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Volumn 128, Issue , 2018, Pages 43-57

Glutathione system in animal model of solid tumors: From regulation to therapeutic target

Author keywords

Cancer therapeutic; Glutathione; Oxidative stress; Preclinical models; Solid tumors

Indexed keywords

3 METHYLCHOLANTHRENE; ARSENIC TRIOXIDE; AZATHIOPRINE; BRUSATOL; BUTHIONINE SULFOXIMINE; CANFOSFAMIDE; CARBOPLATIN; CISPLATIN; CISPLATIN DERIVATIVE; CYCLOPHOSPHAMIDE; DIMETHYLBENZ[A]ANTHRACENE; DISULFIRAM; DOCETAXEL; DOXORUBICIN; EZATIOSTAT; GEMCITABINE; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLUTATHIONE PEROXIDASE; GOLD NANOPARTICLE; IMEXON; MELPHALAN; NOV 002; PACLITAXEL; REACTIVE OXYGEN METABOLITE; TEMOZOLOMIDE; UNCLASSIFIED DRUG; VINORELBINE TARTRATE; ANTINEOPLASTIC AGENT;

EID: 85048492179     PISSN: 10408428     EISSN: 18790461     Source Type: Journal    
DOI: 10.1016/j.critrevonc.2018.05.014     Document Type: Review
Times cited : (77)

References (201)
  • 2
    • 0034787464 scopus 로고    scopus 로고
    • Radiation induced oxidative stress: II studies in liver as a distant organ of tumor bearing mice
    • Agrawal, A., Chandra, D., Kale, R.K., Radiation induced oxidative stress: II studies in liver as a distant organ of tumor bearing mice. Mol. Cell. Biochem. 224 (2001), 9–17, 10.1023/A:1011990704575.
    • (2001) Mol. Cell. Biochem. , vol.224 , pp. 9-17
    • Agrawal, A.1    Chandra, D.2    Kale, R.K.3
  • 3
    • 84870400923 scopus 로고    scopus 로고
    • Amelioration of chemical-induced skin carcinogenesis by aegle marmelos, an Indian medicinal plant, fruit extract
    • Agrawal, A., Jahan, S., Soyal, D., Goyal, E., Goyal, P.K., Amelioration of chemical-induced skin carcinogenesis by aegle marmelos, an Indian medicinal plant, fruit extract. Integr. Cancer Ther. 11 (2012), 257–266, 10.1177/1534735411417127.
    • (2012) Integr. Cancer Ther. , vol.11 , pp. 257-266
    • Agrawal, A.1    Jahan, S.2    Soyal, D.3    Goyal, E.4    Goyal, P.K.5
  • 4
    • 0031305347 scopus 로고    scopus 로고
    • Signaling pathways in the induction of c-fos and c-jun proto-oncogenes by 3-methylcholanthrene
    • Ainbinder, E., Bergelson, S., Daniel, V., Signaling pathways in the induction of c-fos and c-jun proto-oncogenes by 3-methylcholanthrene. Recept. Signal Transduct. 7 (1997), 279–289.
    • (1997) Recept. Signal Transduct. , vol.7 , pp. 279-289
    • Ainbinder, E.1    Bergelson, S.2    Daniel, V.3
  • 5
    • 0033066323 scopus 로고    scopus 로고
    • Arsenic trioxide induces apoptosis in neuroblastoma cell lines through the activation of caspase 3 in vitro
    • Akao, Y., Nakagawa, Y., Akiyama, K., Arsenic trioxide induces apoptosis in neuroblastoma cell lines through the activation of caspase 3 in vitro. FEBS Lett. 455 (1999), 59–62.
    • (1999) FEBS Lett. , vol.455 , pp. 59-62
    • Akao, Y.1    Nakagawa, Y.2    Akiyama, K.3
  • 6
    • 0027931790 scopus 로고
    • Anticarcinogenic effect of Commiphora molmol on solid tumors induced by ehrlich carcinoma cells in mice
    • Al-Harbi, M.M., Quereshi, S., Raza, M., Ahmed, M.M., Giangreco, A.B., Shak, A.H., Anticarcinogenic effect of Commiphora molmol on solid tumors induced by ehrlich carcinoma cells in mice. Exp. Chemother. 40 (1994), 337–347, 10.1017/CBO9781107415324.004.
    • (1994) Exp. Chemother. , vol.40 , pp. 337-347
    • Al-Harbi, M.M.1    Quereshi, S.2    Raza, M.3    Ahmed, M.M.4    Giangreco, A.B.5    Shak, A.H.6
  • 7
    • 85029540659 scopus 로고    scopus 로고
    • Antioxidant and hepatoprotective activities of grape seeds and skin against Ehrlich solid tumor induced oxidative stress in mice
    • Ali, D.A., El-Din, N.K.B., Abou-El-magd, R.F., Antioxidant and hepatoprotective activities of grape seeds and skin against Ehrlich solid tumor induced oxidative stress in mice. Egypt. J. Basic Appl. Sci. 2 (2015), 98–109, 10.1016/j.ejbas.2015.02.003.
    • (2015) Egypt. J. Basic Appl. Sci. , vol.2 , pp. 98-109
    • Ali, D.A.1    El-Din, N.K.B.2    Abou-El-magd, R.F.3
  • 8
    • 84933035746 scopus 로고    scopus 로고
    • Quercetin attenuates the development of 7,12-dimethylbenz(a)anthracene (DMBA) and croton oil-induced skin cancer in mice
    • Ali, H., Dixit, S., Quercetin attenuates the development of 7,12-dimethylbenz(a)anthracene (DMBA) and croton oil-induced skin cancer in mice. J. Biomed. Res. 29 (2015), 139–144, 10.7555/JBR.29.20130025.
    • (2015) J. Biomed. Res. , vol.29 , pp. 139-144
    • Ali, H.1    Dixit, S.2
  • 11
    • 0035008292 scopus 로고    scopus 로고
    • Inhibition of chemical carcinogenesis by berberine in rats and mice
    • Anis, K.V., Rajeshkumar, N.V., Kuttan, R., Inhibition of chemical carcinogenesis by berberine in rats and mice. J. Pharm. Pharmacol. 53 (2001), 763–768, 10.1211/0022357011775901.
    • (2001) J. Pharm. Pharmacol. , vol.53 , pp. 763-768
    • Anis, K.V.1    Rajeshkumar, N.V.2    Kuttan, R.3
  • 12
    • 84906239247 scopus 로고    scopus 로고
    • Glutathione: new roles in redox signaling for an old antioxidant
    • Aquilano, K., Baldelli, S., Ciriolo, M.R., Glutathione: new roles in redox signaling for an old antioxidant. Front. Pharmacol. 5 (2014), 1–12, 10.3389/fphar.2014.00196.
    • (2014) Front. Pharmacol. , vol.5 , pp. 1-12
    • Aquilano, K.1    Baldelli, S.2    Ciriolo, M.R.3
  • 13
    • 0025753267 scopus 로고
    • The energy state of tumor-bearing rats
    • Argilés, J.M., López-Soriano, F.J., The energy state of tumor-bearing rats. J. Biol. Chem. 266 (1991), 2978–2982.
    • (1991) J. Biol. Chem. , vol.266 , pp. 2978-2982
    • Argilés, J.M.1    López-Soriano, F.J.2
  • 14
    • 0036673665 scopus 로고    scopus 로고
    • Glutathione depletion enforces the mitochondrial permeability transition and causes cell death in HL60 cells that overexpress Bcl2
    • Armstrong, J.S., Jones, D.P., Glutathione depletion enforces the mitochondrial permeability transition and causes cell death in HL60 cells that overexpress Bcl2. FASEB J. 16 (2002), 1263–1265, 10.1096/fj.02-0097fje.
    • (2002) FASEB J. , vol.16 , pp. 1263-1265
    • Armstrong, J.S.1    Jones, D.P.2
  • 16
    • 62249096975 scopus 로고    scopus 로고
    • Glutathione dysregulation and the etiology and progression of human diseases
    • Ballatori, N., Krance, S.M., Notenboom, S., Shi, S., Tieu, K., Hammond, C.L., Glutathione dysregulation and the etiology and progression of human diseases. Biol. Chem. 390 (2009), 191–214, 10.1515/BC.2009.033.Glutathione.
    • (2009) Biol. Chem. , vol.390 , pp. 191-214
    • Ballatori, N.1    Krance, S.M.2    Notenboom, S.3    Shi, S.4    Tieu, K.5    Hammond, C.L.6
  • 18
    • 33644909056 scopus 로고    scopus 로고
    • Estresse oxidativo: Relação entre geração de espécies reativas e defesa do organismo
    • Barreiros, A.L.B.S., David, J.M., David, J.P., Estresse oxidativo: Relação entre geração de espécies reativas e defesa do organismo. Quim. Nova 29 (2006), 113–123, 10.1590/S0100-40422006000100021.
    • (2006) Quim. Nova , vol.29 , pp. 113-123
    • Barreiros, A.L.B.S.1    David, J.M.2    David, J.P.3
  • 21
    • 84988515291 scopus 로고    scopus 로고
    • Dual targeting of the thioredoxin and glutathione systems in cancer and HIV
    • Benhar, M., Shytaj, I.L., Stamler, J.S., Savarino, A., Dual targeting of the thioredoxin and glutathione systems in cancer and HIV. J. Clin., 126, 2016, 10.1172/JCI85339.treatment.
    • (2016) J. Clin. , vol.126
    • Benhar, M.1    Shytaj, I.L.2    Stamler, J.S.3    Savarino, A.4
  • 22
    • 84871325235 scopus 로고    scopus 로고
    • Chemopreventive property of Trichosanthes dioica root against 3-methylcholanthrene-induced carcinogenesis in albino mice
    • Bhattacharya, S., Haldar, P.K., Chemopreventive property of Trichosanthes dioica root against 3-methylcholanthrene-induced carcinogenesis in albino mice. J. Environ. Pathol. Toxicol. Oncol. 31 (2012), 109–119.
    • (2012) J. Environ. Pathol. Toxicol. Oncol. , vol.31 , pp. 109-119
    • Bhattacharya, S.1    Haldar, P.K.2
  • 23
    • 0031825806 scopus 로고    scopus 로고
    • Dithiocarbamate toxicity toward thymocytes involves their copper-catalyzed conversion to thiuram disulfides, which oxidize glutathione in a redox cycle without the release of reactive oxygen species
    • Burkitt, M.J., Bishop, H.S., Milne, L., Tsang, S.Y., Provan, G.J., Nobel, C.S.I., Orrenius, S., Slater, A.F.G., Dithiocarbamate toxicity toward thymocytes involves their copper-catalyzed conversion to thiuram disulfides, which oxidize glutathione in a redox cycle without the release of reactive oxygen species. Arch. Biochem. Biophys. 353 (1998), 73–84.
    • (1998) Arch. Biochem. Biophys. , vol.353 , pp. 73-84
    • Burkitt, M.J.1    Bishop, H.S.2    Milne, L.3    Tsang, S.Y.4    Provan, G.J.5    Nobel, C.S.I.6    Orrenius, S.7    Slater, A.F.G.8
  • 24
    • 0034864297 scopus 로고    scopus 로고
    • Effect of 7,12-dimethylbenz[a]anthracene (DMBA) on gut glutathione metabolism
    • Cao, Y., Wang, J., Henry-Tillman, R., Klimberg, V.S., Effect of 7,12-dimethylbenz[a]anthracene (DMBA) on gut glutathione metabolism. J. Surg. Res. 100 (2001), 135–140, 10.1006/jsre.2001.6229.
    • (2001) J. Surg. Res. , vol.100 , pp. 135-140
    • Cao, Y.1    Wang, J.2    Henry-Tillman, R.3    Klimberg, V.S.4
  • 26
    • 11144224746 scopus 로고    scopus 로고
    • Disulfiram facilitates intracellular Cu uptake and induces apoptosis in human melanoma cells
    • Cen, D., Brayton, D., Shahandeh, B., Meyskens, F.L., Farmer, P.J., Disulfiram facilitates intracellular Cu uptake and induces apoptosis in human melanoma cells. J. Med. Chem. 47 (2004), 6914–6920, 10.1021/jm049568z.
    • (2004) J. Med. Chem. , vol.47 , pp. 6914-6920
    • Cen, D.1    Brayton, D.2    Shahandeh, B.3    Meyskens, F.L.4    Farmer, P.J.5
  • 27
    • 33845794791 scopus 로고    scopus 로고
    • Buthionine sulfoximine enhancement of arsenic trioxide-induced apoptosis in leukemia and lymphoma cells is mediated via activation of c-Jun NH 2-terminal kinase and up-regulation of death receptors
    • Chen, D., Chan, R., Waxman, S., Jing, Y., Buthionine sulfoximine enhancement of arsenic trioxide-induced apoptosis in leukemia and lymphoma cells is mediated via activation of c-Jun NH 2-terminal kinase and up-regulation of death receptors. Cancer Res. 66 (2006), 11416–11423, 10.1158/0008-5472.CAN-06-0409.
    • (2006) Cancer Res. , vol.66 , pp. 11416-11423
    • Chen, D.1    Chan, R.2    Waxman, S.3    Jing, Y.4
  • 29
    • 43049147936 scopus 로고    scopus 로고
    • Antioxidative effects of hesperetin against 7,12-dimethylbenz(a)anthracene-induced oxidative stress in mice
    • Choi, E.J., Antioxidative effects of hesperetin against 7,12-dimethylbenz(a)anthracene-induced oxidative stress in mice. Life Sci. 82 (2008), 1059–1064, 10.1016/j.lfs.2008.03.002.
    • (2008) Life Sci. , vol.82 , pp. 1059-1064
    • Choi, E.J.1
  • 30
    • 84951916217 scopus 로고    scopus 로고
    • A phase 2 randomized, double-blind, multicenter trial of imexon plus gemcitabine versus gemcitabine plus placebo in patients with metastatic chemotherapy-naïve pancreatic adenocarcinoma
    • Cohen, S.J., Zalupski, M.M., Conkling, P., Nugent, F., Ma, W.W., Modiano, M., Pascual, R., Lee, F.C., Wong, L., Hersh, E., A phase 2 randomized, double-blind, multicenter trial of imexon plus gemcitabine versus gemcitabine plus placebo in patients with metastatic chemotherapy-naïve pancreatic adenocarcinoma. Am. J. Clin. Oncol., 2015, 1–6, 10.1097/COC.0000000000000260.
    • (2015) Am. J. Clin. Oncol. , pp. 1-6
    • Cohen, S.J.1    Zalupski, M.M.2    Conkling, P.3    Nugent, F.4    Ma, W.W.5    Modiano, M.6    Pascual, R.7    Lee, F.C.8    Wong, L.9    Hersh, E.10
  • 32
    • 84891960443 scopus 로고    scopus 로고
    • Leucine-rich diet supplementation modulates foetal muscle protein metabolism impaired by Walker-256 tumour
    • Cruz, B., Gomes-Marcondes, M.C.C., Leucine-rich diet supplementation modulates foetal muscle protein metabolism impaired by Walker-256 tumour. Reprod. Biol. Endocrinol. 12 (2014), 2–10, 10.1186/1477-7827-12-2.
    • (2014) Reprod. Biol. Endocrinol. , vol.12 , pp. 2-10
    • Cruz, B.1    Gomes-Marcondes, M.C.C.2
  • 33
    • 84861534652 scopus 로고    scopus 로고
    • Effect of tea polyphenol on oxidative injury in S180 cells induced hepatocarcinoma mice
    • Cui, B.K., Liu, S., Li, S.H., Wang, J., Wang, Q.B., Li, S.P., Lin, X.J., Effect of tea polyphenol on oxidative injury in S180 cells induced hepatocarcinoma mice. Int. J. Mol. Sci. 13 (2012), 5571–5583, 10.3390/ijms13055571.
    • (2012) Int. J. Mol. Sci. , vol.13 , pp. 5571-5583
    • Cui, B.K.1    Liu, S.2    Li, S.H.3    Wang, J.4    Wang, Q.B.5    Li, S.P.6    Lin, X.J.7
  • 34
    • 84875269990 scopus 로고    scopus 로고
    • Estrogen synthesis and signaling pathways during aging: from periphery to brain
    • Cui, J., Shen, Y., Li, R., Estrogen synthesis and signaling pathways during aging: from periphery to brain. Trends Mol. Med. 19 (2013), 197–209, 10.1016/j.molmed.2012.12.007.
    • (2013) Trends Mol. Med. , vol.19 , pp. 197-209
    • Cui, J.1    Shen, Y.2    Li, R.3
  • 36
    • 79952685372 scopus 로고    scopus 로고
    • Oxidative photodamage induced by photodynamic therapy with methoxyphenyl porphyrin derivatives in tumour-bearing rats
    • Daicoviciu, D., Filip, A.G., Ion, R.M., Clichici, S., Decea, N., Muresan, A., Oxidative photodamage induced by photodynamic therapy with methoxyphenyl porphyrin derivatives in tumour-bearing rats. Folia Biol. (Praha) 57 (2011), 12–19.
    • (2011) Folia Biol. (Praha) , vol.57 , pp. 12-19
    • Daicoviciu, D.1    Filip, A.G.2    Ion, R.M.3    Clichici, S.4    Decea, N.5    Muresan, A.6
  • 37
    • 59849129012 scopus 로고    scopus 로고
    • Protein S -glutathionylation: a regulatory device from bacteria to humans
    • Dalle-Donne, I., Rossi, R., Colombo, G., Giustarini, D., Milzani, A., Protein S -glutathionylation: a regulatory device from bacteria to humans. Trends Biochem. Sci. 34 (2009), 85–96, 10.1016/j.tibs.2008.11.002.
    • (2009) Trends Biochem. Sci. , vol.34 , pp. 85-96
    • Dalle-Donne, I.1    Rossi, R.2    Colombo, G.3    Giustarini, D.4    Milzani, A.5
  • 38
    • 0032694302 scopus 로고    scopus 로고
    • The broad spectrum of responses to oxidants in proliferating cells: a new paradigm for oxidative stress
    • Davies, K.J.A., The broad spectrum of responses to oxidants in proliferating cells: a new paradigm for oxidative stress. IUBMB Life 48 (1999), 41–47, 10.1080/713803463.
    • (1999) IUBMB Life , vol.48 , pp. 41-47
    • Davies, K.J.A.1
  • 40
    • 0023877990 scopus 로고
    • Toxic effects of acute glutathione depletion by buthionine sulfoximine and dimethylfumarate on murine mammary carcinoma cells
    • Dethlefsen, L.A., Lehman, C.M., Biaglow, J.E., Peck, V.M., Toxic effects of acute glutathione depletion by buthionine sulfoximine and dimethylfumarate on murine mammary carcinoma cells. Radiat. Res. 114 (1988), 215–224.
    • (1988) Radiat. Res. , vol.114 , pp. 215-224
    • Dethlefsen, L.A.1    Lehman, C.M.2    Biaglow, J.E.3    Peck, V.M.4
  • 42
    • 26644446906 scopus 로고    scopus 로고
    • Induction of apoptosis and cell cycle arrest by imexon in human pancreatic cancer cell lines
    • Dorr, R.T., Raymond, M.A., Landowski, T.H., Roman, N.O., Fukushima, S., Induction of apoptosis and cell cycle arrest by imexon in human pancreatic cancer cell lines. Int. J. Gastrointest. Cancer 36 (2005), 15–28, 10.1385/IJGC:36:1:015.
    • (2005) Int. J. Gastrointest. Cancer , vol.36 , pp. 15-28
    • Dorr, R.T.1    Raymond, M.A.2    Landowski, T.H.3    Roman, N.O.4    Fukushima, S.5
  • 44
    • 77953812740 scopus 로고    scopus 로고
    • Antitumoral and antioxidant effects of a hydroalcoholic extract of cat's claw (Uncaria tomentosa) (Willd. Ex Roem. & Schult) in an in vivo carcinosarcoma model
    • Dreifuss, A.A., Bastos-Pereira, A.L., Ávila, T.V., Soley, B., da, S., Rivero, A.J., Aguilar, J.L., Acco, A., Antitumoral and antioxidant effects of a hydroalcoholic extract of cat's claw (Uncaria tomentosa) (Willd. Ex Roem. & Schult) in an in vivo carcinosarcoma model. J. Ethnopharmacol. 130 (2010), 127–133, 10.1016/j.jep.2010.04.029.
    • (2010) J. Ethnopharmacol. , vol.130 , pp. 127-133
    • Dreifuss, A.A.1    Bastos-Pereira, A.L.2    Ávila, T.V.3    Soley, B.4    da, S.5    Rivero, A.J.6    Aguilar, J.L.7    Acco, A.8
  • 46
    • 0022512449 scopus 로고
    • Glutathione augments the activation of cytotoxic T lymphocytes in vivo
    • Dröge, W., Pottmeyer-Gerber, C., Schmidt, H., Nick, S., Glutathione augments the activation of cytotoxic T lymphocytes in vivo. Immunobiology 172 (1986), 151–156.
    • (1986) Immunobiology , vol.172 , pp. 151-156
    • Dröge, W.1    Pottmeyer-Gerber, C.2    Schmidt, H.3    Nick, S.4
  • 47
    • 0034666730 scopus 로고    scopus 로고
    • Induction of oxidative stress and apoptosis in myeloma cells by the aziridine-containing agent imexon
    • Dvorakova, K., Payne, C.M., Tome, M.E., Briehl, M.M., McClure, T., Dorr, R.T., Induction of oxidative stress and apoptosis in myeloma cells by the aziridine-containing agent imexon. Biochem. Pharmacol. 60 (2000), 749–758.
    • (2000) Biochem. Pharmacol. , vol.60 , pp. 749-758
    • Dvorakova, K.1    Payne, C.M.2    Tome, M.E.3    Briehl, M.M.4    McClure, T.5    Dorr, R.T.6
  • 51
    • 0141605898 scopus 로고    scopus 로고
    • Antitumor activities of iodoacetate and dimethylsulphoxide against solid Ehrlich carcinoma growth in mice
    • Fahim, F.A., Esmat, A.Y., Mady, E.A., Ibrahim, E.K., Antitumor activities of iodoacetate and dimethylsulphoxide against solid Ehrlich carcinoma growth in mice. Biol. Res. 36 (2003), 253–262, 10.4067/S0716-97602003000200015.
    • (2003) Biol. Res. , vol.36 , pp. 253-262
    • Fahim, F.A.1    Esmat, A.Y.2    Mady, E.A.3    Ibrahim, E.K.4
  • 52
    • 85044245537 scopus 로고    scopus 로고
    • Food and Drug Administration
    • Acessed April 3, 2018. URL
    • FDA, Food and Drug Administration. Acessed April 3, 2018. URL, 2018 https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=209780.
    • (2018)
    • FDA1
  • 53
    • 0027990215 scopus 로고
    • Apoptosis or necrosis: intracellular levels of glutathione influence mode of cell death
    • Fernandes, R.S., Cotter, T.G., Apoptosis or necrosis: intracellular levels of glutathione influence mode of cell death. Biochem. Pharmacol. 48 (1994), 675–681, 10.1016/0006-2952(94)90044-2.
    • (1994) Biochem. Pharmacol. , vol.48 , pp. 675-681
    • Fernandes, R.S.1    Cotter, T.G.2
  • 54
  • 55
    • 84882331967 scopus 로고    scopus 로고
    • Anticarcinogenic activity of meso-zeaxanthin in rodents and its possible mechanism of action
    • Firdous, A.P., Sindhu, E.R., Ramnath, V., Kuttan, R., Anticarcinogenic activity of meso-zeaxanthin in rodents and its possible mechanism of action. Nutr. Cancer, 2013, 10.1080/01635581.2013.801501.
    • (2013) Nutr. Cancer
    • Firdous, A.P.1    Sindhu, E.R.2    Ramnath, V.3    Kuttan, R.4
  • 56
    • 85048464764 scopus 로고    scopus 로고
    • Phase 2 study of neoadjuvant treatment with nov-002 in combination with doxorubicin and cyclophosphamide followed by docetaxel in patients with HER-2 negative clinical stage II- IIIc breast cancer
    • Fonslow, B.R., Stein, B.D., Webb, K.J., Xu, T., Choi, J., Kyu, S., Iii, J.R.Y., Phase 2 study of neoadjuvant treatment with nov-002 in combination with doxorubicin and cyclophosphamide followed by docetaxel in patients with HER-2 negative clinical stage II- IIIc breast cancer. Breast Cancer Res. Treat. 132 (2012), 215–223, 10.1038/nmeth.2250.Digestion.
    • (2012) Breast Cancer Res. Treat. , vol.132 , pp. 215-223
    • Fonslow, B.R.1    Stein, B.D.2    Webb, K.J.3    Xu, T.4    Choi, J.5    Kyu, S.6    Iii, J.R.Y.7
  • 57
    • 65049087190 scopus 로고    scopus 로고
    • Glutathione: overview of its protective roles, measurement, and biosynthesis
    • Forman, H.J., Zhang, H., Rinna, A., Glutathione: overview of its protective roles, measurement, and biosynthesis. Mol. Asp. Med. 30 (2010), 1–12, 10.1016/j.mam.2008.08.006.Glutathione.
    • (2010) Mol. Asp. Med. , vol.30 , pp. 1-12
    • Forman, H.J.1    Zhang, H.2    Rinna, A.3
  • 59
    • 0035045079 scopus 로고    scopus 로고
    • Walker-256 tumor growth causes oxidative stress in rat brain
    • Freitas, J.J., Pompéia, C., Miyasaka, C.K., Curi, R., Walker-256 tumor growth causes oxidative stress in rat brain. J. Neurochem. 77 (2001), 655–663.
    • (2001) J. Neurochem. , vol.77 , pp. 655-663
    • Freitas, J.J.1    Pompéia, C.2    Miyasaka, C.K.3    Curi, R.4
  • 60
    • 34548163922 scopus 로고    scopus 로고
    • Mechanisms of reversible protein glutathionylation in redox signaling and oxidative stress
    • Gallogly, M.M., Mieyal, J.J., Mechanisms of reversible protein glutathionylation in redox signaling and oxidative stress. Curr. Opin. Pharmacol. 7 (2007), 381–391, 10.1016/j.coph.2007.06.003.
    • (2007) Curr. Opin. Pharmacol. , vol.7 , pp. 381-391
    • Gallogly, M.M.1    Mieyal, J.J.2
  • 63
    • 0020444895 scopus 로고
    • Mechanism of action, metabolism, and toxicity of buthionine sulfoximine and its higher homologs, potent inhibitors of glutathione synthesis
    • Griffith, O.W., Mechanism of action, metabolism, and toxicity of buthionine sulfoximine and its higher homologs, potent inhibitors of glutathione synthesis. J. Biol. Chem. 257 (1982), 13704–13712.
    • (1982) J. Biol. Chem. , vol.257 , pp. 13704-13712
    • Griffith, O.W.1
  • 64
    • 0018666729 scopus 로고
    • Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-Butyl homocysteine sulfoximine)
    • Griffith, W., Meister, A., Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-Butyl homocysteine sulfoximine). J. Biol. Chem. 254 (1979), 7558–7560.
    • (1979) J. Biol. Chem. , vol.254 , pp. 7558-7560
    • Griffith, W.1    Meister, A.2
  • 66
    • 84906674886 scopus 로고    scopus 로고
    • NOV-002, a glutathione disulfide mimetic, suppresses tumor cell invasion and metastasis
    • Gumireddy, K., Li, A., Cao, L., Yan, J., Liu, L., NOV-002, a glutathione disulfide mimetic, suppresses tumor cell invasion and metastasis. J. Carcinog. Mutagen S7 (2013), 997–1003, 10.4172/2157-2518.S7-002.
    • (2013) J. Carcinog. Mutagen , vol.S7 , pp. 997-1003
    • Gumireddy, K.1    Li, A.2    Cao, L.3    Yan, J.4    Liu, L.5
  • 67
    • 4644321604 scopus 로고    scopus 로고
    • The use of gold nanoparticles to enhance radiotherapy in mice
    • Hainfeld, J.F., Slatkin, D.N., Smilowitz, H.M., The use of gold nanoparticles to enhance radiotherapy in mice. Phys. Med. Biol. 49 (2004), 309–315, 10.1088/0031-9155/49/18/N03.
    • (2004) Phys. Med. Biol. , vol.49 , pp. 309-315
    • Hainfeld, J.F.1    Slatkin, D.N.2    Smilowitz, H.M.3
  • 68
    • 0033088957 scopus 로고    scopus 로고
    • The role of glutathione in the regulation of apoptosis
    • Hall, A.G., The role of glutathione in the regulation of apoptosis. Eur. J. Clin. Invest. 29 (1999), 238–245.
    • (1999) Eur. J. Clin. Invest. , vol.29 , pp. 238-245
    • Hall, A.G.1
  • 69
    • 23244453323 scopus 로고    scopus 로고
    • TLK-199 (Telik)
    • Hamilton, D., Batist, G., TLK-199 (Telik). IDrugs 8 (2005), 662–669.
    • (2005) IDrugs , vol.8 , pp. 662-669
    • Hamilton, D.1    Batist, G.2
  • 70
    • 0021878218 scopus 로고
    • Augmentation of adriamycin, melphalan, and cisplatin cytotoxicity in drug-resistant and -sensitive human ovarian carcinoma cell lines by buthionine sulfoximine mediated glutathione depletion
    • Hamilton, T.C., Winker, M.A., Louie, K.G., Batist, G., Behrens, B.C., Tsuruo, T., Grotzinger, K.R., McKoy, W.M., Young, R.C., Ozols, R.F., Augmentation of adriamycin, melphalan, and cisplatin cytotoxicity in drug-resistant and -sensitive human ovarian carcinoma cell lines by buthionine sulfoximine mediated glutathione depletion. Biochem. Pharmacol. 34 (1985), 2583–2586, 10.1016/0006-2952(85)90551-9.
    • (1985) Biochem. Pharmacol. , vol.34 , pp. 2583-2586
    • Hamilton, T.C.1    Winker, M.A.2    Louie, K.G.3    Batist, G.4    Behrens, B.C.5    Tsuruo, T.6    Grotzinger, K.R.7    McKoy, W.M.8    Young, R.C.9    Ozols, R.F.10
  • 71
    • 84951021829 scopus 로고    scopus 로고
    • Disulfiram inhibits TGF-β-induced epithelial-mesenchymal transition and stem-like features in breast cancer via ERK/NF-κB/Snail pathway
    • Han, D., Wu, G., Chang, C., Zhu, F., Xiao, Y., Li, Q., Zhang, T., Zhang, L., Disulfiram inhibits TGF-β-induced epithelial-mesenchymal transition and stem-like features in breast cancer via ERK/NF-κB/Snail pathway. Oncotarget 6 (2015), 40907–40919, 10.18632/oncotarget.5723.
    • (2015) Oncotarget , vol.6 , pp. 40907-40919
    • Han, D.1    Wu, G.2    Chang, C.3    Zhu, F.4    Xiao, Y.5    Li, Q.6    Zhang, T.7    Zhang, L.8
  • 72
    • 68349109741 scopus 로고    scopus 로고
    • The effects of N-acetyl cysteine, buthionine sulfoximine, diethyldithiocarbamate or 3-amino-1,2,4-triazole on antimycin A-treated calu-6 lung cells in relation to cell growth, reactive oxygen species and glutathione
    • Han, Y.H., Park, W.H., The effects of N-acetyl cysteine, buthionine sulfoximine, diethyldithiocarbamate or 3-amino-1,2,4-triazole on antimycin A-treated calu-6 lung cells in relation to cell growth, reactive oxygen species and glutathione. Oncol. Rep. 22 (2009), 385–391.
    • (2009) Oncol. Rep. , vol.22 , pp. 385-391
    • Han, Y.H.1    Park, W.H.2
  • 73
    • 0026634285 scopus 로고
    • Regulation of antioxidant enzymes
    • Harris, E.D., Regulation of antioxidant enzymes. FASEB J. 6 (1992), 2675–2683.
    • (1992) FASEB J. , vol.6 , pp. 2675-2683
    • Harris, E.D.1
  • 75
    • 33644856080 scopus 로고    scopus 로고
    • The double-edged sword of Nrf2: subversion of redox homeostasis during the evolution of cancer
    • Hayes, J.D., McMahon, M., The double-edged sword of Nrf2: subversion of redox homeostasis during the evolution of cancer. Mol. Cell 21 (2006), 732–734, 10.1016/j.molcel.2006.03.004.
    • (2006) Mol. Cell , vol.21 , pp. 732-734
    • Hayes, J.D.1    McMahon, M.2
  • 76
    • 0029561598 scopus 로고
    • The glut athione S-transferase supergene family: regulation of GST and the contribution of the lsoenzymes to cancer chemoprotection and drug resistance part I
    • Hayseda, J.D., Pulford, D.J., The glut athione S-transferase supergene family: regulation of GST and the contribution of the lsoenzymes to cancer chemoprotection and drug resistance part I. Crit. Rev. Biochem. Mol. Biol. 30 (1995), 445–520, 10.3109/10409239509083491.
    • (1995) Crit. Rev. Biochem. Mol. Biol. , vol.30 , pp. 445-520
    • Hayseda, J.D.1    Pulford, D.J.2
  • 79
    • 0029671117 scopus 로고    scopus 로고
    • y-Glutamyl Transpeptidase Mediation of Tumor Glutathione Utilization In vivo
    • Hochwald, S.N., Harrison Lawrence, E., Rose, D.M., Burt, M.E., y-Glutamyl Transpeptidase Mediation of Tumor Glutathione Utilization In vivo. J. Natl. Cancer Inst. 88 (1996), 193–197.
    • (1996) J. Natl. Cancer Inst. , vol.88 , pp. 193-197
    • Hochwald, S.N.1    Harrison Lawrence, E.2    Rose, D.M.3    Burt, M.E.4
  • 80
    • 0036709885 scopus 로고    scopus 로고
    • Glutathionylation of proteins by glutathione disulfide S-oxide
    • Huang, K.P., Huang, F.L., Glutathionylation of proteins by glutathione disulfide S-oxide. Biochem. Pharmacol. 64 (2002), 1049–1056, 10.1016/S0006-2952(02)01175-9.
    • (2002) Biochem. Pharmacol. , vol.64 , pp. 1049-1056
    • Huang, K.P.1    Huang, F.L.2
  • 81
    • 0026698060 scopus 로고
    • Oxidized redox state of glutathione in the endoplasmic reticulum
    • Hwang, C., Sinskey, A.J., Lodish, H.F., Oxidized redox state of glutathione in the endoplasmic reticulum. Science 257 (1992), 1496–1502, 10.1126/science.1523409.
    • (1992) Science , vol.257 , pp. 1496-1502
    • Hwang, C.1    Sinskey, A.J.2    Lodish, H.F.3
  • 82
    • 70350026351 scopus 로고    scopus 로고
    • Anticancer activity of an Indian medicinal plant, alstonia scholaris, on skin carcinogenesis in mice
    • Jahan, S., Chaudhary, R., Goyal, P.K., Anticancer activity of an Indian medicinal plant, alstonia scholaris, on skin carcinogenesis in mice. Integr. Cancer Ther. 8 (2009), 273–279, 10.1177/1534735409343590.
    • (2009) Integr. Cancer Ther. , vol.8 , pp. 273-279
    • Jahan, S.1    Chaudhary, R.2    Goyal, P.K.3
  • 83
    • 84858974142 scopus 로고    scopus 로고
    • Glutathione is a key player in metal-induced oxidative stress defenses
    • Jozefczak, M., Remans, T., Vangronsveld, J., Cuypers, A., Glutathione is a key player in metal-induced oxidative stress defenses. Int. J. Mol. Sci. 13 (2012), 3145–3175, 10.3390/ijms13033145.
    • (2012) Int. J. Mol. Sci. , vol.13 , pp. 3145-3175
    • Jozefczak, M.1    Remans, T.2    Vangronsveld, J.3    Cuypers, A.4
  • 85
    • 84941353697 scopus 로고    scopus 로고
    • Synergistic efficacy of γ-radiation together with gallium trichloride and/or doxorubicin against Ehrlich carcinoma in female mice
    • Kandil, E., Aziz, N.A., Synergistic efficacy of γ-radiation together with gallium trichloride and/or doxorubicin against Ehrlich carcinoma in female mice. Tumor Biol. 37 (2015), 1825–1834, 10.1007/s13277-015-3954-5.
    • (2015) Tumor Biol. , vol.37 , pp. 1825-1834
    • Kandil, E.1    Aziz, N.A.2
  • 87
    • 46349096329 scopus 로고    scopus 로고
    • Glutamine affects glutathione recycling enzymes in a DMBA-induced breast cancer model
    • Kaufmann, Y., Todorova, V.K., Luo, S., Klimberg, V.S., Glutamine affects glutathione recycling enzymes in a DMBA-induced breast cancer model. Nutr. Cancer 60 (2008), 518–525, 10.1080/01635580801956501.
    • (2008) Nutr. Cancer , vol.60 , pp. 518-525
    • Kaufmann, Y.1    Todorova, V.K.2    Luo, S.3    Klimberg, V.S.4
  • 88
    • 22544443334 scopus 로고    scopus 로고
    • Multi-institutional phase 2 study of TLK286 (TELCYTA, a glutathione S-transferase P1-1 activated glutathione analog prodrug) in patients with platinum and paclitaxel refractory or resistant ovarian cancer
    • Kavanagh, J.J., Gershenson, D.M., Choi, H., Lewis, L., Patel, K., Brown, G.L., Garcia, A., Spriggs, D.R., Multi-institutional phase 2 study of TLK286 (TELCYTA, a glutathione S-transferase P1-1 activated glutathione analog prodrug) in patients with platinum and paclitaxel refractory or resistant ovarian cancer. Int. J. Gynecol. Cancer 15 (2005), 593–600, 10.1111/j.1525-1438.2005.00114.x.
    • (2005) Int. J. Gynecol. Cancer , vol.15 , pp. 593-600
    • Kavanagh, J.J.1    Gershenson, D.M.2    Choi, H.3    Lewis, L.4    Patel, K.5    Brown, G.L.6    Garcia, A.7    Spriggs, D.R.8
  • 89
    • 77949434537 scopus 로고    scopus 로고
    • Phase 2 study of canfosfamide in combination with pegylated liposomal doxorubicin in platinum and paclitaxel refractory or resistant epithelial ovarian cancer
    • Kavanagh, J.J., Levenback, C.F., Ramirez, P.T., Wolf, J.L., Moore, C.L., Jones, M.R., Meng, L., Brown, G.L., Bast, R.C., Phase 2 study of canfosfamide in combination with pegylated liposomal doxorubicin in platinum and paclitaxel refractory or resistant epithelial ovarian cancer. J. Hematol. Oncol., 3, 2010, 9, 10.1186/1756-8722-3-9.
    • (2010) J. Hematol. Oncol. , vol.3 , pp. 9
    • Kavanagh, J.J.1    Levenback, C.F.2    Ramirez, P.T.3    Wolf, J.L.4    Moore, C.L.5    Jones, M.R.6    Meng, L.7    Brown, G.L.8    Bast, R.C.9
  • 90
    • 84971491629 scopus 로고    scopus 로고
    • Disulfiram targets cancer stem-like properties and the HER2/Akt signaling pathway in HER2-positive breast cancer
    • Kim, J.Y., Cho, Y., Oh, E., Lee, N., An, H., Sung, D., Cho, T.-M., Seo, J.H., Disulfiram targets cancer stem-like properties and the HER2/Akt signaling pathway in HER2-positive breast cancer. Cancer Lett. 379 (2016), 39–48, 10.1016/j.canlet.2016.05.026.
    • (2016) Cancer Lett. , vol.379 , pp. 39-48
    • Kim, J.Y.1    Cho, Y.2    Oh, E.3    Lee, N.4    An, H.5    Sung, D.6    Cho, T.-M.7    Seo, J.H.8
  • 91
    • 84937515747 scopus 로고    scopus 로고
    • PABA/NO lead optimization: improved targeting of cytotoxicity to glutathione S-transferase P1-overexpressing cancer cells
    • Kim, Y., Maciag, A.E., Cao, Z., Deschamps, J.R., Saavedra, J.E., Keefer, L.K., Holland, R.J., PABA/NO lead optimization: improved targeting of cytotoxicity to glutathione S-transferase P1-overexpressing cancer cells. Bioorg. Med. Chem. 23 (2015), 4980–4988, 10.1016/j.bmc.2015.05.020.
    • (2015) Bioorg. Med. Chem. , vol.23 , pp. 4980-4988
    • Kim, Y.1    Maciag, A.E.2    Cao, Z.3    Deschamps, J.R.4    Saavedra, J.E.5    Keefer, L.K.6    Holland, R.J.7
  • 92
    • 84155164796 scopus 로고    scopus 로고
    • Growth-inhibitory and chemosensitizing effects of the glutathione-S-transferase-π-activated nitric oxide donor PABA/NO in malignant gliomas
    • Kogias, E., Osterberg, N., Baumer, B., Psarras, N., Koentges, C., Papazoglou, A., Saavedra, J.E., Keefer, L.K., Weyerbrock, A., Growth-inhibitory and chemosensitizing effects of the glutathione-S-transferase-π-activated nitric oxide donor PABA/NO in malignant gliomas. Int. J. Cancer 130 (2012), 1184–1194, 10.1002/ijc.26106.
    • (2012) Int. J. Cancer , vol.130 , pp. 1184-1194
    • Kogias, E.1    Osterberg, N.2    Baumer, B.3    Psarras, N.4    Koentges, C.5    Papazoglou, A.6    Saavedra, J.E.7    Keefer, L.K.8    Weyerbrock, A.9
  • 93
    • 31644451102 scopus 로고    scopus 로고
    • Low expression of MRP1/GS-X pump ATPase in lymphocytes of Walker 256 tumour-bearing rats is associated with cyclopentenone prostaglandin accumulation and cancer immunodeficiency
    • Kolberg, A., Rosa, T.G., Puhl, M.T., Scola, G., Janner, D.D.R., Maslinkiewicz, A., Lagranha, D.J., Heck, T.G., Curi, R., Homem De Bittencourt, P.I., Low expression of MRP1/GS-X pump ATPase in lymphocytes of Walker 256 tumour-bearing rats is associated with cyclopentenone prostaglandin accumulation and cancer immunodeficiency. Cell Biochem. Funct. 24 (2006), 23–39, 10.1002/cbf.1290.
    • (2006) Cell Biochem. Funct. , vol.24 , pp. 23-39
    • Kolberg, A.1    Rosa, T.G.2    Puhl, M.T.3    Scola, G.4    Janner, D.D.R.5    Maslinkiewicz, A.6    Lagranha, D.J.7    Heck, T.G.8    Curi, R.9    Homem De Bittencourt, P.I.10
  • 94
    • 0344927562 scopus 로고    scopus 로고
    • Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance
    • König, J., Nies, A.T., Cui, Y., Leier, I., Keppler, D., Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance. Biochim. Biophys. Acta Biomembr. 1461 (1999), 377–394, 10.1016/S0005-2736(99)00169-8.
    • (1999) Biochim. Biophys. Acta Biomembr. , vol.1461 , pp. 377-394
    • König, J.1    Nies, A.T.2    Cui, Y.3    Leier, I.4    Keppler, D.5
  • 95
    • 14044268132 scopus 로고    scopus 로고
    • Redox mechanisms of cytoprotection by Bcl-2
    • Kowaltowski, A.J., Fiskum, G., Redox mechanisms of cytoprotection by Bcl-2. Antioxid. Redox Signal. 7 (2008), 508–514, 10.1089/ars.2005.7.508.
    • (2008) Antioxid. Redox Signal. , vol.7 , pp. 508-514
    • Kowaltowski, A.J.1    Fiskum, G.2
  • 96
    • 79960318922 scopus 로고    scopus 로고
    • Inhibitory effects of Indigofera aspalathoides on 20-methylcholanthrene-induced chemical carcinogenesis in rats
    • Kumar, S.S., Karrunakaran, C.M., Rao, M.R.K., Balasubramanian, M.P., Inhibitory effects of Indigofera aspalathoides on 20-methylcholanthrene-induced chemical carcinogenesis in rats. J. Carcinog. 10 (2011), 1–18, 10.4103/1477-3163.75458.
    • (2011) J. Carcinog. , vol.10 , pp. 1-18
    • Kumar, S.S.1    Karrunakaran, C.M.2    Rao, M.R.K.3    Balasubramanian, M.P.4
  • 97
    • 79956149755 scopus 로고    scopus 로고
    • Indigofera aspalathoides, protection against 20-methylcholantherene-induced experimental fibrosarcoma growth after transplantation in rats-role of xenobiotic drug metabolizing enzymes
    • Kumar, S.S., Karrunakaran, C.M., Rao, M.R.K., Balasubramanian, M.P., Indigofera aspalathoides, protection against 20-methylcholantherene-induced experimental fibrosarcoma growth after transplantation in rats-role of xenobiotic drug metabolizing enzymes. Asian Pac. J. Cancer Prev. 11 (2010), 1833–1838.
    • (2010) Asian Pac. J. Cancer Prev. , vol.11 , pp. 1833-1838
    • Kumar, S.S.1    Karrunakaran, C.M.2    Rao, M.R.K.3    Balasubramanian, M.P.4
  • 98
    • 0033969838 scopus 로고    scopus 로고
    • Phosphono analogs of glutathione: inhibition of glutathione transferases, metabolic stability, and uptake by cancer cells
    • Kunze, T., Heps, S., Phosphono analogs of glutathione: inhibition of glutathione transferases, metabolic stability, and uptake by cancer cells. Biochem. Pharmacol. 59 (2000), 973–981, 10.1016/S0006-2952(99)00401-3.
    • (2000) Biochem. Pharmacol. , vol.59 , pp. 973-981
    • Kunze, T.1    Heps, S.2
  • 100
    • 0021216714 scopus 로고
    • Hepatic glutathione homeostasis in the rat: efflux accounts for glutathione turnover
    • Lauterburg, B.H., Adams, J.D., Mitchell, J.R., Hepatic glutathione homeostasis in the rat: efflux accounts for glutathione turnover. Hepatology 4 (1984), 586–590.
    • (1984) Hepatology , vol.4 , pp. 586-590
    • Lauterburg, B.H.1    Adams, J.D.2    Mitchell, J.R.3
  • 101
    • 41549142696 scopus 로고    scopus 로고
    • Isoliquiritigenin inhibits tumor growth and protects the kidney and liver against chemotherapy-induced toxicity in a mouse xenograft model of colon carcinoma
    • Lee, C.K., Son, S.H., Park, K.K., Park, J.H., Lim, S.S., Chung, W.Y., Isoliquiritigenin inhibits tumor growth and protects the kidney and liver against chemotherapy-induced toxicity in a mouse xenograft model of colon carcinoma. J. Pharmacol. Sci. 106 (2008), 444–451, 10.1254/jphs.FP0071498.
    • (2008) J. Pharmacol. Sci. , vol.106 , pp. 444-451
    • Lee, C.K.1    Son, S.H.2    Park, K.K.3    Park, J.H.4    Lim, S.S.5    Chung, W.Y.6
  • 102
    • 45749128172 scopus 로고    scopus 로고
    • Licochalcone A inhibits the growth of colon carcinoma and attenuates cisplatin-induced toxicity without a loss of chemotherapeutic efficacy in mice
    • Lee, C.K., Son, S.H., Park, K.K., Park, J.H.Y., Lim, S.S., Kim, S.-H., Chung, W.Y., Licochalcone A inhibits the growth of colon carcinoma and attenuates cisplatin-induced toxicity without a loss of chemotherapeutic efficacy in mice. Basic Clin. Pharmacol. Toxicol. 103 (2008), 48–54, 10.1111/j.1742-7843.2008.00238.x.
    • (2008) Basic Clin. Pharmacol. Toxicol. , vol.103 , pp. 48-54
    • Lee, C.K.1    Son, S.H.2    Park, K.K.3    Park, J.H.Y.4    Lim, S.S.5    Kim, S.-H.6    Chung, W.Y.7
  • 104
    • 0035894104 scopus 로고    scopus 로고
    • Effect of overexpression of BCL-2 on cellular oxidative damage, nitric oxide production, antioxidant defenses, and the proteasome
    • Lee, M., Hyun, D.H., Marshall, K.A., Ellerby, L.M., Bredesen, D.E., Jenner, P., Halliwell, B., Effect of overexpression of BCL-2 on cellular oxidative damage, nitric oxide production, antioxidant defenses, and the proteasome. Free. Radic. Biol. Med. 31 (2001), 1550–1559.
    • (2001) Free. Radic. Biol. Med. , vol.31 , pp. 1550-1559
    • Lee, M.1    Hyun, D.H.2    Marshall, K.A.3    Ellerby, L.M.4    Bredesen, D.E.5    Jenner, P.6    Halliwell, B.7
  • 106
    • 0029912351 scopus 로고    scopus 로고
    • ATP-dependent glutathione disulphide transport mediated by the MRP gene-encoded conjugate export pump
    • Leier, I., Jedlitschky, G., Buchholz, U., Center, M., Cole, S.P., Deeley, R.G., Keppler, D., ATP-dependent glutathione disulphide transport mediated by the MRP gene-encoded conjugate export pump. Biochem J. 314 (1996), 433–437.
    • (1996) Biochem J. , vol.314 , pp. 433-437
    • Leier, I.1    Jedlitschky, G.2    Buchholz, U.3    Center, M.4    Cole, S.P.5    Deeley, R.G.6    Keppler, D.7
  • 107
    • 0033572313 scopus 로고    scopus 로고
    • Arsenic trioxide causes selective necrosis in solid murine tumors by vascular shutdown
    • Lew, Y.S., Brown, S.L., Griffin, R.J., Song, C.W., Kim, J.H., Arsenic trioxide causes selective necrosis in solid murine tumors by vascular shutdown. Cancer Res. 59 (1999), 6033–6037.
    • (1999) Cancer Res. , vol.59 , pp. 6033-6037
    • Lew, Y.S.1    Brown, S.L.2    Griffin, R.J.3    Song, C.W.4    Kim, J.H.5
  • 108
    • 62949186374 scopus 로고    scopus 로고
    • Potential of l-buthionine sulfoximine to enhance the apoptotic action of estradiol to reverse acquired antihormonal resistance in metastatic breast cancer
    • Lewis-Wambi, J.S., Swaby, R., Kim, H., Jordan, V.C., Potential of l-buthionine sulfoximine to enhance the apoptotic action of estradiol to reverse acquired antihormonal resistance in metastatic breast cancer. J. Steroid Biochem. Mol. Biol. 114 (2009), 33–39, 10.1016/j.jsbmb.2008.12.016.
    • (2009) J. Steroid Biochem. Mol. Biol. , vol.114 , pp. 33-39
    • Lewis-Wambi, J.S.1    Swaby, R.2    Kim, H.3    Jordan, V.C.4
  • 109
    • 84988355081 scopus 로고    scopus 로고
    • Targeting ALDH1A1 by disulfiram/copper complex inhibits non-small cell lung cancer recurrence driven by ALDH-positive cancer stem cells
    • Liu, X., Wang, L., Cui, W., Yuan, X., Lin, L., Cao, Q., Wang, N., Li, Y., Guo, W., Zhang, X., Wu, C., Yang, J., Targeting ALDH1A1 by disulfiram/copper complex inhibits non-small cell lung cancer recurrence driven by ALDH-positive cancer stem cells. Oncotarget 7 (2016), 58516–58530, 10.18632/oncotarget.11305.
    • (2016) Oncotarget , vol.7 , pp. 58516-58530
    • Liu, X.1    Wang, L.2    Cui, W.3    Yuan, X.4    Lin, L.5    Cao, Q.6    Wang, N.7    Li, Y.8    Guo, W.9    Zhang, X.10    Wu, C.11    Yang, J.12
  • 110
    • 84897423324 scopus 로고    scopus 로고
    • Biodegradable nanoassemblies of piperlongumine display enhanced anti-angiogenesis and anti-tumor activities
    • Liu, Y., Chang, Y., Yang, C., Sang, Z., Yang, T., Ang, W., Ye, W., Wei, Y., Gong, C., Luo, Y., Biodegradable nanoassemblies of piperlongumine display enhanced anti-angiogenesis and anti-tumor activities. Nanoscale 6 (2014), 4325–4337, 10.1039/c3nr06599e.
    • (2014) Nanoscale , vol.6 , pp. 4325-4337
    • Liu, Y.1    Chang, Y.2    Yang, C.3    Sang, Z.4    Yang, T.5    Ang, W.6    Ye, W.7    Wei, Y.8    Gong, C.9    Luo, Y.10
  • 111
    • 0021815179 scopus 로고
    • Radiation survival parameters of antineoplastic drug-sensitive and -resistant human ovarian cancer cell lines and their modification by buthionine sulfoximine
    • Louie, K.G., Behrens, B.C., Kinsella, T.J., Hamilton, T.C., Grotzinger, K.R., McKoy, W.M., Winker, M.A., Ozols, R.F., Radiation survival parameters of antineoplastic drug-sensitive and -resistant human ovarian cancer cell lines and their modification by buthionine sulfoximine. Cancer Res. 45 (1985), 2110–2115.
    • (1985) Cancer Res. , vol.45 , pp. 2110-2115
    • Louie, K.G.1    Behrens, B.C.2    Kinsella, T.J.3    Hamilton, T.C.4    Grotzinger, K.R.5    McKoy, W.M.6    Winker, M.A.7    Ozols, R.F.8
  • 112
    • 34547644483 scopus 로고    scopus 로고
    • Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide
    • Lu, J., Chew, E.-H., Holmgren, A., Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide. Proc. Natl. Acad. Sci. U. S. A 104 (2007), 12288–12293, 10.1073/pnas.0701549104.
    • (2007) Proc. Natl. Acad. Sci. U. S. A , vol.104 , pp. 12288-12293
    • Lu, J.1    Chew, E.-H.2    Holmgren, A.3
  • 113
    • 84875744148 scopus 로고    scopus 로고
    • Glutathione synthesis
    • Lu, S.C., Glutathione synthesis. Biochim. Biophys. Acta 1830 (2014), 3143–3153, 10.1016/j.bbagen.2012.09.008.GLUTATHIONE.
    • (2014) Biochim. Biophys. Acta , vol.1830 , pp. 3143-3153
    • Lu, S.C.1
  • 115
    • 0035879016 scopus 로고    scopus 로고
    • Tumor growth inhibition by arsenic trioxide (As2O3) in the orthotopic metastasis model of androgen-independent prostate cancer
    • Maeda, H., Hori, S., Nishitoh, H., Ichijo, H., Ogawa, O., Kakehi, Y., Kakizuka, A., Tumor growth inhibition by arsenic trioxide (As2O3) in the orthotopic metastasis model of androgen-independent prostate cancer. Cancer Res. 61 (2001), 5432–5440.
    • (2001) Cancer Res. , vol.61 , pp. 5432-5440
    • Maeda, H.1    Hori, S.2    Nishitoh, H.3    Ichijo, H.4    Ogawa, O.5    Kakehi, Y.6    Kakizuka, A.7
  • 116
    • 3543084996 scopus 로고    scopus 로고
    • Effective treatment of advanced solid tumors by the combination of arsenic trioxide and L-buthionine-sulfoximine
    • Maeda, H., Hori, S., Ohizumi, H., Segawa, T., Kakehi, Y., Ogawa, O., Kakizuka, A., Effective treatment of advanced solid tumors by the combination of arsenic trioxide and L-buthionine-sulfoximine. Cell Death Differ. 11 (2004), 737–746, 10.1038/sj.cdd.4401389.
    • (2004) Cell Death Differ. , vol.11 , pp. 737-746
    • Maeda, H.1    Hori, S.2    Ohizumi, H.3    Segawa, T.4    Kakehi, Y.5    Ogawa, O.6    Kakizuka, A.7
  • 117
    • 84927661903 scopus 로고    scopus 로고
    • Ezatiostat hydrochloride for the treatment of myelodysplastic syndromes
    • Mahadevan, D., Sutton, G.R., Ezatiostat hydrochloride for the treatment of myelodysplastic syndromes. Expert Opin. Investig. Drugs 24 (2015), 725–733, 10.1517/13543784.2015.1021003.
    • (2015) Expert Opin. Investig. Drugs , vol.24 , pp. 725-733
    • Mahadevan, D.1    Sutton, G.R.2
  • 121
    • 34547110841 scopus 로고    scopus 로고
    • Glutathione is recruited into the nucleus in early phases of cell proliferation
    • Markovic, J., Borrás, C., Ortega, A., Sastre, J., Viña, J., Pallardó F.V., Glutathione is recruited into the nucleus in early phases of cell proliferation. J. Biol. Chem. 282 (2007), 20416–20424.
    • (2007) J. Biol. Chem. , vol.282 , pp. 20416-20424
    • Markovic, J.1    Borrás, C.2    Ortega, A.3    Sastre, J.4    Viña, J.5    Pallardó, F.V.6
  • 124
    • 25144482448 scopus 로고    scopus 로고
    • Novel mechanisms of natural antioxidant compounds in biological systems: involvement of glutathione and glutathione-related enzymes
    • Masella, R., Di Benedetto, R., Varì R., Filesi, C., Giovannini, C., Novel mechanisms of natural antioxidant compounds in biological systems: involvement of glutathione and glutathione-related enzymes. J. Nutr. Biochem. 16 (2005), 577–586, 10.1016/j.jnutbio.2005.05.013.
    • (2005) J. Nutr. Biochem. , vol.16 , pp. 577-586
    • Masella, R.1    Di Benedetto, R.2    Varì, R.3    Filesi, C.4    Giovannini, C.5
  • 125
    • 0036849687 scopus 로고    scopus 로고
    • Brusatol-mediated induction of leukemic cell differentiation and G(1) arrest is associated with down-regulation of c-myc
    • Mata-Greenwood, E., Cuendet, M., Sher, D., Gustin, D., Stock, W., Pezzuto, J.M., Brusatol-mediated induction of leukemic cell differentiation and G(1) arrest is associated with down-regulation of c-myc. Leukemia 16 (2002), 2275–2284, 10.1038/sj.leu.2402696.
    • (2002) Leukemia , vol.16 , pp. 2275-2284
    • Mata-Greenwood, E.1    Cuendet, M.2    Sher, D.3    Gustin, D.4    Stock, W.5    Pezzuto, J.M.6
  • 126
    • 33847029844 scopus 로고    scopus 로고
    • Effect of Semecarpus anacardium Linn. Nut extract on mammary and hepatic expression of xenobiotic enzymes in DMBA-induced mammary carcinoma
    • Mathivadhani, P., Shanthi, P., Sachdanandam, P., Effect of Semecarpus anacardium Linn. Nut extract on mammary and hepatic expression of xenobiotic enzymes in DMBA-induced mammary carcinoma. Environ. Toxicol. Pharmacol. 23 (2007), 328–334, 10.1016/j.etap.2006.12.004.
    • (2007) Environ. Toxicol. Pharmacol. , vol.23 , pp. 328-334
    • Mathivadhani, P.1    Shanthi, P.2    Sachdanandam, P.3
  • 127
    • 0038241619 scopus 로고    scopus 로고
    • Mechanisms for sensitization to TNF-induced apoptosis by acute glutathione depletion in murine hepatocytes
    • Matsumaru, K., Ji, C., Kaplowitz, N., Mechanisms for sensitization to TNF-induced apoptosis by acute glutathione depletion in murine hepatocytes. Hepatology 37 (2003), 1425–1434, 10.1053/jhep.2003.50230.
    • (2003) Hepatology , vol.37 , pp. 1425-1434
    • Matsumaru, K.1    Ji, C.2    Kaplowitz, N.3
  • 129
    • 0016904231 scopus 로고
    • Glutathione and related y-glutamyl compounds: biosynthesis and utilization
    • Meister, A., Tate, S.S., Glutathione and related y-glutamyl compounds: biosynthesis and utilization. Annu. Rev. Biochem. 45 (1976), 559–604.
    • (1976) Annu. Rev. Biochem. , vol.45 , pp. 559-604
    • Meister, A.1    Tate, S.S.2
  • 131
    • 0019784877 scopus 로고
    • Differences in blood glutathione levels of tumor-implanted or zinc-deficient rats
    • Mills, B.J., Lindeman, R.D., Lang, C.A., Differences in blood glutathione levels of tumor-implanted or zinc-deficient rats. J. Nutr. 111 (1981), 1586–1592.
    • (1981) J. Nutr. , vol.111 , pp. 1586-1592
    • Mills, B.J.1    Lindeman, R.D.2    Lang, C.A.3
  • 132
    • 84908239764 scopus 로고    scopus 로고
    • Oil rich in carotenoids instead of vitamins C and E as a better option to reduce doxorubicin-induced damage to normal cells of Ehrlich tumor-bearing mice: hematological, toxicological and histopathological evaluations
    • Miranda-Vilela, A.L., Grisolia, C.K., Longo, J.P.F., Peixoto, R.C.A., de Almeida, M.C., Barbosa, L.C.P., Roll, M.M., Portilho, F.A., Estevanato, L.L.C., Bocca, A.L., Báo, S.N., Lacava, Z.G.M., Oil rich in carotenoids instead of vitamins C and E as a better option to reduce doxorubicin-induced damage to normal cells of Ehrlich tumor-bearing mice: hematological, toxicological and histopathological evaluations. J. Nutr. Biochem. 25 (2014), 1161–1176, 10.1016/j.jnutbio.2014.06.005.
    • (2014) J. Nutr. Biochem. , vol.25 , pp. 1161-1176
    • Miranda-Vilela, A.L.1    Grisolia, C.K.2    Longo, J.P.F.3    Peixoto, R.C.A.4    de Almeida, M.C.5    Barbosa, L.C.P.6    Roll, M.M.7    Portilho, F.A.8    Estevanato, L.L.C.9    Bocca, A.L.10    Báo, S.N.11    Lacava, Z.G.M.12
  • 134
    • 84912071089 scopus 로고    scopus 로고
    • Topical (+)-catechin emulsified gel prevents DMBA/TPA-induced squamous cell carcinoma of the skin by modulating antioxidants and inflammatory biomarkers in BALB/c mice
    • Monga, J., Aggarwal, V., Suthar, S.K., Monika, Nongalleima, K., Sharma, M., Topical (+)-catechin emulsified gel prevents DMBA/TPA-induced squamous cell carcinoma of the skin by modulating antioxidants and inflammatory biomarkers in BALB/c mice. Food Funct. 5 (2014), 3197–3207, 10.1039/c4fo00531g.
    • (2014) Food Funct. , vol.5 , pp. 3197-3207
    • Monga, J.1    Aggarwal, V.2    Suthar, S.K.3    Monika4    Nongalleima, K.5    Sharma, M.6
  • 135
    • 35748960805 scopus 로고    scopus 로고
    • Small-molecule inhibitors of glutathione S-transferase P1-1 as anticancer therapeutic agents
    • Chapter 20
    • Morales, G.A., Laborde, E., Small-molecule inhibitors of glutathione S-transferase P1-1 as anticancer therapeutic agents. Chapter 20 Annu. Rep. Med. Chem. 42 (2007), 321–335, 10.1016/S0065-7743(07)42020-6.
    • (2007) Annu. Rep. Med. Chem. , vol.42 , pp. 321-335
    • Morales, G.A.1    Laborde, E.2
  • 136
  • 137
    • 77956056306 scopus 로고    scopus 로고
    • A phase I trial of imexon, a pro-oxidant, in combination with docetaxel for the treatment of patients with advanced breast, non-small cell lung and prostate cancer
    • Moulder, S., Dhillon, N., Ng, C., Hong, D., Wheler, J., Naing, A., Tse, S., La Paglia, A., Dorr, R., Hersh, E., Boytim, M., Kurzrock, R., A phase I trial of imexon, a pro-oxidant, in combination with docetaxel for the treatment of patients with advanced breast, non-small cell lung and prostate cancer. Invest. New Drugs 28 (2010), 634–640, 10.1007/s10637-009-9273-1.
    • (2010) Invest. New Drugs , vol.28 , pp. 634-640
    • Moulder, S.1    Dhillon, N.2    Ng, C.3    Hong, D.4    Wheler, J.5    Naing, A.6    Tse, S.7    La Paglia, A.8    Dorr, R.9    Hersh, E.10    Boytim, M.11    Kurzrock, R.12
  • 138
    • 33746267244 scopus 로고    scopus 로고
    • Enhancement of pro-oxidant effect of 7,12-dimethylbenz (a) anthracene (DMBA) in rats by pre-exposure to restraint stress
    • Muqbil, I., Banu, N., Enhancement of pro-oxidant effect of 7,12-dimethylbenz (a) anthracene (DMBA) in rats by pre-exposure to restraint stress. Cancer Lett. 240 (2006), 213–220, 10.1016/j.canlet.2005.09.008.
    • (2006) Cancer Lett. , vol.240 , pp. 213-220
    • Muqbil, I.1    Banu, N.2
  • 139
    • 84927648045 scopus 로고    scopus 로고
    • A phase IIb trial assessing the addition of disulfiram to chemotherapy for the treatment of metastatic non-small cell lung cancer
    • Nechushtan, H., Hamamreh, Y., Nidal, S., Gotfried, M., Baron, A., Shalev, Y.I., Nisman, B., Peretz, T., Peylan-Ramu, N., A phase IIb trial assessing the addition of disulfiram to chemotherapy for the treatment of metastatic non-small cell lung cancer. Oncologist 20 (2015), 366–367, 10.1634/theoncologist.2014-0424.
    • (2015) Oncologist , vol.20 , pp. 366-367
    • Nechushtan, H.1    Hamamreh, Y.2    Nidal, S.3    Gotfried, M.4    Baron, A.5    Shalev, Y.I.6    Nisman, B.7    Peretz, T.8    Peylan-Ramu, N.9
  • 140
    • 48549084303 scopus 로고    scopus 로고
    • Antioxidant potential by arabinoxylan rice bran, MGN-3/biobran, represents a mechanism for its oncostatic effect against murine solid Ehrlich carcinoma
    • Noaman, E., El-Din, N.K.B., Bibars, M.A., Mossallam, A.A.A., Ghoneum, M., Antioxidant potential by arabinoxylan rice bran, MGN-3/biobran, represents a mechanism for its oncostatic effect against murine solid Ehrlich carcinoma. Cancer Lett. 268 (2008), 348–359, 10.1016/j.canlet.2008.04.012.
    • (2008) Cancer Lett. , vol.268 , pp. 348-359
    • Noaman, E.1    El-Din, N.K.B.2    Bibars, M.A.3    Mossallam, A.A.A.4    Ghoneum, M.5
  • 143
    • 84925467097 scopus 로고    scopus 로고
    • Enhancement of melphalan activity by buthionine sulfoximine and electroporation in melanoma cells
    • Ongaro, A., Pellati, A., De Mattei, M., De Terlizzi, F., Rossi, C.R., Campana, L.G., Enhancement of melphalan activity by buthionine sulfoximine and electroporation in melanoma cells. Anticancer Drugs 26 (2015), 284–292, 10.1097/CAD.0000000000000192.
    • (2015) Anticancer Drugs , vol.26 , pp. 284-292
    • Ongaro, A.1    Pellati, A.2    De Mattei, M.3    De Terlizzi, F.4    Rossi, C.R.5    Campana, L.G.6
  • 144
    • 0023119841 scopus 로고
    • Enhanced melphalan cytotoxicity in human ovarian cancer in vitro and in tumor-bearing nude mice by buthionine sulfoximine depletion of glutathione
    • Ozols, R.F., Louie, K.G., Plowman, J., Behrens, B.C., Fine, R.L., Dykes, D., Hamilton, T.C., Enhanced melphalan cytotoxicity in human ovarian cancer in vitro and in tumor-bearing nude mice by buthionine sulfoximine depletion of glutathione. Biochem. Pharmacol. 36 (1987), 147–153, 10.1016/0006-2952(87)90392-3.
    • (1987) Biochem. Pharmacol. , vol.36 , pp. 147-153
    • Ozols, R.F.1    Louie, K.G.2    Plowman, J.3    Behrens, B.C.4    Fine, R.L.5    Dykes, D.6    Hamilton, T.C.7
  • 145
    • 65049087578 scopus 로고    scopus 로고
    • Role of nuclear glutathione as a key regulator of cell proliferation
    • Pallardó F.V., Markovic, J., García, J.L., Viña, J., Role of nuclear glutathione as a key regulator of cell proliferation. Mol. Aspects Med. 30 (2009), 77–85, 10.1016/j.mam.2009.01.001.
    • (2009) Mol. Aspects Med. , vol.30 , pp. 77-85
    • Pallardó, F.V.1    Markovic, J.2    García, J.L.3    Viña, J.4
  • 146
    • 84855364702 scopus 로고    scopus 로고
    • Elimination of deleterious effects of DMBA-induced skin carcinogenesis in mice by Syzygium cumini seed extract
    • Parmar, J., Sharma, P., Verma, P., Sharma, P., Goyal, P.K., Elimination of deleterious effects of DMBA-induced skin carcinogenesis in mice by Syzygium cumini seed extract. Integr. Cancer Ther. 10 (2011), 289–297, 10.1177/1534735410385112.
    • (2011) Integr. Cancer Ther. , vol.10 , pp. 289-297
    • Parmar, J.1    Sharma, P.2    Verma, P.3    Sharma, P.4    Goyal, P.K.5
  • 147
    • 77951634950 scopus 로고    scopus 로고
    • Pyridine nucleotide cycling and control of intracellular redox state in relation to poly (ADP-ribose) polymerase activity and nuclear localization of glutathione during exponential growth of Arabidopsis cells in culture
    • Pellny, T.K., Locato, V., Vivancos, P.D., Markovic, J., De Gara, L., Pallardó F.V., Foyer, C.H., Pyridine nucleotide cycling and control of intracellular redox state in relation to poly (ADP-ribose) polymerase activity and nuclear localization of glutathione during exponential growth of Arabidopsis cells in culture. Mol. Plant 2 (2009), 442–456, 10.1093/mp/ssp008.
    • (2009) Mol. Plant , vol.2 , pp. 442-456
    • Pellny, T.K.1    Locato, V.2    Vivancos, P.D.3    Markovic, J.4    De Gara, L.5    Pallardó, F.V.6    Foyer, C.H.7
  • 148
    • 84926080810 scopus 로고    scopus 로고
    • Antitumor efficacy of tangeretin by targeting the oxidative stress mediated on 7,12-dimethylbenz(a) anthracene-induced proliferative breast cancer in Sprague-Dawley rats
    • Periyasamy, K., Baskaran, K., Ilakkia, A., Vanitha, K., Selvaraj, S., Sakthisekaran, D., Antitumor efficacy of tangeretin by targeting the oxidative stress mediated on 7,12-dimethylbenz(a) anthracene-induced proliferative breast cancer in Sprague-Dawley rats. Cancer Chemother. Pharmacol. 75 (2015), 263–272, 10.1007/s00280-014-2629-z.
    • (2015) Cancer Chemother. Pharmacol. , vol.75 , pp. 263-272
    • Periyasamy, K.1    Baskaran, K.2    Ilakkia, A.3    Vanitha, K.4    Selvaraj, S.5    Sakthisekaran, D.6
  • 151
    • 84924185989 scopus 로고    scopus 로고
    • Dose response chemopreventive potential of allyl isothiocyanate against 7,12-dimethylbenz(a)anthracene induced mammary carcinogenesis in female Sprague-Dawley rats
    • Rajakumar, T., Pugalendhi, P., Thilagavathi, S., Dose response chemopreventive potential of allyl isothiocyanate against 7,12-dimethylbenz(a)anthracene induced mammary carcinogenesis in female Sprague-Dawley rats. Chem. Biol. Interact. 231 (2015), 35–43, 10.1016/j.cbi.2015.02.015.
    • (2015) Chem. Biol. Interact. , vol.231 , pp. 35-43
    • Rajakumar, T.1    Pugalendhi, P.2    Thilagavathi, S.3
  • 152
    • 85048499382 scopus 로고    scopus 로고
    • Effect of Semecarpus anacardium Linn. Nut milk extract on rat neutrophil functions in adjuvant arthritis
    • Ramprasath, V.R., Shanthi, P., Sachdanandam, P., Effect of Semecarpus anacardium Linn. Nut milk extract on rat neutrophil functions in adjuvant arthritis.. J. Med. Food 9 (2006), 265–269, 10.1002/cbf.1243.
    • (2006) J. Med. Food , vol.9 , pp. 265-269
    • Ramprasath, V.R.1    Shanthi, P.2    Sachdanandam, P.3
  • 154
    • 79952122321 scopus 로고    scopus 로고
    • Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism
    • Ren, D., Villeneuve, N.F., Jiang, T., Wu, T., Lau, A., Toppin, H.A., Zhang, D.D., Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism. Proc. Natl. Acad. Sci. U. S. A. 108 (2011), 1433–1438, 10.1073/pnas.1014275108.
    • (2011) Proc. Natl. Acad. Sci. U. S. A. , vol.108 , pp. 1433-1438
    • Ren, D.1    Villeneuve, N.F.2    Jiang, T.3    Wu, T.4    Lau, A.5    Toppin, H.A.6    Zhang, D.D.7
  • 156
    • 0031710649 scopus 로고    scopus 로고
    • The effect of Walker-256 tumour development upon kupffer cell metabolism
    • Rosa, L.F.B.P.C., Kazantzis, M., Seelaender, M.C.L., The effect of Walker-256 tumour development upon kupffer cell metabolism. Cell Biochem. Funct. 16 (1998), 195–202.
    • (1998) Cell Biochem. Funct. , vol.16 , pp. 195-202
    • Rosa, L.F.B.P.C.1    Kazantzis, M.2    Seelaender, M.C.L.3
  • 160
    • 30844452908 scopus 로고    scopus 로고
    • Correlates of imexon sensitivity in human multiple myeloma cell lines
    • Samulitis, B.K., Landowski, T.H., Dorr, R.T., Correlates of imexon sensitivity in human multiple myeloma cell lines. Leuk. Lymphoma 47 (2006), 97–109, 10.1080/10428190500266210.
    • (2006) Leuk. Lymphoma , vol.47 , pp. 97-109
    • Samulitis, B.K.1    Landowski, T.H.2    Dorr, R.T.3
  • 161
    • 84871432020 scopus 로고    scopus 로고
    • Identification of a novel calotropis procera protein that can suppress tumor growth in breast cancer through the suppression of NF-kB pathway
    • Samy, R.P., Rajendran, P., Li, F., Anandi, N.M., Stiles, B.G., Ignacimuthu, S., Sethi, G., Chow, V.T.K., Identification of a novel calotropis procera protein that can suppress tumor growth in breast cancer through the suppression of NF-kB pathway. PLoS One 7 (2012), 1–14, 10.1371/journal.pone.0048514.
    • (2012) PLoS One , vol.7 , pp. 1-14
    • Samy, R.P.1    Rajendran, P.2    Li, F.3    Anandi, N.M.4    Stiles, B.G.5    Ignacimuthu, S.6    Sethi, G.7    Chow, V.T.K.8
  • 162
    • 0035371184 scopus 로고    scopus 로고
    • Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple
    • Schafer, F.Q., Buettner, G.R., Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. Free Radic. Biol. Med. 30 (2001), 1191–1212, 10.1016/S0891-5849(01)00480-4.
    • (2001) Free Radic. Biol. Med. , vol.30 , pp. 1191-1212
    • Schafer, F.Q.1    Buettner, G.R.2
  • 163
    • 84987827808 scopus 로고    scopus 로고
    • Glutamate release inhibitor, riluzole, inhibited proliferation of human hepatocellular carcinoma cells by elevated ROS production
    • Seol, H.S., Lee, S.E., Song, J.S., Lee, H.Y., Park, S., Kim, I., Singh, S.R., Chang, S., Jang, S.J., Glutamate release inhibitor, riluzole, inhibited proliferation of human hepatocellular carcinoma cells by elevated ROS production. Cancer Lett. 382 (2016), 157–165, 10.1016/j.canlet.2016.08.028.
    • (2016) Cancer Lett. , vol.382 , pp. 157-165
    • Seol, H.S.1    Lee, S.E.2    Song, J.S.3    Lee, H.Y.4    Park, S.5    Kim, I.6    Singh, S.R.7    Chang, S.8    Jang, S.J.9
  • 165
    • 84989291067 scopus 로고    scopus 로고
    • Disulfiram and its novel derivative sensitize prostate cancer cells to the growth regulatory mechanisms of the cell by re-expressing the epigenetically repressed tumor suppressor-estrogen receptor β
    • Sharma, V., Verma, V., Lal, N., Yadav, S.K., Sarkar, S., Mandalapu, D., Porwal, K., Rawat, T., Maikhuri, J.P., Rajender, S., Sharma, V.L., Gupta, G., Disulfiram and its novel derivative sensitize prostate cancer cells to the growth regulatory mechanisms of the cell by re-expressing the epigenetically repressed tumor suppressor-estrogen receptor β. Mol. Carcinog. 55 (2016), 1843–1857, 10.1002/mc.22433.
    • (2016) Mol. Carcinog. , vol.55 , pp. 1843-1857
    • Sharma, V.1    Verma, V.2    Lal, N.3    Yadav, S.K.4    Sarkar, S.5    Mandalapu, D.6    Porwal, K.7    Rawat, T.8    Maikhuri, J.P.9    Rajender, S.10    Sharma, V.L.11    Gupta, G.12
  • 166
    • 79959429865 scopus 로고    scopus 로고
    • Influence of glutathione levels and activity of glutathione-related enzymes in the brains of tumor-bearing mice
    • Shen, K., Ji, L., Chen, Y., Yu, Q., Wang, Z., Influence of glutathione levels and activity of glutathione-related enzymes in the brains of tumor-bearing mice. Biosci. Trends 5 (2011), 30–37, 10.5582/bst.2011.v5.1.30.
    • (2011) Biosci. Trends , vol.5 , pp. 30-37
    • Shen, K.1    Ji, L.2    Chen, Y.3    Yu, Q.4    Wang, Z.5
  • 167
    • 0033623452 scopus 로고    scopus 로고
    • Usefulness of 99mTc-d,l-HMPAO for estimation of GSH content in tumor tissues
    • Shimura, N., Musya, A., Hashimoto, T., Kojima, S., Kubodera, A., Sasaki, T., Usefulness of 99mTc-d,l-HMPAO for estimation of GSH content in tumor tissues. Nucl. Med. Biol. 27 (2000), 577–580, 10.1016/S0969-8051(00)00131-1.
    • (2000) Nucl. Med. Biol. , vol.27 , pp. 577-580
    • Shimura, N.1    Musya, A.2    Hashimoto, T.3    Kojima, S.4    Kubodera, A.5    Sasaki, T.6
  • 168
    • 85015584389 scopus 로고    scopus 로고
    • Brusatol enhances the radiosensitivity of A549 cells by promoting ROS production and enhancing DNA damage
    • Sun, X., Wang, Q., Wang, Y., Du, L., Xu, C., Liu, Q., Brusatol enhances the radiosensitivity of A549 cells by promoting ROS production and enhancing DNA damage. Int. J. Mol. Sci., 17, 2016, 10.3390/ijms17070997.
    • (2016) Int. J. Mol. Sci. , vol.17
    • Sun, X.1    Wang, Q.2    Wang, Y.3    Du, L.4    Xu, C.5    Liu, Q.6
  • 169
    • 0025312043 scopus 로고
    • Glutathione regulates activation-dependent DNA synthesis in highly purified normal human T lymphocytes stimulated via the CD2 and CD3 antigens
    • Suthanthiran, M., Anderson, M.E., Sharma, V.K., Meister, A., Glutathione regulates activation-dependent DNA synthesis in highly purified normal human T lymphocytes stimulated via the CD2 and CD3 antigens. Proc. Natl. Acad. Sci. U. S. A. 87 (1990), 3343–3347.
    • (1990) Proc. Natl. Acad. Sci. U. S. A. , vol.87 , pp. 3343-3347
    • Suthanthiran, M.1    Anderson, M.E.2    Sharma, V.K.3    Meister, A.4
  • 170
    • 84922496712 scopus 로고    scopus 로고
    • Anti-tumor potential of nitroxyl derivative pirolin in the DMBA-induced rat mammary carcinoma model: a comparison with quercetin
    • Tabaczar, S., Domeradzka, K., Czepas, J., Piasecka-Zelga, J., Stetkiewicz, J., Gwozdzinski, K., Koceva-Chyla, A., Anti-tumor potential of nitroxyl derivative pirolin in the DMBA-induced rat mammary carcinoma model: a comparison with quercetin. Pharmacol. Rep. 67 (2015), 527–534, 10.1016/j.pharep.2014.12.010.
    • (2015) Pharmacol. Rep. , vol.67 , pp. 527-534
    • Tabaczar, S.1    Domeradzka, K.2    Czepas, J.3    Piasecka-Zelga, J.4    Stetkiewicz, J.5    Gwozdzinski, K.6    Koceva-Chyla, A.7
  • 171
    • 84905366253 scopus 로고    scopus 로고
    • The glutathione synthesis inhibitor buthionine sulfoximine synergistically enhanced melphalan activity against preclinical models of multiple myeloma
    • Tagde, A., Singh, H., Kang, M.H., Reynolds, C.P., The glutathione synthesis inhibitor buthionine sulfoximine synergistically enhanced melphalan activity against preclinical models of multiple myeloma. Blood Cancer J., 4, 2014, e229, 10.1038/bcj.2014.45.
    • (2014) Blood Cancer J. , vol.4 , pp. e229
    • Tagde, A.1    Singh, H.2    Kang, M.H.3    Reynolds, C.P.4
  • 172
    • 0018337084 scopus 로고
    • Reduction of ribonucleotides
    • Thelander, L., Reichard, P., Reduction of ribonucleotides. Annu. Rev. Biochem. 48 (1979), 133–158, 10.1016/S0079-6603(08)60955-1.
    • (1979) Annu. Rev. Biochem. , vol.48 , pp. 133-158
    • Thelander, L.1    Reichard, P.2
  • 173
    • 85014064108 scopus 로고    scopus 로고
    • The diverse roles of glutathione-associated cell resistance against hypericin photodynamic therapy
    • Theodossiou, T.A., Olsen, C.E., Jonsson, M., Kubin, A., Hothersall, S., Berg, K., The diverse roles of glutathione-associated cell resistance against hypericin photodynamic therapy. Redox Biol. 12 (2017), 191–197, 10.1016/j.redox.2017.02.018.
    • (2017) Redox Biol. , vol.12 , pp. 191-197
    • Theodossiou, T.A.1    Olsen, C.E.2    Jonsson, M.3    Kubin, A.4    Hothersall, S.5    Berg, K.6
  • 174
    • 84942911444 scopus 로고    scopus 로고
    • Oral administration of Aloe vera (L.) Burm. f. (Xanthorrhoeaceae) and honey improves the host body composition and modulates proteolysis through reduction of tumor progression and oxidative stress in rats
    • Tomasin, R., de Andrade, R.S., Gomes-Marcondes, M.C.C., Oral administration of Aloe vera (L.) Burm. f. (Xanthorrhoeaceae) and honey improves the host body composition and modulates proteolysis through reduction of tumor progression and oxidative stress in rats. J. Med. Food 18 (2015), 1128–1135, 10.1089/jmf.2014.0129.
    • (2015) J. Med. Food , vol.18 , pp. 1128-1135
    • Tomasin, R.1    de Andrade, R.S.2    Gomes-Marcondes, M.C.C.3
  • 175
    • 30144441610 scopus 로고    scopus 로고
    • Glutathione S-transferases as regulators of kinase pathways and anticancer drug targets
    • Townsend, D.M., Findlay, V.L., Tew, K.D., Glutathione S-transferases as regulators of kinase pathways and anticancer drug targets. Methods Enzymol. 401 (2005), 287–307, 10.1016/S0076-6879(05)01019-0.
    • (2005) Methods Enzymol. , vol.401 , pp. 287-307
    • Townsend, D.M.1    Findlay, V.L.2    Tew, K.D.3
  • 177
    • 58949103855 scopus 로고    scopus 로고
    • Pharmacology of a mimetic glutathione disulfide, NOV-002
    • Townsend, D.M., Tew, K.D., Pharmacology of a mimetic glutathione disulfide, NOV-002. Biomed. Pharmacother. 63 (2010), 75–78, 10.1016/j.biopha.2008.08.019.Pharmacology.
    • (2010) Biomed. Pharmacother. , vol.63 , pp. 75-78
    • Townsend, D.M.1    Tew, K.D.2
  • 178
    • 67650071137 scopus 로고    scopus 로고
    • Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
    • Trachootham, D., Alexandre, J., Huang, P., Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?. Nat. Rev. Drug Discov. 8 (2009), 579–591, 10.1038/nrd2803.
    • (2009) Nat. Rev. Drug Discov. , vol.8 , pp. 579-591
    • Trachootham, D.1    Alexandre, J.2    Huang, P.3
  • 180
    • 84893174750 scopus 로고    scopus 로고
    • Effect of indirect nonequilibrium atmospheric pressure plasma on anti-proliferative activity against chronic chemo-resistant ovarian cancer cells in vitro and in vivo
    • Utsumi, F., Kajiyama, H., Nakamura, K., Tanaka, H., Mizuno, M., Ishikawa, K., Kondo, H., Kano, H., Hori, M., Kikkawa, F., Effect of indirect nonequilibrium atmospheric pressure plasma on anti-proliferative activity against chronic chemo-resistant ovarian cancer cells in vitro and in vivo. PLoS One 8 (2013), 1–10, 10.1371/journal.pone.0081576.
    • (2013) PLoS One , vol.8 , pp. 1-10
    • Utsumi, F.1    Kajiyama, H.2    Nakamura, K.3    Tanaka, H.4    Mizuno, M.5    Ishikawa, K.6    Kondo, H.7    Kano, H.8    Hori, M.9    Kikkawa, F.10
  • 181
    • 0030469778 scopus 로고    scopus 로고
    • D, L-buthionine-(S,R)-sulfoximine in vivo the therapeutic efficacy of doxorubicin against multidrug resistance protein-expressing tumors
    • Vanheofer, U., Cao, S., Minderman, H., Toth, K., Skenderis, B.S. II, Slovak, M.L., Rustum, Y.M., D, L-buthionine-(S,R)-sulfoximine in vivo the therapeutic efficacy of doxorubicin against multidrug resistance protein-expressing tumors. Clin. Cancer Res. 2 (1996), 1961–1968.
    • (1996) Clin. Cancer Res. , vol.2 , pp. 1961-1968
    • Vanheofer, U.1    Cao, S.2    Minderman, H.3    Toth, K.4    Skenderis, B.S.5    Slovak, M.L.6    Rustum, Y.M.7
  • 183
    • 0345708307 scopus 로고    scopus 로고
    • Hypochlorous acid alters bronchial epithelial cell membrane properties and prevention by extracellular glutathione
    • Venglarik, C.J., Girón-Calle, J., Wigley, A.F., Malle, E., Watanabe, N., Forman, H.J., Hypochlorous acid alters bronchial epithelial cell membrane properties and prevention by extracellular glutathione. J. Appl. Physiol. 95 (2003), 2444–2452.
    • (2003) J. Appl. Physiol. , vol.95 , pp. 2444-2452
    • Venglarik, C.J.1    Girón-Calle, J.2    Wigley, A.F.3    Malle, E.4    Watanabe, N.5    Forman, H.J.6
  • 184
    • 68749089764 scopus 로고    scopus 로고
    • Phase 3 randomised study of canfosfamide (Telcyta, TLK286) versus pegylated liposomal doxorubicin or topotecan as third-line therapy in patients with platinum-refractory or -resistant ovarian cancer
    • Vergote, I., Finkler, N., del Campo, J., Lohr, A., Hunter, J., Matei, D., Kavanagh, J., Vermorken, J.B., Meng, L., Jones, M., Brown, G., Kaye, S., Phase 3 randomised study of canfosfamide (Telcyta, TLK286) versus pegylated liposomal doxorubicin or topotecan as third-line therapy in patients with platinum-refractory or -resistant ovarian cancer. Eur. J. Cancer 45 (2009), 2324–2332, 10.1016/j.ejca.2009.05.016.
    • (2009) Eur. J. Cancer , vol.45 , pp. 2324-2332
    • Vergote, I.1    Finkler, N.2    del Campo, J.3    Lohr, A.4    Hunter, J.5    Matei, D.6    Kavanagh, J.7    Vermorken, J.B.8    Meng, L.9    Jones, M.10    Brown, G.11    Kaye, S.12
  • 189
    • 70449107252 scopus 로고    scopus 로고
    • Redox-directed cancer therapeutics: molecular mechanisms and opportunities
    • Wondrak, G.T., Redox-directed cancer therapeutics: molecular mechanisms and opportunities. Antioxid. Redox Signal. 11 (2009), 3013–3069, 10.1089/ars.2009.2541.
    • (2009) Antioxid. Redox Signal. , vol.11 , pp. 3013-3069
    • Wondrak, G.T.1
  • 190
    • 84869236062 scopus 로고    scopus 로고
    • Human cytosolic glutathione transferases: structure, function, and drug discovery
    • Wu, B., Dong, D., Human cytosolic glutathione transferases: structure, function, and drug discovery. Trends Pharmacol. Sci. 33 (2012), 656–668, 10.1016/j.tips.2012.09.007.
    • (2012) Trends Pharmacol. Sci. , vol.33 , pp. 656-668
    • Wu, B.1    Dong, D.2
  • 191
    • 84875723942 scopus 로고    scopus 로고
    • Glutathione and glutathione analogues; Therapeutic potentials
    • Wu, J.H., Batist, G., Glutathione and glutathione analogues; Therapeutic potentials. Biochim. Biophys. Acta Gen. Subj. 1830 (2013), 3350–3353, 10.1016/j.bbagen.2012.11.016.
    • (2013) Biochim. Biophys. Acta Gen. Subj. , vol.1830 , pp. 3350-3353
    • Wu, J.H.1    Batist, G.2
  • 193
    • 85002579647 scopus 로고    scopus 로고
    • Disulfiram chelated with copper promotes apoptosis in human breast cancer cells by impairing the mitochondria functions
    • Yang, Y., Zhang, K., Wang, Y., Li, M., Sun, X., Liang, Z., Wang, L., Chen, L., Yang, H., Zhu, L., Disulfiram chelated with copper promotes apoptosis in human breast cancer cells by impairing the mitochondria functions. Scanning 38 (2016), 825–836, 10.1002/sca.21332.
    • (2016) Scanning , vol.38 , pp. 825-836
    • Yang, Y.1    Zhang, K.2    Wang, Y.3    Li, M.4    Sun, X.5    Liang, Z.6    Wang, L.7    Chen, L.8    Yang, H.9    Zhu, L.10
  • 194
    • 84866996133 scopus 로고    scopus 로고
    • Comparative evaluation of small-molecule chemosensitizers in reversal of cisplatin resistance in ovarian cancer cells
    • Yellepeddi, V.K., Vangara, K.K., Kumar, A., Palakurthi, S., Comparative evaluation of small-molecule chemosensitizers in reversal of cisplatin resistance in ovarian cancer cells. Anticancer Res. 32 (2012), 3651–3658.
    • (2012) Anticancer Res. , vol.32 , pp. 3651-3658
    • Yellepeddi, V.K.1    Vangara, K.K.2    Kumar, A.3    Palakurthi, S.4
  • 195
    • 84994358602 scopus 로고    scopus 로고
    • Study on antitumor, antioxidant and immunoregulatory activities of the purified polyphenols from pinecone of Pinus koraiensis on tumor-bearing S180 mice in vivo
    • Yi, J., Qu, H., Wu, Y., Wang, Z., Wang, L., Study on antitumor, antioxidant and immunoregulatory activities of the purified polyphenols from pinecone of Pinus koraiensis on tumor-bearing S180 mice in vivo. Int. J. Biol. Macromol. 94 (2017), 735–744, 10.1016/j.ijbiomac.2016.10.071.
    • (2017) Int. J. Biol. Macromol. , vol.94 , pp. 735-744
    • Yi, J.1    Qu, H.2    Wu, Y.3    Wang, Z.4    Wang, L.5
  • 197
    • 84894258268 scopus 로고    scopus 로고
    • DLJ14, a novel chemo-sensitization agent, enhances therapeutic effects of adriamycin against MCF-7 / a cells both in vitro and in vivo
    • Zhang, P., Zheng, B.-B., Wang, H.-Y., Chen, J.-H., Liu, X.-Y., Guo, X.-L., DLJ14, a novel chemo-sensitization agent, enhances therapeutic effects of adriamycin against MCF-7 / a cells both in vitro and in vivo. J. Pharm. Pharmacol. 66 (2013), 398–407, 10.1111/jphp.12168.
    • (2013) J. Pharm. Pharmacol. , vol.66 , pp. 398-407
    • Zhang, P.1    Zheng, B.-B.2    Wang, H.-Y.3    Chen, J.-H.4    Liu, X.-Y.5    Guo, X.-L.6
  • 198
    • 0032773828 scopus 로고    scopus 로고
    • Induction of apoptosis and inhibition of human gastric cancer MGC-803 cell growth by arsenic trioxide
    • Zhang, T.C., Cao, E.H., Li, J.F., Ma, W., Qin, J.F., Induction of apoptosis and inhibition of human gastric cancer MGC-803 cell growth by arsenic trioxide. Eur. J. Cancer 35 (1999), 1258–1263.
    • (1999) Eur. J. Cancer , vol.35 , pp. 1258-1263
    • Zhang, T.C.1    Cao, E.H.2    Li, J.F.3    Ma, W.4    Qin, J.F.5
  • 199
    • 84923864133 scopus 로고    scopus 로고
    • Ultrasmall glutathione-protected gold nanoclusters as next generation radiotherapy sensitizers with high tumor uptake and high renal clearance
    • Zhang, X.-D., Luo, Z., Chen, J., Song, S., Yuan, X., Shen, X., Wang, H., Sun, Y., Gao, K., Zhang, L., Fan, S., Leong, D.T., Guo, M., Xie, J., Ultrasmall glutathione-protected gold nanoclusters as next generation radiotherapy sensitizers with high tumor uptake and high renal clearance. Sci. Rep., 5, 2015, 8669, 10.1038/srep08669.
    • (2015) Sci. Rep. , vol.5 , pp. 8669
    • Zhang, X.-D.1    Luo, Z.2    Chen, J.3    Song, S.4    Yuan, X.5    Shen, X.6    Wang, H.7    Sun, Y.8    Gao, K.9    Zhang, L.10    Fan, S.11    Leong, D.T.12    Guo, M.13    Xie, J.14
  • 200
    • 35748976238 scopus 로고    scopus 로고
    • Glutathione binding to the Bcl-2 homology-3 domain groove: a MOLECULAR BASIS FOR Bcl-2 ANTIOXIDANT FUNCTION AT MITOCHONDRIA
    • Zimmermann, A.K., Loucks, F.A., Schroeder, E.K., Bouchard, R.J., Tyler, K.L., Linseman, D.A., Glutathione binding to the Bcl-2 homology-3 domain groove: a MOLECULAR BASIS FOR Bcl-2 ANTIOXIDANT FUNCTION AT MITOCHONDRIA. J. Biol. Chem. 282 (2007), 29296–29304, 10.1016/j.drugalcdep.2008.02.002.A.
    • (2007) J. Biol. Chem. , vol.282 , pp. 29296-29304
    • Zimmermann, A.K.1    Loucks, F.A.2    Schroeder, E.K.3    Bouchard, R.J.4    Tyler, K.L.5    Linseman, D.A.6
  • 201
    • 84949292783 scopus 로고    scopus 로고
    • Significance of polymorphisms and expression of enzyme-encoding genes related to glutathione in hematopoietic cancers and solid tumors
    • Zmorzyński, S., Świderska-Kołacz, G., Koczkodaj, D., Filip, A.A., Significance of polymorphisms and expression of enzyme-encoding genes related to glutathione in hematopoietic cancers and solid tumors. Biomed. Res. Int. 2015 (2015), 1–6, 10.1155/2015/853573.
    • (2015) Biomed. Res. Int. , vol.2015 , pp. 1-6
    • Zmorzyński, S.1    Świderska-Kołacz, G.2    Koczkodaj, D.3    Filip, A.A.4


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