Ex vivo permeability experiments in excised rat intestinal tissue and in vitro solubility measurements in aspirated human intestinal fluids support age-dependent oral drug absorption

European Journal of Pharmaceutical Sciences

Volumn 39, Issue 1-3, 2010, Pages 15-22

  Annaert, Pieter ^a   Brouwers, Joachim ^a   Bijnens, Ann ^a   Lammert, Frank ^c   Tack, Jan ^b   Augustijns, Patrick ^a  

^a DEPARTMENT OF PHARMACEUTICAL AND PHARMACOLOGICAL SCIENCES   (Belgium)

^b UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^c SAARLAND UNIVERSITY   (Germany)

Author keywords

Age dependent Pharmacokinetics; Drug solubility; Human intestinal fluids; Intestinal drug absorption; Intestinal permeability

Indexed keywords

ATENOLOL; BILE SALT; CARBAMAZEPINE; DANAZOL; DIAZEPAM; GLIBENCLAMIDE; GLIPIZIDE; GLYCOPROTEIN P; GRISEOFULVIN; INDOMETACIN; KETOCONAZOLE; LOVIRIDE; METOPROLOL; NIFEDIPINE; TALINOLOL;

ADULT; AGED; AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG PENETRATION; DRUG SOLUBILITY; DRUG TRANSPORT; EX VIVO STUDY; FEMALE; HUMAN; IN VITRO STUDY; INTESTINE; INTESTINE FLUID; INTESTINE MUCOSA PERMEABILITY; MALE; NONHUMAN; PH; PRIORITY JOURNAL; RAT;

ADMINISTRATION, ORAL; ADOLESCENT; ADULT; AGED; AGING; ANIMALS; BIOLOGICAL TRANSPORT; BODY FLUIDS; FEMALE; HUMANS; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; MALE; MIDDLE AGED; PERMEABILITY; PHARMACEUTICAL PREPARATIONS; RATS; RATS, WISTAR; SOLUBILITY;

EID: 73749083820     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2009.10.005     Document Type: Article

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