Disulfiram chelated with copper promotes apoptosis in human breast cancer cells by impairing the mitochondria functions

Scanning

Volumn 38, Issue 6, 2016, Pages 825-836

  Yang, Yaping ^a   Zhang, Kefan ^b   Wang, Yawei ^b   Li, Mengjia ^b   Sun, Xiaoxue ^b   Liang, Zhihong ^a   Wang, Liwei ^b   Chen, Lixin ^b   Yang, Haifeng ^c   Zhu, Linyan ^b  

^a JINAN UNIVERSITY   (China)

^b MEDICAL COLLEGE OF JINAN UNIVERSITY   (China)

^c GUANGDONG PROVINCIAL HOSPITAL OF CHINESE MEDICINE   (China)

Author keywords

atomic force microscopy; cytoskeleton; disulfiram Cu complex; mitochondrial membrane potential; reactive oxygen species

Indexed keywords

ATOMIC FORCE MICROSCOPY; CELL DEATH; CELL MEMBRANES; CELLS; CHELATION; CYTOLOGY; DISEASES; MAGNESIUM PRINTING PLATES; MITOCHONDRIA; TUMORS;

ANTI-TUMOR ACTIVITIES; CONCENTRATION-DEPENDENT MANNERS; CONFOCAL LASER SCANNING MICROSCOPE; CU COMPLEXES; CYTOSKELETONS; HUMAN BREAST CANCER CELLS; MITOCHONDRIAL MEMBRANE POTENTIAL; REACTIVE OXYGEN SPECIES;

COPPER COMPOUNDS;

ANTINEOPLASTIC METAL COMPLEX; CALCIUM ION; COPPER COMPLEX; DISULFIRAM; DISULFIRAM COPPER CHLORIDE COMPLEX; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; CALCIUM; COPPER;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; ATOMIC FORCE MICROSCOPY; BREAST CANCER; CALCIUM CELL LEVEL; CELL MEMBRANE; CELL SIZE; CELL STRUCTURE; CELL ULTRASTRUCTURE; CONCENTRATION RESPONSE; CONFOCAL LASER SCANNING MICROSCOPY; CONTROLLED STUDY; CYTOSKELETON; DRUG MECHANISM; FEMALE; FILOPODIUM; FLOW CYTOMETRY; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IN VITRO STUDY; MCF 7 CELL LINE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; OXIDATIVE STRESS; PRIORITY JOURNAL; BREAST TUMOR; DRUG EFFECTS; MCF-7 CELL LINE; METABOLISM; PATHOLOGY; ULTRASTRUCTURE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BREAST NEOPLASMS; CALCIUM; COPPER; CYTOSKELETON; DISULFIRAM; FEMALE; HUMANS; MCF-7 CELLS; MICROSCOPY, ATOMIC FORCE; MITOCHONDRIA; REACTIVE OXYGEN SPECIES;

EID: 85002579647     PISSN: 01610457     EISSN: 19328745     Source Type: Journal    
DOI: 10.1002/sca.21332     Document Type: Article

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