A simple statistical parameter for use in evaluation and validation of high throughput screening assays

Journal of Biomolecular Screening

Volumn 4, Issue 2, 1999, Pages 67-73

  Zhang, Ji Hu ^a   Chung, Thomas D Y ^a   Oldenburg, Kevin R ^a  

^a DUPONT COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL AGENT;

ACCURACY; ARTICLE; AUTOANALYSIS; AUTOMATION; HISTOGRAM; MATERIALS HANDLING; PRIORITY JOURNAL; QUALITY CONTROL; REPRODUCIBILITY; SIGNAL DETECTION; SIGNAL NOISE RATIO; STATISTICAL MODEL; VALIDATION PROCESS;

EID: 0033003760     PISSN: 10870571     EISSN: None     Source Type: Journal    
DOI: 10.1177/108705719900400206     Document Type: Article

References (8)

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3. Fasman, K.H., Letovsky, S.I., Li, P., Cottingham, R.W., Kingsbury, D.T. (1997). The GDB Human Genetic Database Anno. 1997. Nucleic Acids Res. 25: 1, 72-81.
4. Gordon, E.M., Gallop, M.A., Campbell, D., Holmes, C., Bermak, J., Look, G., Murphy, M., Needels, M., Jacobs, J., Sugarman, J., Chinn, J., Ruhland-Fritsch, B., Jones, D. (1995). Combinatorial organic synthesis: Application to drug discovery. Eur. J. Med. Chem. 30:S337-S348.
5. Gordon, E.M., Barrett, R.W., Dower, W.J., Fodor, S.P.A., Gallop, M.A. (1994). Application of combinatorial technologies to drug discovery. 2. Combinatorial organic synthesis, library screening strategies and future directions. J. Med. Chem. 37:1385-1401.
6. Oldenburg, K.R., Zhang, J.-H., Chen, T., Maffia, A., Blom, K.A., Combs, A.P., Chung, T.D. (1998). Assay miniaturization for ultra-high throughput screening of combinatorial and discrete compound libraries: A 9600-well (0.2 microliter) assay system. J. Biomol. Screen. 3:55-62.
7. Stevens, M.E., Bouchard, P.J., Kariv, I., Chung, T.D-Y., Oldenburg, K.R. (1998). Comparison of automation equipment in high Throughput Screening. J. Biomol. Screen, 3:305-311.
8. Sittampalam, G.S., Iversen, P.W., Boadt, J.A., Kahl, S.D., Bright, S., Zock, J.M., Janzen, W.P., Lister, M.D. (1997). Design of signal windows in high throughput screening assays for drug discovery. J. Biomol. Screen. 2:159-169.