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Volumn 146, Issue 6, 2014, Pages 1554-1563

Manipulation of the microbiota for treatment of IBS and IBD - Challenges and controversies

Author keywords

Fecal Transplantation; Pharmabiotic; Prebiotic; Probiotic

Indexed keywords

ANTIBIOTIC AGENT; PROBIOTIC AGENT; RIFAXIMIN;

EID: 84898835480     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2014.01.050     Document Type: Article
Times cited : (146)

References (66)
  • 1
    • 84867214356 scopus 로고    scopus 로고
    • The gut microbiota-A clinical perspective on lessons learned
    • F. Shanahan The gut microbiota-a clinical perspective on lessons learned Nat Rev Gastroenterol Hepatol 9 2012 609 614
    • (2012) Nat Rev Gastroenterol Hepatol , vol.9 , pp. 609-614
    • Shanahan, F.1
  • 2
    • 78149295964 scopus 로고    scopus 로고
    • Alleviating cancer drug toxicity by inhibiting a bacterial enzyme
    • B.D. Wallace, H. Wang, and K.T. Lane et al. Alleviating cancer drug toxicity by inhibiting a bacterial enzyme Science 330 2010 831 835
    • (2010) Science , vol.330 , pp. 831-835
    • Wallace, B.D.1    Wang, H.2    Lane, K.T.3
  • 3
    • 78649712604 scopus 로고    scopus 로고
    • Probiotics in perspective
    • F. Shanahan Probiotics in perspective Gastroenterology 139 2010 1808 1812
    • (2010) Gastroenterology , vol.139 , pp. 1808-1812
    • Shanahan, F.1
  • 5
    • 84864756966 scopus 로고    scopus 로고
    • The microbiota in inflammatory bowel disease: Friend, bystander, and sometime-villain
    • F. Shanahan The microbiota in inflammatory bowel disease: friend, bystander, and sometime-villain Nutr Rev 70 Suppl 1 2012 S31 S37
    • (2012) Nutr Rev , vol.70 , Issue.SUPPL. 1
    • Shanahan, F.1
  • 6
    • 65449125343 scopus 로고    scopus 로고
    • Targeting the human microbiome with antibiotics, probiotics, and prebiotics: Gastroenterology enters the metagenomics era
    • G.A. Preidis, and J. Versalovic Targeting the human microbiome with antibiotics, probiotics, and prebiotics: gastroenterology enters the metagenomics era Gastroenterology 136 2009 2015 2031
    • (2009) Gastroenterology , vol.136 , pp. 2015-2031
    • Preidis, G.A.1    Versalovic, J.2
  • 7
    • 77749318556 scopus 로고    scopus 로고
    • The efficacy of probiotics in the treatment of irritable bowel syndrome: A systematic review
    • P. Moayyedi, A.C. Ford, and N.J. Talley et al. The efficacy of probiotics in the treatment of irritable bowel syndrome: a systematic review Gut 59 2010 325 332
    • (2010) Gut , vol.59 , pp. 325-332
    • Moayyedi, P.1    Ford, A.C.2    Talley, N.J.3
  • 8
    • 56349126039 scopus 로고    scopus 로고
    • Efficacy of probiotics in irritable bowel syndrome: A meta-analysis of randomized, controlled trials
    • S. Nikfar, R. Rahimi, and F. Rahimi et al. Efficacy of probiotics in irritable bowel syndrome: a meta-analysis of randomized, controlled trials Dis Colon Rectum 51 2008 1775 1780
    • (2008) Dis Colon Rectum , vol.51 , pp. 1775-1780
    • Nikfar, S.1    Rahimi, R.2    Rahimi, F.3
  • 9
    • 49649088887 scopus 로고    scopus 로고
    • Meta-analysis of probiotics for the treatment of irritable bowel syndrome
    • L.V. McFarland, and S. Dublin Meta-analysis of probiotics for the treatment of irritable bowel syndrome World J Gastroenterol 14 2008 2650 2661
    • (2008) World J Gastroenterol , vol.14 , pp. 2650-2661
    • McFarland, L.V.1    Dublin, S.2
  • 10
    • 65449172901 scopus 로고    scopus 로고
    • The utility of probiotics in the treatment of irritable bowel syndrome: A systematic review
    • D.M. Brenner, M.J. Moeller, and W.D. Chey et al. The utility of probiotics in the treatment of irritable bowel syndrome: a systematic review Am J Gastroenterol 104 2009 1033 1049
    • (2009) Am J Gastroenterol , vol.104 , pp. 1033-1049
    • Brenner, D.M.1    Moeller, M.J.2    Chey, W.D.3
  • 11
    • 42749105936 scopus 로고    scopus 로고
    • Probiotics for maintenance of remission in Crohn's disease
    • V.E. Rolfe, P.J. Fortun, and C.J. Hawkey et al. Probiotics for maintenance of remission in Crohn's disease Cochrane Database Syst Rev 4 2006 CD004826
    • (2006) Cochrane Database Syst Rev , vol.4 , pp. 004826
    • Rolfe, V.E.1    Fortun, P.J.2    Hawkey, C.J.3
  • 12
    • 50249087428 scopus 로고    scopus 로고
    • A meta-analysis on the efficacy of probiotics for maintenance of remission and prevention of clinical and endoscopic relapse in Crohn's disease
    • R. Rahimi, S. Nikfar, and F. Rahimi et al. A meta-analysis on the efficacy of probiotics for maintenance of remission and prevention of clinical and endoscopic relapse in Crohn's disease Dig Dis Sci 53 2008 2524 2531
    • (2008) Dig Dis Sci , vol.53 , pp. 2524-2531
    • Rahimi, R.1    Nikfar, S.2    Rahimi, F.3
  • 13
    • 63849175266 scopus 로고    scopus 로고
    • Meta-analysis: The effect and adverse events of Lactobacilli versus placebo in maintenance therapy for Crohn disease
    • J. Shen, H.Z. Ran, and M.H. Yin et al. Meta-analysis: the effect and adverse events of Lactobacilli versus placebo in maintenance therapy for Crohn disease Intern Med J 39 2009 103 109
    • (2009) Intern Med J , vol.39 , pp. 103-109
    • Shen, J.1    Ran, H.Z.2    Yin, M.H.3
  • 14
    • 77949770445 scopus 로고    scopus 로고
    • Interventions for prevention of post-operative recurrence of Crohn's disease
    • G. Doherty, G. Bennett, and S. Patil et al. Interventions for prevention of post-operative recurrence of Crohn's disease Cochrane Database Syst Rev 4 2009 CD006873
    • (2009) Cochrane Database Syst Rev , vol.4 , pp. 006873
    • Doherty, G.1    Bennett, G.2    Patil, S.3
  • 15
    • 77949737175 scopus 로고    scopus 로고
    • Meta-analysis: Targeting the intestinal microbiota in prophylaxis for post-operative Crohn's disease
    • G.A. Doherty, G.C. Bennett, and A.S. Cheifetz et al. Meta-analysis: targeting the intestinal microbiota in prophylaxis for post-operative Crohn's disease Aliment Pharmacol Ther 31 2010 802 809
    • (2010) Aliment Pharmacol Ther , vol.31 , pp. 802-809
    • Doherty, G.A.1    Bennett, G.C.2    Cheifetz, A.S.3
  • 16
    • 77951449179 scopus 로고    scopus 로고
    • Remission induction and maintenance effect of probiotics on ulcerative colitis: A meta-analysis
    • L.X. Sang, B. Chang, and W.L. Zhang et al. Remission induction and maintenance effect of probiotics on ulcerative colitis: a meta-analysis World J Gastroenterol 16 2010 1908 1915
    • (2010) World J Gastroenterol , vol.16 , pp. 1908-1915
    • Sang, L.X.1    Chang, B.2    Zhang, W.L.3
  • 17
    • 84856239877 scopus 로고    scopus 로고
    • Probiotics for maintenance of remission in ulcerative colitis
    • K. Naidoo, M. Gordon, and A.O. Fagbemi et al. Probiotics for maintenance of remission in ulcerative colitis Cochrane Database Syst Rev 12 2011 CD007443
    • (2011) Cochrane Database Syst Rev , vol.12 , pp. 007443
    • Naidoo, K.1    Gordon, M.2    Fagbemi, A.O.3
  • 18
    • 4244163078 scopus 로고
    • Accessed Dec 17, 2013
    • Orwell G. Politics of the English language. 1946. Available at: http://www.npr.org/blogs/ombudsman/Politics-and-the-English-Language-1.pdf. Accessed Dec 17, 2013.
    • (1946) Politics of the English Language
    • Orwell, G.1
  • 20
    • 77953904042 scopus 로고    scopus 로고
    • Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine
    • K. Cadwell, K.K. Patel, and N.S. Maloney et al. Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine Cell 141 2010 1135 1145
    • (2010) Cell , vol.141 , pp. 1135-1145
    • Cadwell, K.1    Patel, K.K.2    Maloney, N.S.3
  • 21
    • 84866436436 scopus 로고    scopus 로고
    • Acute gastrointestinal infection induces long-lived microbiota-specific T cell responses
    • T.H. Hand, L.M. Dos Santos, and N. Bouladoux et al. Acute gastrointestinal infection induces long-lived microbiota-specific T cell responses Science 337 2012 1553 1556
    • (2012) Science , vol.337 , pp. 1553-1556
    • Hand, T.H.1    Dos Santos, L.M.2    Bouladoux, N.3
  • 22
    • 0026715041 scopus 로고
    • The role of gastrointestinal microflora in postsurgical adhesion formation-A study in germfree rats
    • C. Bothin, and T. Midtvedt The role of gastrointestinal microflora in postsurgical adhesion formation-a study in germfree rats Eur Surg Res 24 1992 309 312
    • (1992) Eur Surg Res , vol.24 , pp. 309-312
    • Bothin, C.1    Midtvedt, T.2
  • 23
    • 0031889086 scopus 로고    scopus 로고
    • Stimulation of transforming growth factor beta1 by enteric bacteria in the pathogenesis of rat intestinal fibrosis
    • M. Mourelle, A. Salas, and F. Guarner et al. Stimulation of transforming growth factor beta1 by enteric bacteria in the pathogenesis of rat intestinal fibrosis Gastroenterology 114 1998 519 526
    • (1998) Gastroenterology , vol.114 , pp. 519-526
    • Mourelle, M.1    Salas, A.2    Guarner, F.3
  • 24
    • 0032782852 scopus 로고    scopus 로고
    • Bacterial cell wall polymers promote intestinal fibrosis by direct stimulation of myofibroblasts
    • E.A.F. Van Tol, L. Holt, and F. Ling Li et al. Bacterial cell wall polymers promote intestinal fibrosis by direct stimulation of myofibroblasts Am J Physiol 277 1999 G245 G255
    • (1999) Am J Physiol , vol.277
    • Van Tol, E.A.F.1    Holt, L.2    Ling Li, F.3
  • 25
    • 67650239557 scopus 로고    scopus 로고
    • A new animal model of postsurgical bowel inflammation and fibrosis: The effect of commensal microflora
    • R.J. Rigby, M.R. Hunt, and B.P. Scull et al. A new animal model of postsurgical bowel inflammation and fibrosis: the effect of commensal microflora Gut 58 2009 1104 1112
    • (2009) Gut , vol.58 , pp. 1104-1112
    • Rigby, R.J.1    Hunt, M.R.2    Scull, B.P.3
  • 26
    • 84871633923 scopus 로고    scopus 로고
    • The colonic microbiota in health and disease
    • F. Shanahan The colonic microbiota in health and disease Curr Opin Gastroenterol 29 2013 49 54
    • (2013) Curr Opin Gastroenterol , vol.29 , pp. 49-54
    • Shanahan, F.1
  • 27
    • 0018876339 scopus 로고
    • Irritable bowel syndrome: Physiological and psychological differences between diarrhea-predominant and constipation-predominant patients
    • W.E. Whitehead, B.T. Engel, and M.M. Schuster Irritable bowel syndrome: physiological and psychological differences between diarrhea-predominant and constipation-predominant patients Dig Dis Sci 25 1980 404 413
    • (1980) Dig Dis Sci , vol.25 , pp. 404-413
    • Whitehead, W.E.1    Engel, B.T.2    Schuster, M.M.3
  • 29
    • 84872283009 scopus 로고    scopus 로고
    • Bugs on the brain; Brain in the gut-seeking explanations for common gastrointestinal symptoms
    • E.M. Quigley Bugs on the brain; brain in the gut-seeking explanations for common gastrointestinal symptoms Ir J Med Sci 182 2012 1 6
    • (2012) Ir J Med Sci , vol.182 , pp. 1-6
    • Quigley, E.M.1
  • 30
    • 43649100298 scopus 로고    scopus 로고
    • Bacterial flora in irritable bowel syndrome: Role in pathophysiology, implications for management
    • E.M. Quigley Bacterial flora in irritable bowel syndrome: role in pathophysiology, implications for management J Dig Dis 8 2007 2 7
    • (2007) J Dig Dis , vol.8 , pp. 2-7
    • Quigley, E.M.1
  • 31
    • 84875230726 scopus 로고    scopus 로고
    • Helicobacter pylori infection in functional dyspepsia
    • H. Suzuki, and P. Moayyedi Helicobacter pylori infection in functional dyspepsia Nat Rev Gastroenterol Hepatol 10 2013 168 174
    • (2013) Nat Rev Gastroenterol Hepatol , vol.10 , pp. 168-174
    • Suzuki, H.1    Moayyedi, P.2
  • 32
    • 84859131881 scopus 로고    scopus 로고
    • Use of broad-spectrum antibiotics and the development of irritable bowel syndrome
    • A.A. Villarreal, F.J. Aberger, and R. Benrud et al. Use of broad-spectrum antibiotics and the development of irritable bowel syndrome WMJ 111 2012 17 20
    • (2012) WMJ , vol.111 , pp. 17-20
    • Villarreal, A.A.1    Aberger, F.J.2    Benrud, R.3
  • 33
    • 0033636668 scopus 로고    scopus 로고
    • Eradication of small intestinal bacterial overgrowth reduces symptoms of irritable bowel syndrome
    • M. Pimentel, E.J. Chow, and H.C. Lin Eradication of small intestinal bacterial overgrowth reduces symptoms of irritable bowel syndrome Am J Gastroenterol 95 2000 3503 3506
    • (2000) Am J Gastroenterol , vol.95 , pp. 3503-3506
    • Pimentel, M.1    Chow, E.J.2    Lin, H.C.3
  • 34
    • 84868555218 scopus 로고    scopus 로고
    • The microbiota link to irritable bowel syndrome: An emerging story
    • I.B. Jeffery, E.M. Quigley, and L. Ohman et al. The microbiota link to irritable bowel syndrome: an emerging story Gut Microbes 3 2012 572 576
    • (2012) Gut Microbes , vol.3 , pp. 572-576
    • Jeffery, I.B.1    Quigley, E.M.2    Ohman, L.3
  • 35
    • 80054119513 scopus 로고    scopus 로고
    • Molecular analysis of the luminal- and mucosal-associated intestinal microbiota in diarrhea-predominant irritable bowel syndrome
    • I.M. Carroll, T. Ringel-Kulka, and T.O. Keku et al. Molecular analysis of the luminal- and mucosal-associated intestinal microbiota in diarrhea-predominant irritable bowel syndrome Am J Physiol Gastrointest Liver Physiol 301 2011 G799 G807
    • (2011) Am J Physiol Gastrointest Liver Physiol , vol.301
    • Carroll, I.M.1    Ringel-Kulka, T.2    Keku, T.O.3
  • 36
    • 84861578319 scopus 로고    scopus 로고
    • An irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota
    • I.B. Jeffery, P.W. O'Toole, and L. Öhman et al. An irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota Gut 61 2012 997 1006
    • (2012) Gut , vol.61 , pp. 997-1006
    • Jeffery, I.B.1    O'Toole, P.W.2    Öhman, L.3
  • 37
    • 84861201380 scopus 로고    scopus 로고
    • Increase in fecal primary bile acids and dysbiosis in patients with diarrhea-predominant irritable bowel syndrome
    • e246-e247
    • H. Duboc, D. Rainteau, and S. Rajca et al. Increase in fecal primary bile acids and dysbiosis in patients with diarrhea-predominant irritable bowel syndrome Neurogastroenterol Motil 24 2012 513 520 e246-e247
    • (2012) Neurogastroenterol Motil , vol.24 , pp. 513-520
    • Duboc, H.1    Rainteau, D.2    Rajca, S.3
  • 38
    • 84893741669 scopus 로고    scopus 로고
    • Anal gas evacuation and colonic microbiota in patients with flatulence: Effect of diet
    • C. Manichanh, A. Eck, and E. Varela et al. Anal gas evacuation and colonic microbiota in patients with flatulence: effect of diet Gut 63 2014 401 408
    • (2014) Gut , vol.63 , pp. 401-408
    • Manichanh, C.1    Eck, A.2    Varela, E.3
  • 39
    • 85047689124 scopus 로고    scopus 로고
    • Bacteria, colonic fermentation, and gastrointestinal health
    • G.T. Macfarlane, and S. Macfarlane Bacteria, colonic fermentation, and gastrointestinal health J AOAC Int 95 2012 50 60
    • (2012) J AOAC Int , vol.95 , pp. 50-60
    • Macfarlane, G.T.1    Macfarlane, S.2
  • 40
    • 79951570315 scopus 로고    scopus 로고
    • Therapies aimed at the gut microbiota and inflammation. Antibiotics, probiotics/prebiotics/synbiotics, anti-inflammatory therapies
    • E.M.M. Quigley Therapies aimed at the gut microbiota and inflammation. Antibiotics, probiotics/prebiotics/synbiotics, anti-inflammatory therapies Gastroenterol Clin North Am 40 2011 207 222
    • (2011) Gastroenterol Clin North Am , vol.40 , pp. 207-222
    • Quigley, E.M.M.1
  • 41
    • 78650864077 scopus 로고    scopus 로고
    • Rifaximin therapy for patients with irritable bowel syndrome without constipation
    • M. Pimentel, A. Lembo, and W.D. Chey et al. Rifaximin therapy for patients with irritable bowel syndrome without constipation N Engl J Med 364 2011 22 32
    • (2011) N Engl J Med , vol.364 , pp. 22-32
    • Pimentel, M.1    Lembo, A.2    Chey, W.D.3
  • 42
    • 79551694651 scopus 로고    scopus 로고
    • The microbiome-gut-brain axis: From bowel to behavior
    • J.F. Cryan, and S.M. O'Mahony The microbiome-gut-brain axis: from bowel to behavior Neurogastroenterol Motil 23 2011 187 192
    • (2011) Neurogastroenterol Motil , vol.23 , pp. 187-192
    • Cryan, J.F.1    O'Mahony, S.M.2
  • 43
    • 78651252504 scopus 로고    scopus 로고
    • Antibiotic use in inflammatory bowel diseases in childhood
    • A. Hviid, H. Svanström, and M. Frisch Antibiotic use in inflammatory bowel diseases in childhood Gut 60 2011 49 54
    • (2011) Gut , vol.60 , pp. 49-54
    • Hviid, A.1    Svanström, H.2    Frisch, M.3
  • 44
    • 78649868190 scopus 로고    scopus 로고
    • Association between the use of antibiotics in the first year of life and pediatric inflammatory bowel disease
    • S.Y. Shaw, J.F. Blanchard, and C.N. Bernstein Association between the use of antibiotics in the first year of life and pediatric inflammatory bowel disease Am J Gastroenterol 105 2010 2687 2692
    • (2010) Am J Gastroenterol , vol.105 , pp. 2687-2692
    • Shaw, S.Y.1    Blanchard, J.F.2    Bernstein, C.N.3
  • 45
    • 0029837011 scopus 로고    scopus 로고
    • The immunomodulation of enteric neuromuscular function: Implications for motility and inflammatory disorders
    • S.M. Collins The immunomodulation of enteric neuromuscular function: implications for motility and inflammatory disorders Gastroenterology 111 1996 1683 1699
    • (1996) Gastroenterology , vol.111 , pp. 1683-1699
    • Collins, S.M.1
  • 46
    • 33644514222 scopus 로고    scopus 로고
    • Interactions between commensal gut flora and gut sensorimotor function in health and disease
    • G. Barbara, V. Stanghellini, and G. Brandi et al. Interactions between commensal gut flora and gut sensorimotor function in health and disease Am J Gastroenterol 100 2005 2560 2568
    • (2005) Am J Gastroenterol , vol.100 , pp. 2560-2568
    • Barbara, G.1    Stanghellini, V.2    Brandi, G.3
  • 47
    • 57649208538 scopus 로고    scopus 로고
    • Clinical trial: The effects of a fermented milk product containing bifidobacteriumlactis DN-173-010 on abdominal distension and gastrointestinal transit in irritable bowel syndrome with constipation
    • A. Agrawal, L.A. Houghton, and J. Morris et al. Clinical trial: the effects of a fermented milk product containing bifidobacteriumlactis DN-173-010 on abdominal distension and gastrointestinal transit in irritable bowel syndrome with constipation Aliment Pharmacol Ther 29 2009 104 114
    • (2009) Aliment Pharmacol Ther , vol.29 , pp. 104-114
    • Agrawal, A.1    Houghton, L.A.2    Morris, J.3
  • 48
    • 0037392231 scopus 로고    scopus 로고
    • A randomized controlled trial of a probiotic, VSL#3, on gut transit and symptoms in diarrhoea-predominant irritable bowel syndrome
    • H.J. Kim, M. Camilleri, and S. McKinzie et al. A randomized controlled trial of a probiotic, VSL#3, on gut transit and symptoms in diarrhoea- predominant irritable bowel syndrome Aliment Pharmacol Ther 17 2003 895 904
    • (2003) Aliment Pharmacol Ther , vol.17 , pp. 895-904
    • Kim, H.J.1    Camilleri, M.2    McKinzie, S.3
  • 49
    • 25844477007 scopus 로고    scopus 로고
    • A randomized controlled trial of a probiotic combination VSL# 3 and placebo in irritable bowel syndrome with bloating
    • H.J. Kim, M.I. Vazquez Roque, and M. Camilleri et al. A randomized controlled trial of a probiotic combination VSL# 3 and placebo in irritable bowel syndrome with bloating Neurogastroenterol Motil 17 2005 687 696
    • (2005) Neurogastroenterol Motil , vol.17 , pp. 687-696
    • Kim, H.J.1    Vazquez Roque, M.I.2    Camilleri, M.3
  • 50
    • 84878287270 scopus 로고    scopus 로고
    • Consumption of fermented milk product with probiotic modulates brain activity
    • K. Tillisch, J. Labus, and L. Kilpatrick et al. Consumption of fermented milk product with probiotic modulates brain activity Gastroenterology 144 2013 1394 1401
    • (2013) Gastroenterology , vol.144 , pp. 1394-1401
    • Tillisch, K.1    Labus, J.2    Kilpatrick, L.3
  • 51
    • 84880484582 scopus 로고    scopus 로고
    • Bifidobacterium infantis 35624 modulates host inflammatory processes beyond the gut
    • D. Groeger, L. O'Mahoney, and E.F. Murphy et al. Bifidobacterium infantis 35624 modulates host inflammatory processes beyond the gut Gut Microbes 4 2013 325 339
    • (2013) Gut Microbes , vol.4 , pp. 325-339
    • Groeger, D.1    O'Mahoney, L.2    Murphy, E.F.3
  • 52
    • 33645072746 scopus 로고    scopus 로고
    • Gut motor inflammation: Immunological control in enteric infection and inflammation
    • W.I. Khan, and S.M. Collins Gut motor inflammation: immunological control in enteric infection and inflammation Clin Exp Immunol 143 2005 389 397
    • (2005) Clin Exp Immunol , vol.143 , pp. 389-397
    • Khan, W.I.1    Collins, S.M.2
  • 53
    • 77954832198 scopus 로고    scopus 로고
    • Probiotics-host communication: Modulation of signaling pathways in the intestine
    • C.M. Thomas, and J. Versalovic Probiotics-host communication: modulation of signaling pathways in the intestine Gut Microbes 1 2010 148 163
    • (2010) Gut Microbes , vol.1 , pp. 148-163
    • Thomas, C.M.1    Versalovic, J.2
  • 54
    • 58149291318 scopus 로고    scopus 로고
    • Early life stress alters behavior, immunity, and microbiota in rats: Implications for irritable bowel syndrome and psychiatric illnesses
    • S.M. O'Mahony, J.R. Marchesi, and P. Scully et al. Early life stress alters behavior, immunity, and microbiota in rats: implications for irritable bowel syndrome and psychiatric illnesses Biol Psychiatry 65 2009 263 267
    • (2009) Biol Psychiatry , vol.65 , pp. 263-267
    • O'Mahony, S.M.1    Marchesi, J.R.2    Scully, P.3
  • 55
    • 84898787457 scopus 로고    scopus 로고
    • Early-life dysbiosis-induced visceral hypersensitivity in adulthood
    • S.M. O'Mahony, H.M. Savignac, and T. O'Brien et al. Early-life dysbiosis-induced visceral hypersensitivity in adulthood Gastroenterology 138 2010 S4 S5
    • (2010) Gastroenterology , vol.138
    • O'Mahony, S.M.1    Savignac, H.M.2    O'Brien, T.3
  • 56
    • 84870866715 scopus 로고    scopus 로고
    • An update on post-infectious irritable bowel syndrome: Role of genetics, immune activation, serotonin and altered microbiome
    • R. Spiller, and C. Lam An update on post-infectious irritable bowel syndrome: role of genetics, immune activation, serotonin and altered microbiome J Neurogastroenterol Motil 18 2012 258 268
    • (2012) J Neurogastroenterol Motil , vol.18 , pp. 258-268
    • Spiller, R.1    Lam, C.2
  • 57
    • 33846926968 scopus 로고    scopus 로고
    • Probiotics and irritable bowel syndrome: A rationale for their use and an assessment of the evidence to date
    • E.M. Quigley, and B. Flourie Probiotics and irritable bowel syndrome: a rationale for their use and an assessment of the evidence to date Neurogastroenterol Motil 19 2007 166 172
    • (2007) Neurogastroenterol Motil , vol.19 , pp. 166-172
    • Quigley, E.M.1    Flourie, B.2
  • 58
    • 79952110888 scopus 로고    scopus 로고
    • Probiotics in gastrointestinal disorders
    • E.M.M. Quigley Probiotics in gastrointestinal disorders Hosp Pract 38 2010 122 129
    • (2010) Hosp Pract , vol.38 , pp. 122-129
    • Quigley, E.M.M.1
  • 59
    • 58149137305 scopus 로고    scopus 로고
    • Clinical trial on the efficacy of a new symbiotic formulation, Flortec, in patients with irritable bowel syndrome: A multicenter, randomized study
    • A. Andriulli, M. Neri, and C. Loguercio et al. Clinical trial on the efficacy of a new symbiotic formulation, Flortec, in patients with irritable bowel syndrome: a multicenter, randomized study J Clin Gastroenterol 42 Suppl 3 2008 S218 S223
    • (2008) J Clin Gastroenterol , vol.42 , Issue.SUPPL. 3
    • Andriulli, A.1    Neri, M.2    Loguercio, C.3
  • 60
    • 84867944463 scopus 로고    scopus 로고
    • A commentary on the safety of probiotics
    • F. Shanahan A commentary on the safety of probiotics Gastroenterol Clin North Am 41 2012 869 876
    • (2012) Gastroenterol Clin North Am , vol.41 , pp. 869-876
    • Shanahan, F.1
  • 61
    • 84865494677 scopus 로고    scopus 로고
    • Systematic review: Faecal microbiota transplantation in the management of inflammatory bowel disease
    • J.L. Anderson, R.J. Edney, and K. Whelan Systematic review: faecal microbiota transplantation in the management of inflammatory bowel disease Aliment Pharmacol Ther 36 2012 503 516
    • (2012) Aliment Pharmacol Ther , vol.36 , pp. 503-516
    • Anderson, J.L.1    Edney, R.J.2    Whelan, K.3
  • 62
    • 84867057848 scopus 로고    scopus 로고
    • The microbiome and inflammatory bowel disease: Is there a role for fecal microbiota transplantation?
    • C.J. Damman, S.I. Miller, and C.M. Surawicz et al. The microbiome and inflammatory bowel disease: is there a role for fecal microbiota transplantation? Am J Gastroenterol 107 2012 1452 1459
    • (2012) Am J Gastroenterol , vol.107 , pp. 1452-1459
    • Damman, C.J.1    Miller, S.I.2    Surawicz, C.M.3
  • 63
    • 84880282496 scopus 로고    scopus 로고
    • An overview of fecal microbiota transplantation: Techniques, indications, and outcomes
    • L.J. Brandt, and O.C. Aroniadis An overview of fecal microbiota transplantation: techniques, indications, and outcomes Gastrointest Endosc 78 2013 240 249
    • (2013) Gastrointest Endosc , vol.78 , pp. 240-249
    • Brandt, L.J.1    Aroniadis, O.C.2
  • 64
    • 76349083598 scopus 로고    scopus 로고
    • Gut microbes: From bugs to drugs
    • F. Shanahan Gut microbes: from bugs to drugs Am J Gastroenterol 105 2012 275 279
    • (2012) Am J Gastroenterol , vol.105 , pp. 275-279
    • Shanahan, F.1
  • 65
    • 80054091498 scopus 로고    scopus 로고
    • Intestinal microbiota promote enteric virus replication and systemic pathogenesis
    • S.K. Kuss, G.T. Best, and C.A. Etheredge et al. Intestinal microbiota promote enteric virus replication and systemic pathogenesis Science 334 2011 249 252
    • (2011) Science , vol.334 , pp. 249-252
    • Kuss, S.K.1    Best, G.T.2    Etheredge, C.A.3
  • 66
    • 80053462850 scopus 로고    scopus 로고
    • Metagenomics and personalized medicine
    • H.V. Virgin, and J.A. Todd Metagenomics and personalized medicine Cell 147 2011 44 56
    • (2011) Cell , vol.147 , pp. 44-56
    • Virgin, H.V.1    Todd, J.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.