Assessing similarity to primary tissue and cortical layer identity in induced pluripotent stem cell-derived cortical neurons through single-cell transcriptomics

Human Molecular Genetics

Volumn 25, Issue 5, 2016, Pages 989-1000

  Handel, Adam E ^a,b   Chintawar, Satyan ^b   Lalic, Tatjana ^b   Whiteley, Emma ^a   Vowles, Jane ^c   Giustacchini, Alice ^b   Argoud, Karene ^d   Sopp, Paul ^b   Nakanishi, Mahito ^e   Bowden, Rory ^d   Cowley, Sally ^c   Newey, Sarah ^a   Akerman, Colin ^a   Ponting, Chris P ^a   Cader, M Zameel ^b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADAMTS3 PROTEIN; AMPA RECEPTOR; BCL11B PROTEIN; CUX1 PROTEIN; FEZF2 PROTEIN; GRIA1 PROTEIN; GRIA2 PROTEIN; GRIA3 PROTEIN; MICROTUBULE ASSOCIATED PROTEIN 2; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; NCAM1 PROTEIN; NEUROD6 PROTEIN; POU3F2 PROTEIN; PROTEIN; TUBB3 PROTEIN; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; GLUTAMATE RECEPTOR; NERVE PROTEIN; TRANSCRIPTOME;

ADULT; ARTICLE; BRAIN CELL; BRAIN CORTEX LAYER; CONTROLLED STUDY; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; GENE EXPRESSION; GLUTAMATERGIC SYNAPSE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE MICROSCOPY; MARKER GENE; NERVE CELL DIFFERENTIATION; NEUROEPITHELIUM CELL; PHENOTYPE; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; REVERSE TRANSCRIPTASE QUANTITATIVE POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SEQUENCE; SINGLE CELL TRANSCRIPTOMIC; SKIN BIOPSY; TRANSCRIPTOMICS; AGED; BRAIN CORTEX; CELL DIFFERENTIATION; CELL LINE; CYTOLOGY; FETUS; FIBROBLAST; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; INDUCED PLURIPOTENT STEM CELL; METABOLISM; NERVE CELL; NERVOUS SYSTEM DEVELOPMENT; REAL TIME POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; SINGLE CELL ANALYSIS;

ADULT; AGED; BIOMARKERS; CELL DIFFERENTIATION; CELL LINE; CEREBRAL CORTEX; FEMALE; FETUS; FIBROBLASTS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; INDUCED PLURIPOTENT STEM CELLS; NERVE TISSUE PROTEINS; NEUROGENESIS; NEURONS; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, GLUTAMATE; SEQUENCE ANALYSIS, RNA; SINGLE-CELL ANALYSIS; TRANSCRIPTOME;

EID: 84959475041     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddv637     Document Type: Article

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