Intestinal Permeability Biomarker Zonulin is Elevated in Healthy Aging

Journal of the American Medical Directors Association

Volumn 18, Issue 9, 2017, Pages 810.e1-810.e4

  Qi, YanFei ^a   Goel, Ruby ^a   Kim, Seungbum ^a   Richards, Elaine M ^a   Carter, Christy S ^a   Pepine, Carl J ^a   Raizada, Mohan K ^a   Buford, Thomas W ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Aging; inflammation; leaky gut; physical frailty; zonulin

Indexed keywords

BIOLOGICAL MARKER; HIGH MOBILITY GROUP B1 PROTEIN; INTERLEUKIN 6; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; ZONULIN; CHOLERA TOXIN;

ADULT; AGED; AGING; ARTICLE; COHORT ANALYSIS; FLEXOR MUSCLE; FRAILTY; HUMAN; HUMAN EXPERIMENT; INFLAMMATION; INTESTINE MUCOSA PERMEABILITY; MUSCLE STRENGTH; NORMAL HUMAN; PROTEIN BLOOD LEVEL; SKELETAL MUSCLE; ADOLESCENT; BLOOD; DYSBIOSIS; FEMALE; HEALTHY AGING; INTESTINE; MALE; METABOLISM; PERMEABILITY; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BIOMARKERS; CHOLERA TOXIN; DYSBIOSIS; FEMALE; HEALTHY AGING; HUMANS; INTESTINES; MALE; PERMEABILITY; YOUNG ADULT;

EID: 85021420086     PISSN: 15258610     EISSN: 15389375     Source Type: Journal    
DOI: 10.1016/j.jamda.2017.05.018     Document Type: Article

References (15)

1. Franceschi, C., Motta, L., Motta, M., et al. The extreme longevity: The state of the art in Italy. Exp Gerontol 43 (2008), 45–52.
2. Troen, B.R., The biology of aging. Mt Sinai J Med 70 (2003), 3–22.
3. Cevenini, E., Caruso, C., Candore, G., et al. Age-related inflammation: The contribution of different organs, tissues and systems. How to face it for therapeutic approaches. Curr Pharm Des 16 (2010), 609–618.
4. Thaiss, C.A., Zmora, N., Levy, M., Elinav, E., The microbiome and innate immunity. Nature 535 (2016), 65–74.
5. Biagi, E., Nylund, L., Candela, M., et al. Through ageing, and beyond: Gut microbiota and inflammatory status in seniors and centenarians. PLoS One, 5, 2010, e10667.
6. Jeffery, I.B., Lynch, D.B., O'Toole, P.W., Composition and temporal stability of the gut microbiota in older persons. ISME J 10 (2016), 170–182.
7. Cattaneo, A., Cattane, N., Galluzzi, S., et al. Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly. Neurobiol Aging 49 (2017), 60–68.
8. Jackson, M.A., Jeffery, I.B., Beaumont, M., et al. Signatures of early frailty in the gut microbiota. Genome Med, 8, 2016, 8.
9. Nicoletti, C., Age-associated changes of the intestinal epithelial barrier: Local and systemic implications. Expert Rev Gastroenterol Hepatol 9 (2015), 1467–1469.
10. Sturgeon, C., Fasano, A., Zonulin, a regulator of epithelial and endothelial barrier functions, and its involvement in chronic inflammatory diseases. Tissue Barriers, 4, 2016, e1251384.
11. Lotze, M.T., Tracey, K.J., High-mobility group box 1 protein (HMGB1): Nuclear weapon in the immune arsenal. Nat Rev Immunol 5 (2005), 331–342.
12. Buford, T.W., Macneil, R.G., Clough, L.G., et al. Active muscle regeneration following eccentric contraction-induced injury is similar between healthy young and older adults. J Appl Physiol 116 (2014), 1481–1490.
13. Mackey, D.C., Manini, T.M., Schoeller, D.A., et al. Validation of an armband to measure daily energy expenditure in older adults. J Gerontol A Biol Sci Med Sci 66 (2011), 1108–1113.
14. Belkaid, Y., Hand, T.W., Role of the microbiota in immunity and inflammation. Cell 157 (2014), 121–141.
15. Man, A.L., Bertelli, E., Rentini, S., et al. Age-associated modifications of intestinal permeability and innate immunity in human small intestine. Clin Sci (Lond) 129 (2015), 515–527.