Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

Nature Neuroscience

Volumn 22, Issue 3, 2019, Pages 401-412

  Fang, Evandro F ^a,b   Hou, Yujun ^a   Palikaras, Konstantinos ^c,d   Adriaanse, Bryan A ^e   Kerr, Jesse S ^a   Yang, Beimeng ^a   Lautrup, Sofie ^a   Hasan Olive, Md Mahdi ^b   Caponio, Domenica ^b   Dan, Xiuli ^a   Rocktäschel, Paula ^e   Croteau, Deborah L ^a   Akbari, Mansour ^f   Greig, Nigel H ^a   Fladby, Tormod ^b,g   Nilsen, Hilde ^b   Cader, M Zameel ^e   Mattson, Mark P ^a,h   Tavernarakis, Nektarios ^c,d   Bohr, Vilhelm A ^a,f  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b AKERSHUS UNIVERSITY HOSPITAL   (Norway)

^c INSTITUTE OF MOLECULAR BIOLOGY AND BIOTECHNOLOGY   (Greece)

^d UNIVERSITY OF CRETE   (Greece)

^e UNIVERSITY OF OXFORD   (United Kingdom)

^f UNIVERSITY OF COPENHAGEN   (Denmark)

^g UNIVERSITY OF OSLO   (Norway)

^h JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; PARKIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; TAU PROTEIN; TRANSCRIPTION FACTOR DAF 16;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN FUNCTION; CAENORHABDITIS ELEGANS; COGNITIVE DEFECT; CONTROLLED STUDY; ELECTRON MICROSCOPY; FEAR CONDITIONING TEST; HIPPOCAMPUS; HUMAN; IMMUNOHISTOCHEMISTRY; INDUCED PLURIPOTENT STEM CELL; MITOPHAGY; MOLECULAR CLONING; MORRIS WATER MAZE TEST; NONHUMAN; NOVEL OBJECT RECOGNITION TEST; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN LOCALIZATION; WESTERN BLOTTING; Y-MAZE TEST; ANIMAL; DISEASE MODEL; FEMALE; MALE; MEMORY; METABOLISM; MOUSE; NERVE CELL; NEURAL STEM CELL; PATHOLOGY; PSYCHOLOGY; TRANSGENIC ANIMAL;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; ANIMALS, GENETICALLY MODIFIED; CAENORHABDITIS ELEGANS; DISEASE MODELS, ANIMAL; FEMALE; HIPPOCAMPUS; INDUCED PLURIPOTENT STEM CELLS; MALE; MEMORY; MICE; MITOCHONDRIAL DEGRADATION; NEURAL STEM CELLS; NEURONS;

EID: 85061514056     PISSN: 10976256     EISSN: 15461726     Source Type: Journal    
DOI: 10.1038/s41593-018-0332-9     Document Type: Article

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