Induction of oxidative stress and apoptosis in myeloma cells by the aziridine-containing agent imexon

Biochemical Pharmacology

Volumn 60, Issue 6, 2000, Pages 749-758

  Dvorakova, Katerina ^a   Payne, Claire M ^b   Tome, Margaret E ^b   Briehl, Margaret M ^b   McClure, Thomas ^c   Dorr, Robert T ^a  

^a UNIVERSITY OF ARIZONA   (United States)

^b UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^c SYNGENTA BIOTECHNOLOGY INC   (United States)

Author keywords

Apoptosis; Cyanoaziridine; Imexon; Multiple myeloma; Oxidative stress

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ACETYLCYSTEINE; AZIRIDINE DERIVATIVE; BUTHIONINE SULFOXIMINE; CELL DNA; CYSTEINE; GLUTATHIONE; IMEXON; LIPOCORTIN 5; MONOCLONAL ANTIBODY; PHOSPHATIDYLSERINE; PROTEIN BCL 2; TERT BUTYL HYDROPEROXIDE; THIOL GROUP;

ALKYLATION; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL COMPARTMENTALIZATION; CELL LEVEL; CELL PROTECTION; CELL ULTRASTRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA ALKYLATION; DOSE TIME EFFECT RELATION; DRUG CONJUGATION; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG SENSITIVITY; DRUG STRUCTURE; HUMAN; HUMAN CELL; MYELOMA; MYELOMA CELL; OXIDATIVE STRESS; PRIORITY JOURNAL; THYMOMA;

ALKYLATION; ANTINEOPLASTIC AGENTS; APOPTOSIS; CYSTEINE; DNA; GENE EXPRESSION; GLUTATHIONE; HEXANONES; HUMANS; INHIBITORY CONCENTRATION 50; MULTIPLE MYELOMA; OXIDATIVE STRESS; PROTO-ONCOGENE PROTEINS C-BCL-2; SULFHYDRYL COMPOUNDS; THYMOMA; TUMOR CELLS, CULTURED;

EID: 0034666730     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(00)00380-4     Document Type: Article

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