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Volumn 19, Issue 10, 2013, Pages 604-613

Nuclear factor kappa B (NF-κB) in multiple sclerosis pathology

Author keywords

Cuprizone; Demyelination; Experimental autoimmune encephalomyelitis; Multiple sclerosis; NF B; Th17

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NONSTEROID ANTIINFLAMMATORY AGENT; PREDNISOLONE; TRANSCRIPTION FACTOR FOXP3;

EID: 84884753706     PISSN: 14714914     EISSN: 1471499X     Source Type: Journal    
DOI: 10.1016/j.molmed.2013.08.001     Document Type: Review
Times cited : (127)

References (124)
  • 1
    • 80051987703 scopus 로고    scopus 로고
    • Crosstalk in NF-kappaB signaling pathways
    • Oeckinghaus A., et al. Crosstalk in NF-kappaB signaling pathways. Nat. Immunol. 2011, 12:695-708.
    • (2011) Nat. Immunol. , vol.12 , pp. 695-708
    • Oeckinghaus, A.1
  • 4
    • 67349216357 scopus 로고    scopus 로고
    • Autoimmune T cell responses in the central nervous system
    • Goverman J. Autoimmune T cell responses in the central nervous system. Nat. Rev. Immunol. 2009, 9:393-407.
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 393-407
    • Goverman, J.1
  • 5
    • 84864446952 scopus 로고    scopus 로고
    • Animal models of multiple sclerosis: the good, the bad and the bottom line
    • Ransohoff R.M. Animal models of multiple sclerosis: the good, the bad and the bottom line. Nat. Neurosci. 2012, 15:1074-1077.
    • (2012) Nat. Neurosci. , vol.15 , pp. 1074-1077
    • Ransohoff, R.M.1
  • 6
    • 0031951041 scopus 로고    scopus 로고
    • Transcription factor NF-kappaB and inhibitor I kappaBalpha are localized in macrophages in active multiple sclerosis lesions
    • Gveric D., et al. Transcription factor NF-kappaB and inhibitor I kappaBalpha are localized in macrophages in active multiple sclerosis lesions. J. Neuropathol. Exp. Neurol. 1998, 57:168-178.
    • (1998) J. Neuropathol. Exp. Neurol. , vol.57 , pp. 168-178
    • Gveric, D.1
  • 7
    • 0032589563 scopus 로고    scopus 로고
    • Activation of NF-kappaB and c-jun transcription factors in multiple sclerosis lesions. Implications for oligodendrocyte pathology
    • Bonetti B., et al. Activation of NF-kappaB and c-jun transcription factors in multiple sclerosis lesions. Implications for oligodendrocyte pathology. Am. J. Pathol. 1999, 155:1433-1438.
    • (1999) Am. J. Pathol. , vol.155 , pp. 1433-1438
    • Bonetti, B.1
  • 8
    • 0036105484 scopus 로고    scopus 로고
    • Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis
    • Lock C., et al. Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis. Nat. Med. 2002, 8:500-508.
    • (2002) Nat. Med. , vol.8 , pp. 500-508
    • Lock, C.1
  • 9
    • 0242432319 scopus 로고    scopus 로고
    • CDNA microarray analysis in multiple sclerosis lesions: detection of genes associated with disease activity
    • Mycko M.P., et al. cDNA microarray analysis in multiple sclerosis lesions: detection of genes associated with disease activity. Brain 2003, 126:1048-1057.
    • (2003) Brain , vol.126 , pp. 1048-1057
    • Mycko, M.P.1
  • 10
    • 0032882174 scopus 로고    scopus 로고
    • Analysis of gene expression in mutiple sclerosis lesions using cDNA microarrays
    • Whitney L.W., et al. Analysis of gene expression in mutiple sclerosis lesions using cDNA microarrays. Ann. Neurol. 1999, 46:425-428.
    • (1999) Ann. Neurol. , vol.46 , pp. 425-428
    • Whitney, L.W.1
  • 11
    • 0036615454 scopus 로고    scopus 로고
    • Inhibitors in the NFkappaB cascade comprise prime candidate genes predisposing to multiple sclerosis, especially in selected combinations
    • Miterski B., et al. Inhibitors in the NFkappaB cascade comprise prime candidate genes predisposing to multiple sclerosis, especially in selected combinations. Genes Immun. 2002, 3:211-219.
    • (2002) Genes Immun. , vol.3 , pp. 211-219
    • Miterski, B.1
  • 12
    • 77952512771 scopus 로고    scopus 로고
    • Learning from nature: pregnancy changes the expression of inflammation-related genes in patients with multiple sclerosis
    • Gilli F., et al. Learning from nature: pregnancy changes the expression of inflammation-related genes in patients with multiple sclerosis. PLoS ONE 2010, 5:e8962.
    • (2010) PLoS ONE , vol.5
    • Gilli, F.1
  • 13
    • 67649876123 scopus 로고    scopus 로고
    • Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci
    • De Jager P.L., et al. Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. Nat. Genet. 2009, 41:776-782.
    • (2009) Nat. Genet. , vol.41 , pp. 776-782
    • De Jager, P.L.1
  • 14
    • 79960171362 scopus 로고    scopus 로고
    • Loss of braking signals during inflammation: a factor affecting the development and disease course of multiple sclerosis
    • Gilli F., et al. Loss of braking signals during inflammation: a factor affecting the development and disease course of multiple sclerosis. Arch. Neurol. 2011, 68:879-888.
    • (2011) Arch. Neurol. , vol.68 , pp. 879-888
    • Gilli, F.1
  • 15
    • 80051684615 scopus 로고    scopus 로고
    • Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
    • Sawcer S., et al. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature 2011, 476:214-219.
    • (2011) Nature , vol.476 , pp. 214-219
    • Sawcer, S.1
  • 16
    • 84865261493 scopus 로고    scopus 로고
    • TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis
    • Gregory A.P., et al. TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis. Nature 2012, 488:508-511.
    • (2012) Nature , vol.488 , pp. 508-511
    • Gregory, A.P.1
  • 17
    • 78651496815 scopus 로고    scopus 로고
    • Gene expression changes in multiple sclerosis relapse suggest activation of T and non-T cells
    • Lindsey J.W., et al. Gene expression changes in multiple sclerosis relapse suggest activation of T and non-T cells. Mol. Med. 2011, 17:95-102.
    • (2011) Mol. Med. , vol.17 , pp. 95-102
    • Lindsey, J.W.1
  • 18
    • 50249125248 scopus 로고    scopus 로고
    • Molecular network analysis of T-cell transcriptome suggests aberrant regulation of gene expression by NF-kappaB as a biomarker for relapse of multiple sclerosis
    • Satoh J., et al. Molecular network analysis of T-cell transcriptome suggests aberrant regulation of gene expression by NF-kappaB as a biomarker for relapse of multiple sclerosis. Dis. Markers 2008, 25:27-35.
    • (2008) Dis. Markers , vol.25 , pp. 27-35
    • Satoh, J.1
  • 19
    • 84858712873 scopus 로고    scopus 로고
    • NF-kappaB function in B lymphocytes
    • Kaileh M., Sen R. NF-kappaB function in B lymphocytes. Immunol. Rev. 2012, 246:254-271.
    • (2012) Immunol. Rev. , vol.246 , pp. 254-271
    • Kaileh, M.1    Sen, R.2
  • 20
    • 82955203797 scopus 로고    scopus 로고
    • B cells in multiple sclerosis: connecting the dots
    • von Budingen H.C., et al. B cells in multiple sclerosis: connecting the dots. Curr. Opin. Immunol. 2011, 23:713-720.
    • (2011) Curr. Opin. Immunol. , vol.23 , pp. 713-720
    • von Budingen, H.C.1
  • 21
    • 84868525833 scopus 로고    scopus 로고
    • B cells and antibodies in multiple sclerosis pathogenesis and therapy
    • Krumbholz M., et al. B cells and antibodies in multiple sclerosis pathogenesis and therapy. Nat. Rev. Neurol. 2012, 8:613-623.
    • (2012) Nat. Rev. Neurol. , vol.8 , pp. 613-623
    • Krumbholz, M.1
  • 22
    • 0036781052 scopus 로고    scopus 로고
    • NF-kappaB regulation in the immune system
    • Li Q., Verma I.M. NF-kappaB regulation in the immune system. Nat. Rev. Immunol. 2002, 2:725-734.
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 725-734
    • Li, Q.1    Verma, I.M.2
  • 23
    • 48249139449 scopus 로고    scopus 로고
    • Multiple sclerosis: an immune or neurodegenerative disorder?
    • Trapp B.D., Nave K.A. Multiple sclerosis: an immune or neurodegenerative disorder?. Annu. Rev. Neurosci. 2008, 31:247-269.
    • (2008) Annu. Rev. Neurosci. , vol.31 , pp. 247-269
    • Trapp, B.D.1    Nave, K.A.2
  • 24
    • 35549010987 scopus 로고    scopus 로고
    • The origin and application of experimental autoimmune encephalomyelitis
    • Baxter A.G. The origin and application of experimental autoimmune encephalomyelitis. Nat. Rev. Immunol. 2007, 7:904-912.
    • (2007) Nat. Rev. Immunol. , vol.7 , pp. 904-912
    • Baxter, A.G.1
  • 25
    • 0344406188 scopus 로고    scopus 로고
    • + T cells reveals an essential requirement for nuclear factor kappaB in regulating mature T cell survival and in vivo function
    • + T cells reveals an essential requirement for nuclear factor kappaB in regulating mature T cell survival and in vivo function. J. Exp. Med. 2003, 197:861-874.
    • (2003) J. Exp. Med. , vol.197 , pp. 861-874
    • Zheng, Y.1
  • 26
    • 0029150389 scopus 로고
    • Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression
    • Kontgen F., et al. Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression. Genes Dev. 1995, 9:1965-1977.
    • (1995) Genes Dev. , vol.9 , pp. 1965-1977
    • Kontgen, F.1
  • 27
    • 0033023431 scopus 로고    scopus 로고
    • C-Rel is crucial for lymphocyte proliferation but dispensable for T cell effector function
    • Liou H.C., et al. c-Rel is crucial for lymphocyte proliferation but dispensable for T cell effector function. Int. Immunol. 1999, 11:361-371.
    • (1999) Int. Immunol. , vol.11 , pp. 361-371
    • Liou, H.C.1
  • 28
    • 0036738421 scopus 로고    scopus 로고
    • Critical roles of c-Rel in autoimmune inflammation and helper T cell differentiation
    • Hilliard B.A., et al. Critical roles of c-Rel in autoimmune inflammation and helper T cell differentiation. J. Clin. Invest. 2002, 110:843-850.
    • (2002) J. Clin. Invest. , vol.110 , pp. 843-850
    • Hilliard, B.A.1
  • 29
    • 82955228112 scopus 로고    scopus 로고
    • T(H)17 cytokines in autoimmune neuro-inflammation
    • Becher B., Segal B.M. T(H)17 cytokines in autoimmune neuro-inflammation. Curr. Opin. Immunol. 2011, 23:707-712.
    • (2011) Curr. Opin. Immunol. , vol.23 , pp. 707-712
    • Becher, B.1    Segal, B.M.2
  • 30
    • 80555133361 scopus 로고    scopus 로고
    • The NF-kappaB transcription factor c-Rel is required for Th17 effector cell development in experimental autoimmune encephalomyelitis
    • Chen G., et al. The NF-kappaB transcription factor c-Rel is required for Th17 effector cell development in experimental autoimmune encephalomyelitis. J. Immunol. 2011, 187:4483-4491.
    • (2011) J. Immunol. , vol.187 , pp. 4483-4491
    • Chen, G.1
  • 31
    • 80055116357 scopus 로고    scopus 로고
    • The Th17 immune response is controlled by the Rel-RORgamma-RORgamma T transcriptional axis
    • Ruan Q., et al. The Th17 immune response is controlled by the Rel-RORgamma-RORgamma T transcriptional axis. J. Exp. Med. 2011, 208:2321-2333.
    • (2011) J. Exp. Med. , vol.208 , pp. 2321-2333
    • Ruan, Q.1
  • 32
    • 79956116032 scopus 로고    scopus 로고
    • RORgammat drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation
    • Codarri L., et al. RORgammat drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation. Nat. Immunol. 2011, 12:560-567.
    • (2011) Nat. Immunol. , vol.12 , pp. 560-567
    • Codarri, L.1
  • 33
    • 79956152607 scopus 로고    scopus 로고
    • The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF
    • El-Behi M., et al. The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF. Nat. Immunol. 2011, 12:568-575.
    • (2011) Nat. Immunol. , vol.12 , pp. 568-575
    • El-Behi, M.1
  • 34
    • 61749093508 scopus 로고    scopus 로고
    • IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice
    • Haak S., et al. IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice. J. Clin. Invest. 2009, 119:61-69.
    • (2009) J. Clin. Invest. , vol.119 , pp. 61-69
    • Haak, S.1
  • 35
    • 46749133961 scopus 로고    scopus 로고
    • IL-21 and IL-21R are not required for development of Th17 cells and autoimmunity in vivo
    • Sonderegger I., et al. IL-21 and IL-21R are not required for development of Th17 cells and autoimmunity in vivo. Eur. J. Immunol. 2008, 38:1833-1838.
    • (2008) Eur. J. Immunol. , vol.38 , pp. 1833-1838
    • Sonderegger, I.1
  • 36
    • 0029866670 scopus 로고    scopus 로고
    • Rel-deficient T cells exhibit defects in production of interleukin 3 and granulocyte-macrophage colony-stimulating factor
    • Gerondakis S., et al. Rel-deficient T cells exhibit defects in production of interleukin 3 and granulocyte-macrophage colony-stimulating factor. Proc. Natl. Acad. Sci. U.S.A. 1996, 93:3405-3409.
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , pp. 3405-3409
    • Gerondakis, S.1
  • 37
    • 0030294284 scopus 로고    scopus 로고
    • High mobility group protein I(Y) is required for function and for c-Rel binding to CD28 response elements within the GM-CSF and IL-2 promoters
    • Himes S.R., et al. High mobility group protein I(Y) is required for function and for c-Rel binding to CD28 response elements within the GM-CSF and IL-2 promoters. Immunity 1996, 5:479-489.
    • (1996) Immunity , vol.5 , pp. 479-489
    • Himes, S.R.1
  • 38
    • 73949090725 scopus 로고    scopus 로고
    • + CD4 regulatory T cells
    • + CD4 regulatory T cells. J. Exp. Med. 2009, 206:3001-3014.
    • (2009) J. Exp. Med. , vol.206 , pp. 3001-3014
    • Isomura, I.1
  • 39
    • 77749245828 scopus 로고    scopus 로고
    • + T cells but not T(H)17 cells
    • + T cells but not T(H)17 cells. Eur. J. Immunol. 2010, 40:671-676.
    • (2010) Eur. J. Immunol. , vol.40 , pp. 671-676
    • Visekruna, A.1
  • 40
    • 76749133610 scopus 로고    scopus 로고
    • Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate
    • Zheng Y., et al. Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate. Nature 2010, 463:808-812.
    • (2010) Nature , vol.463 , pp. 808-812
    • Zheng, Y.1
  • 41
    • 0029059060 scopus 로고
    • Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B
    • Beg A.A., et al. Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B. Nature 1995, 376:167-170.
    • (1995) Nature , vol.376 , pp. 167-170
    • Beg, A.A.1
  • 42
    • 0030999057 scopus 로고    scopus 로고
    • NF-kappa B RelA-deficient lymphocytes: normal development of T cells and B cells, impaired production of IgA and IgG1 and reduced proliferative responses
    • Doi T.S., et al. NF-kappa B RelA-deficient lymphocytes: normal development of T cells and B cells, impaired production of IgA and IgG1 and reduced proliferative responses. J. Exp. Med. 1997, 185:953-961.
    • (1997) J. Exp. Med. , vol.185 , pp. 953-961
    • Doi, T.S.1
  • 43
    • 79952769599 scopus 로고    scopus 로고
    • RelA and RelB transcription factors in distinct thymocyte populations control lymphotoxin-dependent interleukin-17 production in gammadelta T cells
    • Powolny-Budnicka I., et al. RelA and RelB transcription factors in distinct thymocyte populations control lymphotoxin-dependent interleukin-17 production in gammadelta T cells. Immunity 2011, 34:364-374.
    • (2011) Immunity , vol.34 , pp. 364-374
    • Powolny-Budnicka, I.1
  • 44
    • 0034674520 scopus 로고    scopus 로고
    • Activation of nuclear factor-kB in the spinal cord of experimental allergic encephalomyelitis
    • Pahan K., Schmid M. Activation of nuclear factor-kB in the spinal cord of experimental allergic encephalomyelitis. Neurosci. Lett. 2000, 287:17-20.
    • (2000) Neurosci. Lett. , vol.287 , pp. 17-20
    • Pahan, K.1    Schmid, M.2
  • 45
    • 79960836123 scopus 로고    scopus 로고
    • Experimental autoimmune encephalomyelitis: association with mutual regulation of RelA (p65)/NF-kappaB and phospho-IkappaB in the CNS
    • Hwang I., et al. Experimental autoimmune encephalomyelitis: association with mutual regulation of RelA (p65)/NF-kappaB and phospho-IkappaB in the CNS. Biochem. Biophys. Res. Commun. 2011, 411:464-470.
    • (2011) Biochem. Biophys. Res. Commun. , vol.411 , pp. 464-470
    • Hwang, I.1
  • 46
    • 34249879045 scopus 로고    scopus 로고
    • Pancreas-specific RelA/p65 truncation increases susceptibility of acini to inflammation-associated cell death following cerulein pancreatitis
    • Algul H., et al. Pancreas-specific RelA/p65 truncation increases susceptibility of acini to inflammation-associated cell death following cerulein pancreatitis. J. Clin. Invest. 2007, 117:1490-1501.
    • (2007) J. Clin. Invest. , vol.117 , pp. 1490-1501
    • Algul, H.1
  • 47
    • 42149171210 scopus 로고    scopus 로고
    • Loss of epithelial RelA results in deregulated intestinal proliferative/apoptotic homeostasis and susceptibility to inflammation
    • Steinbrecher K.A., et al. Loss of epithelial RelA results in deregulated intestinal proliferative/apoptotic homeostasis and susceptibility to inflammation. J. Immunol. 2008, 180:2588-2599.
    • (2008) J. Immunol. , vol.180 , pp. 2588-2599
    • Steinbrecher, K.A.1
  • 48
    • 0033198141 scopus 로고    scopus 로고
    • Experimental autoimmune encephalomyelitis in NF-kappa B-deficient mice:roles of NF-kappa B in the activation and differentiation of autoreactive T cells
    • Hilliard B., et al. Experimental autoimmune encephalomyelitis in NF-kappa B-deficient mice:roles of NF-kappa B in the activation and differentiation of autoreactive T cells. J. Immunol. 1999, 163:2937-2943.
    • (1999) J. Immunol. , vol.163 , pp. 2937-2943
    • Hilliard, B.1
  • 49
    • 0035222187 scopus 로고    scopus 로고
    • A critical role for NF-kappa B in GATA3 expression and TH2 differentiation in allergic airway inflammation
    • Das J., et al. A critical role for NF-kappa B in GATA3 expression and TH2 differentiation in allergic airway inflammation. Nat. Immunol. 2001, 2:45-50.
    • (2001) Nat. Immunol. , vol.2 , pp. 45-50
    • Das, J.1
  • 50
    • 73349109145 scopus 로고    scopus 로고
    • Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes
    • Jager A., et al. Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes. J. Immunol. 2009, 183:7169-7177.
    • (2009) J. Immunol. , vol.183 , pp. 7169-7177
    • Jager, A.1
  • 51
    • 24644454660 scopus 로고    scopus 로고
    • Organ-specific roles for transcription factor NF-kappaB in reovirus-induced apoptosis and disease
    • O'Donnell S.M., et al. Organ-specific roles for transcription factor NF-kappaB in reovirus-induced apoptosis and disease. J. Clin. Invest. 2005, 115:2341-2350.
    • (2005) J. Clin. Invest. , vol.115 , pp. 2341-2350
    • O'Donnell, S.M.1
  • 52
    • 78650883911 scopus 로고    scopus 로고
    • Regulation of NF-kappaB signaling by caspases and MALT1 paracaspase
    • Staal J., et al. Regulation of NF-kappaB signaling by caspases and MALT1 paracaspase. Cell Res. 2011, 21:40-54.
    • (2011) Cell Res. , vol.21 , pp. 40-54
    • Staal, J.1
  • 53
    • 0038375851 scopus 로고    scopus 로고
    • Requirement for CARMA1 in antigen receptor-induced NF-kappa B activation and lymphocyte proliferation
    • Egawa T., et al. Requirement for CARMA1 in antigen receptor-induced NF-kappa B activation and lymphocyte proliferation. Curr. Biol. 2003, 13:1252-1258.
    • (2003) Curr. Biol. , vol.13 , pp. 1252-1258
    • Egawa, T.1
  • 54
    • 0037490078 scopus 로고    scopus 로고
    • The MAGUK family protein CARD11 is essential for lymphocyte activation
    • Hara H., et al. The MAGUK family protein CARD11 is essential for lymphocyte activation. Immunity 2003, 18:763-775.
    • (2003) Immunity , vol.18 , pp. 763-775
    • Hara, H.1
  • 55
    • 0345374583 scopus 로고    scopus 로고
    • Regulation of NF-kappaB-dependent lymphocyte activation and development by paracaspase
    • Ruefli-Brasse A.A., et al. Regulation of NF-kappaB-dependent lymphocyte activation and development by paracaspase. Science 2003, 302:1581-1584.
    • (2003) Science , vol.302 , pp. 1581-1584
    • Ruefli-Brasse, A.A.1
  • 56
    • 17744386318 scopus 로고    scopus 로고
    • Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure
    • Ruland J., et al. Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure. Cell 2001, 104:33-42.
    • (2001) Cell , vol.104 , pp. 33-42
    • Ruland, J.1
  • 57
    • 0345358541 scopus 로고    scopus 로고
    • Differential requirement for Malt1 in T and B cell antigen receptor signaling
    • Ruland J., et al. Differential requirement for Malt1 in T and B cell antigen receptor signaling. Immunity 2003, 19:749-758.
    • (2003) Immunity , vol.19 , pp. 749-758
    • Ruland, J.1
  • 58
    • 84870521827 scopus 로고    scopus 로고
    • The NF-kappaB regulator MALT1 determines the encephalitogenic potential of Th17 cells
    • Brustle A., et al. The NF-kappaB regulator MALT1 determines the encephalitogenic potential of Th17 cells. J. Clin. Invest. 2012, 122:4698-4709.
    • (2012) J. Clin. Invest. , vol.122 , pp. 4698-4709
    • Brustle, A.1
  • 59
    • 84874928867 scopus 로고    scopus 로고
    • Paracaspase MALT1 deficiency protects mice from autoimmune-mediated demyelination
    • Mc Guire C., et al. Paracaspase MALT1 deficiency protects mice from autoimmune-mediated demyelination. J. Immunol. 2013, 190:2896-2903.
    • (2013) J. Immunol. , vol.190 , pp. 2896-2903
    • Mc Guire, C.1
  • 60
    • 84868548958 scopus 로고    scopus 로고
    • T cell receptor/CARMA1/NF-kappaB signaling controls T-helper (Th) 17 differentiation
    • Molinero L.L., et al. T cell receptor/CARMA1/NF-kappaB signaling controls T-helper (Th) 17 differentiation. Proc. Natl. Acad. Sci. U.S.A. 2012, 109:18529-18534.
    • (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109 , pp. 18529-18534
    • Molinero, L.L.1
  • 61
    • 39449131430 scopus 로고    scopus 로고
    • T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20
    • Coornaert B., et al. T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20. Nat. Immunol. 2008, 9:263-271.
    • (2008) Nat. Immunol. , vol.9 , pp. 263-271
    • Coornaert, B.1
  • 62
    • 73949114883 scopus 로고    scopus 로고
    • Essential role of MALT1 protease activity in activated B cell-like diffuse large B-cell lymphoma
    • Hailfinger S., et al. Essential role of MALT1 protease activity in activated B cell-like diffuse large B-cell lymphoma. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:19946-19951.
    • (2009) Proc. Natl. Acad. Sci. U.S.A. , vol.106 , pp. 19946-19951
    • Hailfinger, S.1
  • 63
    • 39449085547 scopus 로고    scopus 로고
    • The proteolytic activity of the paracaspase MALT1 is key in T cell activation
    • Rebeaud F., et al. The proteolytic activity of the paracaspase MALT1 is key in T cell activation. Nat. Immunol. 2008, 9:272-281.
    • (2008) Nat. Immunol. , vol.9 , pp. 272-281
    • Rebeaud, F.1
  • 64
    • 79955592698 scopus 로고    scopus 로고
    • T-cell receptor-induced JNK activation requires proteolytic inactivation of CYLD by MALT1
    • Staal J., et al. T-cell receptor-induced JNK activation requires proteolytic inactivation of CYLD by MALT1. EMBO J. 2011, 30:1742-1752.
    • (2011) EMBO J. , vol.30 , pp. 1742-1752
    • Staal, J.1
  • 65
    • 80052282195 scopus 로고    scopus 로고
    • Malt1-dependent RelB cleavage promotes canonical NF-kappaB activation in lymphocytes and lymphoma cell lines
    • Hailfinger S., et al. Malt1-dependent RelB cleavage promotes canonical NF-kappaB activation in lymphocytes and lymphoma cell lines. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:14596-14601.
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 14596-14601
    • Hailfinger, S.1
  • 66
    • 0141678951 scopus 로고    scopus 로고
    • Mature T cells depend on signaling through the IKK complex
    • Schmidt-Supprian M., et al. Mature T cells depend on signaling through the IKK complex. Immunity 2003, 19:377-389.
    • (2003) Immunity , vol.19 , pp. 377-389
    • Schmidt-Supprian, M.1
  • 67
    • 3242781555 scopus 로고    scopus 로고
    • I kappa B kinase 2 deficiency in T cells leads to defects in priming, B cell help, germinal center reactions, and homeostatic expansion
    • Schmidt-Supprian M., et al. I kappa B kinase 2 deficiency in T cells leads to defects in priming, B cell help, germinal center reactions, and homeostatic expansion. J. Immunol. 2004, 173:1612-1619.
    • (2004) J. Immunol. , vol.173 , pp. 1612-1619
    • Schmidt-Supprian, M.1
  • 68
    • 1842480966 scopus 로고    scopus 로고
    • + regulatory and natural killer-like T cells on signals leading to NF-kappaB activation
    • + regulatory and natural killer-like T cells on signals leading to NF-kappaB activation. Proc. Natl. Acad. Sci. U.S.A. 2004, 101:4566-4571.
    • (2004) Proc. Natl. Acad. Sci. U.S.A. , vol.101 , pp. 4566-4571
    • Schmidt-Supprian, M.1
  • 69
    • 34250848216 scopus 로고    scopus 로고
    • I kappa B kinase 2/beta deficiency controls expansion of autoreactive T cells and suppresses experimental autoimmune encephalomyelitis
    • Greve B., et al. I kappa B kinase 2/beta deficiency controls expansion of autoreactive T cells and suppresses experimental autoimmune encephalomyelitis. J. Immunol. 2007, 179:179-185.
    • (2007) J. Immunol. , vol.179 , pp. 179-185
    • Greve, B.1
  • 70
    • 0028817585 scopus 로고
    • Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-kappa B/Rel family
    • Weih F., et al. Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-kappa B/Rel family. Cell 1995, 80:331-340.
    • (1995) Cell , vol.80 , pp. 331-340
    • Weih, F.1
  • 71
    • 23444461535 scopus 로고    scopus 로고
    • Opposing roles for RelB and Bcl-3 in regulation of T-box expressed in T cells, GATA-3, and Th effector differentiation
    • Corn R.A., et al. Opposing roles for RelB and Bcl-3 in regulation of T-box expressed in T cells, GATA-3, and Th effector differentiation. J. Immunol. 2005, 175:2102-2110.
    • (2005) J. Immunol. , vol.175 , pp. 2102-2110
    • Corn, R.A.1
  • 72
    • 79955718316 scopus 로고    scopus 로고
    • Transcriptional regulation of the Th17 immune response by IKK(alpha)
    • Li L., et al. Transcriptional regulation of the Th17 immune response by IKK(alpha). J. Exp. Med. 2011, 208:787-796.
    • (2011) J. Exp. Med. , vol.208 , pp. 787-796
    • Li, L.1
  • 73
    • 77957021670 scopus 로고    scopus 로고
    • γδ T cells enhance autoimmunity by restraining regulatory T cell responses via an interleukin-23-dependent mechanism
    • Petermann F., et al. γδ T cells enhance autoimmunity by restraining regulatory T cell responses via an interleukin-23-dependent mechanism. Immunity 2010, 33:351-363.
    • (2010) Immunity , vol.33 , pp. 351-363
    • Petermann, F.1
  • 74
    • 33846514266 scopus 로고    scopus 로고
    • T-bet regulates the fate of Th1 and Th17 lymphocytes in autoimmunity
    • Gocke A.R., et al. T-bet regulates the fate of Th1 and Th17 lymphocytes in autoimmunity. J. Immunol. 2007, 178:1341-1348.
    • (2007) J. Immunol. , vol.178 , pp. 1341-1348
    • Gocke, A.R.1
  • 75
    • 68649088121 scopus 로고    scopus 로고
    • Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity
    • Sutton C.E., et al. Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity. Immunity 2009, 31:331-341.
    • (2009) Immunity , vol.31 , pp. 331-341
    • Sutton, C.E.1
  • 76
    • 0038165436 scopus 로고    scopus 로고
    • RelB forms transcriptionally inactive complexes with RelA/p65
    • Marienfeld R., et al. RelB forms transcriptionally inactive complexes with RelA/p65. J. Biol. Chem. 2003, 278:19852-19860.
    • (2003) J. Biol. Chem. , vol.278 , pp. 19852-19860
    • Marienfeld, R.1
  • 77
    • 69249223474 scopus 로고    scopus 로고
    • Regulation of Th17 cell differentiation and EAE induction by MAP3K NIK
    • Jin W., et al. Regulation of Th17 cell differentiation and EAE induction by MAP3K NIK. Blood 2009, 113:6603-6610.
    • (2009) Blood , vol.113 , pp. 6603-6610
    • Jin, W.1
  • 78
    • 80054837244 scopus 로고    scopus 로고
    • NIK signaling in dendritic cells but not in T cells is required for the development of effector T cells and cell-mediated immune responses
    • Hofmann J., et al. NIK signaling in dendritic cells but not in T cells is required for the development of effector T cells and cell-mediated immune responses. J. Exp. Med. 2011, 208:1917-1929.
    • (2011) J. Exp. Med. , vol.208 , pp. 1917-1929
    • Hofmann, J.1
  • 79
    • 33646010041 scopus 로고    scopus 로고
    • Roles for NF-kappaB in nerve cell survival, plasticity, and disease
    • Mattson M.P., Meffert M.K. Roles for NF-kappaB in nerve cell survival, plasticity, and disease. Cell Death Differ. 2006, 13:852-860.
    • (2006) Cell Death Differ. , vol.13 , pp. 852-860
    • Mattson, M.P.1    Meffert, M.K.2
  • 80
    • 0032587072 scopus 로고    scopus 로고
    • NF-kappaB is activated and promotes cell death in focal cerebral ischemia
    • Schneider A., et al. NF-kappaB is activated and promotes cell death in focal cerebral ischemia. Nat. Med. 1999, 5:554-559.
    • (1999) Nat. Med. , vol.5 , pp. 554-559
    • Schneider, A.1
  • 81
    • 0033570299 scopus 로고    scopus 로고
    • Lack of the p50 subunit of nuclear factor-kappaB increases the vulnerability of hippocampal neurons to excitotoxic injury
    • Yu Z., et al. Lack of the p50 subunit of nuclear factor-kappaB increases the vulnerability of hippocampal neurons to excitotoxic injury. J. Neurosci. 1999, 19:8856-8865.
    • (1999) J. Neurosci. , vol.19 , pp. 8856-8865
    • Yu, Z.1
  • 82
    • 0142157608 scopus 로고    scopus 로고
    • Forebrain-specific neuronal inhibition of nuclear factor-kappaB activity leads to loss of neuroprotection
    • Fridmacher V., et al. Forebrain-specific neuronal inhibition of nuclear factor-kappaB activity leads to loss of neuroprotection. J. Neurosci. 2003, 23:9403-9408.
    • (2003) J. Neurosci. , vol.23 , pp. 9403-9408
    • Fridmacher, V.1
  • 83
    • 33747609345 scopus 로고    scopus 로고
    • Inhibition of transcription factor NF-kappaB in the central nervous system ameliorates autoimmune encephalomyelitis in mice
    • van Loo G., et al. Inhibition of transcription factor NF-kappaB in the central nervous system ameliorates autoimmune encephalomyelitis in mice. Nat. Immunol. 2006, 7:954-961.
    • (2006) Nat. Immunol. , vol.7 , pp. 954-961
    • van Loo, G.1
  • 84
    • 76249086119 scopus 로고    scopus 로고
    • Neuronal I kappa B kinase beta protects mice from autoimmune encephalomyelitis by mediating neuroprotective and immunosuppressive effects in the central nervous system
    • Emmanouil M., et al. Neuronal I kappa B kinase beta protects mice from autoimmune encephalomyelitis by mediating neuroprotective and immunosuppressive effects in the central nervous system. J. Immunol. 2009, 183:7877-7889.
    • (2009) J. Immunol. , vol.183 , pp. 7877-7889
    • Emmanouil, M.1
  • 85
    • 80052956995 scopus 로고    scopus 로고
    • Transmembrane tumour necrosis factor is neuroprotective and regulates experimental autoimmune encephalomyelitis via neuronal nuclear factor-kappaB
    • Taoufik E., et al. Transmembrane tumour necrosis factor is neuroprotective and regulates experimental autoimmune encephalomyelitis via neuronal nuclear factor-kappaB. Brain 2011, 134:2722-2735.
    • (2011) Brain , vol.134 , pp. 2722-2735
    • Taoufik, E.1
  • 86
    • 80052926089 scopus 로고    scopus 로고
    • Inhibition of soluble tumour necrosis factor is therapeutic in experimental autoimmune encephalomyelitis and promotes axon preservation and remyelination
    • Brambilla R., et al. Inhibition of soluble tumour necrosis factor is therapeutic in experimental autoimmune encephalomyelitis and promotes axon preservation and remyelination. Brain 2011, 134:2736-2754.
    • (2011) Brain , vol.134 , pp. 2736-2754
    • Brambilla, R.1
  • 87
    • 2442547563 scopus 로고    scopus 로고
    • TNFR1-dependent VCAM-1 expression by astrocytes exposes the CNS to destructive inflammation
    • Gimenez M.A., et al. TNFR1-dependent VCAM-1 expression by astrocytes exposes the CNS to destructive inflammation. J. Neuroimmunol. 2004, 151:116-125.
    • (2004) J. Neuroimmunol. , vol.151 , pp. 116-125
    • Gimenez, M.A.1
  • 88
    • 64849094450 scopus 로고    scopus 로고
    • Transgenic inhibition of astroglial NF-kappa B improves functional outcome in experimental autoimmune encephalomyelitis by suppressing chronic central nervous system inflammation
    • Brambilla R., et al. Transgenic inhibition of astroglial NF-kappa B improves functional outcome in experimental autoimmune encephalomyelitis by suppressing chronic central nervous system inflammation. J. Immunol. 2009, 182:2628-2640.
    • (2009) J. Immunol. , vol.182 , pp. 2628-2640
    • Brambilla, R.1
  • 89
    • 40449120318 scopus 로고    scopus 로고
    • + regulatory T cells in the recovery from experimental autoimmune encephalomyelitis
    • + regulatory T cells in the recovery from experimental autoimmune encephalomyelitis. J. Immunol. 2008, 180:825-832.
    • (2008) J. Immunol. , vol.180 , pp. 825-832
    • Lee, Y.H.1
  • 90
    • 84861193712 scopus 로고    scopus 로고
    • Two discreet subsets of CD8 T cells modulate PLP(91-110) induced experimental autoimmune encephalomyelitis in HLA-DR3 transgenic mice
    • Mangalam A.K., et al. Two discreet subsets of CD8 T cells modulate PLP(91-110) induced experimental autoimmune encephalomyelitis in HLA-DR3 transgenic mice. J. Autoimmun. 2012, 38:344-353.
    • (2012) J. Autoimmun. , vol.38 , pp. 344-353
    • Mangalam, A.K.1
  • 91
  • 92
    • 84864947510 scopus 로고    scopus 로고
    • Astrocyte-specific IKK2 activation in mice is sufficient to induce neuroinflammation but does not increase susceptibility to MPTP
    • Oeckl P., et al. Astrocyte-specific IKK2 activation in mice is sufficient to induce neuroinflammation but does not increase susceptibility to MPTP. Neurobiol. Dis. 2012, 48:481-487.
    • (2012) Neurobiol. Dis. , vol.48 , pp. 481-487
    • Oeckl, P.1
  • 93
    • 84860209140 scopus 로고    scopus 로고
    • Neuronal NF-kappaB ablation does not influence neuro-axonal degeneration in experimental autoimmune demyelination
    • Lee D.H., et al. Neuronal NF-kappaB ablation does not influence neuro-axonal degeneration in experimental autoimmune demyelination. J. Neuroimmunol. 2012, 246:38-42.
    • (2012) J. Neuroimmunol. , vol.246 , pp. 38-42
    • Lee, D.H.1
  • 94
    • 68749103771 scopus 로고    scopus 로고
    • The NF-kappaB-independent functions of IKK subunits in immunity and cancer
    • Chariot A. The NF-kappaB-independent functions of IKK subunits in immunity and cancer. Trends Cell Biol. 2009, 19:404-413.
    • (2009) Trends Cell Biol. , vol.19 , pp. 404-413
    • Chariot, A.1
  • 95
    • 84868687471 scopus 로고    scopus 로고
    • IkappaB kinase 2 regulates TPL-2 activation of extracellular signal-regulated kinases 1 and 2 by direct phosphorylation of TPL-2 serine 400
    • Roget K., et al. IkappaB kinase 2 regulates TPL-2 activation of extracellular signal-regulated kinases 1 and 2 by direct phosphorylation of TPL-2 serine 400. Mol. Cell. Biol. 2012, 32:4684-4690.
    • (2012) Mol. Cell. Biol. , vol.32 , pp. 4684-4690
    • Roget, K.1
  • 96
    • 33646470960 scopus 로고    scopus 로고
    • -/- mice exhibit Th1 cell polarization and increased susceptibility to experimental autoimmune encephalomyelitis
    • -/- mice exhibit Th1 cell polarization and increased susceptibility to experimental autoimmune encephalomyelitis. J. Immunol. 2006, 176:5788-5796.
    • (2006) J. Immunol. , vol.176 , pp. 5788-5796
    • Agrawal, A.1
  • 97
    • 16244388563 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinase 1/2 mediates survival, but not axon regeneration, of adult injured central nervous system neurons in vivo
    • Pernet V., et al. Extracellular signal-regulated kinase 1/2 mediates survival, but not axon regeneration, of adult injured central nervous system neurons in vivo. J. Neurochem. 2005, 93:72-83.
    • (2005) J. Neurochem. , vol.93 , pp. 72-83
    • Pernet, V.1
  • 98
    • 84862900786 scopus 로고    scopus 로고
    • ERK1/ERK2 MAPK signaling is required to increase myelin thickness independent of oligodendrocyte differentiation and initiation of myelination
    • Ishii A., et al. ERK1/ERK2 MAPK signaling is required to increase myelin thickness independent of oligodendrocyte differentiation and initiation of myelination. J. Neurosci. 2012, 32:8855-8864.
    • (2012) J. Neurosci. , vol.32 , pp. 8855-8864
    • Ishii, A.1
  • 99
    • 79953672493 scopus 로고    scopus 로고
    • IkappaB kinase 2 determines oligodendrocyte loss by non-cell-autonomous activation of NF-kappaB in the central nervous system
    • Raasch J., et al. IkappaB kinase 2 determines oligodendrocyte loss by non-cell-autonomous activation of NF-kappaB in the central nervous system. Brain 2011, 134:1184-1198.
    • (2011) Brain , vol.134 , pp. 1184-1198
    • Raasch, J.1
  • 100
    • 84855992548 scopus 로고    scopus 로고
    • Constitutive activity of NF-kappa B in myeloid cells drives pathogenicity of monocytes and macrophages during autoimmune neuroinflammation
    • Ellrichmann G., et al. Constitutive activity of NF-kappa B in myeloid cells drives pathogenicity of monocytes and macrophages during autoimmune neuroinflammation. J. Neuroinflammation 2012, 9:15.
    • (2012) J. Neuroinflammation , vol.9 , pp. 15
    • Ellrichmann, G.1
  • 101
    • 77949616373 scopus 로고    scopus 로고
    • Myelin activates FAK/Akt/NF-kappaB pathways and provokes CR3-dependent inflammatory response in murine system
    • Sun X., et al. Myelin activates FAK/Akt/NF-kappaB pathways and provokes CR3-dependent inflammatory response in murine system. PLoS ONE 2010, 5:e9380.
    • (2010) PLoS ONE , vol.5
    • Sun, X.1
  • 102
    • 55749113001 scopus 로고    scopus 로고
    • Role of microglial IKKbeta in kainic acid-induced hippocampal neuronal cell death
    • Cho I.H., et al. Role of microglial IKKbeta in kainic acid-induced hippocampal neuronal cell death. Brain 2008, 131:3019-3033.
    • (2008) Brain , vol.131 , pp. 3019-3033
    • Cho, I.H.1
  • 103
    • 65149093082 scopus 로고    scopus 로고
    • + myeloid precursors migrate to the CNS and play a pathogenic role during autoimmune demyelinating disease
    • + myeloid precursors migrate to the CNS and play a pathogenic role during autoimmune demyelinating disease. Blood 2009, 113:3190-3197.
    • (2009) Blood , vol.113 , pp. 3190-3197
    • King, I.L.1
  • 104
    • 71549167047 scopus 로고    scopus 로고
    • +Ly-6Chi monocytes are crucial for the effector phase of autoimmunity in the central nervous system
    • +Ly-6Chi monocytes are crucial for the effector phase of autoimmunity in the central nervous system. Brain 2009, 132:2487-2500.
    • (2009) Brain , vol.132 , pp. 2487-2500
    • Mildner, A.1
  • 105
    • 0037317077 scopus 로고    scopus 로고
    • Activation of the transcription factor NF-kappaB in Schwann cells is required for peripheral myelin formation
    • Nickols J.C., et al. Activation of the transcription factor NF-kappaB in Schwann cells is required for peripheral myelin formation. Nat. Neurosci. 2003, 6:161-167.
    • (2003) Nat. Neurosci. , vol.6 , pp. 161-167
    • Nickols, J.C.1
  • 106
    • 84878833042 scopus 로고    scopus 로고
    • Activation of NF-kappaB in Schwann cells is dispensable for myelination in vivo
    • Morton P.D., et al. Activation of NF-kappaB in Schwann cells is dispensable for myelination in vivo. J. Neurosci. 2013, 33:9932-9936.
    • (2013) J. Neurosci. , vol.33 , pp. 9932-9936
    • Morton, P.D.1
  • 107
    • 0035705454 scopus 로고    scopus 로고
    • TNF alpha promotes proliferation of oligodendrocyte progenitors and remyelination
    • Arnett H.A., et al. TNF alpha promotes proliferation of oligodendrocyte progenitors and remyelination. Nat. Neurosci. 2001, 4:1116-1122.
    • (2001) Nat. Neurosci. , vol.4 , pp. 1116-1122
    • Arnett, H.A.1
  • 108
    • 0035883161 scopus 로고    scopus 로고
    • Interleukin-1beta promotes repair of the CNS
    • Mason J.L., et al. Interleukin-1beta promotes repair of the CNS. J. Neurosci. 2001, 21:7046-7052.
    • (2001) J. Neurosci. , vol.21 , pp. 7046-7052
    • Mason, J.L.1
  • 109
    • 0033759283 scopus 로고    scopus 로고
    • Interferon-gamma protects against cuprizone-induced demyelination
    • Gao X., et al. Interferon-gamma protects against cuprizone-induced demyelination. Mol. Cell. Neurosci. 2000, 16:338-349.
    • (2000) Mol. Cell. Neurosci. , vol.16 , pp. 338-349
    • Gao, X.1
  • 110
    • 77954653333 scopus 로고    scopus 로고
    • CXCR4 promotes differentiation of oligodendrocyte progenitors and remyelination
    • Patel J.R., et al. CXCR4 promotes differentiation of oligodendrocyte progenitors and remyelination. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:11062-11067.
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 11062-11067
    • Patel, J.R.1
  • 111
    • 70350011787 scopus 로고    scopus 로고
    • NF-kappa B, a potential therapeutic target for the treatment of multiple sclerosis
    • Yan J., Greer J.M. NF-kappa B, a potential therapeutic target for the treatment of multiple sclerosis. CNS Neurol. Disord. Drug Targets 2008, 7:536-557.
    • (2008) CNS Neurol. Disord. Drug Targets , vol.7 , pp. 536-557
    • Yan, J.1    Greer, J.M.2
  • 112
    • 6344274849 scopus 로고    scopus 로고
    • Green tea epigallocatechin-3-gallate mediates T cellular NF-kappa B inhibition and exerts neuroprotection in autoimmune encephalomyelitis
    • Aktas O., et al. Green tea epigallocatechin-3-gallate mediates T cellular NF-kappa B inhibition and exerts neuroprotection in autoimmune encephalomyelitis. J. Immunol. 2004, 173:5794-5800.
    • (2004) J. Immunol. , vol.173 , pp. 5794-5800
    • Aktas, O.1
  • 113
    • 80055113428 scopus 로고    scopus 로고
    • Amelioration of experimental autoimmune encephalomyelitis by plumbagin through down-regulation of JAK-STAT and NF-kappaB signaling pathways
    • Jia Y., et al. Amelioration of experimental autoimmune encephalomyelitis by plumbagin through down-regulation of JAK-STAT and NF-kappaB signaling pathways. PLoS ONE 2011, 6:e27006.
    • (2011) PLoS ONE , vol.6
    • Jia, Y.1
  • 114
    • 0037097660 scopus 로고    scopus 로고
    • Curcumin inhibits experimental allergic encephalomyelitis by blocking IL-12 signaling through Janus kinase-STAT pathway in T lymphocytes
    • Natarajan C., Bright J.J. Curcumin inhibits experimental allergic encephalomyelitis by blocking IL-12 signaling through Janus kinase-STAT pathway in T lymphocytes. J. Immunol. 2002, 168:6506-6513.
    • (2002) J. Immunol. , vol.168 , pp. 6506-6513
    • Natarajan, C.1    Bright, J.J.2
  • 115
    • 75149156175 scopus 로고    scopus 로고
    • Antiinflammatory properties of a plant-derived nonsteroidal, dissociated glucocorticoid receptor modulator in experimental autoimmune encephalomyelitis
    • van Loo G., et al. Antiinflammatory properties of a plant-derived nonsteroidal, dissociated glucocorticoid receptor modulator in experimental autoimmune encephalomyelitis. Mol. Endocrinol. 2010, 24:310-322.
    • (2010) Mol. Endocrinol. , vol.24 , pp. 310-322
    • van Loo, G.1
  • 116
    • 0018246802 scopus 로고
    • Incidence and severity of experimental allergic encephalomyelitis and cerebral prostaglandin synthesis in essential fatty acid deficient and aspirin-treated rats
    • Weston P.G., Johnston P.V. Incidence and severity of experimental allergic encephalomyelitis and cerebral prostaglandin synthesis in essential fatty acid deficient and aspirin-treated rats. Lipids 1978, 13:867-872.
    • (1978) Lipids , vol.13 , pp. 867-872
    • Weston, P.G.1    Johnston, P.V.2
  • 117
    • 0032487857 scopus 로고    scopus 로고
    • The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta
    • Yin M.J., et al. The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta. Nature 1998, 396:77-80.
    • (1998) Nature , vol.396 , pp. 77-80
    • Yin, M.J.1
  • 118
    • 3142774208 scopus 로고    scopus 로고
    • Antineuroinflammatory effect of NF-kappaB essential modifier-binding domain peptides in the adoptive transfer model of experimental allergic encephalomyelitis
    • Dasgupta S., et al. Antineuroinflammatory effect of NF-kappaB essential modifier-binding domain peptides in the adoptive transfer model of experimental allergic encephalomyelitis. J. Immunol. 2004, 173:1344-1354.
    • (2004) J. Immunol. , vol.173 , pp. 1344-1354
    • Dasgupta, S.1
  • 119
    • 34547858171 scopus 로고    scopus 로고
    • Glucocorticoids in the control of neuroinflammation
    • Tischner D., Reichardt H.M. Glucocorticoids in the control of neuroinflammation. Mol. Cell. Endocrinol. 2007, 275:62-70.
    • (2007) Mol. Cell. Endocrinol. , vol.275 , pp. 62-70
    • Tischner, D.1    Reichardt, H.M.2
  • 120
    • 0033596126 scopus 로고    scopus 로고
    • Diverse agents act at multiple levels to inhibit the Rel/NF-kappaB signal transduction pathway
    • Epinat J.C., Gilmore T.D. Diverse agents act at multiple levels to inhibit the Rel/NF-kappaB signal transduction pathway. Oncogene 1999, 18:6896-6909.
    • (1999) Oncogene , vol.18 , pp. 6896-6909
    • Epinat, J.C.1    Gilmore, T.D.2
  • 121
    • 83755195187 scopus 로고    scopus 로고
    • The role of cell type-specific responses in IFN-beta therapy of multiple sclerosis
    • Zula J.A., et al. The role of cell type-specific responses in IFN-beta therapy of multiple sclerosis. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:19689-19694.
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 19689-19694
    • Zula, J.A.1
  • 122
    • 84865863065 scopus 로고    scopus 로고
    • Reduced astrocytic NF-kappaB activation by laquinimod protects from cuprizone-induced demyelination
    • Bruck W., et al. Reduced astrocytic NF-kappaB activation by laquinimod protects from cuprizone-induced demyelination. Acta Neuropathol. 2012, 124:411-424.
    • (2012) Acta Neuropathol. , vol.124 , pp. 411-424
    • Bruck, W.1
  • 123
    • 84870856936 scopus 로고    scopus 로고
    • MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivo
    • Fontan L., et al. MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivo. Cancer Cell 2012, 22:812-824.
    • (2012) Cancer Cell , vol.22 , pp. 812-824
    • Fontan, L.1
  • 124
    • 84870769441 scopus 로고    scopus 로고
    • Pharmacologic inhibition of MALT1 protease by phenothiazines as a therapeutic approach for the treatment of aggressive ABC-DLBCL
    • Nagel D., et al. Pharmacologic inhibition of MALT1 protease by phenothiazines as a therapeutic approach for the treatment of aggressive ABC-DLBCL. Cancer Cell 2012, 22:825-837.
    • (2012) Cancer Cell , vol.22 , pp. 825-837
    • Nagel, D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.