;103:2229-37.
    • (2004) Blood , vol.103 , pp. 2229-2237
    • Andreakos, E.1    Sacre, S.M.2    Smith, C.3
  • 61
    • 33846932789 scopus 로고    scopus 로고
    • Selective use of TRAM in lipopolysaccharide (LPS) and lipoteichoic acid (LTA) induced NF-kappaB activation and cytokine production in primary human cells: TRAM is an adaptor for LPS and LTA signaling
    • Sacre SM, Lundberg AM, Andreakos E, Taylor C, Feldmann M, Foxwell BM. Selective use of TRAM in lipopolysaccharide (LPS) and lipoteichoic acid (LTA) induced NF-kappaB activation and cytokine production in primary human cells: TRAM is an adaptor for LPS and LTA signaling, J Immunol 2007;178:2148-54.
    • (2007) J Immunol , vol.178 , pp. 2148-2154
    • Sacre, S.M.1    Lundberg, A.M.2    Andreakos, E.3    Taylor, C.4    Feldmann, M.5    Foxwell, B.M.6
  • 62
    • 0034040746 scopus 로고    scopus 로고
    • Presence of bacterial DNA and bacterial peptidoglycans in joints of patients with rheumatoid arthritis and other arthritides
    • van der Heijden IM, Wilbrink B, Tchetverikov I et al. Presence of bacterial DNA and bacterial peptidoglycans in joints of patients with rheumatoid arthritis and other arthritides. Arthritis Rheum 2000;43:593-8.
    • (2000) Arthritis Rheum , vol.43 , pp. 593-598
    • van der Heijden, I.M.1    Wilbrink, B.2    Tchetverikov, I.3
  • 63
    • 33746731651 scopus 로고    scopus 로고
    • HMGB1 signals through toll-like receptor (TLR) 4 and TLR2
    • Yu M, Wang H, Ding A et al. HMGB1 signals through toll-like receptor (TLR) 4 and TLR2. Shock 2006;26:174-9.
    • (2006) Shock , vol.26 , pp. 174-179
    • Yu, M.1    Wang, H.2    Ding, A.3
  • 64
    • 0030461023 scopus 로고    scopus 로고
    • Expression of heat shock protein on lymphocytes in peripheral blood and synovial fluid from patients with rheumatoid arthritis
    • Sato H, Miyata M, Kasukawa R. Expression of heat shock protein on lymphocytes in peripheral blood and synovial fluid from patients with rheumatoid arthritis. J Rheumatol 1996;23:2027-32.
    • (1996) J Rheumatol , vol.23 , pp. 2027-2032
    • Sato, H.1    Miyata, M.2    Kasukawa, R.3
  • 65
    • 0034650427 scopus 로고    scopus 로고
    • Cutting edge: Heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex
    • Ohashi K, Burkart V, Flohe S, Kolb H. Cutting edge: Heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex. J Immunol 2000;164:550-61.
    • (2000) J Immunol , vol.164 , pp. 550-561
    • Ohashi, K.1    Burkart, V.2    Flohe, S.3    Kolb, H.4
  • 66
    • 33646882893 scopus 로고    scopus 로고
    • Ideniffication of small heat shock protein B8 (HSP22) as a novel TLR4 ligand and potential involvement in the pathogenesis of rheumatoid arthritis
    • Roelofs MF, Boolens WC, Joosten LA et al. Ideniffication of small heat shock protein B8 (HSP22) as a novel TLR4 ligand and potential involvement in the pathogenesis of rheumatoid arthritis. J Immunol 2006; 176:7021-7.
    • (2006) J Immunol , vol.176 , pp. 7021-7027
    • Roelofs, M.F.1    Boolens, W.C.2    Joosten, L.A.3
  • 67
    • 0035971217 scopus 로고    scopus 로고
    • The extra domain A of fibronectin activates toll-like receptor 4
    • Okamura Y, Watari M, Jerud ES et al. The extra domain A of fibronectin activates toll-like receptor 4. J Biol Chem 2001;276:10229-33.
    • (2001) J Biol Chem , vol.276 , pp. 10229-10233
    • Okamura, Y.1    Watari, M.2    Jerud, E.S.3
  • 68
    • 0037033364 scopus 로고    scopus 로고
    • Oligosaccharides of hyaluronan activate dendritic cells via toll-like receptor 4
    • Termeer C, Benedix F, Sleeman J et al. Oligosaccharides of hyaluronan activate dendritic cells via toll-like receptor 4. J Exp Med 2002;195:99-111.
    • (2002) J Exp Med , vol.195 , pp. 99-111
    • Termeer, C.1    Benedix, F.2    Sleeman, J.3
  • 69
    • 0037378466 scopus 로고    scopus 로고
    • Expression and regulation of Toll-like receptor 2 in rheumatoid arthritis synovium
    • Seibl R, Birchler T, Loeliger S et al. Expression and regulation of Toll-like receptor 2 in rheumatoid arthritis synovium. Am J Pathol 2003;162:1221-7.
    • (2003) Am J Pathol , vol.162 , pp. 1221-1227
    • Seibl, R.1    Birchler, T.2    Loeliger, S.3
  • 70
    • 2342604896 scopus 로고    scopus 로고
    • Expression of toll-like receptor 2 on CD16+ blood monocytes and synovial tissue macrophages in rheumatoid arthritis
    • Iwahashi M, Yamamura M, Aita T et al. Expression of toll-like receptor 2 on CD16+ blood monocytes and synovial tissue macrophages in rheumatoid arthritis. Arthritis Rheum 2004;50:1457-67.
    • (2004) Arthritis Rheum , vol.50 , pp. 1457-1467
    • Iwahashi, M.1    Yamamura, M.2    Aita, T.3
  • 71
    • 10444278132 scopus 로고    scopus 로고
    • Expression of toll-like receptors 2 and 4 in rheumatoid synovial tissue and regulation by proinflammatory cytokines interleukin-12 and interleukin-18 via interferon-gamma
    • Radstake TR, Roelofs MF, Jenniskens YM et al. Expression of toll-like receptors 2 and 4 in rheumatoid synovial tissue and regulation by proinflammatory cytokines interleukin-12 and interleukin-18 via interferon-gamma. Arthritis Rheum 2004; 50:3856-65.
    • (2004) Arthritis Rheum , vol.50 , pp. 3856-3865
    • Radstake, T.R.1    Roelofs, M.F.2    Jenniskens, Y.M.3
  • 72
    • 25444443335 scopus 로고    scopus 로고
    • RNA released from necrotic synovial fluid cells activates rheumatoid arthritis synovial fibroblasts via toll-like receptor 3
    • Brentano F, Schorr O, Gay RE, Gay S, Kyburz D. RNA released from necrotic synovial fluid cells activates rheumatoid arthritis synovial fibroblasts via toll-like receptor 3. Arthritis Rheum 2005;52:2656-65.
    • (2005) Arthritis Rheum , vol.52 , pp. 2656-2665
    • Brentano, F.1    Schorr, O.2    Gay, R.E.3    Gay, S.4    Kyburz, D.5
  • 73
    • 23644449245 scopus 로고    scopus 로고
    • The expression of toll-like receptors 3 and 7 in rheumatoid arthritis synovium is increased and costimulation of toll-like receptors 3, 4, and 7/8 results in synergistic cytokine production by dendritic cells
    • Roelofs MF, Joosten LA, Abdollahi-Roodsaz S et al. The expression of toll-like receptors 3 and 7 in rheumatoid arthritis synovium is increased and costimulation of toll-like receptors 3, 4, and 7/8 results in synergistic cytokine production by dendritic cells. Arthritis Rheum 2005;52:2313-22.
    • (2005) Arthritis Rheum , vol.52 , pp. 2313-2322
    • Roelofs, M.F.1    Joosten, L.A.2    Abdollahi-Roodsaz, S.3
  • 74
    • 0036164274 scopus 로고    scopus 로고
    • Evidence that rheumatoid arthritis synovial T cells are similar to cytokine-activated T cells: Involvement of phosphatidylinositol 3-kinase and nuclear factor kappaB pathways in tumor necrosis factor alpha production in rheumatoid arthritis
    • Brennan FM, Hayes AL, Ciesielski CJ, Green P, Foxwell BM, Feldmann M. Evidence that rheumatoid arthritis synovial T cells are similar to cytokine-activated T cells: Involvement of phosphatidylinositol 3-kinase and nuclear factor kappaB pathways in tumor necrosis factor alpha production in rheumatoid arthritis. Arthritis Rheum 2002;46:31-41.
    • (2002) Arthritis Rheum , vol.46 , pp. 31-41
    • Brennan, F.M.1    Hayes, A.L.2    Ciesielski, C.J.3    Green, P.4    Foxwell, B.M.5    Feldmann, M.6
  • 75
    • 35148817450 scopus 로고    scopus 로고
    • T-cell contact-dependent regulation of CC and CXC chemokine production in monocytes through differential involvement of NFkappaB: Implications for rheumatoid arthritis
    • Beech JT, Andreakos E, Ciesielski CJ, Green P, Foxwell BM, Brennan FM. T-cell contact-dependent regulation of CC and CXC chemokine production in monocytes through differential involvement of NFkappaB: Implications for rheumatoid arthritis. Arthritis Res Ther 2006;8:R168.
    • (2006) Arthritis Res Ther , vol.8
    • Beech, J.T.1    Andreakos, E.2    Ciesielski, C.J.3    Green, P.4    Foxwell, B.M.5    Brennan, F.M.6
  • 76
    • 35648992652 scopus 로고    scopus 로고
    • Key differences in TLR3/ poly I:C signaling and cytokine induction by human pAimary cells: A phenomenon absent from murine cell systems
    • Lundberg AM, Drexler SK, Monaco C et al. Key differences in TLR3/ poly I:C signaling and cytokine induction by human pAimary cells: a phenomenon absent from murine cell systems. Blood 2007;110:3245-52.
    • (2007) Blood , vol.110 , pp. 3245-3252
    • Lundberg, A.M.1    Drexler, S.K.2    Monaco, C.3
  • 77
  • 78
    • 0031017618 scopus 로고    scopus 로고
    • MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1
    • Malinin NL, Boldin MP, Kovalenko AV, Wallach D. MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1. Nature 1997;385:540-4.
    • (1997) Nature , vol.385 , pp. 540-544
    • Malinin, N.L.1    Boldin, M.P.2    Kovalenko, A.V.3    Wallach, D.4
  • 79
    • 0032930861 scopus 로고    scopus 로고
    • Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-kappa b-inducing kinase
    • Shinkura R, Kitada K, Matsuda F et al. Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-kappa b-inducing kinase. Nat Genet 1999;22:74-7.
    • (1999) Nat Genet , vol.22 , pp. 74-77
    • Shinkura, R.1    Kitada, K.2    Matsuda, F.3
  • 80
    • 0035896422 scopus 로고    scopus 로고
    • Defective lymphotaxin-beta receptor-induced NF-kappaB transcriptional activity in NIK-deficient mice
    • Yin L, Wu L, Wesche H et al. Defective lymphotaxin-beta receptor-induced NF-kappaB transcriptional activity in NIK-deficient mice. Science 2001;291;2162-5.
    • (2001) Science , vol.291 , pp. 2162-2165
    • Yin, L.1    Wu, L.2    Wesche, H.3
  • 82
    • 0346505340 scopus 로고    scopus 로고
    • The IKK NF-kappa B system: A treasure trove for drug development
    • Karin M, Yamamoto Y, Wang QM. The IKK NF-kappa B system: A treasure trove for drug development. Nat Rev Drug Discov 2004;3:17-26.
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 17-26
    • Karin, M.1    Yamamoto, Y.2    Wang, Q.M.3
  • 84
    • 34250330786 scopus 로고    scopus 로고
    • The discovery of 2-amino-3,5- diarylbenzamide inhibitors of IKK-alpha and IKK-beta kinases
    • Christopher JA, Avitabile BG, Bamborough P et al. The discovery of 2-amino-3,5- diarylbenzamide inhibitors of IKK-alpha and IKK-beta kinases. Bioorg Med Chem Lett 2007; 17:3972-7.
    • (2007) Bioorg Med Chem Lett , vol.17 , pp. 3972-3977
    • Christopher, J.A.1    Avitabile, B.G.2    Bamborough, P.3
  • 85
    • 34347394507 scopus 로고    scopus 로고
    • Synthesis and structure-activity relationship of imidazo(1,2-a)thieno(3,2-e)pyrazines as IKK-beta inhibitors
    • Belema M, Bunker A, Nguyen VN et al. Synthesis and structure-activity relationship of imidazo(1,2-a)thieno(3,2-e)pyrazines as IKK-beta inhibitors. Bioorg Med Chem Lett 2007;17:4284-9.
    • (2007) Bioorg Med Chem Lett , vol.17 , pp. 4284-4289
    • Belema, M.1    Bunker, A.2    Nguyen, V.N.3
  • 86
    • 21144447164 scopus 로고    scopus 로고
    • Inhibition of IKK-2 by 2-[(aminocarbonyl) amino]-5-acetylenyl-3-thiophenecarboxamides
    • Bonafoux D, Bonar S, Christine L et al. Inhibition of IKK-2 by 2-[(aminocarbonyl) amino]-5-acetylenyl-3-thiophenecarboxamides. Bioorg Med Chem Lett 2009;15:2870-5.
    • (2009) Bioorg Med Chem Lett , vol.15 , pp. 2870-2875
    • Bonafoux, D.1    Bonar, S.2    Christine, L.3
  • 87
    • 11844305963 scopus 로고    scopus 로고
    • Attenuation of murine collagen-induced arthritis by a novel, potent, selective small molecule inhibitor of IkappaB Kinase 2, TPCA-1 (2-[(aminocarbonyl) amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide), occurs via reduction of proinflammatory cytokines and antigen-induced T cell proliferation
    • Podolin PL, Callahan JF, Bolognese BJ et al. Attenuation of murine collagen-induced arthritis by a novel, potent, selective small molecule inhibitor of IkappaB Kinase 2, TPCA-1 (2-[(aminocarbonyl) amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide), occurs via reduction of proinflammatory cytokines and antigen-induced T cell proliferation. J Pharmacol Exp Ther 2005;312:373-81.
    • (2005) J Pharmacol Exp Ther , vol.312 , pp. 373-381
    • Podolin, P.L.1    Callahan, J.F.2    Bolognese, B.J.3
  • 88
    • 0141676361 scopus 로고    scopus 로고
    • A highly selective inhibitor of I kappa B kinase, BMS-345541, blocks both joint inflammation and destruction in collagen-induced arthritis in mice
    • McIntyre KW, Shuster DJ, Gillooly KM et al. A highly selective inhibitor of I kappa B kinase, BMS-345541, blocks both joint inflammation and destruction in collagen-induced arthritis in mice. Arthritis Rheum 2003;48:2652-9.
    • (2003) Arthritis Rheum , vol.48 , pp. 2652-2659
    • McIntyre, K.W.1    Shuster, D.J.2    Gillooly, K.M.3
  • 89
    • 33846200742 scopus 로고    scopus 로고
    • Use of molecular imaging to quantify response to IKK-2 inhibitor treatment in murine arthritis
    • Izmailova ES, Paz N, Alencar H et al. Use of molecular imaging to quantify response to IKK-2 inhibitor treatment in murine arthritis. Arthritis Rheum 2007;56:117-28.
    • (2007) Arthritis Rheum , vol.56 , pp. 117-128
    • Izmailova, E.S.1    Paz, N.2    Alencar, H.3
  • 90
    • 9144219693 scopus 로고    scopus 로고
    • An efficient proteomics method to identify the cellular targets of protein kinase inhibitors
    • Godl K, Wissing J, Kurtenbach A et al. An efficient proteomics method to identify the cellular targets of protein kinase inhibitors. Proc Natl Acad Sci USA 2003;100:15434-9.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 15434-15439
    • Godl, K.1    Wissing, J.2    Kurtenbach, A.3
  • 91
    • 33750577799 scopus 로고    scopus 로고
    • Amelioration of arthritis by intraarticular dominant negative Ikk beta gene therapy using adeno-associated virus type 5
    • Tas SW, Adriaansen J, Hajji N & et al. Amelioration of arthritis by intraarticular dominant negative Ikk beta gene therapy using adeno-associated virus type 5. Hum Gene Ther 2006;17:821-32.
    • (2006) Hum Gene Ther , vol.17 , pp. 821-832
    • Tas, S.W.1    Adriaansen, J.2    Hajji, N.3    & et, al.4
  • 92
    • 0035920176 scopus 로고    scopus 로고
    • A novel IkappaB protein, IkappaB-zeta, induced by proinflammatory stimuli negatively regulates nuclear factor-kappaB in the nuclei
    • Yamazaki S, Muta T, Takeshige K. A novel IkappaB protein, IkappaB-zeta, induced by proinflammatory stimuli negatively regulates nuclear factor-kappaB in the nuclei. J Biol Chem 2001;276:27657-62.
    • (2001) J Biol Chem , vol.276 , pp. 27657-27662
    • Yamazaki, S.1    Muta, T.2    Takeshige, K.3


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