메뉴 건너뛰기




Volumn 4, Issue 4, 2018, Pages 267-285

Gut microbiome and aging: Physiological and mechanistic insights

Author keywords

Aging; enteric nervous system; gut dysbiosis; gut permeability; intestinal microbiota; metabolic inflammation; prebiotics; probiotics

Indexed keywords


EID: 85048722540     PISSN: 24519480     EISSN: 24519502     Source Type: Journal    
DOI: 10.3233/NHA-170030     Document Type: Review
Times cited : (458)

References (196)
  • 1
    • 77950200010 scopus 로고    scopus 로고
    • The genetics of aging
    • Kenyon CJ. The genetics of aging. Nature. 2010;464(7288):504-12
    • (2010) Nature , vol.464 , Issue.7288 , pp. 504-512
    • Kenyon, C.J.1
  • 5
    • 84888146253 scopus 로고    scopus 로고
    • Clostridium difficile infection in the elderly
    • Keller JM, Surawicz CM. Clostridium difficile infection in the elderly. Clin Geriatr Med. 2014;30(1):79-93
    • (2014) Clin Geriatr Med , vol.30 , Issue.1 , pp. 79-93
    • Keller, J.M.1    Surawicz, C.M.2
  • 6
    • 84928419459 scopus 로고    scopus 로고
    • The microbiota and microbiome in aging: Potential implications in health and age-related diseases
    • Zapata HJ, Quagliarello VJ. The microbiota and microbiome in aging: Potential implications in health and age-related diseases. JAmGeriatr Soc. 2015;63(4):776-81
    • (2015) JAmGeriatr Soc , vol.63 , Issue.4 , pp. 776-781
    • Zapata, H.J.1    Quagliarello, V.J.2
  • 7
    • 85037660225 scopus 로고    scopus 로고
    • Dis Trust your gut: The gut microbiome in age-related inflammation, health, and disease
    • Buford TW. Dis Trust your gut: The gut microbiome in age-related inflammation, health, and disease. Microbiome. 2017;5(80):1-11
    • (2017) Microbiome , vol.5 , Issue.80 , pp. 1-11
    • Buford, T.W.1
  • 9
    • 72449121799 scopus 로고    scopus 로고
    • The human superorganism of microbes and men
    • Sleator RD. The human superorganism of microbes and men. Med Hypotheses. 2010;74(2):214-5
    • (2010) Med Hypotheses , vol.74 , Issue.2 , pp. 214-215
    • Sleator, R.D.1
  • 12
    • 77952178908 scopus 로고    scopus 로고
    • Detection of urea plasmas by the polymerase chain reaction in the amniotic fluid of patients with cervical insufficiency
    • Oh KJ, Lee SE, Jung H, Kim G, Romero R, Yoon BH. Detection of urea plasmas by the polymerase chain reaction in the amniotic fluid of patients with cervical insufficiency. J Perinat Med. 2010;38:261-8
    • (2010) J Perinat Med , vol.38 , pp. 261-268
    • Oh, K.J.1    Lee, S.E.2    Jung, H.3    Kim, G.4    Romero, R.5    Yoon, B.H.6
  • 14
    • 84961620579 scopus 로고    scopus 로고
    • Human gut colonisation may be initiated in utero by distinct microbial communities in the placenta and amniotic fluid
    • Collado MC, Rautava S, Aakko J, Isolauri E, Salminen S. Human gut colonisation may be initiated in utero by distinct microbial communities in the placenta and amniotic fluid. Sci Rep. 2016;6(1):23129
    • (2016) Sci Rep , vol.6 , Issue.1 , pp. 23129
    • Collado, M.C.1    Rautava, S.2    Aakko, J.3    Isolauri, E.4    Salminen, S.5
  • 15
    • 85008887102 scopus 로고    scopus 로고
    • Sensitive quantitative analysis of the meconium bacterial microbiota in healthy term infants born vaginally or by cesarean section
    • Nagpal R, Tsuji H, Takahashi T, Kawashima K, Nagata S, Nomoto K, Yamashiro Y. Sensitive quantitative analysis of the meconium bacterial microbiota in healthy term infants born vaginally or by cesarean section. Front Microbiol. 2016a;7:1997
    • (2016) Front Microbiol , vol.7 , pp. 1997
    • Nagpal, R.1    Tsuji, H.2    Takahashi, T.3    Kawashima, K.4    Nagata, S.5    Nomoto, K.6    Yamashiro, Y.7
  • 16
    • 85028619321 scopus 로고    scopus 로고
    • Dynamics of the gut Bifidobacterium microbiota during the first three years of life: A quantitative assessment
    • Nagpal R, Kurakawa T, Tsuji H, Takahashi T, Kawashima K, Nagata S, Nomoto K, Yamashiro Y. Dynamics of the gut Bifidobacterium microbiota during the first three years of life: A quantitative assessment. Sci Rep. 2017a;7(1): 10097
    • (2017) Sci Rep , vol.7 , Issue.1 , pp. 10097
    • Nagpal, R.1    Kurakawa, T.2    Tsuji, H.3    Takahashi, T.4    Kawashima, K.5    Nagata, S.6    Nomoto, K.7    Yamashiro, Y.8
  • 18
    • 85025661506 scopus 로고    scopus 로고
    • Ontogenesis of the gut microbiota development in healthy fullterm vaginally-born breast-fed infants over the first 3 years of life:Aquantitative bird's-eye view
    • Nagpal R, Tsuji H, Takahashi T, Nomoto K, Kawashima K, Nagata S, Yamashiro Y. Ontogenesis of the gut microbiota development in healthy fullterm vaginally-born breast-fed infants over the first 3 years of life:Aquantitative bird's-eye view. Front Microbiol. 2017c.8:1388
    • (2017) Front Microbiol , vol.8 , pp. 1388
    • Nagpal, R.1    Tsuji, H.2    Takahashi, T.3    Nomoto, K.4    Kawashima, K.5    Nagata, S.6    Yamashiro, Y.7
  • 26
    • 84951797079 scopus 로고    scopus 로고
    • Early life gut microbial composition
    • Nagpal R, Yamashiro Y. Early life gut microbial composition. J Ped Biochem. 2015;5(2):41-50
    • (2015) J Ped Biochem , vol.5 , Issue.2 , pp. 41-50
    • Nagpal, R.1    Yamashiro, Y.2
  • 27
    • 0032974177 scopus 로고    scopus 로고
    • Fecal microflora in healthy infants born by different methods of delivery: Permanent changes in intestinal flora after cesarean delivery
    • Gronlund MM, Lehtonen OP, Eerola E, Kero P. Fecal microflora in healthy infants born by different methods of delivery: Permanent changes in intestinal flora after cesarean delivery. J Ped Gastroenterol Nutr. 1999;28(1): 19-25
    • (1999) J Ped Gastroenterol Nutr , vol.28 , Issue.1 , pp. 19-25
    • Gronlund, M.M.1    Lehtonen, O.P.2    Eerola, E.3    Kero, P.4
  • 28
    • 0036135946 scopus 로고    scopus 로고
    • Molecular monitoring of succession of bacterial communities in human neonates
    • Favier CF, Vaughan EE, Vos WM, Akkermans AD. Molecular monitoring of succession of bacterial communities in human neonates. Appl Environ Microbiol. 2002;68(1):219-26
    • (2002) Appl Environ Microbiol , vol.68 , Issue.1 , pp. 219-226
    • Favier, C.F.1    Vaughan, E.E.2    Vos, W.M.3    Akkermans, A.D.4
  • 31
    • 2942592005 scopus 로고    scopus 로고
    • Characterization of bacterial communities in feces from healthy elderly volunteers and hospitalized elderly patients by using real-time PCR and effects of antibiotic treatment on the fecal microbiota
    • Bartosch S, Fite A, Macfarlane GT, McMurdo M. E. T. Characterization of bacterial communities in feces from healthy elderly volunteers and hospitalized elderly patients by using real-time PCR and effects of antibiotic treatment on the fecal microbiota. Appl Environ Microbiol. 2004;70(6):3575-81
    • (2004) Appl Environ Microbiol , vol.70 , Issue.6 , pp. 3575-3581
    • Bartosch, S.1    Fite, A.2    Macfarlane, G.T.3    McMurdo, M.E.T.4
  • 33
    • 84948992933 scopus 로고    scopus 로고
    • Gut microbiota and aging
    • O'ToolePW, Jeffery IB. Gut microbiota and aging. Science. 2015;350(6265):1214-5
    • (2015) Science , vol.350 , Issue.6265 , pp. 1214-1215
    • O'Toole, P.W.1    Jeffery, I.B.2
  • 37
    • 0035079331 scopus 로고    scopus 로고
    • Differences in the distribution of bifidobacterial and enterobacterial species in human faecal microflora of three different (children, adults, elderly) age groups
    • Gavini F, Cayuela C, Antoine J-M, Lecoq C, Lefebvre B, Membre JM, Neut C. Differences in the distribution of bifidobacterial and enterobacterial species in human faecal microflora of three different (children, adults, elderly) age groups. Microb Ecol Health Dis. 2001;13(1): 40-5
    • (2001) Microb Ecol Health Dis , vol.13 , Issue.1 , pp. 40-45
    • Gavini, F.1    Cayuela, C.2    Antoine, J.-M.3    Lecoq, C.4    Lefebvre, B.5    Membre, J.M.6    Neut, C.7
  • 38
    • 0034761174 scopus 로고    scopus 로고
    • Differences in composition and mucosal adhesion of bifidobacteria isolated from healthy adults and healthy seniors
    • HeF, OuwehandAC, Isolauri E, Hosoda M, BennoY, Seppo S. Differences in composition and mucosal adhesion of bifidobacteria isolated from healthy adults and healthy seniors. Curr Microbiol. 2001;43(5):351-4
    • (2001) Curr Microbiol , vol.43 , Issue.5 , pp. 351-354
    • He, F.1    Ouwehand, A.C.2    Isolauri, E.3    Hosoda, M.4    Benno, Y.5    Seppo, S.6
  • 39
    • 0036241355 scopus 로고    scopus 로고
    • Changes in predominant bacterial populations in human faeces with age and with Clostridium difficile infection
    • Hopkins MJ, Macfarlane GT. Changes in predominant bacterial populations in human faeces with age and with Clostridium difficile infection. J Med Microbiol. 2002;51(5):448-54
    • (2002) J Med Microbiol , vol.51 , Issue.5 , pp. 448-454
    • Hopkins, M.J.1    Macfarlane, G.T.2
  • 40
    • 75549083189 scopus 로고    scopus 로고
    • The effect of age and non-steroidal antiinflammatory drugs on human intestinal microbiota composition
    • Makivuokko H, Tiihonen K, Tynkkynen S, Paulin L, Rautonen N. The effect of age and non-steroidal antiinflammatory drugs on human intestinal microbiota composition. Br J Nutr. 2010;103(2):227-34
    • (2010) Br J Nutr , vol.103 , Issue.2 , pp. 227-234
    • Makivuokko, H.1    Tiihonen, K.2    Tynkkynen, S.3    Paulin, L.4    Rautonen, N.5
  • 41
    • 84857434378 scopus 로고    scopus 로고
    • Clostridium difficile carriage in elderly subjects and associated changes in the intestinal microbiota
    • Rea MC, O'Sullivan O, Shanahan F, O'Toole PW, Stanton C, Ross RP, Hill C. Clostridium difficile carriage in elderly subjects and associated changes in the intestinal microbiota. J Clin Microbiol. 2012;50(3):867-75
    • (2012) J Clin Microbiol , vol.50 , Issue.3 , pp. 867-875
    • Rea, M.C.1    O'Sullivan, O.2    Shanahan, F.3    O'Toole, P.W.4    Stanton, C.5    Ross, R.P.6    Hill, C.7
  • 42
    • 0024510314 scopus 로고
    • Comparison of fecal microflora of elderly persons in rural and urban areas of Japan
    • Benno Y, Endo K, Mizutani T, Namba Y, Komori T, Mitsuoka T. Comparison of fecal microflora of elderly persons in rural and urban areas of Japan. Appl Environ Microbiol. 1989;55(5):1100-5
    • (1989) Appl Environ Microbiol , vol.55 , Issue.5 , pp. 1100-1105
    • Benno, Y.1    Endo, K.2    Mizutani, T.3    Namba, Y.4    Komori, T.5    Mitsuoka, T.6
  • 43
    • 0042471955 scopus 로고    scopus 로고
    • Molecular analysis of fecal microbiota in elderly individuals using 16S rDNA library and T-RFLP
    • Hayashi H, Sakamoto M, Kitahara M, Benno Y. Molecular analysis of fecal microbiota in elderly individuals using 16S rDNA library and T-RFLP. Microbiol Immunol. 2003;47(8):557-70
    • (2003) Microbiol Immunol , vol.47 , Issue.8 , pp. 557-570
    • Hayashi, H.1    Sakamoto, M.2    Kitahara, M.3    Benno, Y.4
  • 45
    • 66049127999 scopus 로고    scopus 로고
    • Combined PCR-DGGE fingerprinting and quantitative-PCR indicates shifts in fecal population sizes and diversity of Bacteroides, bifidobacteria and Clostridium cluster IV in institutionalized elderly
    • Zwielehner J, Liszt K, Handschur M, Lassl C, Lapin A, Haslberger AG. Combined PCR-DGGE fingerprinting and quantitative-PCR indicates shifts in fecal population sizes and diversity of Bacteroides, bifidobacteria and Clostridium cluster IV in institutionalized elderly. Exp Gerontol. 2009;44(6-7):440-6
    • (2009) Exp Gerontol , vol.44 , Issue.6-7 , pp. 440-446
    • Zwielehner, J.1    Liszt, K.2    Handschur, M.3    Lassl, C.4    Lapin, A.5    Haslberger, A.G.6
  • 47
    • 33845874101 scopus 로고    scopus 로고
    • An obesity-associated gut microbiome with increased capacity for energy harvest
    • Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, Gordon JI. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature. 2006;444(7122):1027-31
    • (2006) Nature , vol.444 , Issue.7122 , pp. 1027-1031
    • Turnbaugh, P.J.1    Ley, R.E.2    Mahowald, M.A.3    Magrini, V.4    Mardis, E.R.5    Gordon, J.I.6
  • 55
    • 85028557487 scopus 로고    scopus 로고
    • Metformin, the aspirin of the 21st century: Its role in gestational diabetes mellitus, prevention of preeclampsia and cancer, and the promotion of longevity
    • Romero R, Erez O, Huttemann M, Maymon E, Panaitescu B, Conde-Agudelo A, Pacora P, Yoon BH, Grossman LI. Metformin, the aspirin of the 21st century: Its role in gestational diabetes mellitus, prevention of preeclampsia and cancer, and the promotion of longevity. Am J Obstet Gynecol. 2017;217(3):282-302
    • (2017) Am J Obstet Gynecol , vol.217 , Issue.3 , pp. 282-302
    • Romero, R.1    Erez, O.2    Huttemann, M.3    Maymon, E.4    Panaitescu, B.5    Conde-Agudelo, A.6    Pacora, P.7    Yoon, B.H.8    Grossman, L.I.9
  • 59
    • 33644860220 scopus 로고    scopus 로고
    • Frailty in older adults: Insights and interventions
    • Espinoza S,Walston JD. Frailty in older adults: Insights and interventions. Cleve Clin J Med. 2005;72(12):1105-12
    • (2005) Cleve Clin J Med , vol.72 , Issue.12 , pp. 1105-1112
    • Espinoza, S.1    Walston, J.D.2
  • 60
    • 68949166843 scopus 로고    scopus 로고
    • Factors associated with changing cognitive function in older adults: Implications for nursing rehabilitation
    • Myers JS. Factors associated with changing cognitive function in older adults: Implications for nursing rehabilitation. Rehabil Nurs. 2008;33(3):117-23
    • (2008) Rehabil Nurs , vol.33 , Issue.3 , pp. 117-123
    • Myers, J.S.1
  • 61
    • 84892844794 scopus 로고    scopus 로고
    • Nutritional supplementation during resistance training improved skeletal muscle mass in community-dwelling frail older adults
    • Yamada M, Arai H, Yoshimura K, Kajiwara Y, Sonoda T, Nishiguchi S, Aoyama T. Nutritional supplementation during resistance training improved skeletal muscle mass in community-dwelling frail older adults. J Frailty Aging 2012;1(2):64-70
    • (2012) J Frailty Aging , vol.1 , Issue.2 , pp. 64-70
    • Yamada, M.1    Arai, H.2    Yoshimura, K.3    Kajiwara, Y.4    Sonoda, T.5    Nishiguchi, S.6    Aoyama, T.7
  • 62
    • 84925284836 scopus 로고    scopus 로고
    • Compositional dynamics of the human intestinal microbiota with aging: Implications for health
    • Lakshminarayanan B, Stanton C, O'Toole PW, Ross RP. Compositional dynamics of the human intestinal microbiota with aging: Implications for health. J Nutr Health Aging. 2014;18(9):773-86
    • (2014) J Nutr Health Aging , vol.18 , Issue.9 , pp. 773-786
    • Lakshminarayanan, B.1    Stanton, C.2    O'Toole, P.W.3    Ross, R.P.4
  • 63
    • 3242664636 scopus 로고    scopus 로고
    • Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis
    • Rakoff-Nahoum S, Paglino J, Eslami-Varzaneh F, Edberg S, Medzhitov R. Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell. 2004;118(2):229-41
    • (2004) Cell , vol.118 , Issue.2 , pp. 229-241
    • Rakoff-Nahoum, S.1    Paglino, J.2    Eslami-Varzaneh, F.3    Edberg, S.4    Medzhitov, R.5
  • 64
    • 84897138296 scopus 로고    scopus 로고
    • Role of the microbiota in immunity and inflammation
    • Belkaid Y, Hand TW. Role of the microbiota in immunity and inflammation. Cell. 2014;157(1):121-41
    • (2014) Cell , vol.157 , Issue.1 , pp. 121-141
    • Belkaid, Y.1    Hand, T.W.2
  • 66
    • 84879338344 scopus 로고    scopus 로고
    • Compartmentalized and systemic control of tissue immunity by commensals
    • Belkaid Y, Naik S. Compartmentalized and systemic control of tissue immunity by commensals. Nat Immunol. 2013;14(7):646-53
    • (2013) Nat Immunol , vol.14 , Issue.7 , pp. 646-653
    • Belkaid, Y.1    Naik, S.2
  • 67
    • 85027566080 scopus 로고    scopus 로고
    • The enteric network: Interactions between the immune and nervous systems of the gut
    • Yoo BB, Mazmanian SK. The enteric network: Interactions between the immune and nervous systems of the gut. Immunity. 2017;46(6):910-26
    • (2017) Immunity , vol.46 , Issue.6 , pp. 910-926
    • Yoo, B.B.1    Mazmanian, S.K.2
  • 68
    • 56749146467 scopus 로고    scopus 로고
    • Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis
    • Bouskra D, Brezillon C, Berard M, Werts C, Varona R, Boneca IG, Eberl G. Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis. Nature. 2008;456(7221):507-10
    • (2008) Nature , vol.456 , Issue.7221 , pp. 507-510
    • Bouskra, D.1    Brezillon, C.2    Berard, M.3    Werts, C.4    Varona, R.5    Boneca, I.G.6    Eberl, G.7
  • 69
    • 22144490199 scopus 로고    scopus 로고
    • An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system
    • Mazmanian SK, Liu CH, Tzianabos AO, Kasper DL. An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. Cell. 2005;122(1):107-18
    • (2005) Cell , vol.122 , Issue.1 , pp. 107-118
    • Mazmanian, S.K.1    Liu, C.H.2    Tzianabos, A.O.3    Kasper, D.L.4
  • 71
    • 0036136282 scopus 로고    scopus 로고
    • Lactobacilli differentially modulate expression of cytokines and maturation surface markers in murine dendritic cells
    • Christensen HR, Frokiar H, Petska JJ. Lactobacilli differentially modulate expression of cytokines and maturation surface markers in murine dendritic cells. J Immunol. 2002;168(1):171-8
    • (2002) J Immunol , vol.168 , Issue.1 , pp. 171-178
    • Christensen, H.R.1    Frokiar, H.2    Petska, J.J.3
  • 72
    • 23344440450 scopus 로고    scopus 로고
    • Involvement of intestinal dendritic cells in oral tolerance, immunity to pathogens, and inflammatory bowel disease
    • Kelsall BL, Leon F. Involvement of intestinal dendritic cells in oral tolerance, immunity to pathogens, and inflammatory bowel disease. Immunol Rev. 2005;20(1):132-48
    • (2005) Immunol Rev , vol.20 , Issue.1 , pp. 132-148
    • Kelsall, B.L.1    Leon, F.2
  • 75
    • 84931451067 scopus 로고    scopus 로고
    • Composition and temporal stability of the gut microbiota in older persons
    • Jeffery IB, Lynch DB, O'Toole PW. Composition and temporal stability of the gut microbiota in older persons. ISME J. 2016;10(1):170-82
    • (2016) ISME J , vol.10 , Issue.1 , pp. 170-182
    • Jeffery, I.B.1    Lynch, D.B.2    O'Toole, P.W.3
  • 78
    • 35548944019 scopus 로고    scopus 로고
    • Immune responses to commensal and environmental microbes
    • Pamer EG. Immune responses to commensal and environmental microbes. Nat Immunol. 2007;8(11):1173-8
    • (2007) Nat Immunol , vol.8 , Issue.11 , pp. 1173-1178
    • Pamer, E.G.1
  • 79
    • 78650843522 scopus 로고    scopus 로고
    • To be or not to be a pathogen: That is the mucosally relevant question
    • Sansonetti PJ. To be or not to be a pathogen: That is the mucosally relevant question. Mucosal Immunol. 2011;4(1):8-14
    • (2011) Mucosal Immunol , vol.4 , Issue.1 , pp. 8-14
    • Sansonetti, P.J.1
  • 80
    • 2942625911 scopus 로고    scopus 로고
    • Interactions between commensal intestinal bacteria and the immune system
    • Macpherson AJ, Harris NL. Interactions between commensal intestinal bacteria and the immune system. Nat Rev Immunol. 2004;4(6):478-85
    • (2004) Nat Rev Immunol , vol.4 , Issue.6 , pp. 478-485
    • Macpherson, A.J.1    Harris, N.L.2
  • 84
    • 84899119256 scopus 로고    scopus 로고
    • The impact of aging on the intestinal epithelial barrier and immune system
    • Man AL, Gicheva N, Nicoletti C. The impact of aging on the intestinal epithelial barrier and immune system. Cell Immunol. 2014;289(1-2):112-8
    • (2014) Cell Immunol , vol.289 , Issue.1-2 , pp. 112-118
    • Man, A.L.1    Gicheva, N.2    Nicoletti, C.3
  • 85
    • 85030262529 scopus 로고    scopus 로고
    • Bacterial translocation from the gut to the distant organs: An overview
    • Nagpal R, Yadav H. Bacterial translocation from the gut to the distant organs: An overview. Ann Nutr Metab. 2017;71(1):11-6
    • (2017) Ann Nutr Metab , vol.71 , Issue.1 , pp. 11-16
    • Nagpal, R.1    Yadav, H.2
  • 87
    • 84898824175 scopus 로고    scopus 로고
    • Interactions between the intestinal microbiome and liver diseases
    • Schnabl B, Brenner DA. Interactions between the intestinal microbiome and liver diseases. Gastroenterology. 2014;146(6):1513-24
    • (2014) Gastroenterology , vol.146 , Issue.6 , pp. 1513-1524
    • Schnabl, B.1    Brenner, D.A.2
  • 89
    • 84355166655 scopus 로고    scopus 로고
    • Gut microbiota and diabetes: From pathogenesis to therapeutic perspective
    • Burcelin R, Serino M, Chabo C, Blasco-Baque V, Amar J. Gut microbiota and diabetes: From pathogenesis to therapeutic perspective. Acta Diabetol. 2011;48(4):257-73
    • (2011) Acta Diabetol , vol.48 , Issue.4 , pp. 257-273
    • Burcelin, R.1    Serino, M.2    Chabo, C.3    Blasco-Baque, V.4    Amar, J.5
  • 90
    • 84867845255 scopus 로고    scopus 로고
    • The interplay between the intestinal microbiota and the brain
    • Collins SM, Surette M, Bercik P. The interplay between the intestinal microbiota and the brain. Nat Rev Microbiol. 2012;10(11):735-42
    • (2012) Nat Rev Microbiol , vol.10 , Issue.11 , pp. 735-742
    • Collins, S.M.1    Surette, M.2    Bercik, P.3
  • 91
    • 84911485386 scopus 로고    scopus 로고
    • Gut brain axis: Diet microbiota interactions and implications for modulation of anxiety and depression
    • Luna RA, Foster JA. Gut brain axis: Diet microbiota interactions and implications for modulation of anxiety and depression. Curr Opin Biotechnol. 2015;32:35-41
    • (2015) Curr Opin Biotechnol , vol.32 , pp. 35-41
    • Luna, R.A.1    Foster, J.A.2
  • 92
    • 85009973266 scopus 로고    scopus 로고
    • Gut microbiota: A player in aging and a target for anti-aging intervention
    • Vaiserman AM, Koliada AK, Marotta F. Gut microbiota: A player in aging and a target for anti-aging intervention. Ageing Res Rev. 2017;35:36-45
    • (2017) Ageing Res Rev , vol.35 , pp. 36-45
    • Vaiserman, A.M.1    Koliada, A.K.2    Marotta, F.3
  • 93
    • 84870210992 scopus 로고    scopus 로고
    • Role of the gut microbiota in age-related chronic inflammation
    • Rehman T. Role of the gut microbiota in age-related chronic inflammation. Endocr Metab Immune Disord Drug Targets. 2012;12(4):361-7
    • (2012) Endocr Metab Immune Disord Drug Targets , vol.12 , Issue.4 , pp. 361-367
    • Rehman, T.1
  • 94
    • 84925348854 scopus 로고    scopus 로고
    • Mechanisms of molecular mimicry involving the microbiota in neurodegeneration
    • Friedland RP. Mechanisms of molecular mimicry involving the microbiota in neurodegeneration. J Alzheimers Dis. 2015;45(2):349-62
    • (2015) J Alzheimers Dis , vol.45 , Issue.2 , pp. 349-362
    • Friedland, R.P.1
  • 96
    • 84862501292 scopus 로고    scopus 로고
    • The enteric nervous system and neurogastroenterology
    • Furness JB. The enteric nervous system and neurogastroenterology. Nat Rev Gastroenterol Hepatol. 2012;9(5): 286-94
    • (2012) Nat Rev Gastroenterol Hepatol , vol.9 , Issue.5 , pp. 286-294
    • Furness, J.B.1
  • 97
    • 84989249009 scopus 로고    scopus 로고
    • Modulation of type 1 and type 2 diabetes risk by the intestinal microbiome Pediatr
    • Paun A, Danska JS. Modulation of type 1 and type 2 diabetes risk by the intestinal microbiome Pediatr. Diabetes. 2016;17(7):469-77
    • (2016) Diabetes , vol.17 , Issue.7 , pp. 469-477
    • Paun, A.1    Danska, J.S.2
  • 98
    • 84905367737 scopus 로고    scopus 로고
    • Aging of the mammalian gastrointestinal tract: A complex organ system
    • Saffrey M. Aging of the mammalian gastrointestinal tract: A complex organ system. AGE. 2014;36(3):1019-32
    • (2014) AGE , vol.36 , Issue.3 , pp. 1019-1032
    • Saffrey, M.1
  • 100
    • 77955649024 scopus 로고    scopus 로고
    • Postnatal development of myenteric neuro-chemical phenotype and impact on neuromuscular transmission in the rat colon
    • Vries P, Soret R, Suply E, Heloury Y., Neunlist M. Postnatal development of myenteric neuro-chemical phenotype and impact on neuromuscular transmission in the rat colon. Am J Physiol Gastrointest Liver Physiol. 2010;299(2):G539-47
    • (2010) Am J Physiol Gastrointest Liver Physiol , vol.299 , Issue.2 , pp. G539-G547
    • Vries, P.1    Soret, R.2    Suply, E.3    Heloury, Y.4    Neunlist, M.5
  • 101
    • 84861008807 scopus 로고    scopus 로고
    • Myenteric neurons of the mouse small intestine undergo significant electrophysiological and morphological changes during postnatal development
    • Foong JP, Nguyen TV, Furness JB, Bornstein JC, Young HM. Myenteric neurons of the mouse small intestine undergo significant electrophysiological and morphological changes during postnatal development. J Physiol. 2012;590(10):2375-90
    • (2012) J Physiol , vol.590 , Issue.10 , pp. 2375-2390
    • Foong, J.P.1    Nguyen, T.V.2    Furness, J.B.3    Bornstein, J.C.4    Young, H.M.5
  • 102
    • 0033762532 scopus 로고    scopus 로고
    • Restricted diet rescues rat enteric motor neurons from age related cell death
    • Cowen T, Johnson RJR, Soubeyre V, Santer RM. Restricted diet rescues rat enteric motor neurons from age related cell death. Gut. 2000;47(5):653-60
    • (2000) Gut , vol.47 , Issue.5 , pp. 653-660
    • Cowen, T.1    Johnson, R.J.R.2    Soubeyre, V.3    Santer, R.M.4
  • 103
    • 84884411102 scopus 로고    scopus 로고
    • Cellular changes in the enteric nervous system during aging
    • Saffrey MJ. Cellular changes in the enteric nervous system during aging. Dev Biol. 2013;382(1):344-55
    • (2013) Dev Biol , vol.382 , Issue.1 , pp. 344-355
    • Saffrey, M.J.1
  • 104
    • 79951946473 scopus 로고    scopus 로고
    • Morphological changes in the enteric nervous system of aging and APP23 transgenic mice
    • Van Ginneken C, Schafer KH, Van Dam D, Huygelen V, Deyn PP.Morphological changes in the enteric nervous system of aging and APP23 transgenic mice. Brain Res. 2011;1378:43-53
    • (2011) Brain Res , vol.1378 , pp. 43-53
    • Van Ginneken, C.1    Schafer, K.H.2    Van Dam, D.3    Huygelen, V.4    Deyn, P.P.5
  • 106
    • 0038488561 scopus 로고    scopus 로고
    • Aging of the myenteric plexus: Neuronal loss is specific to cholinergic neurons
    • Phillips RJ, Kieffer EJ, Powley TL. Aging of the myenteric plexus: Neuronal loss is specific to cholinergic neurons. Auton Neurosci. 2003;106(2):69-83
    • (2003) Auton Neurosci , vol.106 , Issue.2 , pp. 69-83
    • Phillips, R.J.1    Kieffer, E.J.2    Powley, T.L.3
  • 107
    • 3543127161 scopus 로고    scopus 로고
    • Age-related changes in the morphology of the myenteric plexus of the human colon
    • Hanani M, Fellig Y, Udassin R, Freund HR. Age-related changes in the morphology of the myenteric plexus of the human colon. Auton Neurosci. 2004;113(1-2): 71-8
    • (2004) Auton Neurosci , vol.113 , Issue.1-2 , pp. 71-78
    • Hanani, M.1    Fellig, Y.2    Udassin, R.3    Freund, H.R.4
  • 108
    • 34249303746 scopus 로고    scopus 로고
    • Age-related changes in the gastrointestinal tract: A functional and immune histochemical study in Guinea-pig ileum
    • Abalo R, Vera G, Rivera AJ, Martin MI. Age-related changes in the gastrointestinal tract: A functional and immune histochemical study in guinea-pig ileum. Life Sci. 2007;80(26):2436-45
    • (2007) Life Sci , vol.80 , Issue.26 , pp. 2436-2445
    • Abalo, R.1    Vera, G.2    Rivera, A.J.3    Martin, M.I.4
  • 109
    • 11244326684 scopus 로고    scopus 로고
    • Loss of glia and neurons in the myenteric plexus of the aged Fischer 344 rat
    • Phillips RJ, Kieffer EJ, Powley TL. Loss of glia and neurons in the myenteric plexus of the aged Fischer 344 rat. Anat Embryol. 2004;209(1):19-30
    • (2004) Anat Embryol , vol.209 , Issue.1 , pp. 19-30
    • Phillips, R.J.1    Kieffer, E.J.2    Powley, T.L.3
  • 110
    • 70349743692 scopus 로고    scopus 로고
    • Alpha-synuclein immune-positive aggregates in the myenteric plexus of the aging Fischer 344 rat
    • Phillips RJ, Walter GC, Ringer BE, Higgs KM, Powley TL. Alpha-synuclein immune-positive aggregates in the myenteric plexus of the aging Fischer 344 rat. Exp Neurol. 2009;220(1):109-19
    • (2009) Exp Neurol , vol.220 , Issue.1 , pp. 109-119
    • Phillips, R.J.1    Walter, G.C.2    Ringer, B.E.3    Higgs, K.M.4    Powley, T.L.5
  • 113
    • 13444280429 scopus 로고    scopus 로고
    • Ileal myenteric plexus in aged Guinea pigs: Loss of structure and calretin in immune-reactive neurons
    • Abalo R, Jose Rivera A, Vera G, Isabel Martin M. Ileal myenteric plexus in aged guinea pigs: Loss of structure and calretin in immune-reactive neurons. Neurogastroenterol Motil. 2005;17(1):123-32
    • (2005) Neurogastroenterol Motil , vol.17 , Issue.1 , pp. 123-132
    • Abalo, R.1    Jose Rivera, A.2    Vera, G.3    Isabel Martin, M.4
  • 115
  • 117
    • 84872686051 scopus 로고    scopus 로고
    • The microbiome is essential for normal gut intrinsic primary afferent neuron excitability in the mouse
    • McVey Neufeld KA, Mao YK, Bienenstock J, Foster JA, Kunze WA. The microbiome is essential for normal gut intrinsic primary afferent neuron excitability in the mouse. Neurogastroenterol Motil. 2013;25(2):183-8
    • (2013) Neurogastroenterol Motil , vol.25 , Issue.2 , pp. 183-188
    • McVey Neufeld, K.A.1    Mao, Y.K.2    Bienenstock, J.3    Foster, J.A.4    Kunze, W.A.5
  • 118
    • 85018951975 scopus 로고    scopus 로고
    • A Specific gut microbiota dysbiosis of type 2 diabetic mice induces GLP-1 resistance through an enteric no-dependent and gut-brain axis mechanism
    • Grasset E, Puel A, Charpentier J, Collet X, Christensen JE, Terce F, Burcelin R. A Specific gut microbiota dysbiosis of type 2 diabetic mice induces GLP-1 resistance through an enteric no-dependent and gut-brain axis mechanism. Cell Metabolism. 2017;25(5):1075-90
    • (2017) Cell Metabolism , vol.25 , Issue.5 , pp. 1075-1090
    • Grasset, E.1    Puel, A.2    Charpentier, J.3    Collet, X.4    Christensen, J.E.5    Terce, F.6    Burcelin, R.7
  • 120
    • 84865445024 scopus 로고    scopus 로고
    • Intestinal aganglionosis is associated with early and sustained disruption of the colonic microbiome
    • Ward NL, Pieretti A, Dowd SE, Cox SB, Goldstein AM. Intestinal aganglionosis is associated with early and sustained disruption of the colonic microbiome. Neurogastroenterol Motil. 2012;24(9):874-e400
    • (2012) Neurogastroenterol Motil , vol.24 , Issue.9 , pp. e400-e874
    • Ward, N.L.1    Pieretti, A.2    Dowd, S.E.3    Cox, S.B.4    Goldstein, A.M.5
  • 121
    • 84995665715 scopus 로고    scopus 로고
    • Microbe-host interactions: Influence of the gut microbiota on the enteric nervous system
    • Hyland NP, Cryan JF. Microbe-host interactions: Influence of the gut microbiota on the enteric nervous system. Dev Biol. 2016;417(2):182-7
    • (2016) Dev Biol , vol.417 , Issue.2 , pp. 182-187
    • Hyland, N.P.1    Cryan, J.F.2
  • 122
    • 84994834941 scopus 로고    scopus 로고
    • The effect of microbiota and the immune system on the development and organization of the enteric nervous system
    • Obata Y, Pachnis V. The effect of microbiota and the immune system on the development and organization of the enteric nervous system. Gastroenterology. 2016;151(5):836-44
    • (2016) Gastroenterology , vol.151 , Issue.5 , pp. 836-844
    • Obata, Y.1    Pachnis, V.2
  • 124
    • 85007609864 scopus 로고    scopus 로고
    • The gut-brain axis, including the microbiome, leaky gut and bacterial translocation: Mechanisms and pathophysiological role in Alzheimer's disease
    • Kohler CA, Maes M, Slyepchenko A, Berk M, Solmi M, Lanctot KL, Carvalho AF. The gut-brain axis, including the microbiome, leaky gut and bacterial translocation: Mechanisms and pathophysiological role in Alzheimer's disease. Curr Pharm Des. 2016;22(40):6152-66
    • (2016) Curr Pharm des , vol.22 , Issue.40 , pp. 6152-6166
    • Kohler, C.A.1    Maes, M.2    Slyepchenko, A.3    Berk, M.4    Solmi, M.5    Lanctot, K.L.6    Carvalho, A.F.7
  • 125
    • 48249125862 scopus 로고    scopus 로고
    • Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice
    • Cani PD, Bibiloni R, Knauf C, Waget A, Neyrinck AM, Delzenne NM, Burcelin R. Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes. 2008;57(6):1470-81
    • (2008) Diabetes , vol.57 , Issue.6 , pp. 1470-1481
    • Cani, P.D.1    Bibiloni, R.2    Knauf, C.3    Waget, A.4    Neyrinck, A.M.5    Delzenne, N.M.6    Burcelin, R.7
  • 127
    • 85007564412 scopus 로고    scopus 로고
    • Intestinal dysbiosis, gut hyperpermeability and bacterial translocation: Missing links between depression, obesity and type 2 diabetes
    • Slyepchenko A, Maes M, Machado-Vieira R, Anderson G, Solmi M, Sanz Y, Berk M, Kohler CA, Carvalho AF. Intestinal dysbiosis, gut hyperpermeability and bacterial translocation: Missing links between depression, obesity and type 2 diabetes. Curr Pharm Des. 2016;22(40):6087-106
    • (2016) Curr Pharm des , vol.22 , Issue.40 , pp. 6087-6106
    • Slyepchenko, A.1    Maes, M.2    Machado-Vieira, R.3    Anderson, G.4    Solmi, M.5    Sanz, Y.6    Berk, M.7    Kohler, C.A.8    Carvalho, A.F.9
  • 128
    • 85028953521 scopus 로고    scopus 로고
    • Markers of intestinal permeability are already altered in early stages of non-alcoholic fatty liver disease: Studies in children
    • Nier A, Engstler AJ, Maier IB, Bergheim I. Markers of intestinal permeability are already altered in early stages of non-alcoholic fatty liver disease: Studies in children. PLoS One. 2017;12(9):e0183282
    • (2017) PLoS One , vol.12 , Issue.9 , pp. e0183282
    • Nier, A.1    Engstler, A.J.2    Maier, I.B.3    Bergheim, I.4
  • 129
    • 85043482167 scopus 로고    scopus 로고
    • Increased human intestinal barrier permeability plasma biomarkers zonulin and FABP2 correlated with plasma LPS and altered gut microbiome in anxiety or depression
    • Stevens BR, Goel R, Seungbum K, Richards EM, Holbert RC, Pepine CJ, Raizada MK. Increased human intestinal barrier permeability plasma biomarkers zonulin and FABP2 correlated with plasma LPS and altered gut microbiome in anxiety or depression. Gut. 2017. pii: gutjnl-2017-314759
    • (2017) Gut
    • Stevens, B.R.1    Goel, R.2    Seungbum, K.3    Richards, E.M.4    Holbert, R.C.5    Pepine, C.J.6    Raizada, M.K.7
  • 132
    • 85028771900 scopus 로고    scopus 로고
    • Impaired intestinal permeability contributes to ongoing bowel symptoms in patients with inflammatory bowel disease and mucosal healing
    • Chang J, Leong RW, Wasinger VC, Ip M, Yang M, Phan TG. Impaired intestinal permeability contributes to ongoing bowel symptoms in patients with inflammatory bowel disease and mucosal healing. Gastroenterol. 2017;153(3):723-31
    • (2017) Gastroenterol , vol.153 , Issue.3 , pp. 723-731
    • Chang, J.1    Leong, R.W.2    Wasinger, V.C.3    Ip, M.4    Yang, M.5    Phan, T.G.6
  • 133
    • 85020044788 scopus 로고    scopus 로고
    • Leaky gut as a danger signal for autoimmune diseases
    • Mu Q, Kirby J, Reilly CM, Luo XM. Leaky gut as a danger signal for autoimmune diseases. Front Immunol. 2017;8:598
    • (2017) Front Immunol , vol.8 , pp. 598
    • Mu, Q.1    Kirby, J.2    Reilly, C.M.3    Luo, X.M.4
  • 134
    • 26844577657 scopus 로고    scopus 로고
    • American gastroenterological association future trends committee report: Effects of aging of the population on gastroenterology practice, education, and research
    • Hall KE, Proctor DD, Fisher L, Rose S. American gastroenterological association future trends committee report: Effects of aging of the population on gastroenterology practice, education, and research. Gastroenterology. 2005;129(4):1305-38
    • (2005) Gastroenterology , vol.129 , Issue.4 , pp. 1305-1338
    • Hall, K.E.1    Proctor, D.D.2    Fisher, L.3    Rose, S.4
  • 135
    • 0036039387 scopus 로고    scopus 로고
    • Aging and intestinal motility: A review of factors that affect intestinal motility in the aged
    • O'MahonyD, O'Leary P, Quigley EM. Aging and intestinal motility: A review of factors that affect intestinal motility in the aged. Drugs Aging. 2002;19(7):515-27
    • (2002) Drugs Aging , vol.19 , Issue.7 , pp. 515-527
    • O'Mahony, D.1    O'Leary, P.2    Quigley, E.M.3
  • 136
    • 34548525132 scopus 로고    scopus 로고
    • Innervation of the gastrointestinal tract: Patterns of aging
    • Phillips RJ, Powley TL. Innervation of the gastrointestinal tract: Patterns of aging. Auton Neurosci. 2007;136(1-2):1-19
    • (2007) Auton Neurosci , vol.136 , Issue.1-2 , pp. 1-19
    • Phillips, R.J.1    Powley, T.L.2
  • 137
    • 0036796922 scopus 로고    scopus 로고
    • Ageand diet-related increase in transepithelial colon permeability of Fischer 344 rats
    • Mullin JM, Valenzano MC, Verrecchio JJ, Kothari R. Ageand diet-related increase in transepithelial colon permeability of Fischer 344 rats. Dig Dis Sci. 2002;47(10):2262-70
    • (2002) Dig Dis Sci , vol.47 , Issue.10 , pp. 2262-2270
    • Mullin, J.M.1    Valenzano, M.C.2    Verrecchio, J.J.3    Kothari, R.4
  • 138
    • 73749083820 scopus 로고    scopus 로고
    • Ex vivo permeability experiments in excised rat intestinal tissue and in vitro solubility measurements in aspirated human intestinal fluids support age-dependent oral drug absorption
    • Annaert P, Brouwers J, Bijnens A, Lammert F, Tack J, Augustijns P. Ex vivo permeability experiments in excised rat intestinal tissue and in vitro solubility measurements in aspirated human intestinal fluids support age-dependent oral drug absorption. Eur J Pharm Sci. 2010;39(1-3):15-22
    • (2010) Eur J Pharm Sci , vol.39 , Issue.1-3 , pp. 15-22
    • Annaert, P.1    Brouwers, J.2    Bijnens, A.3    Lammert, F.4    Tack, J.5    Augustijns, P.6
  • 139
    • 33947631511 scopus 로고    scopus 로고
    • IL-1beta causes an increase in intestinal epithelial tight junction permeability
    • Al-Sadi RM, Ma TY. IL-1beta causes an increase in intestinal epithelial tight junction permeability. J Immunol. 2007;178(7):4641-9
    • (2007) J Immunol , vol.178 , Issue.7 , pp. 4641-4649
    • Al-Sadi, R.M.1    Ma, T.Y.2
  • 142
    • 70349899283 scopus 로고    scopus 로고
    • The intestinal epithelial barrier: Does it become impaired with age?
    • Meier J, Sturm A. The intestinal epithelial barrier: Does it become impaired with age?. Dig Dis. 2009;27(3):240-5
    • (2009) Dig Dis , vol.27 , Issue.3 , pp. 240-245
    • Meier, J.1    Sturm, A.2
  • 144
    • 0034127354 scopus 로고    scopus 로고
    • The adherent gastric antral and duodenal mucus gel layer thins with advancing age in subjects infected with Helicobacter pylori
    • Newton JL, Jordan N, Pearson J, Williams GV, Allen A, James OF. The adherent gastric antral and duodenal mucus gel layer thins with advancing age in subjects infected with Helicobacter pylori. Gerontology. 2000;46(3): 153-57
    • (2000) Gerontology , vol.46 , Issue.3 , pp. 153-157
    • Newton, J.L.1    Jordan, N.2    Pearson, J.3    Williams, G.V.4    Allen, A.5    James, O.F.6
  • 146
    • 85014563489 scopus 로고    scopus 로고
    • Gut permeability and mucosal inflammation: Bad, good or context dependent
    • Ahmad R, Sorrell MF, Batra SK, Dhawan P, Singh AB. Gut permeability and mucosal inflammation: Bad, good or context dependent. Mucosal Immunol. 2017;10(2): 307-17
    • (2017) Mucosal Immunol , vol.10 , Issue.2 , pp. 307-317
    • Ahmad, R.1    Sorrell, M.F.2    Batra, S.K.3    Dhawan, P.4    Singh, A.B.5
  • 150
    • 33745301716 scopus 로고    scopus 로고
    • The effects of short-chain fatty acids on colon epithelial proliferation and survival depend on the cellular phenotype
    • Comalada M, Bailon E, Haro O, Lara-Villoslada F, Xaus J, Zarzuelo A, Galvez J. The effects of short-chain fatty acids on colon epithelial proliferation and survival depend on the cellular phenotype. J Cancer Res Clin Oncol. 2006;132(8):487-97
    • (2006) J Cancer Res Clin Oncol , vol.132 , Issue.8 , pp. 487-497
    • Comalada, M.1    Bailon, E.2    Haro, O.3    Lara-Villoslada, F.4    Xaus, J.5    Zarzuelo, A.6    Galvez, J.7
  • 151
    • 0036674501 scopus 로고    scopus 로고
    • Dissemination and growth of cancer cells in metastatic sites
    • Chambers AF, Groom AC, MacDonald IC. Dissemination and growth of cancer cells in metastatic sites. Nat Rev Cancer. 2002;2(8):563-72
    • (2002) Nat Rev Cancer , vol.2 , Issue.8 , pp. 563-572
    • Chambers, A.F.1    Groom, A.C.2    MacDonald, I.C.3
  • 152
    • 77949285392 scopus 로고    scopus 로고
    • Human intestinal microbiota and healthy aging
    • Tiihonen K, Ouwehand AC, Rautonen N. Human intestinal microbiota and healthy aging. Ageing Res Rev. 2010;9(2):107-16
    • (2010) Ageing Res Rev , vol.9 , Issue.2 , pp. 107-116
    • Tiihonen, K.1    Ouwehand, A.C.2    Rautonen, N.3
  • 154
    • 78650408264 scopus 로고    scopus 로고
    • Diet, gut microbiota and immune responses
    • Maslowski KM, Mackay CR. Diet, gut microbiota and immune responses. Nature Immunol. 2011;12(1):5-9
    • (2011) Nature Immunol , vol.12 , Issue.1 , pp. 5-9
    • Maslowski, K.M.1    Mackay, C.R.2
  • 155
    • 84887611901 scopus 로고    scopus 로고
    • Is butyrate the link between diet, intestinal microbiota and obesity-related metabolic diseases?
    • Brahe LK, Astrup A, Larsen LH. Is butyrate the link between diet, intestinal microbiota and obesity-related metabolic diseases? Obes Rev. 2013;14(12):950-9
    • (2013) Obes Rev , vol.14 , Issue.12 , pp. 950-959
    • Brahe, L.K.1    Astrup, A.2    Larsen, L.H.3
  • 158
    • 85006340468 scopus 로고    scopus 로고
    • Gut instincts: Microbiota as a key regulator of brain development, ageing and neurodegeneration
    • Dinan TG, Cryan JF. Gut instincts: Microbiota as a key regulator of brain development, ageing and neurodegeneration. J Physiol. 2017;595(2):489-503
    • (2017) J Physiol , vol.595 , Issue.2 , pp. 489-503
    • Dinan, T.G.1    Cryan, J.F.2
  • 160
    • 84899887691 scopus 로고    scopus 로고
    • Recycling Metchnikoff: Probiotics, the intestinal microbiome and the quest for long life
    • Mackowiak PA. Recycling Metchnikoff: Probiotics, the intestinal microbiome and the quest for long life. Front Public Health. 2013;1:52
    • (2013) Front Public Health , vol.1 , pp. 52
    • Mackowiak, P.A.1
  • 161
    • 79959201412 scopus 로고    scopus 로고
    • Human nutrition, the gut microbiome and the immune system
    • Kau AL, Ahern PP, Griffin NW, Goodman AL, Gordon JI. Human nutrition, the gut microbiome and the immune system. Nature. 2011;474(7351):327-36
    • (2011) Nature , vol.474 , Issue.7351 , pp. 327-336
    • Kau, A.L.1    Ahern, P.P.2    Griffin, N.W.3    Goodman, A.L.4    Gordon, J.I.5
  • 162
    • 0029013322 scopus 로고
    • Dietary modulation of the human colonic microbiota: Introducing the concept of prebiotics
    • Gibson GR and Roberfroid MB. Dietary modulation of the human colonic microbiota: Introducing the concept of prebiotics. J Nutr. 1995;125(6):1401-12
    • (1995) J Nutr , vol.125 , Issue.6 , pp. 1401-1412
    • Gibson, G.R.1    Roberfroid, M.B.2
  • 163
    • 84858596184 scopus 로고    scopus 로고
    • Effect of prebiotics on the human gut microbiota of elderly persons
    • Toward R, Montandon S, Walton G, Gibson GR. Effect of prebiotics on the human gut microbiota of elderly persons. Gut Microbes. 2012;3(1):57-60
    • (2012) Gut Microbes , vol.3 , Issue.1 , pp. 57-60
    • Toward, R.1    Montandon, S.2    Walton, G.3    Gibson, G.R.4
  • 164
    • 55849146633 scopus 로고    scopus 로고
    • Modulation of the fecal microflora profile and immune function by a novel trans-galactooligosaccharide mixture (B-GOS) in healthy elderly volunteers
    • Vulevic J, Drakoularakou A, Yaqoob P, Tzortzis G, Gibson GR. Modulation of the fecal microflora profile and immune function by a novel trans-galactooligosaccharide mixture (B-GOS) in healthy elderly volunteers. Am J Clin Nutr. 2008;88(5):1438-46
    • (2008) Am J Clin Nutr , vol.88 , Issue.5 , pp. 1438-1446
    • Vulevic, J.1    Drakoularakou, A.2    Yaqoob, P.3    Tzortzis, G.4    Gibson, G.R.5
  • 166
    • 80053022702 scopus 로고    scopus 로고
    • Effect of the continuous intake of probiotic-fermented milk containing Lactobacillus casei strain Shirota on fever in a mass outbreak of norovirus gastroenteritis and the faecal microflora in a health service facility for the aged
    • Nagata S, Asahara T, Ohta T, Yamada T, Kondo S, Bian L, Wang C, Yamashiro Y, Nomoto K. Effect of the continuous intake of probiotic-fermented milk containing Lactobacillus casei strain Shirota on fever in a mass outbreak of norovirus gastroenteritis and the faecal microflora in a health service facility for the aged. Br J Nutr. 2011;106(4):549-56
    • (2011) Br J Nutr , vol.106 , Issue.4 , pp. 549-556
    • Nagata, S.1    Asahara, T.2    Ohta, T.3    Yamada, T.4    Kondo, S.5    Bian, L.6    Wang, C.7    Yamashiro, Y.8    Nomoto, K.9
  • 167
    • 84864498285 scopus 로고    scopus 로고
    • Probiotics, their health benefits and applications for developing healthier foods: A review
    • Nagpal R,Kumar A,Kumar M, Behare PV, Jain S,YadavH. Probiotics, their health benefits and applications for developing healthier foods: A review. FEMS Microbiol Lett. 2012;334(1):1-15
    • (2012) FEMS Microbiol Lett , vol.334 , Issue.1 , pp. 1-15
    • Nagpal, R.1    Kumar, A.2    Kumar, M.3    Behare, P.V.4    Jain, S.5    Yadav, H.6
  • 169
    • 84862338872 scopus 로고    scopus 로고
    • Probiotic cheese containing Lactobacillus rhamnosus HN001 and Lactobacillus acidophilus NCFM® modifies subpopulations of fecal lactobacilli and Clostridium difficile in the elderly
    • Lahtinen SJ, Forssten S, Aakko J, Granlund L, Rautonen N, Salminen S, Viitanen M, Ouwehand AC. Probiotic cheese containing Lactobacillus rhamnosus HN001 and Lactobacillus acidophilus NCFM® modifies subpopulations of fecal lactobacilli and Clostridium difficile in the elderly. Age (Dordr). 2012;34(1):133-43
    • (2012) Age (Dordr) , vol.34 , Issue.1 , pp. 133-143
    • Lahtinen, S.J.1    Forssten, S.2    Aakko, J.3    Granlund, L.4    Rautonen, N.5    Salminen, S.6    Viitanen, M.7    Ouwehand, A.C.8
  • 170
    • 84863588844 scopus 로고    scopus 로고
    • Arandomised crossover study investigating the effects of galactooligosaccharides on the faecal microbiota in men and women over 50 years of age
    • Walton GE, Heuvel EGHM,KostersMHW, Rastall RA, TuohyKM, Gibson GR.Arandomised crossover study investigating the effects of galactooligosaccharides on the faecal microbiota in men and women over 50 years of age. Br J Nutr. 2012;107(10):1466-75
    • (2012) Br J Nutr , vol.107 , Issue.10 , pp. 1466-1475
    • Walton, G.E.1    Heuvel, E.G.H.M.2    Kosters, M.H.W.3    Rastall, R.A.4    Tuohy, K.M.5    Gibson, G.R.6
  • 171
    • 34447630803 scopus 로고    scopus 로고
    • Use of probiotic Lactobacillus preparation to prevent diarrhoea associated with antibiotics: Randomised double blind placebo controlled trial
    • Hickson M, D'Souza AL, Muthu N, Rogers TR, Want S, Rajkumar C, Bulpitt CJ. Use of probiotic Lactobacillus preparation to prevent diarrhoea associated with antibiotics: Randomised double blind placebo controlled trial. BMJ. 2007;335(7610):80
    • (2007) BMJ , vol.335 , Issue.7610 , pp. 80
    • Hickson, M.1    D'Souza, A.L.2    Muthu, N.3    Rogers, T.R.4    Want, S.5    Rajkumar, C.6    Bulpitt, C.J.7
  • 172
    • 34547202163 scopus 로고    scopus 로고
    • Fermented cereal with specific bifidobacteria normalizes bowel movements in elderly nursing home residents A randomized, controlled trial
    • Pitkala KH, Strandberg TE, Finne Soveri UH, Ouwehand AC, Poussa T, Salminen S. Fermented cereal with specific bifidobacteria normalizes bowel movements in elderly nursing home residents. A randomized, controlled trial. J Nutr Health Aging. 2007;11(4):305-11
    • (2007) J Nutr Health Aging , vol.11 , Issue.4 , pp. 305-311
    • Pitkala, K.H.1    Strandberg, T.E.2    Finne Soveri, U.H.3    Ouwehand, A.C.4    Poussa, T.5    Salminen, S.6
  • 173
    • 77951921882 scopus 로고    scopus 로고
    • Efficacy of lactic acid bacteria (LAB) supplement in management of constipation among nursing home residents
    • An HM, Baek EH, Jang S, Lee DK, Kim MJ, Kim JR, Lee KO, Park JG, Ha NJ. Efficacy of lactic acid bacteria (LAB) supplement in management of constipation among nursing home residents. J Nutr. 2010;9(5)
    • (2010) J Nutr , vol.9 , Issue.5
    • An, H.M.1    Baek, E.H.2    Jang, S.3    Lee, D.K.4    Kim, M.J.5    Kim, J.R.6    Lee, K.O.7    Park, J.G.8    Ha, N.J.9
  • 174
    • 75549091605 scopus 로고    scopus 로고
    • Consumption of a fermented dairy product containing the probiotic Lactobacillus casei DN-114 001 reduces the duration of respiratory infections in the elderly in a randomised controlled trial
    • Guillemard E, Tondu F, Lacoin F, Schrezenmeir J. Consumption of a fermented dairy product containing the probiotic Lactobacillus casei DN-114 001 reduces the duration of respiratory infections in the elderly in a randomised controlled trial. Br J Nutr. 2010;103(1):58-68
    • (2010) Br J Nutr , vol.103 , Issue.1 , pp. 58-68
    • Guillemard, E.1    Tondu, F.2    Lacoin, F.3    Schrezenmeir, J.4
  • 175
    • 0035179295 scopus 로고    scopus 로고
    • Enhancement of immunity in the elderly by dietary supplementation with the probiotic Bifidobacterium lactis HN019
    • Gill HS, Rutherfurd KJ, Cross ML, Gopal PK. Enhancement of immunity in the elderly by dietary supplementation with the probiotic Bifidobacterium lactis HN019.AmJ Clin Nutr. 2001;74(6):833-9
    • (2001) AmJ Clin Nutr , vol.74 , Issue.6 , pp. 833-839
    • Gill, H.S.1    Rutherfurd, K.J.2    Cross, M.L.3    Gopal, P.K.4
  • 176
    • 33745500984 scopus 로고    scopus 로고
    • Anti-inflammatory metabolite production in the gut from the consumption of probiotic yogurt containing Bifidobacterium animalis subsp
    • Matsumoto M, Benno Y. Anti-inflammatory metabolite production in the gut from the consumption of probiotic yogurt containing Bifidobacterium animalis subsp. lactis LKM512. Biosci Biotechnol Biochem. 2006;70(6): 1287-92
    • (2006) Lactis LKM512. Biosci Biotechnol Biochem , vol.70 , Issue.6 , pp. 1287-1292
    • Matsumoto, M.1    Benno, Y.2
  • 178
    • 84876432991 scopus 로고    scopus 로고
    • Probiotics and prebiotics and health in ageing populations
    • Duncan SH, Flint HJ. Probiotics and prebiotics and health in ageing populations. Maturitas. 2013;75(1):44-50
    • (2013) Maturitas , vol.75 , Issue.1 , pp. 44-50
    • Duncan, S.H.1    Flint, H.J.2
  • 179
    • 65349157701 scopus 로고    scopus 로고
    • Oral administration of live Bifidobacterium substrains isolated from healthy centenarians enhanced immune function in BALB/c mice
    • Yang H-Y, Liu S-L, Ibrahim SA, Zhao L, Jiang J-L, Sun W-F, et al. Oral administration of live Bifidobacterium substrains isolated from healthy centenarians enhanced immune function in BALB/c mice. Nutr Res. 2009;29(4):281-9
    • (2009) Nutr Res , vol.29 , Issue.4 , pp. 281-289
    • Yang, H.-Y.1    Liu, S.-L.2    Ibrahim, S.A.3    Zhao, L.4    Jiang, J.-L.5    Sun, W.-F.6
  • 180
    • 79955569490 scopus 로고    scopus 로고
    • Development of the human gastrointestinal microbiota and insights from high-throughput sequencing
    • Dominguez-Bello MG, Blaser MJ, Ley RE, Knight R. Development of the human gastrointestinal microbiota and insights from high-throughput sequencing. Gastroenterology. 2011;140(6):1713-9
    • (2011) Gastroenterology , vol.140 , Issue.6 , pp. 1713-1719
    • Dominguez-Bello, M.G.1    Blaser, M.J.2    Ley, R.E.3    Knight, R.4
  • 181
    • 79954422661 scopus 로고    scopus 로고
    • In vitro and in vivo antioxidant activity of Bifidobacterium animalis 01 isolated from centenarians
    • Shen Q, Shang N, Li P. In vitro and in vivo antioxidant activity of Bifidobacterium animalis 01 isolated from centenarians. Curr Microbiol. 2011;62(4):1097-103
    • (2011) Curr Microbiol , vol.62 , Issue.4 , pp. 1097-1103
    • Shen, Q.1    Shang, N.2    Li, P.3
  • 182
    • 80053150201 scopus 로고    scopus 로고
    • Barcoded pyrosequencing reveals that consumption of galactooligosaccharides results in a highly specific bifidogenic response in humans
    • Davis LM, Martinez I, Walter J, Caitlin G, Hutkins RW. Barcoded pyrosequencing reveals that consumption of galactooligosaccharides results in a highly specific bifidogenic response in humans. PLoS One. 2011;6(9): e25200
    • (2011) PLoS One , vol.6 , Issue.9 , pp. e25200
    • Davis, L.M.1    Martinez, I.2    Walter, J.3    Caitlin, G.4    Hutkins, R.W.5
  • 183
    • 0030904993 scopus 로고    scopus 로고
    • Effects of inulin and lactose on fecal microflora, microbial activity, and bowel habit in elderly constipated persons
    • Kleessen B, Sykura B, Zunft HJ, Blaut M. Effects of inulin and lactose on fecal microflora, microbial activity, and bowel habit in elderly constipated persons. Am J Clin Nutr. 1997;65(5):1397-402
    • (1997) Am J Clin Nutr , vol.65 , Issue.5 , pp. 1397-1402
    • Kleessen, B.1    Sykura, B.2    Zunft, H.J.3    Blaut, M.4
  • 184
    • 38949200638 scopus 로고    scopus 로고
    • Four-week short chain fructo-oligosaccharides ingestion leads to increasing fecal bifidobacteria and cholesterol excretion in healthy elderly volunteers
    • BouhnikY, Achour L, PaineauDRiottot M, Attar A, Bornet F. Four-week short chain fructo-oligosaccharides ingestion leads to increasing fecal bifidobacteria and cholesterol excretion in healthy elderly volunteers. Nutr J. 2007;6(42)
    • (2007) Nutr J , vol.6 , Issue.42
    • Bouhnik, Y.1    Achour, L.2    Paineau, D.3    Riottot, M.4    Attar, A.5    Bornet, F.6
  • 185
    • 84874720592 scopus 로고    scopus 로고
    • A mixture of trans-galactooligosaccharides reduces markers of metabolic syndrome and modulates the fecal microbiota and immune function of overweight adults
    • Vulevic J, Juric A, Tzortzis G, Gibson GR. A mixture of trans-galactooligosaccharides reduces markers of metabolic syndrome and modulates the fecal microbiota and immune function of overweight adults. J Nutr. 2013;143(3):324-31
    • (2013) J Nutr , vol.143 , Issue.3 , pp. 324-331
    • Vulevic, J.1    Juric, A.2    Tzortzis, G.3    Gibson, G.R.4
  • 186
    • 79958248593 scopus 로고    scopus 로고
    • Prebiotic effects of wheat arabinoxylan related to the increase in bifidobacteria, Roseburia and Bacteroides/Prevotella in diet-induced obese mice
    • Neyrinck AM, Possemiers S, Druart C, Van Wiele T, Backer F, Cani PD, Larondelle Y, Delzenne NM. Prebiotic effects of wheat arabinoxylan related to the increase in bifidobacteria, Roseburia and Bacteroides/Prevotella in diet-induced obese mice. PLoS One. 2011;6(6):e20944
    • (2011) PLoS One , vol.6 , Issue.6 , pp. e20944
    • Neyrinck, A.M.1    Possemiers, S.2    Druart, C.3    Van Wiele, T.4    Backer, F.5    Cani, P.D.6    Larondelle, Y.7    Delzenne, N.M.8
  • 187
    • 84863537082 scopus 로고    scopus 로고
    • 454 pyrosequencing reveals a shift in fecal microbiota of healthy adult men consuming polydextrose or soluble corn fiber
    • Hooda S, Boler BM, Serao MC, Brulc JM, Staeger MA, Boileau TW, Dowd SE, Fahey GC Jr, Swanson KS. 454 pyrosequencing reveals a shift in fecal microbiota of healthy adult men consuming polydextrose or soluble corn fiber. J Nutr. 2012;142(7):1259-65
    • (2012) J Nutr , vol.142 , Issue.7 , pp. 1259-1265
    • Hooda, S.1    Boler, B.M.2    Serao, M.C.3    Brulc, J.M.4    Staeger, M.A.5    Boileau, T.W.6    Dowd, S.E.7    Fahey, G.C.8    Swanson, K.S.9
  • 189
    • 33751112482 scopus 로고    scopus 로고
    • Probiotics, prebiotics and synbiotics: A role in chemoprevention for colorectal cancer?
    • Geier MS, Butler RN, Howarth GS. Probiotics, prebiotics and synbiotics: A role in chemoprevention for colorectal cancer? Cancer Biol Ther. 2006;5(10):1265-9
    • (2006) Cancer Biol Ther , vol.5 , Issue.10 , pp. 1265-1269
    • Geier, M.S.1    Butler, R.N.2    Howarth, G.S.3
  • 190
    • 84886085899 scopus 로고    scopus 로고
    • Faecal microbiota transplantation for the treatment of recurrent Clostridium difficile infection: Current promise and future needs
    • Koenigsknecht MJ, Young VB. Faecal microbiota transplantation for the treatment of recurrent Clostridium difficile infection: Current promise and future needs. Curr Opin Gastroenterol. 2013;29(6):628-32
    • (2013) Curr Opin Gastroenterol , vol.29 , Issue.6 , pp. 628-632
    • Koenigsknecht, M.J.1    Young, V.B.2
  • 191
    • 84922764903 scopus 로고    scopus 로고
    • Fecal microbiota transplantation for the management of Clostridium difficile infection
    • Rao K, Young VB. Fecal microbiota transplantation for the management of Clostridium difficile infection. Infect Dis Clin North Am. 2015;29(1):109-22
    • (2015) Infect Dis Clin North Am , vol.29 , Issue.1 , pp. 109-122
    • Rao, K.1    Young, V.B.2
  • 192
    • 84945454259 scopus 로고    scopus 로고
    • First implementation of frozen, capsulized faecal microbiota transplantation for recurrent Clostridium difficile infection into clinical practice in Europe
    • Tacke D, Wisplinghoff H, Kretzschmar A, Farowski F, Koehler P, Herweg J, Cornely OA, Vehreschild MJ. First implementation of frozen, capsulized faecal microbiota transplantation for recurrent Clostridium difficile infection into clinical practice in Europe. Clin Microbiol Infect. 2015;2015;21(11):e82-4
    • (2015) Clin Microbiol Infect. 2015 , vol.21 , Issue.11 , pp. e82-e84
    • Tacke, D.1    Wisplinghoff, H.2    Kretzschmar, A.3    Farowski, F.4    Koehler, P.5    Herweg, J.6    Cornely, O.A.7    Vehreschild, M.J.8
  • 194
    • 84898835480 scopus 로고    scopus 로고
    • Manipulation of the microbiota for treatment of IBS and IBD-challenges and controversies
    • Shanahan F, Quigley EM. Manipulation of the microbiota for treatment of IBS and IBD-challenges and controversies. Gastroenterology. 2014;146(6):1554-63
    • (2014) Gastroenterology , vol.146 , Issue.6 , pp. 1554-1563
    • Shanahan, F.1    Quigley, E.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.