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Volumn 8, Issue MAY, 2017, Pages

Leaky gut as a danger signal for autoimmune diseases

Author keywords

Autoimmunity; Gut microbiota; Leaky gut; Microbial translocation; Probiotics

Indexed keywords

IMMUNOGLOBULIN A;

EID: 85020044788     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2017.00598     Document Type: Review
Times cited : (401)

References (143)
  • 1
    • 84896851032 scopus 로고    scopus 로고
    • Intestinal epithelial cells: regulators of barrier function and immune homeostasis
    • Peterson LW, Artis D. Intestinal epithelial cells: regulators of barrier function and immune homeostasis. Nat Rev Immunol (2014) 14(3):141-53. doi: 10.1038/nri3608
    • (2014) Nat Rev Immunol , vol.14 , Issue.3 , pp. 141-153
    • Peterson, L.W.1    Artis, D.2
  • 2
    • 84937924335 scopus 로고    scopus 로고
    • Abnormal intestinal permeability and microbiota in patients with autoimmune hepatitis
    • Lin R, Zhou L, Zhang J, Wang B. Abnormal intestinal permeability and microbiota in patients with autoimmune hepatitis. Int J Clin Exp Pathol (2015) 8(5):5153-60.
    • (2015) Int J Clin Exp Pathol , vol.8 , Issue.5 , pp. 5153-5160
    • Lin, R.1    Zhou, L.2    Zhang, J.3    Wang, B.4
  • 3
    • 84951755788 scopus 로고    scopus 로고
    • The potential utility of tight junction regulation in celiac disease: focus on larazotide acetate
    • Khaleghi S, Ju JM, Lamba A, Murray JA. The potential utility of tight junction regulation in celiac disease: focus on larazotide acetate. Therap Adv Gastroenterol (2016) 9(1):37-49. doi:10.1177/1756283X15616576
    • (2016) Therap Adv Gastroenterol , vol.9 , Issue.1 , pp. 37-49
    • Khaleghi, S.1    Ju, J.M.2    Lamba, A.3    Murray, J.A.4
  • 4
    • 27144489109 scopus 로고    scopus 로고
    • Mechanisms of disease: the role of intestinal barrier function in the pathogenesis of gastrointestinal autoimmune diseases
    • Fasano A, Shea-Donohue T. Mechanisms of disease: the role of intestinal barrier function in the pathogenesis of gastrointestinal autoimmune diseases. Nat Clin Pract Gastroenterol Hepatol (2005) 2(9):416-22. doi:10.1038/ncpgasthep0259
    • (2005) Nat Clin Pract Gastroenterol Hepatol , vol.2 , Issue.9 , pp. 416-422
    • Fasano, A.1    Shea-Donohue, T.2
  • 5
    • 79952384278 scopus 로고    scopus 로고
    • The role of gut microbiota (commensal bacteria) and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer: contribution of germ-free and gnotobiotic animal models of human diseases
    • Tlaskalova-Hogenova H, Stepankova R, Kozakova H, Hudcovic T, Vannucci L, Tuckova L, et al. The role of gut microbiota (commensal bacteria) and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer: contribution of germ-free and gnotobiotic animal models of human diseases. Cell Mol Immunol (2011) 8(2):110-20. doi:10.1038/cmi.2010.67
    • (2011) Cell Mol Immunol , vol.8 , Issue.2 , pp. 110-120
    • Tlaskalova-Hogenova, H.1    Stepankova, R.2    Kozakova, H.3    Hudcovic, T.4    Vannucci, L.5    Tuckova, L.6
  • 6
    • 84862983459 scopus 로고    scopus 로고
    • Zonulin, regulation of tight junctions, and autoimmune diseases
    • Fasano A. Zonulin, regulation of tight junctions, and autoimmune diseases. Ann N Y Acad Sci (2012) 1258:25-33. doi:10.1111/j.1749-6632.2012.06538.x
    • (2012) Ann N Y Acad Sci , vol.1258 , pp. 25-33
    • Fasano, A.1
  • 7
    • 84947087731 scopus 로고    scopus 로고
    • Animal models to study acute and chronic intestinal inflammation in mammals
    • Jiminez JA, Uwiera TC, Douglas Inglis G, Uwiera RR. Animal models to study acute and chronic intestinal inflammation in mammals. Gut Pathog (2015) 7:29. doi:10.1186/s13099-015-0076-y
    • (2015) Gut Pathog , vol.7 , pp. 29
    • Jiminez, J.A.1    Uwiera, T.C.2    Douglas Inglis, G.3    Uwiera, R.R.4
  • 8
    • 84959386541 scopus 로고    scopus 로고
    • The zebrafish as a model to study intestinal inflammation
    • Brugman S. The zebrafish as a model to study intestinal inflammation. Dev Comp Immunol (2016) 64:82-92. doi:10.1016/j.dci.2016.02.020
    • (2016) Dev Comp Immunol , vol.64 , pp. 82-92
    • Brugman, S.1
  • 9
    • 84861980130 scopus 로고    scopus 로고
    • Interactions between the microbiota and the immune system
    • Hooper LV, Littman DR, Macpherson AJ. Interactions between the microbiota and the immune system. Science (2012) 336(6086):1268-73. doi:10.1126/science.1223490
    • (2012) Science , vol.336 , Issue.6086 , pp. 1268-1273
    • Hooper, L.V.1    Littman, D.R.2    Macpherson, A.J.3
  • 10
    • 84865016748 scopus 로고    scopus 로고
    • The intestinal epithelium tuft cells: specification and function
    • Gerbe F, Legraverend C, Jay P. The intestinal epithelium tuft cells: specification and function. Cell Mol Life Sci (2012) 69(17):2907-17. doi:10.1007/s00018-012-0984-7
    • (2012) Cell Mol Life Sci , vol.69 , Issue.17 , pp. 2907-2917
    • Gerbe, F.1    Legraverend, C.2    Jay, P.3
  • 11
    • 80054122238 scopus 로고    scopus 로고
    • The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestine
    • Vaishnava S, Yamamoto M, Severson KM, Ruhn KA, Yu X, Koren O, et al. The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestine. Science (2011) 334(6053):255-8. doi:10.1126/science.1209791
    • (2011) Science , vol.334 , Issue.6053 , pp. 255-258
    • Vaishnava, S.1    Yamamoto, M.2    Severson, K.M.3    Ruhn, K.A.4    Yu, X.5    Koren, O.6
  • 12
    • 33748039462 scopus 로고    scopus 로고
    • Symbiotic bacteria direct expression of an intestinal bactericidal lectin
    • Cash HL, Whitham CV, Behrendt CL, Hooper LV. Symbiotic bacteria direct expression of an intestinal bactericidal lectin. Science (2006) 313(5790):1126-30. doi:10.1126/science.1127119
    • (2006) Science , vol.313 , Issue.5790 , pp. 1126-1130
    • Cash, H.L.1    Whitham, C.V.2    Behrendt, C.L.3    Hooper, L.V.4
  • 13
    • 58549111588 scopus 로고    scopus 로고
    • Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface
    • Vaishnava S, Behrendt CL, Ismail AS, Eckmann L, Hooper LV. Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface. Proc Natl Acad Sci U S A (2008) 105(52):20858-63. doi:10.1073/pnas.0808723105
    • (2008) Proc Natl Acad Sci U S A , vol.105 , Issue.52 , pp. 20858-20863
    • Vaishnava, S.1    Behrendt, C.L.2    Ismail, A.S.3    Eckmann, L.4    Hooper, L.V.5
  • 14
    • 84879336857 scopus 로고    scopus 로고
    • Microfold (M) cells: important immunosurveillance posts in the intestinal epithelium
    • Mabbott NA, Donaldson DS, Ohno H, Williams IR, Mahajan A. Microfold (M) cells: important immunosurveillance posts in the intestinal epithelium. Mucosal Immunol (2013) 6(4):666-77. doi:10.1038/mi.2013.30
    • (2013) Mucosal Immunol , vol.6 , Issue.4 , pp. 666-677
    • Mabbott, N.A.1    Donaldson, D.S.2    Ohno, H.3    Williams, I.R.4    Mahajan, A.5
  • 15
    • 67651159312 scopus 로고    scopus 로고
    • Stem cells, self-renewal, and differentiation in the intestinal epithelium
    • van der Flier LG, Clevers H. Stem cells, self-renewal, and differentiation in the intestinal epithelium. Annu Rev Physiol (2009) 71:241-60. doi:10.1146/annurev.physiol.010908.163145
    • (2009) Annu Rev Physiol , vol.71 , pp. 241-260
    • van der Flier, L.G.1    Clevers, H.2
  • 17
    • 43249083518 scopus 로고    scopus 로고
    • Optimized proteomic analysis on gels of cell-cell adhering junctional membrane proteins
    • Yamazaki Y, Okawa K, Yano T, Tsukita S, Tsukita S. Optimized proteomic analysis on gels of cell-cell adhering junctional membrane proteins. Biochemistry (2008) 47(19):5378-86. doi:10.1021/bi8002567
    • (2008) Biochemistry , vol.47 , Issue.19 , pp. 5378-5386
    • Yamazaki, Y.1    Okawa, K.2    Yano, T.3    Tsukita, S.4    Tsukita, S.5
  • 18
    • 0037198693 scopus 로고    scopus 로고
    • A component of innate immunity prevents bacterial biofilm development
    • Singh PK, Parsek MR, Greenberg EP, Welsh MJ. A component of innate immunity prevents bacterial biofilm development. Nature (2002) 417(6888):552-5. doi:10.1038/417552a
    • (2002) Nature , vol.417 , Issue.6888 , pp. 552-555
    • Singh, P.K.1    Parsek, M.R.2    Greenberg, E.P.3    Welsh, M.J.4
  • 19
    • 84856098171 scopus 로고    scopus 로고
    • Role of mucus layers in gut infection and inflammation
    • Hansson GC. Role of mucus layers in gut infection and inflammation. Curr Opin Microbiol (2012) 15(1):57-62. doi:10.1016/j.mib.2011.11.002
    • (2012) Curr Opin Microbiol , vol.15 , Issue.1 , pp. 57-62
    • Hansson, G.C.1
  • 20
    • 84902578841 scopus 로고    scopus 로고
    • The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system
    • Pelaseyed T, Bergstrom JH, Gustafsson JK, Ermund A, Birchenough GM, Schutte A, et al. The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system. Immunol Rev (2014) 260(1):8-20. doi:10.1111/imr.12182
    • (2014) Immunol Rev , vol.260 , Issue.1 , pp. 8-20
    • Pelaseyed, T.1    Bergstrom, J.H.2    Gustafsson, J.K.3    Ermund, A.4    Birchenough, G.M.5    Schutte, A.6
  • 21
    • 33745746660 scopus 로고    scopus 로고
    • Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection
    • Van der Sluis M, De Koning BA, De Bruijn AC, Velcich A, Meijerink JP, Van Goudoever JB, et al. Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection. Gastroenterology (2006) 131(1):117-29. doi:10.1053/j.gastro.2006.04.020
    • (2006) Gastroenterology , vol.131 , Issue.1 , pp. 117-129
    • Van der Sluis, M.1    De Koning, B.A.2    De Bruijn, A.C.3    Velcich, A.4    Meijerink, J.P.5    Van Goudoever, J.B.6
  • 22
  • 23
    • 84977620054 scopus 로고    scopus 로고
    • Interactions between the microbiota and pathogenic bacteria in the gut
    • Baumler AJ, Sperandio V. Interactions between the microbiota and pathogenic bacteria in the gut. Nature (2016) 535(7610):85-93. doi:10.1038/nature18849
    • (2016) Nature , vol.535 , Issue.7610 , pp. 85-93
    • Baumler, A.J.1    Sperandio, V.2
  • 24
    • 84931287886 scopus 로고    scopus 로고
    • Comparison of antibacterial effects between antimicrobial peptide and bacteriocins isolated from Lactobacillus plantarum on three common pathogenic bacteria
    • Ming L, Zhang Q, Yang L, Huang JA. Comparison of antibacterial effects between antimicrobial peptide and bacteriocins isolated from Lactobacillus plantarum on three common pathogenic bacteria. Int J Clin Exp Med (2015) 8(4):5806-11.
    • (2015) Int J Clin Exp Med , vol.8 , Issue.4 , pp. 5806-5811
    • Ming, L.1    Zhang, Q.2    Yang, L.3    Huang, J.A.4
  • 25
    • 84897628732 scopus 로고    scopus 로고
    • Role of the gut microbiota in human nutrition and metabolism
    • Ramakrishna BS. Role of the gut microbiota in human nutrition and metabolism. J Gastroenterol Hepatol (2013) 28(Suppl 4):9-17. doi:10.1111/jgh.12294
    • (2013) J Gastroenterol Hepatol , vol.28 , pp. 9-17
    • Ramakrishna, B.S.1
  • 26
    • 84859360110 scopus 로고    scopus 로고
    • Effects of gut microbes on nutrient absorption and energy regulation
    • Krajmalnik-Brown R, Ilhan ZE, Kang DW, DiBaise JK. Effects of gut microbes on nutrient absorption and energy regulation. Nutr Clin Pract (2012) 27(2):201-14. doi:10.1177/0884533611436116
    • (2012) Nutr Clin Pract , vol.27 , Issue.2 , pp. 201-214
    • Krajmalnik-Brown, R.1    Ilhan, Z.E.2    Kang, D.W.3    DiBaise, J.K.4
  • 27
    • 84922022651 scopus 로고    scopus 로고
    • Antimicrobial peptides and the enteric mucus layer act in concert to protect the intestinal mucosa
    • Dupont A, Heinbockel L, Brandenburg K, Hornef MW. Antimicrobial peptides and the enteric mucus layer act in concert to protect the intestinal mucosa. Gut Microbes (2014) 5(6):761-5. doi:10.4161/19490976.2014.972238
    • (2014) Gut Microbes , vol.5 , Issue.6 , pp. 761-765
    • Dupont, A.1    Heinbockel, L.2    Brandenburg, K.3    Hornef, M.W.4
  • 28
    • 84921304368 scopus 로고    scopus 로고
    • Antimicrobial defense of the intestine
    • Mukherjee S, Hooper LV. Antimicrobial defense of the intestine. Immunity (2015) 42(1):28-39. doi:10.1016/j.immuni.2014.12.028
    • (2015) Immunity , vol.42 , Issue.1 , pp. 28-39
    • Mukherjee, S.1    Hooper, L.V.2
  • 29
    • 33645230000 scopus 로고    scopus 로고
    • How bile acids confer gut mucosal protection against bacteria
    • Hofmann AF, Eckmann L. How bile acids confer gut mucosal protection against bacteria. Proc Natl Acad Sci U S A (2006) 103(12):4333-4. doi:10.1073/pnas.0600780103
    • (2006) Proc Natl Acad Sci U S A , vol.103 , Issue.12 , pp. 4333-4334
    • Hofmann, A.F.1    Eckmann, L.2
  • 30
    • 84884928600 scopus 로고    scopus 로고
    • Antimicrobial peptides and gut microbiota in homeostasis and pathology
    • Ostaff MJ, Stange EF, Wehkamp J. Antimicrobial peptides and gut microbiota in homeostasis and pathology. EMBO Mol Med (2013) 5(10):1465-83. doi:10.1002/emmm.201201773
    • (2013) EMBO Mol Med , vol.5 , Issue.10 , pp. 1465-1483
    • Ostaff, M.J.1    Stange, E.F.2    Wehkamp, J.3
  • 31
    • 84926646935 scopus 로고    scopus 로고
    • Do antimicrobial peptides and complement collaborate in the intestinal mucosa?
    • Kopp ZA, Jain U, Van Limbergen J, Stadnyk AW. Do antimicrobial peptides and complement collaborate in the intestinal mucosa? Front Immunol (2015) 6:17. doi:10.3389/fimmu.2015.00017
    • (2015) Front Immunol , vol.6 , pp. 17
    • Kopp, Z.A.1    Jain, U.2    Van Limbergen, J.3    Stadnyk, A.W.4
  • 32
    • 84900346021 scopus 로고    scopus 로고
    • The uptake of soluble and particulate antigens by epithelial cells in the mouse small intestine
    • Howe SE, Lickteig DJ, Plunkett KN, Ryerse JS, Konjufca V. The uptake of soluble and particulate antigens by epithelial cells in the mouse small intestine. PLoS One (2014) 9(1):e86656. doi:10.1371/journal.pone.0086656
    • (2014) PLoS One , vol.9 , Issue.1
    • Howe, S.E.1    Lickteig, D.J.2    Plunkett, K.N.3    Ryerse, J.S.4    Konjufca, V.5
  • 33
    • 84863230541 scopus 로고    scopus 로고
    • Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine
    • McDole JR, Wheeler LW, McDonald KG, Wang B, Konjufca V, Knoop KA, et al. Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine. Nature (2012) 483(7389):345-9. doi:10.1038/nature10863
    • (2012) Nature , vol.483 , Issue.7389 , pp. 345-349
    • McDole, J.R.1    Wheeler, L.W.2    McDonald, K.G.3    Wang, B.4    Konjufca, V.5    Knoop, K.A.6
  • 34
    • 84922600148 scopus 로고    scopus 로고
    • Microbial sensing by goblet cells controls immune surveillance of luminal antigens in the colon
    • Knoop KA, McDonald KG, McCrate S, McDole JR, Newberry RD. Microbial sensing by goblet cells controls immune surveillance of luminal antigens in the colon. Mucosal Immunol (2015) 8(1):198-210. doi:10.1038/mi.2014.58
    • (2015) Mucosal Immunol , vol.8 , Issue.1 , pp. 198-210
    • Knoop, K.A.1    McDonald, K.G.2    McCrate, S.3    McDole, J.R.4    Newberry, R.D.5
  • 36
    • 84973861100 scopus 로고    scopus 로고
    • Antibiotics promote inflammation through the translocation of native commensal colonic bacteria
    • Knoop KA, McDonald KG, Kulkarni DH, Newberry RD. Antibiotics promote inflammation through the translocation of native commensal colonic bacteria. Gut (2016) 65(7):1100-9. doi:10.1136/gutjnl-2014-309059
    • (2016) Gut , vol.65 , Issue.7 , pp. 1100-1109
    • Knoop, K.A.1    McDonald, K.G.2    Kulkarni, D.H.3    Newberry, R.D.4
  • 37
    • 0035321325 scopus 로고    scopus 로고
    • Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria
    • Rescigno M, Urbano M, Valzasina B, Francolini M, Rotta G, Bonasio R, et al. Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria. Nat Immunol (2001) 2(4):361-7. doi:10.1038/86373
    • (2001) Nat Immunol , vol.2 , Issue.4 , pp. 361-367
    • Rescigno, M.1    Urbano, M.2    Valzasina, B.3    Francolini, M.4    Rotta, G.5    Bonasio, R.6
  • 38
    • 32044447002 scopus 로고    scopus 로고
    • Transepithelial pathogen uptake into the small intestinal lamina propria
    • Vallon-Eberhard A, Landsman L, Yogev N, Verrier B, Jung S. Transepithelial pathogen uptake into the small intestinal lamina propria. J Immunol (2006) 176(4):2465-9. doi:10.4049/jimmunol.176.4.2465
    • (2006) J Immunol , vol.176 , Issue.4 , pp. 2465-2469
    • Vallon-Eberhard, A.1    Landsman, L.2    Yogev, N.3    Verrier, B.4    Jung, S.5
  • 39
    • 84874688283 scopus 로고    scopus 로고
    • Microbiota restricts trafficking of bacteria to mesenteric lymph nodes by CX(3)CR1(hi) cells
    • Diehl GE, Longman RS, Zhang JX, Breart B, Galan C, Cuesta A, et al. Microbiota restricts trafficking of bacteria to mesenteric lymph nodes by CX(3)CR1(hi) cells. Nature (2013) 494(7435):116-20. doi:10.1038/nature11809
    • (2013) Nature , vol.494 , Issue.7435 , pp. 116-120
    • Diehl, G.E.1    Longman, R.S.2    Zhang, J.X.3    Breart, B.4    Galan, C.5    Cuesta, A.6
  • 40
    • 12244297799 scopus 로고    scopus 로고
    • CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance
    • Niess JH, Brand S, Gu X, Landsman L, Jung S, McCormick BA, et al. CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science (2005) 307(5707):254-8. doi:10.1126/science.1102901
    • (2005) Science , vol.307 , Issue.5707 , pp. 254-258
    • Niess, J.H.1    Brand, S.2    Gu, X.3    Landsman, L.4    Jung, S.5    McCormick, B.A.6
  • 41
    • 84935063959 scopus 로고    scopus 로고
    • Guardians of the gut-murine intestinal macrophages and dendritic cells
    • Gross M, Salame TM, Jung S. Guardians of the gut-murine intestinal macrophages and dendritic cells. Front Immunol (2015) 6:254. doi:10.3389/fimmu.2015.00254
    • (2015) Front Immunol , vol.6 , pp. 254
    • Gross, M.1    Salame, T.M.2    Jung, S.3
  • 42
    • 82155183271 scopus 로고    scopus 로고
    • In vivo structure/function and expression analysis of the CX3C chemokine fractalkine
    • Kim KW, Vallon-Eberhard A, Zigmond E, Farache J, Shezen E, Shakhar G, et al. In vivo structure/function and expression analysis of the CX3C chemokine fractalkine. Blood (2011) 118(22):e156-67. doi:10.1182/blood-2011-04-348946
    • (2011) Blood , vol.118 , Issue.22
    • Kim, K.W.1    Vallon-Eberhard, A.2    Zigmond, E.3    Farache, J.4    Shezen, E.5    Shakhar, G.6
  • 43
    • 80054902426 scopus 로고    scopus 로고
    • Structure and function relationships in IgA
    • Woof JM, Russell MW. Structure and function relationships in IgA. Mucosal Immunol (2011) 4(6):590-7. doi:10.1038/mi.2011.39
    • (2011) Mucosal Immunol , vol.4 , Issue.6 , pp. 590-597
    • Woof, J.M.1    Russell, M.W.2
  • 44
    • 84859399981 scopus 로고    scopus 로고
    • Microbial translocation across the GI tract
    • Brenchley JM, Douek DC. Microbial translocation across the GI tract. Annu Rev Immunol (2012) 30:149-73. doi:10.1146/annurev-immunol-020711-075001
    • (2012) Annu Rev Immunol , vol.30 , pp. 149-173
    • Brenchley, J.M.1    Douek, D.C.2
  • 45
    • 84995739780 scopus 로고    scopus 로고
    • A dietary fiber-deprived gut microbiota degrades the colonic mucus barrier and enhances pathogen susceptibility
    • Desai MS, Seekatz AM, Koropatkin NM, Kamada N, Hickey CA, Wolter M, et al. A dietary fiber-deprived gut microbiota degrades the colonic mucus barrier and enhances pathogen susceptibility. Cell (2016) 167(5):1339-53 e21. doi:10.1016/j.cell.2016.10.043
    • (2016) Cell , vol.167 , Issue.5 , pp. 1339-1353
    • Desai, M.S.1    Seekatz, A.M.2    Koropatkin, N.M.3    Kamada, N.4    Hickey, C.A.5    Wolter, M.6
  • 48
    • 84877913270 scopus 로고    scopus 로고
    • Bacteroides thetaiotaomicron and Faecalibacterium prausnitzii influence the production of mucus glycans and the development of goblet cells in the colonic epithelium of a gnotobiotic model rodent
    • Wrzosek L, Miquel S, Noordine ML, Bouet S, Joncquel Chevalier-Curt M, Robert V, et al. Bacteroides thetaiotaomicron and Faecalibacterium prausnitzii influence the production of mucus glycans and the development of goblet cells in the colonic epithelium of a gnotobiotic model rodent. BMC Biol (2013) 11:61. doi:10.1186/1741-7007-11-61
    • (2013) BMC Biol , vol.11 , pp. 61
    • Wrzosek, L.1    Miquel, S.2    Noordine, M.L.3    Bouet, S.4    Joncquel Chevalier-Curt, M.5    Robert, V.6
  • 49
    • 36049034379 scopus 로고    scopus 로고
    • Bacterial modulation of small intestinal goblet cells and mucin composition during early posthatch development of poultry
    • Forder RE, Howarth GS, Tivey DR, Hughes RJ. Bacterial modulation of small intestinal goblet cells and mucin composition during early posthatch development of poultry. Poult Sci (2007) 86(11):2396-403. doi:10.3382/ps.2007-00222
    • (2007) Poult Sci , vol.86 , Issue.11 , pp. 2396-2403
    • Forder, R.E.1    Howarth, G.S.2    Tivey, D.R.3    Hughes, R.J.4
  • 50
    • 79952763437 scopus 로고    scopus 로고
    • Antibiotic treatment alters the colonic mucus layer and predisposes the host to exacerbated Citrobacter rodentium-induced colitis
    • Wlodarska M, Willing B, Keeney KM, Menendez A, Bergstrom KS, Gill N, et al. Antibiotic treatment alters the colonic mucus layer and predisposes the host to exacerbated Citrobacter rodentium-induced colitis. Infect Immun (2011) 79(4):1536-45. doi:10.1128/IAI.01104-10
    • (2011) Infect Immun , vol.79 , Issue.4 , pp. 1536-1545
    • Wlodarska, M.1    Willing, B.2    Keeney, K.M.3    Menendez, A.4    Bergstrom, K.S.5    Gill, N.6
  • 51
    • 77957906400 scopus 로고    scopus 로고
    • Bacteria penetrate the inner mucus layer before inflammation in the dextran sulfate colitis model
    • Johansson ME, Gustafsson JK, Sjoberg KE, Petersson J, Holm L, Sjovall H, et al. Bacteria penetrate the inner mucus layer before inflammation in the dextran sulfate colitis model. PLoS One (2010) 5(8):e12238. doi:10.1371/journal.pone.0012238
    • (2010) PLoS One , vol.5 , Issue.8
    • Johansson, M.E.1    Gustafsson, J.K.2    Sjoberg, K.E.3    Petersson, J.4    Holm, L.5    Sjovall, H.6
  • 52
    • 85012022783 scopus 로고    scopus 로고
    • Intestinal REG3 lectins protect against alcoholic steatohepatitis by reducing mucosa-associated microbiota and preventing bacterial translocation
    • Wang L, Fouts DE, Starkel P, Hartmann P, Chen P, Llorente C, et al. Intestinal REG3 lectins protect against alcoholic steatohepatitis by reducing mucosa-associated microbiota and preventing bacterial translocation. Cell Host Microbe (2016) 19(2):227-39. doi:10.1016/j.chom.2016.01.003
    • (2016) Cell Host Microbe , vol.19 , Issue.2 , pp. 227-239
    • Wang, L.1    Fouts, D.E.2    Starkel, P.3    Hartmann, P.4    Chen, P.5    Llorente, C.6
  • 53
    • 78751537350 scopus 로고    scopus 로고
    • Enteric dysbiosis associated with a mouse model of alcoholic liver disease
    • Yan AW, Fouts DE, Brandl J, Starkel P, Torralba M, Schott E, et al. Enteric dysbiosis associated with a mouse model of alcoholic liver disease. Hepatology (2011) 53(1):96-105. doi:10.1002/hep.24018
    • (2011) Hepatology , vol.53 , Issue.1 , pp. 96-105
    • Yan, A.W.1    Fouts, D.E.2    Brandl, J.3    Starkel, P.4    Torralba, M.5    Schott, E.6
  • 54
    • 0037340434 scopus 로고    scopus 로고
    • Angiogenins: a new class of microbicidal proteins involved in innate immunity
    • Hooper LV, Stappenbeck TS, Hong CV, Gordon JI. Angiogenins: a new class of microbicidal proteins involved in innate immunity. Nat Immunol (2003) 4(3):269-73. doi:10.1038/ni888
    • (2003) Nat Immunol , vol.4 , Issue.3 , pp. 269-273
    • Hooper, L.V.1    Stappenbeck, T.S.2    Hong, C.V.3    Gordon, J.I.4
  • 55
    • 0025977080 scopus 로고
    • Rat intestinal alkaline phosphatase secretion into lumen and serum is coordinately regulated
    • Eliakim R, Mahmood A, Alpers DH. Rat intestinal alkaline phosphatase secretion into lumen and serum is coordinately regulated. Biochim Biophys Acta (1991) 1091(1):1-8. doi:10.1016/0167-4889(91)90213-H
    • (1991) Biochim Biophys Acta , vol.1091 , Issue.1 , pp. 1-8
    • Eliakim, R.1    Mahmood, A.2    Alpers, D.H.3
  • 56
    • 67650066786 scopus 로고    scopus 로고
    • Role of lysophosphatidylcholine in brush-border intestinal alkaline phosphatase release and restoration
    • Nakano T, Inoue I, Alpers DH, Akiba Y, Katayama S, Shinozaki R, et al. Role of lysophosphatidylcholine in brush-border intestinal alkaline phosphatase release and restoration. Am J Physiol Gastrointest Liver Physiol (2009) 297(1):G207-14. doi:10.1152/ajpgi.90590.2008
    • (2009) Am J Physiol Gastrointest Liver Physiol , vol.297 , Issue.1 , pp. G207-G214
    • Nakano, T.1    Inoue, I.2    Alpers, D.H.3    Akiba, Y.4    Katayama, S.5    Shinozaki, R.6
  • 57
    • 78049510029 scopus 로고    scopus 로고
    • Intestinal alkaline phosphatase preserves the normal homeostasis of gut microbiota
    • Malo MS, Alam SN, Mostafa G, Zeller SJ, Johnson PV, Mohammad N, et al. Intestinal alkaline phosphatase preserves the normal homeostasis of gut microbiota. Gut (2010) 59(11):1476-84. doi:10.1136/gut.2010.211706
    • (2010) Gut , vol.59 , Issue.11 , pp. 1476-1484
    • Malo, M.S.1    Alam, S.N.2    Mostafa, G.3    Zeller, S.J.4    Johnson, P.V.5    Mohammad, N.6
  • 58
    • 30944466824 scopus 로고    scopus 로고
    • Reduced diversity of faecal microbiota in Crohn's disease revealed by a metagenomic approach
    • Manichanh C, Rigottier-Gois L, Bonnaud E, Gloux K, Pelletier E, Frangeul L, et al. Reduced diversity of faecal microbiota in Crohn's disease revealed by a metagenomic approach. Gut (2006) 55(2):205-11. doi:10.1136/gut.2005.073817
    • (2006) Gut , vol.55 , Issue.2 , pp. 205-211
    • Manichanh, C.1    Rigottier-Gois, L.2    Bonnaud, E.3    Gloux, K.4    Pelletier, E.5    Frangeul, L.6
  • 59
    • 84931287751 scopus 로고    scopus 로고
    • A host-microbiome interaction mediates the opposing effects of omega-6 and omega-3 fatty acids on metabolic endotoxemia
    • Kaliannan K, Wang B, Li XY, Kim KJ, Kang JX. A host-microbiome interaction mediates the opposing effects of omega-6 and omega-3 fatty acids on metabolic endotoxemia. Sci Rep (2015) 5:11276. doi:10.1038/srep11276
    • (2015) Sci Rep , vol.5 , pp. 11276
    • Kaliannan, K.1    Wang, B.2    Li, X.Y.3    Kim, K.J.4    Kang, J.X.5
  • 60
    • 36749024487 scopus 로고    scopus 로고
    • Intestinal alkaline phosphatase detoxifies lipopolysaccharide and prevents inflammation in zebrafish in response to the gut microbiota
    • Bates JM, Akerlund J, Mittge E, Guillemin K. Intestinal alkaline phosphatase detoxifies lipopolysaccharide and prevents inflammation in zebrafish in response to the gut microbiota. Cell Host Microbe (2007) 2(6):371-82. doi:10.1016/j.chom.2007.10.010
    • (2007) Cell Host Microbe , vol.2 , Issue.6 , pp. 371-382
    • Bates, J.M.1    Akerlund, J.2    Mittge, E.3    Guillemin, K.4
  • 61
    • 84919466032 scopus 로고    scopus 로고
    • Intestinal alkaline phosphatase deficiency leads to lipopolysaccharide desensitization and faster weight gain
    • Yang Y, Millan JL, Mecsas J, Guillemin K. Intestinal alkaline phosphatase deficiency leads to lipopolysaccharide desensitization and faster weight gain. Infect Immun (2015) 83(1):247-58. doi:10.1128/IAI.02520-14
    • (2015) Infect Immun , vol.83 , Issue.1 , pp. 247-258
    • Yang, Y.1    Millan, J.L.2    Mecsas, J.3    Guillemin, K.4
  • 62
    • 33748468927 scopus 로고    scopus 로고
    • Distinct signals from the microbiota promote different aspects of zebrafish gut differentiation
    • Bates JM, Mittge E, Kuhlman J, Baden KN, Cheesman SE, Guillemin K. Distinct signals from the microbiota promote different aspects of zebrafish gut differentiation. Dev Biol (2006) 297(2):374-86. doi:10.1016/j.ydbio.2006.05.006
    • (2006) Dev Biol , vol.297 , Issue.2 , pp. 374-386
    • Bates, J.M.1    Mittge, E.2    Kuhlman, J.3    Baden, K.N.4    Cheesman, S.E.5    Guillemin, K.6
  • 63
    • 84963956005 scopus 로고    scopus 로고
    • Intestinal alkaline phosphatase regulates tight junction protein levels
    • Liu W, Hu D, Huo H, Zhang W, Adiliaghdam F, Morrison S, et al. Intestinal alkaline phosphatase regulates tight junction protein levels. J Am Coll Surg (2016) 222(6):1009-17. doi:10.1016/j.jamcollsurg.2015.12.006
    • (2016) J Am Coll Surg , vol.222 , Issue.6 , pp. 1009-1017
    • Liu, W.1    Hu, D.2    Huo, H.3    Zhang, W.4    Adiliaghdam, F.5    Morrison, S.6
  • 64
    • 79954915318 scopus 로고    scopus 로고
    • Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis
    • Bevins CL, Salzman NH. Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis. Nat Rev Microbiol (2011) 9(5):356-68. doi:10.1038/nrmicro2546
    • (2011) Nat Rev Microbiol , vol.9 , Issue.5 , pp. 356-368
    • Bevins, C.L.1    Salzman, N.H.2
  • 65
    • 84862862332 scopus 로고    scopus 로고
    • Epithelial antimicrobial defence of the skin and intestine
    • Gallo RL, Hooper LV. Epithelial antimicrobial defence of the skin and intestine. Nat Rev Immunol (2012) 12(7):503-16. doi:10.1038/nri3228
    • (2012) Nat Rev Immunol , vol.12 , Issue.7 , pp. 503-516
    • Gallo, R.L.1    Hooper, L.V.2
  • 66
    • 84930173219 scopus 로고    scopus 로고
    • Epithelial cell shedding and barrier function: a matter of life and death at the small intestinal villus tip
    • Williams JM, Duckworth CA, Burkitt MD, Watson AJ, Campbell BJ, Pritchard DM. Epithelial cell shedding and barrier function: a matter of life and death at the small intestinal villus tip. Vet Pathol (2015) 52(3):445-55. doi:10.1177/0300985814559404
    • (2015) Vet Pathol , vol.52 , Issue.3 , pp. 445-455
    • Williams, J.M.1    Duckworth, C.A.2    Burkitt, M.D.3    Watson, A.J.4    Campbell, B.J.5    Pritchard, D.M.6
  • 67
    • 84939163442 scopus 로고    scopus 로고
    • Site-specific programming of the host epithelial transcriptome by the gut microbiota
    • Sommer F, Nookaew I, Sommer N, Fogelstrand P, Backhed F. Site-specific programming of the host epithelial transcriptome by the gut microbiota. Genome Biol (2015) 16:62. doi:10.1186/s13059-015-0614-4
    • (2015) Genome Biol , vol.16 , pp. 62
    • Sommer, F.1    Nookaew, I.2    Sommer, N.3    Fogelstrand, P.4    Backhed, F.5
  • 68
    • 79952855316 scopus 로고    scopus 로고
    • Depletion of murine intestinal microbiota: effects on gut mucosa and epithelial gene expression
    • Reikvam DH, Erofeev A, Sandvik A, Grcic V, Jahnsen FL, Gaustad P, et al. Depletion of murine intestinal microbiota: effects on gut mucosa and epithelial gene expression. PLoS One (2011) 6(3):e17996. doi:10.1371/journal.pone.0017996
    • (2011) PLoS One , vol.6 , Issue.3
    • Reikvam, D.H.1    Erofeev, A.2    Sandvik, A.3    Grcic, V.4    Jahnsen, F.L.5    Gaustad, P.6
  • 69
    • 85008391878 scopus 로고    scopus 로고
    • [Microbiota-intestinal stem cells dialog: a key element for intestinal regeneration]
    • Stedman A, Nigro G, Sansonetti PJ. [Microbiota-intestinal stem cells dialog: a key element for intestinal regeneration]. Med Sci (Paris) (2016) 32(11):983-90. doi:10.1051/medsci/20163211014
    • (2016) Med Sci (Paris) , vol.32 , Issue.11 , pp. 983-990
    • Stedman, A.1    Nigro, G.2    Sansonetti, P.J.3
  • 70
    • 85012932652 scopus 로고    scopus 로고
    • Bifidobacterium breve reduces apoptotic epithelial cell shedding in an exopolysaccharide and MyD88-dependent manner
    • Hughes KR, Harnisch LC, Alcon-Giner C, Mitra S, Wright CJ, Ketskemety J, et al. Bifidobacterium breve reduces apoptotic epithelial cell shedding in an exopolysaccharide and MyD88-dependent manner. Open Biol (2017) 7(1):160155. doi:10.1098/rsob.160155
    • (2017) Open Biol , vol.7 , Issue.1 , pp. 160155
    • Hughes, K.R.1    Harnisch, L.C.2    Alcon-Giner, C.3    Mitra, S.4    Wright, C.J.5    Ketskemety, J.6
  • 71
    • 84888862182 scopus 로고    scopus 로고
    • A mouse model of pathological small intestinal epithelial cell apoptosis and shedding induced by systemic administration of lipopolysaccharide
    • Williams JM, Duckworth CA, Watson AJ, Frey MR, Miguel JC, Burkitt MD, et al. A mouse model of pathological small intestinal epithelial cell apoptosis and shedding induced by systemic administration of lipopolysaccharide. Dis Model Mech (2013) 6(6):1388-99. doi:10.1242/dmm.013284
    • (2013) Dis Model Mech , vol.6 , Issue.6 , pp. 1388-1399
    • Williams, J.M.1    Duckworth, C.A.2    Watson, A.J.3    Frey, M.R.4    Miguel, J.C.5    Burkitt, M.D.6
  • 72
    • 84868261605 scopus 로고    scopus 로고
    • Toll-like receptor 4 is expressed on intestinal stem cells and regulates their proliferation and apoptosis via the p53 up-regulated modulator of apoptosis
    • Neal MD, Sodhi CP, Jia H, Dyer M, Egan CE, Yazji I, et al. Toll-like receptor 4 is expressed on intestinal stem cells and regulates their proliferation and apoptosis via the p53 up-regulated modulator of apoptosis. J Biol Chem (2012) 287(44):37296-308. doi:10.1074/jbc.M112.375881
    • (2012) J Biol Chem , vol.287 , Issue.44 , pp. 37296-37308
    • Neal, M.D.1    Sodhi, C.P.2    Jia, H.3    Dyer, M.4    Egan, C.E.5    Yazji, I.6
  • 73
    • 84994051877 scopus 로고    scopus 로고
    • The colonic crypt protects stem cells from microbiota-derived metabolites
    • Kaiko GE, Ryu SH, Koues OI, Collins PL, Solnica-Krezel L, Pearce EJ, et al. The colonic crypt protects stem cells from microbiota-derived metabolites. Cell (2016) 167(4):1137. doi:10.1016/j.cell.2016.10.034
    • (2016) Cell , vol.167 , Issue.4 , pp. 1137
    • Kaiko, G.E.1    Ryu, S.H.2    Koues, O.I.3    Collins, P.L.4    Solnica-Krezel, L.5    Pearce, E.J.6
  • 74
    • 79955518664 scopus 로고    scopus 로고
    • Regulation of tight junction permeability by intestinal bacteria and dietary components
    • Ulluwishewa D, Anderson RC, McNabb WC, Moughan PJ, Wells JM, Roy NC. Regulation of tight junction permeability by intestinal bacteria and dietary components. J Nutr (2011) 141(5):769-76. doi:10.3945/jn.110.135657
    • (2011) J Nutr , vol.141 , Issue.5 , pp. 769-776
    • Ulluwishewa, D.1    Anderson, R.C.2    McNabb, W.C.3    Moughan, P.J.4    Wells, J.M.5    Roy, N.C.6
  • 75
    • 78049506125 scopus 로고    scopus 로고
    • Lactobacillus rhamnosus GG attenuates interferon-gamma and tumour necrosis factor-alpha-induced barrier dysfunction and pro-inflammatory signalling
    • Donato KA, Gareau MG, Wang YJ, Sherman PM. Lactobacillus rhamnosus GG attenuates interferon-gamma and tumour necrosis factor-alpha-induced barrier dysfunction and pro-inflammatory signalling. Microbiology (2010) 156(Pt 11):3288-97. doi:10.1099/mic.0.040139-0
    • (2010) Microbiology , vol.156 , pp. 3288-3297
    • Donato, K.A.1    Gareau, M.G.2    Wang, Y.J.3    Sherman, P.M.4
  • 76
    • 42149184871 scopus 로고    scopus 로고
    • Lactobacillus rhamnosus strain GG prevents enterohemorrhagic Escherichia coli O157: H7-induced changes in epithelial barrier function
    • Johnson-Henry KC, Donato KA, Shen-Tu G, Gordanpour M, Sherman PM. Lactobacillus rhamnosus strain GG prevents enterohemorrhagic Escherichia coli O157: H7-induced changes in epithelial barrier function. Infect Immun (2008) 76(4):1340-8. doi:10.1128/IAI.00778-07
    • (2008) Infect Immun , vol.76 , Issue.4 , pp. 1340-1348
    • Johnson-Henry, K.C.1    Donato, K.A.2    Shen-Tu, G.3    Gordanpour, M.4    Sherman, P.M.5
  • 77
    • 67649185700 scopus 로고    scopus 로고
    • Lactobacillus rhamnosus alleviates intestinal barrier dysfunction in part by increasing expression of zonula occludens-1 and myosin light-chain kinase in vivo
    • Miyauchi E, Morita H, Tanabe S. Lactobacillus rhamnosus alleviates intestinal barrier dysfunction in part by increasing expression of zonula occludens-1 and myosin light-chain kinase in vivo. J Dairy Sci (2009) 92(6):2400-8. doi:10.3168/jds.2008-1698
    • (2009) J Dairy Sci , vol.92 , Issue.6 , pp. 2400-2408
    • Miyauchi, E.1    Morita, H.2    Tanabe, S.3
  • 78
    • 42049098409 scopus 로고    scopus 로고
    • Probiotics ameliorate the hydrogen peroxide-induced epithelial barrier disruption by a PKC- and MAP kinase-dependent mechanism
    • Seth A, Yan F, Polk DB, Rao RK. Probiotics ameliorate the hydrogen peroxide-induced epithelial barrier disruption by a PKC- and MAP kinase-dependent mechanism. Am J Physiol Gastrointest Liver Physiol (2008) 294(4):G1060-9. doi:10.1152/ajpgi.00202.2007
    • (2008) Am J Physiol Gastrointest Liver Physiol , vol.294 , Issue.4 , pp. G1060-G1069
    • Seth, A.1    Yan, F.2    Polk, D.B.3    Rao, R.K.4
  • 79
    • 0038460949 scopus 로고    scopus 로고
    • Live probiotics protect intestinal epithelial cells from the effects of infection with enteroinvasive Escherichia coli (EIEC)
    • Resta-Lenert S, Barrett KE. Live probiotics protect intestinal epithelial cells from the effects of infection with enteroinvasive Escherichia coli (EIEC). Gut (2003) 52(7):988-97. doi:10.1136/gut.52.7.988
    • (2003) Gut , vol.52 , Issue.7 , pp. 988-997
    • Resta-Lenert, S.1    Barrett, K.E.2
  • 81
    • 79952046775 scopus 로고    scopus 로고
    • Effect of lactobacilli on paracellular permeability in the gut
    • Ahrne S, Hagslatt ML. Effect of lactobacilli on paracellular permeability in the gut. Nutrients (2011) 3(1):104-17. doi:10.3390/nu3010104
    • (2011) Nutrients , vol.3 , Issue.1 , pp. 104-117
    • Ahrne, S.1    Hagslatt, M.L.2
  • 82
    • 84873716991 scopus 로고    scopus 로고
    • Regulation of intestinal epithelial permeability by tight junctions
    • Suzuki T. Regulation of intestinal epithelial permeability by tight junctions. Cell Mol Life Sci (2013) 70(4):631-59. doi:10.1007/s00018-012-1070-x
    • (2013) Cell Mol Life Sci , vol.70 , Issue.4 , pp. 631-659
    • Suzuki, T.1
  • 84
    • 38349108166 scopus 로고    scopus 로고
    • Novel role of the vitamin D receptor in maintaining the integrity of the intestinal mucosal barrier
    • Kong J, Zhang Z, Musch MW, Ning G, Sun J, Hart J, et al. Novel role of the vitamin D receptor in maintaining the integrity of the intestinal mucosal barrier. Am J Physiol Gastrointest Liver Physiol (2008) 294(1):G208-16. doi:10.1152/ajpgi.00398.2007
    • (2008) Am J Physiol Gastrointest Liver Physiol , vol.294 , Issue.1 , pp. G208-G216
    • Kong, J.1    Zhang, Z.2    Musch, M.W.3    Ning, G.4    Sun, J.5    Hart, J.6
  • 85
    • 84942156417 scopus 로고    scopus 로고
    • Tight junction CLDN2 gene is a direct target of the vitamin D receptor
    • Zhang YG, Wu S, Lu R, Zhou D, Zhou J, Carmeliet G, et al. Tight junction CLDN2 gene is a direct target of the vitamin D receptor. Sci Rep (2015) 5:10642. doi:10.1038/srep10642
    • (2015) Sci Rep , vol.5 , pp. 10642
    • Zhang, Y.G.1    Wu, S.2    Lu, R.3    Zhou, D.4    Zhou, J.5    Carmeliet, G.6
  • 86
    • 84858779974 scopus 로고    scopus 로고
    • Increased gut permeability and microbiota change associate with mesenteric fat inflammation and metabolic dysfunction in diet-induced obese mice
    • Lam YY, Ha CW, Campbell CR, Mitchell AJ, Dinudom A, Oscarsson J, et al. Increased gut permeability and microbiota change associate with mesenteric fat inflammation and metabolic dysfunction in diet-induced obese mice. PLoS One (2012) 7(3):e34233. doi:10.1371/journal.pone.0034233
    • (2012) PLoS One , vol.7 , Issue.3
    • Lam, Y.Y.1    Ha, C.W.2    Campbell, C.R.3    Mitchell, A.J.4    Dinudom, A.5    Oscarsson, J.6
  • 87
    • 84859992839 scopus 로고    scopus 로고
    • Myosin light chain kinase mediates intestinal barrier disruption following burn injury
    • Chen C, Wang P, Su Q, Wang S, Wang F. Myosin light chain kinase mediates intestinal barrier disruption following burn injury. PLoS One (2012) 7(4):e34946. doi:10.1371/journal.pone.0034946
    • (2012) PLoS One , vol.7 , Issue.4
    • Chen, C.1    Wang, P.2    Su, Q.3    Wang, S.4    Wang, F.5
  • 88
    • 84941351063 scopus 로고    scopus 로고
    • Burn injury alters the intestinal microbiome and increases gut permeability and bacterial translocation
    • Earley ZM, Akhtar S, Green SJ, Naqib A, Khan O, Cannon AR, et al. Burn injury alters the intestinal microbiome and increases gut permeability and bacterial translocation. PLoS One (2015) 10(7):e0129996. doi:10.1371/journal.pone.0129996
    • (2015) PLoS One , vol.10 , Issue.7
    • Earley, Z.M.1    Akhtar, S.2    Green, S.J.3    Naqib, A.4    Khan, O.5    Cannon, A.R.6
  • 89
    • 34447281675 scopus 로고    scopus 로고
    • Molecular basis of epithelial barrier regulation: from basic mechanisms to clinical application
    • Turner JR. Molecular basis of epithelial barrier regulation: from basic mechanisms to clinical application. Am J Pathol (2006) 169(6):1901-9. doi:10.2353/ajpath.2006.060681
    • (2006) Am J Pathol , vol.169 , Issue.6 , pp. 1901-1909
    • Turner, J.R.1
  • 90
    • 70350509805 scopus 로고    scopus 로고
    • Intestinal mucosal barrier function in health and disease
    • Turner JR. Intestinal mucosal barrier function in health and disease. Nat Rev Immunol (2009) 9(11):799-809. doi:10.1038/nri2653
    • (2009) Nat Rev Immunol , vol.9 , Issue.11 , pp. 799-809
    • Turner, J.R.1
  • 91
    • 84862853385 scopus 로고    scopus 로고
    • Myosin light chain kinase: pulling the strings of epithelial tight junction function
    • Cunningham KE, Turner JR. Myosin light chain kinase: pulling the strings of epithelial tight junction function. Ann N Y Acad Sci (2012) 1258:34-42. doi:10.1111/j.1749-6632.2012.06526.x
    • (2012) Ann N Y Acad Sci , vol.1258 , pp. 34-42
    • Cunningham, K.E.1    Turner, J.R.2
  • 92
    • 84950142722 scopus 로고    scopus 로고
    • Fecal microbiota transplant restores mucosal integrity in a murine model of burn injury
    • Kuethe JW, Armocida SM, Midura EF, Rice TC, Hildeman DA, Healy DP, et al. Fecal microbiota transplant restores mucosal integrity in a murine model of burn injury. Shock (2016) 45(6):647-52. doi:10.1097/SHK.0000000000000551
    • (2016) Shock , vol.45 , Issue.6 , pp. 647-652
    • Kuethe, J.W.1    Armocida, S.M.2    Midura, E.F.3    Rice, T.C.4    Hildeman, D.A.5    Healy, D.P.6
  • 93
    • 84923468701 scopus 로고    scopus 로고
    • Dysbiosis-induced intestinal inflammation activates tumor necrosis factor receptor I and mediates alcoholic liver disease in mice
    • Chen P, Starkel P, Turner JR, Ho SB, Schnabl B. Dysbiosis-induced intestinal inflammation activates tumor necrosis factor receptor I and mediates alcoholic liver disease in mice. Hepatology (2015) 61(3):883-94. doi:10.1002/hep.27489
    • (2015) Hepatology , vol.61 , Issue.3 , pp. 883-894
    • Chen, P.1    Starkel, P.2    Turner, J.R.3    Ho, S.B.4    Schnabl, B.5
  • 94
    • 84922630906 scopus 로고    scopus 로고
    • Supplementation of saturated long-chain fatty acids maintains intestinal eubiosis and reduces ethanol-induced liver injury in mice
    • Chen P, Torralba M, Tan J, Embree M, Zengler K, Starkel P, et al. Supplementation of saturated long-chain fatty acids maintains intestinal eubiosis and reduces ethanol-induced liver injury in mice. Gastroenterology (2015) 148(1):203-14 e16. doi:10.1053/j.gastro.2014.09.014
    • (2015) Gastroenterology , vol.148 , Issue.1 , pp. 203-214
    • Chen, P.1    Torralba, M.2    Tan, J.3    Embree, M.4    Zengler, K.5    Starkel, P.6
  • 95
    • 0028796860 scopus 로고
    • Antibiotics prevent liver injury in rats following long-term exposure to ethanol
    • Adachi Y, Moore LE, Bradford BU, Gao W, Thurman RG. Antibiotics prevent liver injury in rats following long-term exposure to ethanol. Gastroenterology (1995) 108(1):218-24. doi:10.1016/0016-5085(95)90027-6
    • (1995) Gastroenterology , vol.108 , Issue.1 , pp. 218-224
    • Adachi, Y.1    Moore, L.E.2    Bradford, B.U.3    Gao, W.4    Thurman, R.G.5
  • 98
    • 61349161828 scopus 로고    scopus 로고
    • Lactobacillus GG treatment ameliorates alcohol-induced intestinal oxidative stress, gut leakiness, and liver injury in a rat model of alcoholic steatohepatitis
    • Forsyth CB, Farhadi A, Jakate SM, Tang Y, Shaikh M, Keshavarzian A. Lactobacillus GG treatment ameliorates alcohol-induced intestinal oxidative stress, gut leakiness, and liver injury in a rat model of alcoholic steatohepatitis. Alcohol (2009) 43(2):163-72. doi:10.1016/j.alcohol.2008.12.009
    • (2009) Alcohol , vol.43 , Issue.2 , pp. 163-172
    • Forsyth, C.B.1    Farhadi, A.2    Jakate, S.M.3    Tang, Y.4    Shaikh, M.5    Keshavarzian, A.6
  • 99
    • 81255124178 scopus 로고    scopus 로고
    • Lactobacillus rhamnosus GG treatment potentiates intestinal hypoxia-inducible factor, promotes intestinal integrity and ameliorates alcohol-induced liver injury
    • Wang Y, Kirpich I, Liu Y, Ma Z, Barve S, McClain CJ, et al. Lactobacillus rhamnosus GG treatment potentiates intestinal hypoxia-inducible factor, promotes intestinal integrity and ameliorates alcohol-induced liver injury. Am J Pathol (2011) 179(6):2866-75. doi:10.1016/j.ajpath.2011.08.039
    • (2011) Am J Pathol , vol.179 , Issue.6 , pp. 2866-2875
    • Wang, Y.1    Kirpich, I.2    Liu, Y.3    Ma, Z.4    Barve, S.5    McClain, C.J.6
  • 100
    • 0342699553 scopus 로고    scopus 로고
    • Increased intestinal permeability to macromolecules and endotoxemia in patients with chronic alcohol abuse in different stages of alcohol-induced liver disease
    • Parlesak A, Schafer C, Schutz T, Bode JC, Bode C. Increased intestinal permeability to macromolecules and endotoxemia in patients with chronic alcohol abuse in different stages of alcohol-induced liver disease. J Hepatol (2000) 32(5):742-7. doi:10.1016/S0168-8278(00)80242-1
    • (2000) J Hepatol , vol.32 , Issue.5 , pp. 742-747
    • Parlesak, A.1    Schafer, C.2    Schutz, T.3    Bode, J.C.4    Bode, C.5
  • 101
    • 0034950477 scopus 로고    scopus 로고
    • Toll-like receptor 4 is involved in the mechanism of early alcohol-induced liver injury in mice
    • Uesugi T, Froh M, Arteel GE, Bradford BU, Thurman RG. Toll-like receptor 4 is involved in the mechanism of early alcohol-induced liver injury in mice. Hepatology (2001) 34(1):101-8. doi:10.1053/jhep.2001.25350
    • (2001) Hepatology , vol.34 , Issue.1 , pp. 101-108
    • Uesugi, T.1    Froh, M.2    Arteel, G.E.3    Bradford, B.U.4    Thurman, R.G.5
  • 102
    • 84958020019 scopus 로고    scopus 로고
    • Ethanol production by selected intestinal microorganisms and lactic acid bacteria growing under different nutritional conditions
    • Elshaghabee FM, Bockelmann W, Meske D, de Vrese M, Walte HG, Schrezenmeir J, et al. Ethanol production by selected intestinal microorganisms and lactic acid bacteria growing under different nutritional conditions. Front Microbiol (2016) 7:47. doi:10.3389/fmicb.2016.00047
    • (2016) Front Microbiol , vol.7 , pp. 47
    • Elshaghabee, F.M.1    Bockelmann, W.2    Meske, D.3    de Vrese, M.4    Walte, H.G.5    Schrezenmeir, J.6
  • 103
    • 84884543925 scopus 로고    scopus 로고
    • Characterization of the gut-associated microbiome in inflammatory pouch complications following ileal pouch-anal anastomosis
    • Tyler AD, Knox N, Kabakchiev B, Milgrom R, Kirsch R, Cohen Z, et al. Characterization of the gut-associated microbiome in inflammatory pouch complications following ileal pouch-anal anastomosis. PLoS One (2013) 8(9):e66934. doi:10.1371/journal.pone.0066934
    • (2013) PLoS One , vol.8 , Issue.9
    • Tyler, A.D.1    Knox, N.2    Kabakchiev, B.3    Milgrom, R.4    Kirsch, R.5    Cohen, Z.6
  • 104
    • 57649149258 scopus 로고    scopus 로고
    • Diversity of tight junctions (TJs) between gastrointestinal epithelial cells and their function in maintaining the mucosal barrier
    • Yu QH, Yang Q. Diversity of tight junctions (TJs) between gastrointestinal epithelial cells and their function in maintaining the mucosal barrier. Cell Biol Int (2009) 33(1):78-82. doi:10.1016/j.cellbi.2008.09.007
    • (2009) Cell Biol Int , vol.33 , Issue.1 , pp. 78-82
    • Yu, Q.H.1    Yang, Q.2
  • 105
    • 0038780624 scopus 로고    scopus 로고
    • Disruption of the epithelial apical-junctional complex by Helicobacter pylori CagA
    • Amieva MR, Vogelmann R, Covacci A, Tompkins LS, Nelson WJ, Falkow S. Disruption of the epithelial apical-junctional complex by Helicobacter pylori CagA. Science (2003) 300(5624):1430-4. doi:10.1126/science.1081919
    • (2003) Science , vol.300 , Issue.5624 , pp. 1430-1434
    • Amieva, M.R.1    Vogelmann, R.2    Covacci, A.3    Tompkins, L.S.4    Nelson, W.J.5    Falkow, S.6
  • 106
    • 28444489667 scopus 로고    scopus 로고
    • Helicobacter pylori activates myosin light-chain kinase to disrupt claudin-4 and claudin-5 and increase epithelial permeability
    • Fedwick JP, Lapointe TK, Meddings JB, Sherman PM, Buret AG. Helicobacter pylori activates myosin light-chain kinase to disrupt claudin-4 and claudin-5 and increase epithelial permeability. Infect Immun (2005) 73(12):7844-52. doi:10.1128/IAI.73.12.7844-7852.2005
    • (2005) Infect Immun , vol.73 , Issue.12 , pp. 7844-7852
    • Fedwick, J.P.1    Lapointe, T.K.2    Meddings, J.B.3    Sherman, P.M.4    Buret, A.G.5
  • 107
    • 84978138176 scopus 로고    scopus 로고
    • Bacteriophage infections of microbiota can lead to leaky gut in an experimental rodent model
    • Tetz G, Tetz V. Bacteriophage infections of microbiota can lead to leaky gut in an experimental rodent model. Gut Pathog (2016) 8:33. doi:10.1186/s13099-016-0109-1
    • (2016) Gut Pathog , vol.8 , pp. 33
    • Tetz, G.1    Tetz, V.2
  • 108
    • 84908550245 scopus 로고    scopus 로고
    • Type 1 diabetes and autoimmunity
    • Kawasaki E. Type 1 diabetes and autoimmunity. Clin Pediatr Endocrinol (2014) 23(4):99-105. doi:10.1297/cpe.23.99
    • (2014) Clin Pediatr Endocrinol , vol.23 , Issue.4 , pp. 99-105
    • Kawasaki, E.1
  • 109
    • 84882797836 scopus 로고    scopus 로고
    • Intestinal permeability defects: is it time to treat?
    • Odenwald MA, Turner JR. Intestinal permeability defects: is it time to treat? Clin Gastroenterol Hepatol (2013) 11(9):1075-83. doi:10.1016/j.cgh.2013.07.001
    • (2013) Clin Gastroenterol Hepatol , vol.11 , Issue.9 , pp. 1075-1083
    • Odenwald, M.A.1    Turner, J.R.2
  • 110
    • 0037569417 scopus 로고    scopus 로고
    • Increased intestinal permeability as a cause of fluctuating postprandial blood glucose levels in type 1 diabetic patients
    • Damci T, Nuhoglu I, Devranoglu G, Osar Z, Demir M, Ilkova H. Increased intestinal permeability as a cause of fluctuating postprandial blood glucose levels in type 1 diabetic patients. Eur J Clin Invest (2003) 33(5):397-401. doi:10.1046/j.1365-2362.2003.01161.x
    • (2003) Eur J Clin Invest , vol.33 , Issue.5 , pp. 397-401
    • Damci, T.1    Nuhoglu, I.2    Devranoglu, G.3    Osar, Z.4    Demir, M.5    Ilkova, H.6
  • 111
    • 0032937027 scopus 로고    scopus 로고
    • Increased gastrointestinal permeability is an early lesion in the spontaneously diabetic BB rat
    • Meddings JB, Jarand J, Urbanski SJ, Hardin J, Gall DG. Increased gastrointestinal permeability is an early lesion in the spontaneously diabetic BB rat. Am J Physiol (1999) 276(4 Pt 1):G951-7.
    • (1999) Am J Physiol , vol.276 , Issue.4 , pp. G951-G957
    • Meddings, J.B.1    Jarand, J.2    Urbanski, S.J.3    Hardin, J.4    Gall, D.G.5
  • 112
    • 11144353743 scopus 로고    scopus 로고
    • Ultrastructural mucosal alterations and increased intestinal permeability in non-celiac, type I diabetic patients
    • Secondulfo M, Iafusco D, Carratu R, deMagistris L, Sapone A, Generoso M, et al. Ultrastructural mucosal alterations and increased intestinal permeability in non-celiac, type I diabetic patients. Dig Liver Dis (2004) 36(1):35-45. doi:10.1016/j.dld.2003.09.016
    • (2004) Dig Liver Dis , vol.36 , Issue.1 , pp. 35-45
    • Secondulfo, M.1    Iafusco, D.2    Carratu, R.3    deMagistris, L.4    Sapone, A.5    Generoso, M.6
  • 113
    • 0036829115 scopus 로고    scopus 로고
    • Host-dependent zonulin secretion causes the impairment of the small intestine barrier function after bacterial exposure
    • El Asmar R, Panigrahi P, Bamford P, Berti I, Not T, Coppa GV, et al. Host-dependent zonulin secretion causes the impairment of the small intestine barrier function after bacterial exposure. Gastroenterology (2002) 123(5):1607-15. doi:10.1053/gast.2002.36578
    • (2002) Gastroenterology , vol.123 , Issue.5 , pp. 1607-1615
    • El Asmar, R.1    Panigrahi, P.2    Bamford, P.3    Berti, I.4    Not, T.5    Coppa, G.V.6
  • 114
    • 14544277099 scopus 로고    scopus 로고
    • Role of the intestinal tight junction modulator zonulin in the pathogenesis of type I diabetes in BB diabetic-prone rats
    • Watts T, Berti I, Sapone A, Gerarduzzi T, Not T, Zielke R, et al. Role of the intestinal tight junction modulator zonulin in the pathogenesis of type I diabetes in BB diabetic-prone rats. Proc Natl Acad Sci U S A (2005) 102(8):2916-21. doi:10.1073/pnas.0500178102
    • (2005) Proc Natl Acad Sci U S A , vol.102 , Issue.8 , pp. 2916-2921
    • Watts, T.1    Berti, I.2    Sapone, A.3    Gerarduzzi, T.4    Not, T.5    Zielke, R.6
  • 115
    • 84977625421 scopus 로고    scopus 로고
    • Gut microbiota translocation to the pancreatic lymph nodes triggers NOD2 activation and contributes to T1D onset
    • Costa FR, Francozo MC, de Oliveira GG, Ignacio A, Castoldi A, Zamboni DS, et al. Gut microbiota translocation to the pancreatic lymph nodes triggers NOD2 activation and contributes to T1D onset. J Exp Med (2016) 213(7):1223-39. doi:10.1084/jem.20150744
    • (2016) J Exp Med , vol.213 , Issue.7 , pp. 1223-1239
    • Costa, F.R.1    Francozo, M.C.2    de Oliveira, G.G.3    Ignacio, A.4    Castoldi, A.5    Zamboni, D.S.6
  • 116
    • 82555196095 scopus 로고    scopus 로고
    • Systemic lupus erythematosus
    • Tsokos GC. Systemic lupus erythematosus. N Engl J Med (2011) 365(22):2110-21. doi:10.1056/NEJMra1100359
    • (2011) N Engl J Med , vol.365 , Issue.22 , pp. 2110-2121
    • Tsokos, G.C.1
  • 117
    • 84949565085 scopus 로고    scopus 로고
    • SLE: another autoimmune disorder influenced by microbes and diet?
    • Mu Q, Zhang H, Luo XM. SLE: another autoimmune disorder influenced by microbes and diet? Front Immunol (2015) 6:608. doi:10.3389/fimmu.2015.00608
    • (2015) Front Immunol , vol.6 , pp. 608
    • Mu, Q.1    Zhang, H.2    Luo, X.M.3
  • 118
    • 0028275841 scopus 로고
    • Elevated levels of soluble CD14 in serum of patients with systemic lupus erythematosus
    • Nockher WA, Wigand R, Schoeppe W, Scherberich JE. Elevated levels of soluble CD14 in serum of patients with systemic lupus erythematosus. Clin Exp Immunol (1994) 96(1):15-9. doi:10.1111/j.1365-2249.1994.tb06222.x
    • (1994) Clin Exp Immunol , vol.96 , Issue.1 , pp. 15-19
    • Nockher, W.A.1    Wigand, R.2    Schoeppe, W.3    Scherberich, J.E.4
  • 119
    • 84903374035 scopus 로고    scopus 로고
    • Interactions of surface-expressed TLR-4 and endosomal TLR-9 accelerate lupus progression in anti-dsDNA antibody transgenic mice
    • Lee TP, Huang JC, Liu CJ, Chen HJ, Chen YH, Tsai YT, et al. Interactions of surface-expressed TLR-4 and endosomal TLR-9 accelerate lupus progression in anti-dsDNA antibody transgenic mice. Exp Biol Med (Maywood) (2014) 239(6):715-23. doi:10.1177/1535370214525299
    • (2014) Exp Biol Med (Maywood) , vol.239 , Issue.6 , pp. 715-723
    • Lee, T.P.1    Huang, J.C.2    Liu, C.J.3    Chen, H.J.4    Chen, Y.H.5    Tsai, Y.T.6
  • 120
    • 77958151180 scopus 로고    scopus 로고
    • Transgenic overexpression of anti-double-stranded DNA autoantibody and activation of Toll-like receptor 4 in mice induce severe systemic lupus erythematosus syndromes
    • Lee TP, Tang SJ, Wu MF, Song YC, Yu CL, Sun KH. Transgenic overexpression of anti-double-stranded DNA autoantibody and activation of Toll-like receptor 4 in mice induce severe systemic lupus erythematosus syndromes. J Autoimmun (2010) 35(4):358-67. doi:10.1016/j.jaut.2010.07.007
    • (2010) J Autoimmun , vol.35 , Issue.4 , pp. 358-367
    • Lee, T.P.1    Tang, S.J.2    Wu, M.F.3    Song, Y.C.4    Yu, C.L.5    Sun, K.H.6
  • 121
    • 33750831778 scopus 로고    scopus 로고
    • TLR4 up-regulation at protein or gene level is pathogenic for lupus-like autoimmune disease
    • Liu B, Yang Y, Dai J, Medzhitov R, Freudenberg MA, Zhang PL, et al. TLR4 up-regulation at protein or gene level is pathogenic for lupus-like autoimmune disease. J Immunol (2006) 177(10):6880-8. doi:10.4049/jimmunol.177.10.6880
    • (2006) J Immunol , vol.177 , Issue.10 , pp. 6880-6888
    • Liu, B.1    Yang, Y.2    Dai, J.3    Medzhitov, R.4    Freudenberg, M.A.5    Zhang, P.L.6
  • 122
    • 33750310767 scopus 로고    scopus 로고
    • Immunization with an apoptotic cell-binding protein recapitulates the nephritis and sequential autoantibody emergence of systemic lupus erythematosus
    • Levine JS, Subang R, Nasr SH, Fournier S, Lajoie G, Wither J, et al. Immunization with an apoptotic cell-binding protein recapitulates the nephritis and sequential autoantibody emergence of systemic lupus erythematosus. J Immunol (2006) 177(9):6504-16. doi:10.4049/jimmunol.177.9.6504
    • (2006) J Immunol , vol.177 , Issue.9 , pp. 6504-6516
    • Levine, J.S.1    Subang, R.2    Nasr, S.H.3    Fournier, S.4    Lajoie, G.5    Wither, J.6
  • 123
    • 84903542578 scopus 로고    scopus 로고
    • Phospholipid-binding proteins differ in their capacity to induce autoantibodies and murine systemic lupus erythematosus
    • Levine JS, Subang R, Setty S, Cabrera J, Laplante P, Fritzler MJ, et al. Phospholipid-binding proteins differ in their capacity to induce autoantibodies and murine systemic lupus erythematosus. Lupus (2014) 23(8):752-68. doi:10.1177/0961203314525676
    • (2014) Lupus , vol.23 , Issue.8 , pp. 752-768
    • Levine, J.S.1    Subang, R.2    Setty, S.3    Cabrera, J.4    Laplante, P.5    Fritzler, M.J.6
  • 124
    • 70749133482 scopus 로고    scopus 로고
    • T cells demonstrate a Th1-biased response to native beta2-glycoprotein I in a murine model of anti-phospholipid antibody induction
    • Tolomeo T, Rico De Souza A, Roter E, Dieude M, Amireault P, Subang R, et al. T cells demonstrate a Th1-biased response to native beta2-glycoprotein I in a murine model of anti-phospholipid antibody induction. Autoimmunity (2009) 42(4):292-5. doi:10.1080/08916930902828254
    • (2009) Autoimmunity , vol.42 , Issue.4 , pp. 292-295
    • Tolomeo, T.1    Rico De Souza, A.2    Roter, E.3    Dieude, M.4    Amireault, P.5    Subang, R.6
  • 125
    • 77954237776 scopus 로고    scopus 로고
    • Critical role of TLR2 and TLR4 in autoantibody production and glomerulonephritis in lpr mutation-induced mouse lupus
    • Lartigue A, Colliou N, Calbo S, Francois A, Jacquot S, Arnoult C, et al. Critical role of TLR2 and TLR4 in autoantibody production and glomerulonephritis in lpr mutation-induced mouse lupus. J Immunol (2009) 183(10):6207-16. doi:10.4049/jimmunol.0803219
    • (2009) J Immunol , vol.183 , Issue.10 , pp. 6207-6216
    • Lartigue, A.1    Colliou, N.2    Calbo, S.3    Francois, A.4    Jacquot, S.5    Arnoult, C.6
  • 126
    • 77958151575 scopus 로고    scopus 로고
    • TLR9 and TLR4 are required for the development of autoimmunity and lupus nephritis in pristane nephropathy
    • Summers SA, Hoi A, Steinmetz OM, O'Sullivan KM, Ooi JD, Odobasic D, et al. TLR9 and TLR4 are required for the development of autoimmunity and lupus nephritis in pristane nephropathy. J Autoimmun (2010) 35(4):291-8. doi:10.1016/j.jaut.2010.05.004
    • (2010) J Autoimmun , vol.35 , Issue.4 , pp. 291-298
    • Summers, S.A.1    Hoi, A.2    Steinmetz, O.M.3    O'Sullivan, K.M.4    Ooi, J.D.5    Odobasic, D.6
  • 127
    • 84940960375 scopus 로고    scopus 로고
    • Increased expression of TLR2 in CD4(+) T cells from SLE patients enhances immune reactivity and promotes IL-17 expression through histone modifications
    • Liu Y, Liao J, Zhao M, Wu H, Yung S, Chan TM, et al. Increased expression of TLR2 in CD4(+) T cells from SLE patients enhances immune reactivity and promotes IL-17 expression through histone modifications. Eur J Immunol (2015) 45(9):2683-93. doi:10.1002/eji.201445219
    • (2015) Eur J Immunol , vol.45 , Issue.9 , pp. 2683-2693
    • Liu, Y.1    Liao, J.2    Zhao, M.3    Wu, H.4    Yung, S.5    Chan, T.M.6
  • 128
    • 84879697143 scopus 로고    scopus 로고
    • Pristane-induced lupus as a model of human lupus arthritis: evolvement of autoantibodies, internal organ and joint inflammation
    • Leiss H, Niederreiter B, Bandur T, Schwarzecker B, Bluml S, Steiner G, et al. Pristane-induced lupus as a model of human lupus arthritis: evolvement of autoantibodies, internal organ and joint inflammation. Lupus (2013) 22(8):778-92. doi:10.1177/0961203313492869
    • (2013) Lupus , vol.22 , Issue.8 , pp. 778-792
    • Leiss, H.1    Niederreiter, B.2    Bandur, T.3    Schwarzecker, B.4    Bluml, S.5    Steiner, G.6
  • 129
    • 68249147524 scopus 로고    scopus 로고
    • Bacterial lipopeptide triggers massive albuminuria in murine lupus nephritis by activating toll-like receptor 2 at the glomerular filtration barrier
    • Pawar RD, Castrezana-Lopez L, Allam R, Kulkarni OP, Segerer S, Radomska E, et al. Bacterial lipopeptide triggers massive albuminuria in murine lupus nephritis by activating toll-like receptor 2 at the glomerular filtration barrier. Immunology (2009) 128(1 Suppl):e206-21. doi:10.1111/j.1365-2567.2008.02948.x
    • (2009) Immunology , vol.128 , Issue.1
    • Pawar, R.D.1    Castrezana-Lopez, L.2    Allam, R.3    Kulkarni, O.P.4    Segerer, S.5    Radomska, E.6
  • 130
    • 84878597916 scopus 로고    scopus 로고
    • Toll-like receptor 2 is required for autoantibody production and development of renal disease in pristane-induced lupus
    • Urbonaviciute V, Starke C, Pirschel W, Pohle S, Frey S, Daniel C, et al. Toll-like receptor 2 is required for autoantibody production and development of renal disease in pristane-induced lupus. Arthritis Rheum (2013) 65(6):1612-23. doi:10.1002/art.37914
    • (2013) Arthritis Rheum , vol.65 , Issue.6 , pp. 1612-1623
    • Urbonaviciute, V.1    Starke, C.2    Pirschel, W.3    Pohle, S.4    Frey, S.5    Daniel, C.6
  • 131
    • 84937611284 scopus 로고    scopus 로고
    • Amyloid-DNA composites of bacterial biofilms stimulate autoimmunity
    • Gallo PM, Rapsinski GJ, Wilson RP, Oppong GO, Sriram U, Goulian M, et al. Amyloid-DNA composites of bacterial biofilms stimulate autoimmunity. Immunity (2015) 42(6):1171-84. doi:10.1016/j.immuni.2015.06.002
    • (2015) Immunity , vol.42 , Issue.6 , pp. 1171-1184
    • Gallo, P.M.1    Rapsinski, G.J.2    Wilson, R.P.3    Oppong, G.O.4    Sriram, U.5    Goulian, M.6
  • 132
    • 84949214378 scopus 로고    scopus 로고
    • Toll-like receptors: potential targets for lupus treatment
    • Wu YW, Tang W, Zuo JP. Toll-like receptors: potential targets for lupus treatment. Acta Pharmacol Sin (2015) 36(12):1395-407. doi:10.1038/aps.2015.91
    • (2015) Acta Pharmacol Sin , vol.36 , Issue.12 , pp. 1395-1407
    • Wu, Y.W.1    Tang, W.2    Zuo, J.P.3
  • 133
    • 84875547953 scopus 로고    scopus 로고
    • Signals via the adaptor MyD88 in B cells and DCs make distinct and synergistic contributions to immune activation and tissue damage in lupus
    • Teichmann LL, Schenten D, Medzhitov R, Kashgarian M, Shlomchik MJ. Signals via the adaptor MyD88 in B cells and DCs make distinct and synergistic contributions to immune activation and tissue damage in lupus. Immunity (2013) 38(3):528-40. doi:10.1016/j.immuni.2012.11.017
    • (2013) Immunity , vol.38 , Issue.3 , pp. 528-540
    • Teichmann, L.L.1    Schenten, D.2    Medzhitov, R.3    Kashgarian, M.4    Shlomchik, M.J.5
  • 134
    • 77949903821 scopus 로고    scopus 로고
    • TLR9 regulates TLR7- and MyD88-dependent autoantibody production and disease in a murine model of lupus
    • Nickerson KM, Christensen SR, Shupe J, Kashgarian M, Kim D, Elkon K, et al. TLR9 regulates TLR7- and MyD88-dependent autoantibody production and disease in a murine model of lupus. J Immunol (2010) 184(4):1840-8. doi:10.4049/jimmunol.0902592
    • (2010) J Immunol , vol.184 , Issue.4 , pp. 1840-1848
    • Nickerson, K.M.1    Christensen, S.R.2    Shupe, J.3    Kashgarian, M.4    Kim, D.5    Elkon, K.6
  • 136
  • 137
    • 84937721277 scopus 로고    scopus 로고
    • Deficient NLRP3 and AIM2 inflammasome function in autoimmune NZB mice
    • Sester DP, Sagulenko V, Thygesen SJ, Cridland JA, Loi YS, Cridland SO, et al. Deficient NLRP3 and AIM2 inflammasome function in autoimmune NZB mice. J Immunol (2015) 195(3):1233-41. doi:10.4049/jimmunol.1402859
    • (2015) J Immunol , vol.195 , Issue.3 , pp. 1233-1241
    • Sester, D.P.1    Sagulenko, V.2    Thygesen, S.J.3    Cridland, J.A.4    Loi, Y.S.5    Cridland, S.O.6
  • 138
    • 84954366921 scopus 로고    scopus 로고
    • NLRP3 and ASC suppress lupus-like autoimmunity by driving the immunosuppressive effects of TGF-beta receptor signalling
    • Lech M, Lorenz G, Kulkarni OP, Grosser MO, Stigrot N, Darisipudi MN, et al. NLRP3 and ASC suppress lupus-like autoimmunity by driving the immunosuppressive effects of TGF-beta receptor signalling. Ann Rheum Dis (2015) 74(12):2224-35. doi:10.1136/annrheumdis-2014-205496
    • (2015) Ann Rheum Dis , vol.74 , Issue.12 , pp. 2224-2235
    • Lech, M.1    Lorenz, G.2    Kulkarni, O.P.3    Grosser, M.O.4    Stigrot, N.5    Darisipudi, M.N.6
  • 139
    • 84867116816 scopus 로고    scopus 로고
    • Probiotic supplementation affects markers of intestinal barrier, oxidation, and inflammation in trained men; a randomized, double-blinded, placebo-controlled trial
    • Lamprecht M, Bogner S, Schippinger G, Steinbauer K, Fankhauser F, Hallstroem S, et al. Probiotic supplementation affects markers of intestinal barrier, oxidation, and inflammation in trained men; a randomized, double-blinded, placebo-controlled trial. J Int Soc Sports Nutr (2012) 9(1):45. doi:10.1186/1550-2783-9-45
    • (2012) J Int Soc Sports Nutr , vol.9 , Issue.1 , pp. 45
    • Lamprecht, M.1    Bogner, S.2    Schippinger, G.3    Steinbauer, K.4    Fankhauser, F.5    Hallstroem, S.6
  • 140
    • 84894118144 scopus 로고    scopus 로고
    • Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders
    • Hsiao EY, McBride SW, Hsien S, Sharon G, Hyde ER, McCue T, et al. Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell (2013) 155(7):1451-63. doi:10.1016/j.cell.2013.11.024
    • (2013) Cell , vol.155 , Issue.7 , pp. 1451-1463
    • Hsiao, E.Y.1    McBride, S.W.2    Hsien, S.3    Sharon, G.4    Hyde, E.R.5    McCue, T.6
  • 141
    • 77954738601 scopus 로고    scopus 로고
    • Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota
    • Round JL, Mazmanian SK. Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota. Proc Natl Acad Sci U S A (2010) 107(27):12204-9. doi:10.1073/pnas.0909122107
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.27 , pp. 12204-12209
    • Round, J.L.1    Mazmanian, S.K.2
  • 142
    • 84944445669 scopus 로고    scopus 로고
    • A commensal symbiotic factor derived from Bacteroides fragilis promotes human CD39(+)Foxp3(+) T cells and Treg function
    • Telesford KM, Yan W, Ochoa-Reparaz J, Pant A, Kircher C, Christy MA, et al. A commensal symbiotic factor derived from Bacteroides fragilis promotes human CD39(+)Foxp3(+) T cells and Treg function. Gut Microbes (2015) 6(4):234-42. doi:10.1080/19490976.2015.1056973
    • (2015) Gut Microbes , vol.6 , Issue.4 , pp. 234-242
    • Telesford, K.M.1    Yan, W.2    Ochoa-Reparaz, J.3    Pant, A.4    Kircher, C.5    Christy, M.A.6
  • 143
    • 77955913743 scopus 로고    scopus 로고
    • A polysaccharide from the human commensal Bacteroides fragilis protects against CNS demyelinating disease
    • Ochoa-Reparaz J, Mielcarz DW, Wang Y, Begum-Haque S, Dasgupta S, Kasper DL, et al. A polysaccharide from the human commensal Bacteroides fragilis protects against CNS demyelinating disease. Mucosal Immunol (2010) 3(5):487-95. doi:10.1038/mi.2010.29
    • (2010) Mucosal Immunol , vol.3 , Issue.5 , pp. 487-495
    • Ochoa-Reparaz, J.1    Mielcarz, D.W.2    Wang, Y.3    Begum-Haque, S.4    Dasgupta, S.5    Kasper, D.L.6


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