The effect of age and non-steroidal anti-inflammatory drugs on human intestinal microbiota composition

British Journal of Nutrition

Volumn 103, Issue 2, 2010, Pages 227-234

  Mäkivuokko, Harri ^a,b   Tiihonen, Kirsti ^a   Tynkkynen, Soile ^c   Paulin, Lars ^d   Rautonen, Nina ^a  

^a Danisco Finland Oy   (Finland)

^b FINNISH RED CROSS BLOOD SERVICE   (Finland)

^c VALIO LTD   (Finland)

^d UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Ageing; Microbiota; Non steroidal anti inflammatory drugs; Percentage guanine+cytosine

Indexed keywords

ACETYLSALICYLIC ACID; BISOPROLOL; BUTYRIC ACID; CELECOXIB; CYTOSINE; DICLOFENAC; DNA 16S; ENALAPRIL; ENTACAPONE; FINASTERIDE; GALANTAMINE; GUANINE; IBUPROFEN; INDOMETACIN; KETOPROFEN; LAXATIVE; LOSARTAN; MAGNESIUM HYDROXIDE; MIRTAZAPINE; NIMESULIDE; NONSTEROID ANTIINFLAMMATORY AGENT; OLANZAPINE; OXCARBAZEPINE; PIROXICAM; PRAMIPEXOLE; RANITIDINE; RIBOSOME DNA; RISPERIDONE; SPIRONOLACTONE; UNINDEXED DRUG; BUTYRIC ACID DERIVATIVE;

ACTINOBACTERIA; ADULT; AGED; AGING; ARTICLE; BACTERIAL COUNT; BACTEROIDETES; CARDIOVASCULAR DISEASE; CLINICAL ARTICLE; CLOSTRIDIUM; CONTROLLED STUDY; DNA SEQUENCE; DRUG EXPOSURE; DRUG USE; FECES ANALYSIS; FEMALE; FIRMICUTES; GASTROINTESTINAL DISEASE; GENE EXPRESSION PROFILING; HUMAN; INTESTINE FLORA; LACTOBACILLUS; MALE; MENTAL DISEASE; NEUROLOGIC DISEASE; RUMINOCOCCUS; SEQUENCE ANALYSIS; URINARY TRACT DISEASE; CHEMISTRY; DIGESTIVE SYSTEM DISEASE; DRUG EFFECT; GENETICS; INTESTINE; ISOLATION AND PURIFICATION; METABOLISM; MICROBIOLOGY; PHYSIOLOGY;

ACTINOBACTERIA; BACTEROIDETES; CLOSTRIDIUM; COLLINSELLA; FIRMICUTES; LACTOBACILLUS; ROSEBURIA; RUMINOCOCCUS;

ADULT; AGED; AGED, 80 AND OVER; AGING; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BUTYRATES; CYTOSINE; DIGESTIVE SYSTEM DISEASES; DNA, RIBOSOMAL; FEMALE; GUANINE; HUMANS; INTESTINES; LACTOBACILLUS; LAXATIVES; MALE; MENTAL DISORDERS; NERVOUS SYSTEM DISEASES; UROLOGIC DISEASES; YOUNG ADULT;

EID: 75549083189     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114509991553     Document Type: Article

References (51)

1. Hooper LV, Midtvedt T & Gordon JI (2002) How host-microbial interactions shape the nutrient environment of the mammalian intestine. Annu Rev Nutr 22, 283-307.
2. Mueller S, Saunier K, Hanisch C, et al. (2006) Differences in fecal microbiota in different European study populations in relation to age, gender, and country: a cross-sectional study. Appl Environ Microbiol 72, 1027-1033.
3. Ouwehand A, Isolauri E & Salminen S (2002) The role of the intestinal microflora for the development of the immune system in early childhood. Eur J Nutr 41, Suppl. 1, I32-I37.
4. Bauer E, Williams BA, Smidt H, et al. (2006) Influence of dietary components on development of the microbiota in single-stomached species. Nutr Res Rev 19, 63-78.
5. Rautava S & Walker WA (2007) Commensal bacteria and epithelial cross talk in the developing intestine. Curr Gastroenterol Rep 9, 385-392.
6. Benno Y, Endo K, Mizutani T, et al. (1989) Comparison of fecal microflora of elderly persons in rural and urban areas of Japan. Appl Environ Microbiol 55, 1100-1105.
7. Gill HS, Darragh AJ & Cross ML (2001) Optimizing immunity and gut function in the elderly. J Nutr Health Aging 5, 80-91.
8. Kumar R & Burns EA (2008) Age-related decline in immunity: implications for vaccine responsiveness. Expert Rev Vaccines 7, 467-479.
9. van Duin D & Shaw AC (2007) Toll-like receptors in older adults. J Am Geriatr Soc 55, 1438-1444.
10. Bjarnason I, Hayllar J, MacPherson AJ, et al. (1993) Side effects of nonsteroidal anti-inflammatory drugs on the small and large intestine in humans. Gastroenterology 104, 1832-1847.
11. Gabriel SE, Jaakkimainen RL & Bombardier C (1993) The cost-effectiveness of misoprostol for nonsteroidal antiinflammatory drug-associated adverse gastrointestinal events. Arthritis Rheum 36, 447-459.
12. Laine L, Connors LG, Reicin A, et al. (2003) Serious lower gastrointestinal clinical events with nonselective NSAID or coxib use. Gastroenterology 124, 288-292.
13. Gill HS, Rutherfurd KJ, Cross ML, et al. (2001) Enhancement of immunity in the elderly by dietary supplementation with the probiotic Bifidobacterium lactis HN019. Am J Clin Nutr 74, 833-839.
14. Cohen JE (2003) Human population: the next half century. Science 302, 1172-1175.
15. Hayashi H, Sakamoto M, Kitahara M, et al. (2003) Molecular analysis of fecal microbiota in elderly individuals using 16S rDNA library and T-RFLP. Microbiol Immunol 47, 557-570.
16. Bartosch S, Fite A, Macfarlane GT, et al. (2004) Characterization of bacterial communities in feces from healthy elderly volunteers and hospitalized elderly patients by using real-time PCR and effects of antibiotic treatment on the fecal microbiota. Appl Environ Microbiol 70, 3575-3581.
17. Tiihonen K, Tynkkynen S, Ouwehand A, et al. (2008) The effect of ageing with and without non-steroidal anti-inflammatory drugs on gastrointestinal microbiology and immunology. Br J Nutr 100, 130-137.
18. Woodmansey EJ, McMurdo ME, Macfarlane GT, et al. (2004) Comparison of compositions and metabolic activities of fecal microbiotas in young adults and in antibiotic-treated and non-antibiotic-treated elderly subjects. Appl Environ Microbiol 70, 6113-6122.
19. Turnbaugh PJ, Ley RE, Mahowald MA, et al. (2006) An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444, 1027-1031.
20. Malinen E, Rinttilä T, Kajander K, et al. (2005) Analysis of the fecal microbiota of irritable bowel syndrome patients and healthy controls with real-time PCR. Am J Gastroenterol 100, 373-382.
21. Kassinen A, Krogius-Kurikka L, Makivuokko H, et al. (2007) The fecal microbiota of irritable bowel syndrome patients differs significantly from that of healthy subjects. Gastroenterol-ogy 133, 24-33.
22. Hayashi H, Sakamoto M & Benno Y (2002) Phylogenetic analysis of the human gut microbiota using 16S rDNA clone libraries and strictly anaerobic culture-based methods. Micro-biol Immunol 46, 535-548.
23. Apajalahti JH, Kettunen H, Kettunen A, et al. (2002) Culture-independent microbial community analysis reveals that inulin in the diet primarily affects previously unknown bacteria in the mouse cecum. Appl Environ Microbiol 68, 4986-4995.
24. Apajalahti JH, Sarkilahti LK, Maki BR, et al. (1998) Effective recovery of bacterial DNA and percent-guanine-plus-cytosine-based analysis of community structure in the gastrointestinal tract of broiler chickens. Appl Environ Microbiol 64, 4084-4088.
25. Mäkivuokko HA, Saarinen MT, Ouwehand AC, et al. (2006) Effects of lactose on colon microbial community structure and function in a four-stage semi-continuous culture system. Biosci Biotechnol Biochem 70, 2056-2063.
26. Lane DJ, Pace B, Olsen GJ, et al. (1985) Rapid determination of 16S ribosomal RNA sequences for phylogenetic analyses. Proc Natl Acad Sci USA 82, 6955-6959.
27. Edwards U, Rogall T, Blocker H, et al. (1989) Isolation and direct complete nucleotide determination of entire genes. Characterization of a gene coding for 16S ribosomal RNA. Nucleic Acids Res 17, 7843-7853.
28. Staden R, Beal KF & Bonfield JK (2000) The Staden package, 1998. Methods Mol Biol 132, 115-130.
29. Saarinen MT (2002) Determination of biogenic amines as dansyl derivatives in intestinal digesta and feces by reversed phase HPLC. Chromatographia 55, 297-300.
30. Pinheiro JC & Bates DM (2000) Mixed-Effects Models in S and S-PLUS. New York: Springer-Verlag.
31. Wang Q, Garrity GM, Tiedje JM, et al. (2007) Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy. Appl Environ Microbiol 73, 5261-5267.
32. Audic S & Claverie JM (1997) The significance of digital gene expression profiles. Genome Res 7, 986-995.
33. Fava F, Makivuokko H, Siljander-Rasi H, et al. (2007) Effect of polydextrose on intestinal microbes and immune functions in pigs. Br J Nutr 98, 123-133.
34. Suau A, Bonnet R, Sutren M, et al. (1999) Direct analysis of genes encoding 16S rRNA from complex communities reveals many novel molecular species within the human gut. Appl Environ Microbiol 65, 4799-4807.
35. Wexler HM (2007) Bacteroides: the good, the bad, and the nitty-gritty. Clin Microbiol Rev 20, 593-621.
36. Ley RE, Backhed F, Turnbaugh P, et al. (2005) Obesity alters gut microbial ecology. Proc Natl Acad Sci USA 102, 11070-11075.
37. Ley RE, Hamady M, Lozupone C, et al. (2008) Evolution of mammals and their gut microbes. Science 320, 1647-1651.
38. Turnbaugh PJ, Backhed F, Fulton L, et al. (2008) Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome. Cell Host Microbe 3, 213-223.
39. Barcenilla A, Pryde SE, Martin JC, et al. (2000) Phylogenetic relationships of butyrate-producing bacteria from the human gut. Appl Environ Microbiol 66, 1654-1661.
40. Duncan SH, Hold GL, Barcenilla A, et al. (2002) Roseburia intes-tinalis sp. Nov., a novel saccharolytic, butyrate-producing bacterium from human faeces. Int J Syst Evol Microbiol 52, 1615-1620.
41. Louis P, Scott KP, Duncan SH, et al. (2007) Understanding the effects of diet on bacterial metabolism in the large intestine. J Appl Microbiol 102, 1197-1208.
42. Duncan SH, Belenguer A, Holtrop G, et al. (2007) Reduced dietary intake of carbohydrates by obese subjects results in decreased concentrations of butyrate and butyrate-producing bacteria in feces. Appl Environ Microbiol 73, 1073-1078.
43. Kageyama A, Sakamoto M & Benno Y (2000) Rapid identification and quantification of Collinsella aerofaciens using PCR. FEMS Microbiol Lett 183, 43-47.
44. Zoetendal EG, Ben-Amor K, Harmsen HJ, et al. (2002) Quantification of uncultured Ruminococcus obeum-like bacteria in human fecal samples by fluorescent in situ hybridization and flow cytometry using 16S rRNA-targeted probes. Appl Environ Microbiol 68, 4225-4232.
45. Walker AW, Duncan SH, Harmsen HJ, et al. (2008) The species composition of the human intestinal microbiota differs between particle-associated and liquid phase communities. Environ Microbiol 10, 3275-3283.
46. Duncan SH, Holtrop G, Lobley GE, et al. (2004) Contribution of acetate to butyrate formation by human faecal bacteria. Br J Nutr 91, 915-923.
47. Matsumoto M & Benno Y (2007) The relationship between microbiota and polyamine concentration in the human intestine: a pilot study. Microbiol Immunol 51, 25-35.
48. Thomas T & Thomas TJ (2001) Polyamines in cell growth and cell death: molecular mechanisms and therapeutic applications. Cell Mol Life Sci 58, 244-258.
49. Larque E, Sabater-Molina M & Zamora S (2007) Biological significance of dietary polyamines. Nutrition 23, 87-95.
50. Wang X, Feith DJ, Welsh P, et al. (2007) Studies of the mechanism by which increased spermidine/spermine N1-acetyltrans-ferase activity increases susceptibility to skin carcinogenesis. Carcinogenesis 28, 2404-2411.
51. Seiler N & Raul F (2007) Polyamines and the intestinal tract. Crit Rev Clin Lab Sci 44, 365-411.