-
2
-
-
84858439862
-
Insights into the regulation of protein abundance from proteomic and transcriptomic analyses
-
Vogel C, Marcotte EM (2012) Insights into the regulation of protein abundance from proteomic and transcriptomic analyses. Nat Rev Genet 13:227–232.
-
(2012)
Nat Rev Genet
, vol.13
, pp. 227-232
-
-
Vogel, C.1
Marcotte, E.M.2
-
3
-
-
84964652688
-
New frontiers in translational control of the cancer genome
-
Truitt ML, Ruggero D (2016) New frontiers in translational control of the cancer genome. Nat Rev Cancer 16:288–304.
-
(2016)
Nat Rev Cancer
, vol.16
, pp. 288-304
-
-
Truitt, M.L.1
Ruggero, D.2
-
4
-
-
84892633789
-
Antipsychotics activate mTORC1-dependent translation to enhance neuronal morphological complexity
-
Bowling H, et al. (2014) Antipsychotics activate mTORC1-dependent translation to enhance neuronal morphological complexity. Sci Signal 7:ra4.
-
(2014)
Sci Signal
, vol.7
, pp. ra4
-
-
Bowling, H.1
-
5
-
-
84924347993
-
Immunogenetics. Dynamic profiling of the protein life cycle in response to pathogens
-
Jovanovic M, et al. (2015) Immunogenetics. Dynamic profiling of the protein life cycle in response to pathogens. Science 347:1259038.
-
(2015)
Science
, vol.347
, pp. 1259038
-
-
Jovanovic, M.1
-
6
-
-
45749144385
-
Stable isotopic labeling by amino acids in cultured primary neurons: Application to brain-derived neurotrophic factor-dependent phosphotyrosine-associated signaling
-
Spellman DS, Deinhardt K, Darie CC, Chao MV, Neubert TA (2008) Stable isotopic labeling by amino acids in cultured primary neurons: Application to brain-derived neurotrophic factor-dependent phosphotyrosine-associated signaling. Mol Cell Proteomics 7:1067–1076.
-
(2008)
Mol Cell Proteomics
, vol.7
, pp. 1067-1076
-
-
Spellman, D.S.1
Deinhardt, K.2
Darie, C.C.3
Chao, M.V.4
Neubert, T.A.5
-
7
-
-
0036583926
-
Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics
-
Ong S-E, et al. (2002) Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics. Mol Cell Proteomics 1: 376–386.
-
(2002)
Mol Cell Proteomics
, vol.1
, pp. 376-386
-
-
Ong, S.-E.1
-
8
-
-
33745464039
-
Selective identification of newly synthesized proteins in mammalian cells using bioorthogonal noncanonical amino acid tagging (BONCAT)
-
Dieterich DC, Link AJ, Graumann J, Tirrell DA, Schuman EM (2006) Selective identification of newly synthesized proteins in mammalian cells using bioorthogonal noncanonical amino acid tagging (BONCAT). Proc Natl Acad Sci USA 103:9482–9487.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 9482-9487
-
-
Dieterich, D.C.1
Link, A.J.2
Graumann, J.3
Tirrell, D.A.4
Schuman, E.M.5
-
9
-
-
33751201853
-
Fluorescence visualization of newly synthesized proteins in mammalian cells
-
Beatty KE, et al. (2006) Fluorescence visualization of newly synthesized proteins in mammalian cells. Angew Chem Int Ed Engl 45:7364–7367.
-
(2006)
Angew Chem Int Ed Engl
, vol.45
, pp. 7364-7367
-
-
Beatty, K.E.1
-
10
-
-
84905395119
-
In situ visualization of newly synthesized proteins in environmental microbes using amino acid tagging and click chemistry
-
Hatzenpichler R, et al. (2014) In situ visualization of newly synthesized proteins in environmental microbes using amino acid tagging and click chemistry. Environ Microbiol 16:2568–2590.
-
(2014)
Environ Microbiol
, vol.16
, pp. 2568-2590
-
-
Hatzenpichler, R.1
-
11
-
-
77952996319
-
Genome-wide kinetics of nucleosome turnover determined by metabolic labeling of histones
-
Deal RB, Henikoff JG, Henikoff S (2010) Genome-wide kinetics of nucleosome turnover determined by metabolic labeling of histones. Science 328:1161–1164.
-
(2010)
Science
, vol.328
, pp. 1161-1164
-
-
Deal, R.B.1
Henikoff, J.G.2
Henikoff, S.3
-
12
-
-
84928235837
-
De Novo proteome analysis of genetically modified tumor cells by a metabolic labeling/azide-alkyne cycloaddition approach
-
Ballikaya S, et al. (2014) De Novo proteome analysis of genetically modified tumor cells by a metabolic labeling/azide-alkyne cycloaddition approach. Mol Cell Proteomics 13:3446–3456.
-
(2014)
Mol Cell Proteomics
, vol.13
, pp. 3446-3456
-
-
Ballikaya, S.1
-
13
-
-
84875755186
-
QuaNCAT: Quantitating proteome dynamics in primary cells
-
Howden AJM, et al. (2013) QuaNCAT: Quantitating proteome dynamics in primary cells. Nat Methods 10:343–346.
-
(2013)
Nat Methods
, vol.10
, pp. 343-346
-
-
Howden, A.J.M.1
-
14
-
-
84928928913
-
Direct visualization of newly synthesized target proteins in situ
-
tom Dieck S, et al. (2015) Direct visualization of newly synthesized target proteins in situ. Nat Methods 12:411–414.
-
(2015)
Nat Methods
, vol.12
, pp. 411-414
-
-
Tom Dieck, S.1
-
15
-
-
84907021528
-
Bio-orthogonal labeling as a tool to visualize and identify newly synthesized proteins in Caenorhabditis elegans
-
Ullrich M, et al. (2014) Bio-orthogonal labeling as a tool to visualize and identify newly synthesized proteins in Caenorhabditis elegans. Nat Protoc 9:2237–2255.
-
(2014)
Nat Protoc
, vol.9
, pp. 2237-2255
-
-
Ullrich, M.1
-
16
-
-
84882701594
-
Novel proteomic approach (PUNCH-P) reveals cell cycle-specific fluctuations in mRNA translation
-
Aviner R, Geiger T, Elroy-Stein O (2013) Novel proteomic approach (PUNCH-P) reveals cell cycle-specific fluctuations in mRNA translation. Genes Dev 27:1834–1844.
-
(2013)
Genes Dev
, vol.27
, pp. 1834-1844
-
-
Aviner, R.1
Geiger, T.2
Elroy-Stein, O.3
-
17
-
-
84862908426
-
Imaging protein synthesis in cells and tissues with an alkyne analog of puromycin
-
Liu J, Xu Y, Stoleru D, Salic A (2012) Imaging protein synthesis in cells and tissues with an alkyne analog of puromycin. Proc Natl Acad Sci USA 109:413–418.
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. 413-418
-
-
Liu, J.1
Xu, Y.2
Stoleru, D.3
Salic, A.4
-
18
-
-
84958078801
-
Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8 and S100A9
-
Schneider RK, et al. (2016) Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8 and S100A9. Nat Med 22:288–297.
-
(2016)
Nat Med
, vol.22
, pp. 288-297
-
-
Schneider, R.K.1
-
19
-
-
84898739668
-
Haematopoietic stem cells require a highly regulated protein synthesis rate
-
Signer RAJ, Magee JA, Salic A, Morrison SJ (2014) Haematopoietic stem cells require a highly regulated protein synthesis rate. Nature 509:49–54.
-
(2014)
Nature
, vol.509
, pp. 49-54
-
-
Signer, R.A.J.1
Magee, J.A.2
Salic, A.3
Morrison, S.J.4
-
20
-
-
84983337909
-
The rate of protein synthesis in hematopoietic stem cells is limited partly by 4E-BPs
-
Signer RAJ, et al. (2016) The rate of protein synthesis in hematopoietic stem cells is limited partly by 4E-BPs. Genes Dev 30:1698–1703.
-
(2016)
Genes Dev
, vol.30
, pp. 1698-1703
-
-
Signer, R.A.J.1
-
21
-
-
84976334228
-
Stem cell function and stress response are controlled by protein synthesis
-
Blanco S, et al. (2016) Stem cell function and stress response are controlled by protein synthesis. Nature 534:335–340.
-
(2016)
Nature
, vol.534
, pp. 335-340
-
-
Blanco, S.1
-
22
-
-
84955266172
-
Functional genomic screening reveals asparagine dependence as a metabolic vulnerability in sarcoma
-
Hettmer S, et al. (2015) Functional genomic screening reveals asparagine dependence as a metabolic vulnerability in sarcoma. eLife 4:e09436.
-
(2015)
eLife
, vol.4
, pp. e09436
-
-
Hettmer, S.1
-
23
-
-
85017348777
-
An aberrant phase transition of stress granules triggered by misfolded protein and prevented by chaperone function
-
Mateju D, et al. (2017) An aberrant phase transition of stress granules triggered by misfolded protein and prevented by chaperone function. EMBO J 36:1669–1687.
-
(2017)
EMBO J
, vol.36
, pp. 1669-1687
-
-
Mateju, D.1
-
24
-
-
79960839035
-
Oncogenic AKTivation of translation as a therapeutic target
-
Hsieh AC, Truitt ML, Ruggero D (2011) Oncogenic AKTivation of translation as a therapeutic target. Br J Cancer 105:329–336.
-
(2011)
Br J Cancer
, vol.105
, pp. 329-336
-
-
Hsieh, A.C.1
Truitt, M.L.2
Ruggero, D.3
-
25
-
-
84877965001
-
Regulation of mTORC1 and its impact on gene expression at a glance
-
Laplante M, Sabatini DM (2013) Regulation of mTORC1 and its impact on gene expression at a glance. J Cell Sci 126:1713–1719.
-
(2013)
J Cell Sci
, vol.126
, pp. 1713-1719
-
-
Laplante, M.1
Sabatini, D.M.2
-
26
-
-
61349141302
-
Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2
-
Feldman ME, et al. (2009) Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2. PLoS Biol 7:e38.
-
(2009)
PLoS Biol
, vol.7
, pp. e38
-
-
Feldman, M.E.1
-
27
-
-
84860527756
-
A unifying model for mTORC1-mediated regulation of mRNA translation
-
Thoreen CC, et al. (2012) A unifying model for mTORC1-mediated regulation of mRNA translation. Nature 485:109–113.
-
(2012)
Nature
, vol.485
, pp. 109-113
-
-
Thoreen, C.C.1
-
28
-
-
84862777192
-
The translational landscape of mTOR signalling steers cancer initiation and metastasis
-
Hsieh AC, et al. (2012) The translational landscape of mTOR signalling steers cancer initiation and metastasis. Nature 485:55–61.
-
(2012)
Nature
, vol.485
, pp. 55-61
-
-
Hsieh, A.C.1
-
29
-
-
84875219652
-
Efficacy of the investigational mTOR kinase inhibitor MLN0128/ INK128 in models of B-cell acute lymphoblastic leukemia
-
Janes MR, et al. (2013) Efficacy of the investigational mTOR kinase inhibitor MLN0128/ INK128 in models of B-cell acute lymphoblastic leukemia. Leukemia 27:586–594.
-
(2013)
Leukemia
, vol.27
, pp. 586-594
-
-
Janes, M.R.1
-
30
-
-
84881475940
-
The CRAPome: A contaminant repository for affinity purification-mass spectrometry data
-
Mellacheruvu D, et al. (2013) The CRAPome: A contaminant repository for affinity purification-mass spectrometry data. Nat Methods 10:730–736.
-
(2013)
Nat Methods
, vol.10
, pp. 730-736
-
-
Mellacheruvu, D.1
-
31
-
-
77649286736
-
Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E
-
Hsieh AC, et al. (2010) Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E. Cancer Cell 17:249–261.
-
(2010)
Cancer Cell
, vol.17
, pp. 249-261
-
-
Hsieh, A.C.1
-
32
-
-
84930923864
-
Bmi-1 regulates extensive erythroid self-renewal
-
Kim AR, et al. (2015) Bmi-1 regulates extensive erythroid self-renewal. Stem Cell Reports 4:995–1003.
-
(2015)
Stem Cell Reports
, vol.4
, pp. 995-1003
-
-
Kim, A.R.1
-
33
-
-
79953113338
-
Immature erythroblasts with extensive ex vivo self-renewal capacity emerge from the early mammalian fetus
-
England SJ, McGrath KE, Frame JM, Palis J (2011) Immature erythroblasts with extensive ex vivo self-renewal capacity emerge from the early mammalian fetus. Blood 117:2708–2717.
-
(2011)
Blood
, vol.117
, pp. 2708-2717
-
-
England, S.J.1
McGrath, K.E.2
Frame, J.M.3
Palis, J.4
-
34
-
-
84875382908
-
Snx3 regulates recycling of the transferrin receptor and iron assimilation
-
Chen C, et al. (2013) Snx3 regulates recycling of the transferrin receptor and iron assimilation. Cell Metab 17:343–352.
-
(2013)
Cell Metab
, vol.17
, pp. 343-352
-
-
Chen, C.1
-
35
-
-
79961016545
-
Ddx18 is essential for cell-cycle progression in zebrafish hematopoietic cells and is mutated in human AML
-
Payne EM, et al. (2011) Ddx18 is essential for cell-cycle progression in zebrafish hematopoietic cells and is mutated in human AML. Blood 118:903–915.
-
(2011)
Blood
, vol.118
, pp. 903-915
-
-
Payne, E.M.1
-
36
-
-
84919625829
-
The IKAROS interaction with a complex including chromatin remodeling and transcription elongation activities is required for hematopoiesis
-
Bottardi S, et al. (2014) The IKAROS interaction with a complex including chromatin remodeling and transcription elongation activities is required for hematopoiesis. PLoS Genet 10:e1004827.
-
(2014)
PLoS Genet
, vol.10
, pp. e1004827
-
-
Bottardi, S.1
-
37
-
-
84924284076
-
CDK6 levels regulate quiescence exit in human hematopoietic stem cells
-
Laurenti E, et al. (2015) CDK6 levels regulate quiescence exit in human hematopoietic stem cells. Cell Stem Cell 16:302–313.
-
(2015)
Cell Stem Cell
, vol.16
, pp. 302-313
-
-
Laurenti, E.1
-
38
-
-
84952061852
-
Cohesin loss alters adult hematopoietic stem cell homeostasis, leading to myeloproliferative neoplasms
-
Mullenders J, et al. (2015) Cohesin loss alters adult hematopoietic stem cell homeostasis, leading to myeloproliferative neoplasms. J Exp Med 212:1833–1850.
-
(2015)
J Exp Med
, vol.212
, pp. 1833-1850
-
-
Mullenders, J.1
-
39
-
-
84901295341
-
The Thoc1 encoded ribonucleoprotein is required for myeloid progenitor cell homeostasis in the adult mouse
-
Pitzonka L, et al. (2014) The Thoc1 encoded ribonucleoprotein is required for myeloid progenitor cell homeostasis in the adult mouse. PLoS One 9:e97628.
-
(2014)
PLoS One
, vol.9
, pp. e97628
-
-
Pitzonka, L.1
-
40
-
-
34548208677
-
Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation
-
Chambers SM, et al. (2007) Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation. PLoS Biol 5:e201.
-
(2007)
PLoS Biol
, vol.5
, pp. e201
-
-
Chambers, S.M.1
-
41
-
-
84956600520
-
The LMO2 oncogene regulates DNA replication in hematopoietic cells
-
Sincennes M-C, et al. (2016) The LMO2 oncogene regulates DNA replication in hematopoietic cells. Proc Natl Acad Sci USA 113:1393–1398.
-
(2016)
Proc Natl Acad Sci USA
, vol.113
, pp. 1393-1398
-
-
Sincennes, M.-C.1
-
42
-
-
84884368148
-
Western blots versus selected reaction monitoring assays: Time to turn the tables?
-
Aebersold R, Burlingame AL, Bradshaw RA (2013) Western blots versus selected reaction monitoring assays: Time to turn the tables? Mol Cell Proteomics 12:2381–2382.
-
(2013)
Mol Cell Proteomics
, vol.12
, pp. 2381-2382
-
-
Aebersold, R.1
Burlingame, A.L.2
Bradshaw, R.A.3
-
43
-
-
0033566296
-
The glucocorticoid receptor cooperates with the erythropoietin receptor and c-Kit to enhance and sustain proliferation of erythroid progenitors in vitro
-
von Lindern M, et al. (1999) The glucocorticoid receptor cooperates with the erythropoietin receptor and c-Kit to enhance and sustain proliferation of erythroid progenitors in vitro. Blood 94:550–559.
-
(1999)
Blood
, vol.94
, pp. 550-559
-
-
Von Lindern, M.1
-
44
-
-
80052149787
-
Dexamethasone and lenalidomide have distinct functional effects on erythropoiesis
-
Narla A, et al. (2011) Dexamethasone and lenalidomide have distinct functional effects on erythropoiesis. Blood 118:2296–2304.
-
(2011)
Blood
, vol.118
, pp. 2296-2304
-
-
Narla, A.1
-
45
-
-
79952747383
-
Diamond Blackfan anemia treatment: Past, present, and future
-
Narla A, Vlachos A, Nathan DG (2011) Diamond Blackfan anemia treatment: Past, present, and future. Semin Hematol 48:117–123.
-
(2011)
Semin Hematol
, vol.48
, pp. 117-123
-
-
Narla, A.1
Vlachos, A.2
Nathan, D.G.3
-
46
-
-
20444402200
-
An RNA interference model of RPS19 deficiency in Diamond-Blackfan anemia recapitulates defective hematopoiesis and rescue by dexamethasone: Identification of dexamethasone-responsive genes by microarray
-
Ebert BL, et al. (2005) An RNA interference model of RPS19 deficiency in Diamond-Blackfan anemia recapitulates defective hematopoiesis and rescue by dexamethasone: Identification of dexamethasone-responsive genes by microarray. Blood 105: 4620–4626.
-
(2005)
Blood
, vol.105
, pp. 4620-4626
-
-
Ebert, B.L.1
-
47
-
-
34147144995
-
Diamond-Blackfan anemia: Erythropoiesis lost in translation
-
Flygare J, Karlsson S (2007) Diamond-Blackfan anemia: Erythropoiesis lost in translation. Blood 109:3152–3154.
-
(2007)
Blood
, vol.109
, pp. 3152-3154
-
-
Flygare, J.1
Karlsson, S.2
-
48
-
-
85016719487
-
Broad-spectrum kinase profiling in live cells with lysine-targeted sulfonyl fluoride probes
-
Zhao Q, et al. (2017) Broad-spectrum kinase profiling in live cells with lysine-targeted sulfonyl fluoride probes. J Am Chem Soc 139:680–685.
-
(2017)
J Am Chem Soc
, vol.139
, pp. 680-685
-
-
Zhao, Q.1
|