Microglia-derived ASC specks crossseed amyloid-β in Alzheimer's disease

Nature

Volumn 552, Issue 7685, 2017, Pages 355-361

  Venegas, Carmen ^a   Kumar, Sathish ^a   Franklin, Bernardo S ^a   Dierkes, Tobias ^a   Brinkschulte, Rebecca ^a   Tejera, Dario ^a   Vieira Saecker, Ana ^a   Schwartz, Stephanie ^a   Santarelli, Francesco ^a   Kummer, Markus P ^a   Griep, Angelika ^a   Gelpi, Ellen ^b   Beilharz, Michael ^a   Riedel, Dietmar ^c   Golenbock, Douglas T ^d   Geyer, Matthias ^a   Walter, Jochen ^a   Latz, Eicke ^a,d,e   Heneka, Michael T ^a,d,e  

^a UNIVERSITY OF BONN   (Germany)

^b HOSPITAL CLÍNIC   (Spain)

^c MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^d UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^e GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; APOPTOSIS ASSOCIATED SPECK LIKE PROTEIN CONTAINING A CARD PROTEIN; APOPTOSIS ASSOCIATED SPECK LIKE PROTEIN CONTAINING A CARD PROTEIN ANTIBODY; BETA ACTIN; CD11B ANTIGEN; INFLAMMASOME; INSULINASE; INTERLEUKIN 1BETA CONVERTING ENZYME; MEMBRANE METALLOENDOPEPTIDASE; MONOMER; OLIGOMER; PROTEIN ANTIBODY; RECOMBINANT APOPTOSIS ASSOCIATED SPECK LIKE PROTEIN CONTAINING A CARD PROTEIN; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; AMYLOID PRECURSOR PROTEIN; ANTIBODY; CASPASE RECRUITMENT DOMAIN SIGNALING PROTEIN; PRESENILIN 1; PRESENILIN 1, MOUSE; PYCARD PROTEIN, HUMAN; PYCARD PROTEIN, MOUSE;

ANTIBODY; BRAIN; IMMUNE SYSTEM; NERVOUS SYSTEM DISORDER; PATHOLOGY; PROTEIN;

ALZHEIMER DISEASE; AMYLOID PLAQUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR DISORDER; BRAIN HOMOGENATE; CONTROLLED STUDY; CROSS SEEDING; DISEASE ASSOCIATION; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MEMORY DISORDER; MICROGLIA; MILD COGNITIVE IMPAIRMENT; MOUSE; NEUROPATHOLOGY; NEWBORN; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE, FUNCTION AND VARIABILITY; PYRIN DOMAIN; SPATIAL MEMORY; THP-1 CELL LINE; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CHEMISTRY; CYTOLOGY; DEFICIENCY; FEMALE; GENETICS; HIPPOCAMPUS; IMMUNOLOGY; INFLAMMATION; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PHYSIOLOGY; PROTEIN DOMAIN; PROTEINOSIS;

MUS;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; ANTIBODIES; CARD SIGNALING ADAPTOR PROTEINS; FEMALE; HIPPOCAMPUS; HUMANS; INFLAMMASOMES; INFLAMMATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROGLIA; PRESENILIN-1; PROTEIN AGGREGATION, PATHOLOGICAL; PROTEIN DOMAINS; SPATIAL MEMORY;

EID: 85039992429     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature25158     Document Type: Article

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