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Volumn 126, Issue 5, 2016, Pages 1630-1639

Dual targeting of the thioredoxin and glutathione systems in cancer and HIV

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ALPHA TOCOPHEROL; ANTINEOPLASTIC AGENT; ANTIRETROVIRUS AGENT; ASCORBIC ACID; AURANOFIN; BUTHIONINE SULFOXIMINE; CAROTENOID; DEOXYGLUCOSE; DOXORUBICIN; ETOPOSIDE; FLUDARABINE PHOSPHATE; GLUTATHIONE; MELPHALAN; NITRIC OXIDE; NITRIC OXIDE DONOR; RETINOIC ACID; RETINOL; SELENIUM; THIOREDOXIN; VINCRISTINE; ZINC;

EID: 84988515291     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI85339     Document Type: Review
Times cited : (145)

References (135)
  • 2
    • 45049085873 scopus 로고    scopus 로고
    • Redox-based regulation of signal transduction: Principles, pitfalls, and promises
    • Janssen-Heininger YM, et al. Redox-based regulation of signal transduction: principles, pitfalls, and promises. Free Radic Biol Med. 2008;45(1):1-17.
    • (2008) Free Radic Biol Med. , vol.45 , Issue.1 , pp. 1-17
    • Janssen-Heininger, Y.M.1
  • 3
    • 84884179284 scopus 로고    scopus 로고
    • The redox proteome
    • Go YM, Jones DP. The redox proteome. J Biol Chem. 2013;288(37):26512-26520.
    • (2013) J Biol Chem. , vol.288 , Issue.37 , pp. 26512-26520
    • Go, Y.M.1    Jones, D.P.2
  • 4
    • 33845428642 scopus 로고    scopus 로고
    • Thioredoxin and related molecules - From biology to health and disease
    • Lillig CH, Holmgren A. Thioredoxin and related molecules - from biology to health and disease. Antioxid Redox Signal. 2007;9(1):25-47.
    • (2007) Antioxid Redox Signal , vol.9 , Issue.1 , pp. 25-47
    • Lillig, C.H.1    Holmgren, A.2
  • 5
    • 84875700217 scopus 로고    scopus 로고
    • Protein glutathionylation in health and disease
    • Ghezzi P. Protein glutathionylation in health and disease. Biochim Biophys Acta. 2013;1830(5):3165-3172.
    • (2013) Biochim Biophys Acta , vol.1830 , Issue.5 , pp. 3165-3172
    • Ghezzi, P.1
  • 6
    • 84866601999 scopus 로고    scopus 로고
    • Glutathione synthesis and its role in redox signaling
    • Zhang H, Forman HJ. Glutathione synthesis and its role in redox signaling. Semin Cell Dev Biol. 2012;23(7):722-728.
    • (2012) Semin Cell Dev Biol. , vol.23 , Issue.7 , pp. 722-728
    • Zhang, H.1    Forman, H.J.2
  • 7
    • 70349466515 scopus 로고    scopus 로고
    • Protein denitrosylation: Enzymatic mechanisms and cellular functions
    • Benhar M, Forrester MT, Stamler JS. Protein denitrosylation: enzymatic mechanisms and cellular functions. Nat Rev Mol Cell Biol. 2009;10(10):721-732.
    • (2009) Nat Rev Mol Cell Biol. , vol.10 , Issue.10 , pp. 721-732
    • Benhar, M.1    Forrester, M.T.2    Stamler, J.S.3
  • 8
    • 78549288556 scopus 로고    scopus 로고
    • Loss of thioredoxin reductase 1 renders tumors highly susceptible to pharmacologic glutathione deprivation
    • Mandal PK, et al. Loss of thioredoxin reductase 1 renders tumors highly susceptible to pharmacologic glutathione deprivation. Cancer Res. 2010;70(22):9505-9514.
    • (2010) Cancer Res. , vol.70 , Issue.22 , pp. 9505-9514
    • Mandal, P.K.1
  • 9
    • 84856219754 scopus 로고    scopus 로고
    • Hepatocyte DNA replication in growing liver requires either glutathione or a single allele of txnrd1
    • Prigge JR, et al. Hepatocyte DNA replication in growing liver requires either glutathione or a single allele of txnrd1. Free Radic Biol Med. 2012;52(4):803-810.
    • (2012) Free Radic Biol Med. , vol.52 , Issue.4 , pp. 803-810
    • Prigge, J.R.1
  • 10
    • 84941247999 scopus 로고    scopus 로고
    • Human CD4+ T cells require exogenous cystine for glutathione and DNA synthesis
    • Levring TB, et al. Human CD4+ T cells require exogenous cystine for glutathione and DNA synthesis. Oncotarget. 2015;6(26):21853-21864.
    • (2015) Oncotarget , vol.6 , Issue.26 , pp. 21853-21864
    • Levring, T.B.1
  • 11
    • 84868328588 scopus 로고    scopus 로고
    • Glutathione and glutaredoxin act as a backup of human thioredoxin reductase 1 to reduce thioredoxin 1 preventing cell death by aurothioglucose
    • Du Y, Zhang H, Lu J, Holmgren A. Glutathione and glutaredoxin act as a backup of human thioredoxin reductase 1 to reduce thioredoxin 1 preventing cell death by aurothioglucose. J Biol Chem. 2012;287(45):38210-38219.
    • (2012) J Biol Chem , vol.287 , Issue.45 , pp. 38210-38219
    • Du, Y.1    Zhang, H.2    Lu, J.3    Holmgren, A.4
  • 12
    • 77957315403 scopus 로고    scopus 로고
    • Redox compartmentalization and cellular stress
    • Jones DP, Go YM. Redox compartmentalization and cellular stress. Diabetes Obes Metab. 2010;12(suppl 2):116-125.
    • (2010) Diabetes Obes Metab. , vol.12 , pp. 116-125
    • Jones, D.P.1    Go, Y.M.2
  • 13
    • 84887114785 scopus 로고    scopus 로고
    • Selective targeting of the cysteine proteome by thioredoxin and glutathione redox systems
    • Go YM, et al. Selective targeting of the cysteine proteome by thioredoxin and glutathione redox systems. Mol Cell Proteomics. 2013;12(11):3285-3296.
    • (2013) Mol Cell Proteomics , vol.12 , Issue.11 , pp. 3285-3296
    • Go, Y.M.1
  • 14
    • 84900498924 scopus 로고    scopus 로고
    • Thioredoxin-related protein of 14 kDa is an efficient L-cystine reductase and S-denitrosylase
    • Pader I, et al. Thioredoxin-related protein of 14 kDa is an efficient L-cystine reductase and S-denitrosylase. Proc Natl Acad Sci U S A. 2014;111(19):6964-6969.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , Issue.19 , pp. 6964-6969
    • Pader, I.1
  • 15
    • 84942358036 scopus 로고    scopus 로고
    • Nitric oxide and the thioredoxin system: A complex interplay in redox regulation
    • Benhar M. Nitric oxide and the thioredoxin system: A complex interplay in redox regulation. Biochim Biophys Acta. 2015;1850(12):2476-2484.
    • (2015) Biochim Biophys Acta , vol.1850 , Issue.12 , pp. 2476-2484
    • Benhar, M.1
  • 16
    • 84892366219 scopus 로고    scopus 로고
    • The thioredoxin antioxidant system
    • Lu J, Holmgren A. The thioredoxin antioxidant system. Free Radic Biol Med. 2014;66:75-87.
    • (2014) Free Radic Biol Med , vol.66 , pp. 75-87
    • Lu, J.1    Holmgren, A.2
  • 17
    • 84886587812 scopus 로고    scopus 로고
    • Quantitative redox biology: An approach to understand the role of reactive species in defining the cellular redox environment
    • Buettner GR, Wagner BA, Rodgers VG. Quantitative redox biology: an approach to understand the role of reactive species in defining the cellular redox environment. Cell Biochem Biophys. 2013;67(2):477-483.
    • (2013) Cell Biochem Biophys , vol.67 , Issue.2 , pp. 477-483
    • Buettner, G.R.1    Wagner, B.A.2    Rodgers, V.G.3
  • 18
    • 77954935933 scopus 로고    scopus 로고
    • A model of redox kinetics implicates the thiol proteome in cellular hydrogen peroxide responses
    • Adimora NJ, Jones DP, Kemp ML. A model of redox kinetics implicates the thiol proteome in cellular hydrogen peroxide responses. Antioxid Redox Signal. 2010;13(6):731-743.
    • (2010) Antioxid Redox Signal , vol.13 , Issue.6 , pp. 731-743
    • Adimora, N.J.1    Jones, D.P.2    Kemp, M.L.3
  • 19
    • 84875147636 scopus 로고    scopus 로고
    • Redox regulation of T-cell function: From molecular mechanisms to significance in human health and disease
    • Kesarwani P, Murali AK, Al-Khami AA, Mehrotra S. Redox regulation of T-cell function: from molecular mechanisms to significance in human health and disease. Antioxid Redox Signal. 2013;18(12):1497-1534.
    • (2013) Antioxid Redox Signal , vol.18 , Issue.12 , pp. 1497-1534
    • Kesarwani, P.1    Murali, A.K.2    Al-Khami, A.A.3    Mehrotra, S.4
  • 21
    • 84927924524 scopus 로고    scopus 로고
    • Redox regulation of T-cell receptor signaling
    • Simeoni L, Bogeski I. Redox regulation of T-cell receptor signaling. Biol Chem. 2015;396(5):555-568.
    • (2015) Biol Chem , vol.396 , Issue.5 , pp. 555-568
    • Simeoni, L.1    Bogeski, I.2
  • 22
    • 38449118436 scopus 로고    scopus 로고
    • The requirement of reversible cysteine sulfenic acid formation for T cell activation and function
    • Michalek RD, et al. The requirement of reversible cysteine sulfenic acid formation for T cell activation and function. J Immunol. 2007;179(10):6456-6467.
    • (2007) J Immunol , vol.179 , Issue.10 , pp. 6456-6467
    • Michalek, R.D.1
  • 23
    • 84867871087 scopus 로고    scopus 로고
    • Redox control of cell proliferation
    • Chiu J, Dawes IW. Redox control of cell proliferation. Trends Cell Biol. 2012;22(11):592-601.
    • (2012) Trends Cell Biol , vol.22 , Issue.11 , pp. 592-601
    • Chiu, J.1    Dawes, I.W.2
  • 24
    • 77956300467 scopus 로고    scopus 로고
    • Redox remodeling allows and controls B-cell activation and differentiation
    • Vené R, et al. Redox remodeling allows and controls B-cell activation and differentiation. Antioxid Redox Signal. 2010;13(8):1145-1155.
    • (2010) Antioxid Redox Signal , vol.13 , Issue.8 , pp. 1145-1155
    • Vené, R.1
  • 25
    • 33845432813 scopus 로고    scopus 로고
    • Contribution of thioredoxin reductase to T-cell mitogenesis and NF-kappaB DNA-binding promoted by selenite
    • Ueno H, Kajihara H, Nakamura H, Yodoi J, Nakamuro K. Contribution of thioredoxin reductase to T-cell mitogenesis and NF-kappaB DNA-binding promoted by selenite. Antioxid Redox Signal. 2007;9(1):115-121.
    • (2007) Antioxid Redox Signal , vol.9 , Issue.1 , pp. 115-121
    • Ueno, H.1    Kajihara, H.2    Nakamura, H.3    Yodoi, J.4    Nakamuro, K.5
  • 26
    • 84891751192 scopus 로고    scopus 로고
    • A candidate anti-HIV reservoir compound, auranofin, exerts a selective anti-memory effect by exploiting the baseline oxidative status of lymphocytes
    • Chirullo B, et al. A candidate anti-HIV reservoir compound, auranofin, exerts a selective 'anti-memory' effect by exploiting the baseline oxidative status of lymphocytes. Cell Death Dis. 2013;4:e944.
    • (2013) Cell Death Dis. , vol.4 , pp. e944
    • Chirullo, B.1
  • 27
    • 79960014190 scopus 로고    scopus 로고
    • Gold drug auranofin restricts the viral reservoir in the monkey AIDS model and induces containment of viral load following ART suspension
    • Lewis MG, et al. Gold drug auranofin restricts the viral reservoir in the monkey AIDS model and induces containment of viral load following ART suspension. AIDS. 2011;25(11):1347-1356.
    • (2011) AIDS , vol.25 , Issue.11 , pp. 1347-1356
    • Lewis, M.G.1
  • 28
    • 0037022345 scopus 로고    scopus 로고
    • Antigen-presenting dendritic cells provide the reducing extracellular microenvironment required for T lymphocyte activation
    • Angelini G, et al. Antigen-presenting dendritic cells provide the reducing extracellular microenvironment required for T lymphocyte activation. Proc Natl Acad Sci U S A. 2002;99(3):1491-1496.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , Issue.3 , pp. 1491-1496
    • Angelini, G.1
  • 29
    • 70349314830 scopus 로고    scopus 로고
    • Extracellular redox modulation by regulatory T cells
    • Yan Z, Garg SK, Kipnis J, Banerjee R. Extracellular redox modulation by regulatory T cells. Nat Chem Biol. 2009;5(10):721-723.
    • (2009) Nat Chem Biol. , vol.5 , Issue.10 , pp. 721-723
    • Yan, Z.1    Garg, S.K.2    Kipnis, J.3    Banerjee, R.4
  • 30
    • 84859739753 scopus 로고    scopus 로고
    • + T cells express transporters for both cysteine and cystine
    • Levring TB, et al. Activated human CD4+ T cells express transporters for both cysteine and cystine. Sci Rep. 2012;2:266.
    • (2012) Sci Rep. , vol.2 , pp. 266
    • Levring, T.B.1
  • 31
    • 0024426194 scopus 로고
    • Cell cycle progression of glutathione-depleted human peripheral blood mononuclear cells is inhibited at S phase
    • Messina JP, Lawrence DA. Cell cycle progression of glutathione-depleted human peripheral blood mononuclear cells is inhibited at S phase. J Immunol. 1989;143(6):1974-1981.
    • (1989) J Immunol. , vol.143 , Issue.6 , pp. 1974-1981
    • Messina, J.P.1    Lawrence, D.A.2
  • 32
    • 84884179149 scopus 로고    scopus 로고
    • Causes and consequences of cysteine S-glutathionylation
    • Grek CL, Zhang J, Manevich Y, Townsend DM, Tew KD. Causes and consequences of cysteine S-glutathionylation. J Biol Chem. 2013;288(37):26497-26504.
    • (2013) J Biol Chem. , vol.288 , Issue.37 , pp. 26497-26504
    • Grek, C.L.1    Zhang, J.2    Manevich, Y.3    Townsend, D.M.4    Tew, K.D.5
  • 33
    • 84884194110 scopus 로고    scopus 로고
    • Regulation of protein function and signaling by reversible cysteine S-nitrosylation
    • Gould N, Doulias PT, Tenopoulou M, Raju K, Ischiropoulos H. Regulation of protein function and signaling by reversible cysteine S-nitrosylation. J Biol Chem. 2013;288(37):26473-26479.
    • (2013) J Biol Chem. , vol.288 , Issue.37 , pp. 26473-26479
    • Gould, N.1    Doulias, P.T.2    Tenopoulou, M.3    Raju, K.4    Ischiropoulos, H.5
  • 34
    • 0027437490 scopus 로고
    • The interaction of auranofin and buthionine sulfoximine blocks activation of human peripheral T lymphocytes
    • Vint IA, Chain BM, Foreman JC. The interaction of auranofin and buthionine sulfoximine blocks activation of human peripheral T lymphocytes. Cell Immunol. 1993;152(1):152-161.
    • (1993) Cell Immunol , vol.152 , Issue.1 , pp. 152-161
    • Vint, I.A.1    Chain, B.M.2    Foreman, J.C.3
  • 35
    • 84937682389 scopus 로고    scopus 로고
    • Two-year follow-up of macaques developing intermittent control of the human immunodeficiency virus homolog simian immunodeficiency virus SIVmac251 in the chronic phase of infection
    • Shytaj IL, et al. Two-year follow-up of macaques developing intermittent control of the human immunodeficiency virus homolog simian immunodeficiency virus SIVmac251 in the chronic phase of infection. J Virol. 2015;89(15):7521-7535.
    • (2015) J Virol , vol.89 , Issue.15 , pp. 7521-7535
    • Shytaj, I.L.1
  • 36
    • 84922056020 scopus 로고    scopus 로고
    • The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells
    • Lanna A, Henson SM, Escors D, Akbar AN. The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells. Nat Immunol. 2014;15(10):965-972.
    • (2014) Nat Immunol , vol.15 , Issue.10 , pp. 965-972
    • Lanna, A.1    Henson, S.M.2    Escors, D.3    Akbar, A.N.4
  • 37
    • 84924228289 scopus 로고    scopus 로고
    • Nitric oxide synthase in innate and adaptive immunity: An update
    • Bogdan C. Nitric oxide synthase in innate and adaptive immunity: an update. Trends Immunol. 2015;36(3):161-178.
    • (2015) Trends Immunol , vol.36 , Issue.3 , pp. 161-178
    • Bogdan, C.1
  • 38
    • 0028658374 scopus 로고
    • Nitric oxide produced by human B lymphocytes inhibits apoptosis and Epstein-Barr virus reactivation
    • Mannick JB, Asano K, Izumi K, Kieff E, Stamler JS. Nitric oxide produced by human B lymphocytes inhibits apoptosis and Epstein-Barr virus reactivation. Cell. 1994;79(7):1137-1146.
    • (1994) Cell , vol.79 , Issue.7 , pp. 1137-1146
    • Mannick, J.B.1    Asano, K.2    Izumi, K.3    Kieff, E.4    Stamler, J.S.5
  • 39
    • 33744972519 scopus 로고    scopus 로고
    • Endothelial nitric oxide synthase regulates T cell receptor signaling at the immunological synapse
    • Ibiza S, et al. Endothelial nitric oxide synthase regulates T cell receptor signaling at the immunological synapse. Immunity. 2006;24(6):753-765.
    • (2006) Immunity , vol.24 , Issue.6 , pp. 753-765
    • Ibiza, S.1
  • 40
    • 48749099188 scopus 로고    scopus 로고
    • Endothelial nitric oxide synthase regulates N-Ras activation on the Golgi complex of antigen-stimulated T cells
    • Ibiza S, et al. Endothelial nitric oxide synthase regulates N-Ras activation on the Golgi complex of antigen-stimulated T cells. Proc Natl Acad Sci U S A. 2008;105(30):10507-10512.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , Issue.30 , pp. 10507-10512
    • Ibiza, S.1
  • 41
    • 44449119080 scopus 로고    scopus 로고
    • Regulated protein denitrosylation by cytosolic and mitochondrial thioredoxins
    • Benhar M, Forrester MT, Hess DT, Stamler JS. Regulated protein denitrosylation by cytosolic and mitochondrial thioredoxins. Science. 2008;320(5879):1050-1054.
    • (2008) Science , vol.320 , Issue.5879 , pp. 1050-1054
    • Benhar, M.1    Forrester, M.T.2    Hess, D.T.3    Stamler, J.S.4
  • 42
    • 10744230465 scopus 로고    scopus 로고
    • Essential roles of S-nitrosothiols in vascular homeostasis and endotoxic shock
    • Liu L, et al. Essential roles of S-nitrosothiols in vascular homeostasis and endotoxic shock. Cell. 2004;116(4):617-628.
    • (2004) Cell , vol.116 , Issue.4 , pp. 617-628
    • Liu, L.1
  • 43
    • 0035984912 scopus 로고    scopus 로고
    • ROS, stress-activated kinases and stress signaling in cancer
    • Benhar M, Engelberg D, Levitzki A. ROS, stress-activated kinases and stress signaling in cancer. EMBO Rep. 2002;3(5):420-425.
    • (2002) EMBO Rep. , vol.3 , Issue.5 , pp. 420-425
    • Benhar, M.1    Engelberg, D.2    Levitzki, A.3
  • 44
    • 77955274524 scopus 로고    scopus 로고
    • Redox metabolism and malignancy
    • Grek CL, Tew KD. Redox metabolism and malignancy. Curr Opin Pharmacol. 2010;10(4):362-368.
    • (2010) Curr Opin Pharmacol , vol.10 , Issue.4 , pp. 362-368
    • Grek, C.L.1    Tew, K.D.2
  • 45
    • 84887621539 scopus 로고    scopus 로고
    • Redox molecular machines involved in tumor progression
    • Parri M, Chiarugi P. Redox molecular machines involved in tumor progression. Antioxid Redox Signal. 2013;19(15):1828-1845.
    • (2013) Antioxid Redox Signal , vol.19 , Issue.15 , pp. 1828-1845
    • Parri, M.1    Chiarugi, P.2
  • 46
    • 84886023236 scopus 로고    scopus 로고
    • Redox imbalance and biochemical changes in cancer
    • Jorgenson TC, Zhong W, Oberley TD. Redox imbalance and biochemical changes in cancer. Cancer Res. 2013;73(20):6118-6123.
    • (2013) Cancer Res. , vol.73 , Issue.20 , pp. 6118-6123
    • Jorgenson, T.C.1    Zhong, W.2    Oberley, T.D.3
  • 47
    • 84894031033 scopus 로고    scopus 로고
    • Inflammation, DAMPs, tumor development, and progression: A vicious circle orchestrated by redox signaling
    • Castellani P, Balza E, Rubartelli A. Inflammation, DAMPs, tumor development, and progression: a vicious circle orchestrated by redox signaling. Antioxid Redox Signal. 2014;20(7):1086-1097.
    • (2014) Antioxid Redox Signal , vol.20 , Issue.7 , pp. 1086-1097
    • Castellani, P.1    Balza, E.2    Rubartelli, A.3
  • 48
  • 49
    • 0034011261 scopus 로고    scopus 로고
    • Oxyradicals and DNA damage
    • Marnett LJ. Oxyradicals and DNA damage. Carcinogenesis. 2000;21(3):361-370.
    • (2000) Carcinogenesis , vol.21 , Issue.3 , pp. 361-370
    • Marnett, L.J.1
  • 51
    • 67650071137 scopus 로고    scopus 로고
    • Targeting cancer cells by ROS-mediated mechanisms: A radical therapeutic approach?
    • Trachootham D, Alexandre J, Huang P. Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? Nat Rev Drug Discov. 2009;8(7):579-591.
    • (2009) Nat Rev Drug Discov. , vol.8 , Issue.7 , pp. 579-591
    • Trachootham, D.1    Alexandre, J.2    Huang, P.3
  • 52
    • 84889575198 scopus 로고    scopus 로고
    • Modulation of oxidative stress as an anticancer strategy
    • Gorrini C, Harris IS, Mak TW. Modulation of oxidative stress as an anticancer strategy. Nat Rev Drug Discov. 2013;12(12):931-947.
    • (2013) Nat Rev Drug Discov. , vol.12 , Issue.12 , pp. 931-947
    • Gorrini, C.1    Harris, I.S.2    Mak, T.W.3
  • 53
    • 84908153270 scopus 로고    scopus 로고
    • Targeting antioxidants for cancer therapy
    • Glasauer A, Chandel NS. Targeting antioxidants for cancer therapy. Biochem Pharmacol. 2014;92(1):90-101.
    • (2014) Biochem Pharmacol , vol.92 , Issue.1 , pp. 90-101
    • Glasauer, A.1    Chandel, N.S.2
  • 54
    • 10344238570 scopus 로고    scopus 로고
    • α-Tocopherol and β-carotene supplements and lung cancer incidence in the α-tocopherol, β-carotene cancer prevention study: Effects of base-line characteristics and study compliance
    • Albanes D, et al. α-Tocopherol and β-carotene supplements and lung cancer incidence in the α-tocopherol, β-carotene cancer prevention study: effects of base-line characteristics and study compliance. J Natl Cancer Inst. 1996;88(21):1560-1570.
    • (1996) J Natl Cancer Inst. , vol.88 , Issue.21 , pp. 1560-1570
    • Albanes, D.1
  • 55
    • 9244262406 scopus 로고    scopus 로고
    • Effects of a combination of beta carotene and Vitamin A on lung cancer and cardiovascular disease
    • Omenn GS, et al. Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. N Engl J Med. 1996;334(18):1150-1155.
    • (1996) N Engl J Med. , vol.334 , Issue.18 , pp. 1150-1155
    • Omenn, G.S.1
  • 56
    • 84890843927 scopus 로고    scopus 로고
    • Vitamin and mineral supplements in the primary prevention of cardiovascular disease and cancer: An updated systematic evidence review for the U. S Preventive Services Task Force
    • Fortmann SP, Burda BU, Senger CA, Lin JS, Whitlock EP. Vitamin and mineral supplements in the primary prevention of cardiovascular disease and cancer: An updated systematic evidence review for the U.S. Preventive Services Task Force. Ann Intern Med. 2013;159(12):824-834.
    • (2013) Ann Intern Med. , vol.159 , Issue.12 , pp. 824-834
    • Fortmann, S.P.1    Burda, B.U.2    Senger, C.A.3    Lin, J.S.4    Whitlock, E.P.5
  • 57
    • 84946903513 scopus 로고    scopus 로고
    • Oxidative stress inhibits distant metastasis by human melanoma cells
    • Piskounova E, et al. Oxidative stress inhibits distant metastasis by human melanoma cells. Nature. 2015;5 27(7577):186-191.
    • (2015) Nature , vol.527 , Issue.7577 , pp. 186-191
    • Piskounova, E.1
  • 58
    • 84946919734 scopus 로고    scopus 로고
    • Cancer: The enemy of my enemy is my friend
    • Harris IS, Brugge JS. Cancer: The enemy of my enemy is my friend. Nature. 2015;527(7577):170-171.
    • (2015) Nature , vol.527 , Issue.7577 , pp. 170-171
    • Harris, I.S.1    Brugge, J.S.2
  • 59
    • 84949679802 scopus 로고    scopus 로고
    • Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH
    • Yun J, et al. Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH. Science. 2015;350(6266):1391-1396.
    • (2015) Science , vol.350 , Issue.6266 , pp. 1391-1396
    • Yun, J.1
  • 60
    • 0042807630 scopus 로고    scopus 로고
    • The thioredoxin-thioredoxin reductase system: Over-expression in human cancer
    • Lincoln DT, Ali Emadi EM, Tonissen KF, Clarke FM. The thioredoxin-thioredoxin reductase system: over-expression in human cancer. Anticancer Res. 2003;23(3B):2425-2433.
    • (2003) Anticancer Res , vol.23 , Issue.3 B , pp. 2425-2433
    • Lincoln, D.T.1    Ali Emadi, E.M.2    Tonissen, K.F.3    Clarke, F.M.4
  • 61
    • 0033796101 scopus 로고    scopus 로고
    • The role of the redox protein thioredoxin in cell growth and cancer
    • Powis G, Mustacich D, Coon A. The role of the redox protein thioredoxin in cell growth and cancer. Free Radic Biol Med. 2000;29(3-4):312-322.
    • (2000) Free Radic Biol Med. , vol.29 , Issue.3-4 , pp. 312-322
    • Powis, G.1    Mustacich, D.2    Coon, A.3
  • 62
    • 33751178410 scopus 로고    scopus 로고
    • The thioredoxin system in cancer
    • Arnér ES, Holmgren A. The thioredoxin system in cancer. Semin Cancer Biol. 2006;16(6):419.
    • (2006) Semin Cancer Biol. , vol.16 , Issue.6 , pp. 419
    • Arnér, E.S.1    Holmgren, A.2
  • 63
    • 84951572764 scopus 로고    scopus 로고
    • Thioredoxin 1 in prostate tissue is associated with gleason score, erythrocyte antioxidant enzyme activity, and dietary antioxidants
    • Vance TM, et al. Thioredoxin 1 in prostate tissue is associated with gleason score, erythrocyte antioxidant enzyme activity, and dietary antioxidants. Prostate Cancer. 2015;2015:728046.
    • (2015) Prostate Cancer , vol.2015 , pp. 728046
    • Vance, T.M.1
  • 64
    • 84926322394 scopus 로고    scopus 로고
    • Knockout of mitochondrial thioredoxin reductase stabilizes prolyl hydroxylase 2 and inhibits tumor growth and tumorderived angiogenesis
    • Hellfritsch J, et al. Knockout of mitochondrial thioredoxin reductase stabilizes prolyl hydroxylase 2 and inhibits tumor growth and tumorderived angiogenesis. Antioxid Redox Signal. 2015;22(11):938-950.
    • (2015) Antioxid Redox Signal , vol.22 , Issue.11 , pp. 938-950
    • Hellfritsch, J.1
  • 65
    • 84900019686 scopus 로고    scopus 로고
    • Auranofin induces lethal oxidative and endoplasmic reticulum stress and exerts potent preclinical activity against chronic lymphocytic leukemia
    • Fiskus W, et al. Auranofin induces lethal oxidative and endoplasmic reticulum stress and exerts potent preclinical activity against chronic lymphocytic leukemia. Cancer Res. 2014;74(9):2520-2532.
    • (2014) Cancer Res , vol.74 , Issue.9 , pp. 2520-2532
    • Fiskus, W.1
  • 66
    • 84942509797 scopus 로고    scopus 로고
    • Preclinical activity of the repurposed drug auranofin in classical Hodgkin lymphoma
    • Celegato M, et al. Preclinical activity of the repurposed drug auranofin in classical Hodgkin lymphoma. Blood. 2015;126(11):1394-1397.
    • (2015) Blood , vol.126 , Issue.11 , pp. 1394-1397
    • Celegato, M.1
  • 67
    • 3242772761 scopus 로고    scopus 로고
    • Auranofin induces apoptosis and when combined with retinoic acid enhances differentiation of acute promyelocytic leukaemia cells in vitro
    • Kim IS, Jin JY, Lee IH, Park SJ. Auranofin induces apoptosis and when combined with retinoic acid enhances differentiation of acute promyelocytic leukaemia cells in vitro. Br J Pharmacol. 2004;142(4):749-755.
    • (2004) Br J Pharmacol , vol.142 , Issue.4 , pp. 749-755
    • Kim, I.S.1    Jin, J.Y.2    Lee, I.H.3    Park, S.J.4
  • 69
    • 84940036765 scopus 로고    scopus 로고
    • Spatio-temporal changes in glutathione and thioredoxin redox couples during ionizing radiation-induced oxidative stress regulate tumor radio-resistance
    • Patwardhan RS, Sharma D, Checker R, Thoh M, Sandur SK. Spatio-temporal changes in glutathione and thioredoxin redox couples during ionizing radiation-induced oxidative stress regulate tumor radio-resistance. Free Radic Res. 2015;49(10):1218-1232.
    • (2015) Free Radic Res , vol.49 , Issue.10 , pp. 1218-1232
    • Patwardhan, R.S.1    Sharma, D.2    Checker, R.3    Thoh, M.4    Sandur, S.K.5
  • 70
    • 80053506739 scopus 로고    scopus 로고
    • Enhancement of carboplatin-mediated lung cancer cell killing by simultaneous disruption of glutathione and thioredoxin metabolism
    • Fath MA, Ahmad IM, Smith CJ, Spence J, Spitz DR. Enhancement of carboplatin-mediated lung cancer cell killing by simultaneous disruption of glutathione and thioredoxin metabolism. Clin Cancer Res. 2011;17(19):6206-6217.
    • (2011) Clin Cancer Res. , vol.17 , Issue.19 , pp. 6206-6217
    • Fath, M.A.1    Ahmad, I.M.2    Smith, C.J.3    Spence, J.4    Spitz, D.R.5
  • 71
    • 77649290545 scopus 로고    scopus 로고
    • JS-K, a nitric oxide prodrug, has enhanced cytotoxicity in colon cancer cells with knockdown of thioredoxin reductase 1
    • Edes K, Cassidy P, Shami PJ, Moos PJ. JS-K, a nitric oxide prodrug, has enhanced cytotoxicity in colon cancer cells with knockdown of thioredoxin reductase 1. PLoS One. 2010;5(1):e8786.
    • (2010) PLoS One , vol.5 , Issue.1 , pp. e8786
    • Edes, K.1    Cassidy, P.2    Shami, P.J.3    Moos, P.J.4
  • 72
    • 84870342895 scopus 로고    scopus 로고
    • Maintenance of S-nitrosothiol homeostasis plays an important role in growth suppression of estrogen receptor-positive breast tumors
    • Cañas A, et al. Maintenance of S-nitrosothiol homeostasis plays an important role in growth suppression of estrogen receptor-positive breast tumors. Breast Cancer Res. 2012;14(6):R153.
    • (2012) Breast Cancer Res. , vol.14 , Issue.6 , pp. R153
    • Cañas, A.1
  • 73
    • 84988525471 scopus 로고    scopus 로고
    • Auranofin induces a reversible in-vivo stress response that correlates with a transient clinical effect in patients with chronic lymphocytic leukemia
    • Saba NS, et al. Auranofin induces a reversible in-vivo stress response that correlates with a transient clinical effect in patients with chronic lymphocytic leukemia. Blood. 2013;122(21):3819.
    • (2013) Blood , vol.122 , Issue.21 , pp. 3819
    • Saba, N.S.1
  • 74
    • 84907971362 scopus 로고    scopus 로고
    • CUSP9&z.ast; treatment protocol for recurrent glioblastoma: Aprepitant, artesunate, auranofin, captopril, celecoxib, disulfiram, itraconazole, ritonavir, sertraline augmenting continuous low dose temozolomide
    • Kast RE, Karpel-Massler G, Halatsch ME. CUSP9&z.ast; treatment protocol for recurrent glioblastoma: aprepitant, artesunate, auranofin, captopril, celecoxib, disulfiram, itraconazole, ritonavir, sertraline augmenting continuous low dose temozolomide. Oncotarget. 2014;5(18):8052-8082.
    • (2014) Oncotarget , vol.5 , Issue.18 , pp. 8052-8082
    • Kast, R.E.1    Karpel-Massler, G.2    Halatsch, M.E.3
  • 75
    • 84878711134 scopus 로고    scopus 로고
    • Role of glutathione in cancer progression and chemoresistance
    • Traverso N, et al. Role of glutathione in cancer progression and chemoresistance. Oxid Med Cell Longev. 2013;2013:972913.
    • (2013) Oxid Med Cell Longev , vol.2013 , pp. 972913
    • Traverso, N.1
  • 77
    • 84862777168 scopus 로고    scopus 로고
    • Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukaemia
    • Zhang W, et al. Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukaemia. Nat Cell Biol. 2012;14(3):276-286.
    • (2012) Nat Cell Biol. , vol.14 , Issue.3 , pp. 276-286
    • Zhang, W.1
  • 79
    • 79960060305 scopus 로고    scopus 로고
    • Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
    • DeNicola GM, et al. Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis. Nature. 2011;475(7354):106-109.
    • (2011) Nature , vol.475 , Issue.7354 , pp. 106-109
    • DeNicola, G.M.1
  • 80
    • 0029052835 scopus 로고
    • Evidence for altered regulation of gamma-glutamylcysteine synthetase gene expression among cisplatin-sensitive and cisplatin-resistant human ovarian cancer cell lines
    • Yao KS, Godwin AK, Johnson SW, Ozols RF, O'Dwyer PJ, Hamilton TC. Evidence for altered regulation of gamma-glutamylcysteine synthetase gene expression among cisplatin-sensitive and cisplatin-resistant human ovarian cancer cell lines. Cancer Res. 1995;55(19):4367-4374.
    • (1995) Cancer Res. , vol.55 , Issue.19 , pp. 4367-4374
    • Yao, K.S.1    Godwin, A.K.2    Johnson, S.W.3    Ozols, R.F.4    O'Dwyer, P.J.5    Hamilton, T.C.6
  • 81
    • 0642374221 scopus 로고    scopus 로고
    • The role of glutathione-S-transferase in anti-cancer drug resistance
    • Townsend DM, Tew KD. The role of glutathione-S-transferase in anti-cancer drug resistance. Oncogene. 2003;22(47):7369-7375.
    • (2003) Oncogene , vol.22 , Issue.47 , pp. 7369-7375
    • Townsend, D.M.1    Tew, K.D.2
  • 82
    • 77955713764 scopus 로고    scopus 로고
    • Glutathione transferases as mediators of signaling pathways involved in cell proliferation and cell death
    • Laborde E. Glutathione transferases as mediators of signaling pathways involved in cell proliferation and cell death. Cell Death Differ. 2010;17(9):1373-1380.
    • (2010) Cell Death Differ. , vol.17 , Issue.9 , pp. 1373-1380
    • Laborde, E.1
  • 83
    • 84922783167 scopus 로고    scopus 로고
    • Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression
    • Harris IS, et al. Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression. Cancer Cell. 2015;27(2):211-222.
    • (2015) Cancer Cell , vol.27 , Issue.2 , pp. 211-222
    • Harris, I.S.1
  • 84
    • 84875723942 scopus 로고    scopus 로고
    • Glutathione and glutathione analogues; therapeutic potentials
    • Wu JH, Batist G. Glutathione and glutathione analogues; therapeutic potentials. Biochim Biophys Acta. 2013;1830(5):3350-3353.
    • (2013) Biochim Biophys Acta , vol.1830 , Issue.5 , pp. 3350-3353
    • Wu, J.H.1    Batist, G.2
  • 85
    • 9044254931 scopus 로고    scopus 로고
    • Phase I trial of buthionine sulfoximine in combination with melphalan in patients with cancer
    • O'Dwyer PJ, et al. Phase I trial of buthionine sulfoximine in combination with melphalan in patients with cancer. J Clin Oncol. 1996;14(1):249-256.
    • (1996) J Clin Oncol , vol.14 , Issue.1 , pp. 249-256
    • O'Dwyer, P.J.1
  • 86
    • 0030658870 scopus 로고    scopus 로고
    • Phase I study of continuous-infusion L-S,R-buthionine sulfoximine with intravenous melphalan
    • Bailey HH, et al. Phase I study of continuous-infusion L-S,R-buthionine sulfoximine with intravenous melphalan. J Natl Cancer Inst. 1997;89(23):1789-1796.
    • (1997) J Natl Cancer Inst. , vol.89 , Issue.23 , pp. 1789-1796
    • Bailey, H.H.1
  • 87
    • 84939567183 scopus 로고    scopus 로고
    • Pilot study of intravenous melphalan combined with continuous infusion L-S,R-buthionine sulfoximine for children with recurrent neuroblastoma
    • Anderson CP, et al. Pilot study of intravenous melphalan combined with continuous infusion L-S,R-buthionine sulfoximine for children with recurrent neuroblastoma. Pediatr Blood Cancer. 2015;62(10):1739-1746.
    • (2015) Pediatr Blood Cancer , vol.62 , Issue.10 , pp. 1739-1746
    • Anderson, C.P.1
  • 88
    • 23444435104 scopus 로고    scopus 로고
    • Inhibition of thioredoxin reductase but not of glutathione reductase by the major classes of alkylating and platinum-containing anticancer compounds
    • Witte AB, Anestål K, Jerremalm E, Ehrsson H, Arnér ES. Inhibition of thioredoxin reductase but not of glutathione reductase by the major classes of alkylating and platinum-containing anticancer compounds. Free Radic Biol Med. 2005;39(5):696-703.
    • (2005) Free Radic Biol Med. , vol.39 , Issue.5 , pp. 696-703
    • Witte, A.B.1    Anestål, K.2    Jerremalm, E.3    Ehrsson, H.4    Arnér, E.S.5
  • 89
    • 84925016308 scopus 로고    scopus 로고
    • Dual targeting of the thioredoxin and glutathione antioxidant systems in malignant B cells: A novel synergistic therapeutic approach
    • Kiebala M, et al. Dual targeting of the thioredoxin and glutathione antioxidant systems in malignant B cells: a novel synergistic therapeutic approach. Exp Hematol. 2015;43(2):89-99.
    • (2015) Exp Hematol , vol.43 , Issue.2 , pp. 89-99
    • Kiebala, M.1
  • 90
    • 67649800278 scopus 로고    scopus 로고
    • Molecular mechanisms of thioredoxin and glutaredoxin as hydrogen donors for Mammalian s phase ribonucleotide reductase
    • Zahedi Avval F, Holmgren A. Molecular mechanisms of thioredoxin and glutaredoxin as hydrogen donors for Mammalian s phase ribonucleotide reductase. J Biol Chem. 2009;284(13):8233-8240.
    • (2009) J Biol Chem , vol.284 , Issue.13 , pp. 8233-8240
    • Zahedi Avval, F.1    Holmgren, A.2
  • 91
    • 70349230931 scopus 로고    scopus 로고
    • Inhibition of glutathione and thioredoxin metabolism enhances sensitivity to perifosine in head and neck cancer cells
    • Simons AL, Parsons AD, Foster KA, Orcutt KP, Fath MA, Spitz DR. Inhibition of glutathione and thioredoxin metabolism enhances sensitivity to perifosine in head and neck cancer cells. J Oncol. 2009;2009:519563.
    • (2009) J Oncol , vol.2009 , pp. 519563
    • Simons, A.L.1    Parsons, A.D.2    Foster, K.A.3    Orcutt, K.P.4    Fath, M.A.5    Spitz, D.R.6
  • 92
    • 84868286860 scopus 로고    scopus 로고
    • Susceptibility of human head and neck cancer cells tocombined inhibition of glutathione and thioredoxin metabolism
    • Sobhakumari A, et al. Susceptibility of human head and neck cancer cells tocombined inhibition of glutathione and thioredoxin metabolism. PLoS One. 2012;7(10):e48175.
    • (2012) PLoS One , vol.7 , Issue.10 , pp. e48175
    • Sobhakumari, A.1
  • 93
    • 84855432506 scopus 로고    scopus 로고
    • Simultaneous inhibition of glutathione- and thioredoxindependent metabolism is necessary to potentiate 17AAG-induced cancer cell killing via oxidative stress
    • Scarbrough PM, Mapuskar KA, Mattson DM, Gius D, Watson WH, Spitz DR. Simultaneous inhibition of glutathione- and thioredoxindependent metabolism is necessary to potentiate 17AAG-induced cancer cell killing via oxidative stress. Free Radic Biol Med. 2012;52(2):436-443.
    • (2012) Free Radic Biol Med. , vol.52 , Issue.2 , pp. 436-443
    • Scarbrough, P.M.1    Mapuskar, K.A.2    Mattson, D.M.3    Gius, D.4    Watson, W.H.5    Spitz, D.R.6
  • 94
    • 84937843579 scopus 로고    scopus 로고
    • Redox effects and cytotoxic profiles of MJ25 and auranofin towards malignant melanoma cells
    • Sachweh MC, et al. Redox effects and cytotoxic profiles of MJ25 and auranofin towards malignant melanoma cells. Oncotarget. 2015;6(18):16488-16506.
    • (2015) Oncotarget , vol.6 , Issue.18 , pp. 16488-16506
    • Sachweh, M.C.1
  • 95
    • 84954047445 scopus 로고    scopus 로고
    • Auranofin induces mesothelioma cell death through oxidative stress and GSH depletion
    • You BR, Park WH. Auranofin induces mesothelioma cell death through oxidative stress and GSH depletion. Oncol Rep. 2015;35(1):546-551.
    • (2015) Oncol Rep. , vol.35 , Issue.1 , pp. 546-551
    • You, B.R.1    Park, W.H.2
  • 96
    • 84880096840 scopus 로고    scopus 로고
    • Investigational treatment suspension and enhanced cell-mediated immunity at rebound followed by drug-free remission of simian AIDS
    • Shytaj IL, et al. Investigational treatment suspension and enhanced cell-mediated immunity at rebound followed by drug-free remission of simian AIDS. Retrovirology. 2013;10:71.
    • (2013) Retrovirology , vol.10 , pp. 71
    • Shytaj, I.L.1
  • 97
    • 0032018639 scopus 로고    scopus 로고
    • Glutathione and HIV infection: Reduced, or increased oxidized?
    • Staal FJ. Glutathione and HIV infection: reduced, or increased oxidized? Eur J Clin Invest. 1998;28(3):194-196.
    • (1998) Eur J Clin Invest , vol.28 , Issue.3 , pp. 194-196
    • Staal, F.J.1
  • 98
    • 0025739254 scopus 로고
    • Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1
    • Schreck R, Rieber P, Baeuerle PA. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1. EMBO J. 1991;10(8):2247-2258.
    • (1991) EMBO J. , vol.10 , Issue.8 , pp. 2247-2258
    • Schreck, R.1    Rieber, P.2    Baeuerle, P.A.3
  • 99
    • 0030809090 scopus 로고    scopus 로고
    • Intracellular GSH content and HIV replication in human macrophages
    • Garaci E, et al. Intracellular GSH content and HIV replication in human macrophages. J Leukoc Biol. 1997;62(1):54-59.
    • (1997) J Leukoc Biol. , vol.62 , Issue.1 , pp. 54-59
    • Garaci, E.1
  • 100
  • 101
    • 0032504917 scopus 로고    scopus 로고
    • Effects of Vitamin E and C supplementation on oxidative stress and viral load in HIVinfected subjects
    • Allard JP, et al. Effects of vitamin E and C supplementation on oxidative stress and viral load in HIVinfected subjects. AIDS. 1998;12(13):1653-1659.
    • (1998) AIDS , vol.12 , Issue.13 , pp. 1653-1659
    • Allard, J.P.1
  • 102
    • 0033545464 scopus 로고    scopus 로고
    • Micronutrient supplementation in the AIDS diarrhoea-wasting syndrome in Zambia: A randomized controlled trial
    • Kelly P, Musonda R, Kafwembe E, Kaetano L, Keane E, Farthing M. Micronutrient supplementation in the AIDS diarrhoea-wasting syndrome in Zambia: a randomized controlled trial. AIDS. 1999;13(4):495-500.
    • (1999) AIDS , vol.13 , Issue.4 , pp. 495-500
    • Kelly, P.1    Musonda, R.2    Kafwembe, E.3    Kaetano, L.4    Keane, E.5    Farthing, M.6
  • 103
    • 84906060948 scopus 로고    scopus 로고
    • HIV and noncommunicable disease comorbidities in the era of antiretroviral therapy: A vital agenda for research in low- and middle-income country settings
    • Narayan KM, et al. HIV and noncommunicable disease comorbidities in the era of antiretroviral therapy: a vital agenda for research in low- and middle-income country settings. J Acquir Immune Defic Syndr. 2014;67(suppl 1):S2-S7.
    • (2014) J Acquir Immune Defic Syndr , vol.67 , pp. S2-S7
    • Narayan, K.M.1
  • 105
    • 0032953920 scopus 로고    scopus 로고
    • Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy
    • Finzi D, et al. Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy. Nat Med. 1999;5(5):512-517.
    • (1999) Nat Med. , vol.5 , Issue.5 , pp. 512-517
    • Finzi, D.1
  • 106
    • 0029863314 scopus 로고    scopus 로고
    • Activation of the HIV long terminal repeat and viral production by H2O2-vanadate
    • Kazazi F, Koehler JK, Klebanoff SJ. Activation of the HIV long terminal repeat and viral production by H2O2-vanadate. Free Radic Biol Med. 1996;20(6):813-820.
    • (1996) Free Radic Biol Med. , vol.20 , Issue.6 , pp. 813-820
    • Kazazi, F.1    Koehler, J.K.2    Klebanoff, S.J.3
  • 107
    • 0026030449 scopus 로고
    • Suppression of human immunodeficiency virus expression in chronically infected monocytic cells by glutathione, glutathione ester, and N-acetylcysteine
    • Kalebic T, Kinter A, Poli G, Anderson ME, Meister A, Fauci AS. Suppression of human immunodeficiency virus expression in chronically infected monocytic cells by glutathione, glutathione ester, and N-acetylcysteine. Proc Natl Acad Sci U S A. 1991;88(3):986-990.
    • (1991) Proc Natl Acad Sci U S A , vol.88 , Issue.3 , pp. 986-990
    • Kalebic, T.1    Kinter, A.2    Poli, G.3    Anderson, M.E.4    Meister, A.5    Fauci, A.S.6
  • 109
    • 0028988078 scopus 로고
    • NF-κB transcription factor and human immunodeficiency virus type 1 (HIV-1) activation by methylene blue photosensitization
    • Piret B, Legrand-Poels S, Sappey C, Piette J. NF-κB transcription factor and human immunodeficiency virus type 1 (HIV-1) activation by methylene blue photosensitization. Eur J Biochem. 1995;228(2):447-455.
    • (1995) Eur J Biochem , vol.228 , Issue.2 , pp. 447-455
    • Piret, B.1    Legrand-Poels, S.2    Sappey, C.3    Piette, J.4
  • 110
    • 59449101108 scopus 로고    scopus 로고
    • Induction of HIV-1 latency and reactivation in primary memory CD4+ T cells
    • Bosque A, Planelles V. Induction of HIV-1 latency and reactivation in primary memory CD4+ T cells. Blood. 2009;113(1):58-65.
    • (2009) Blood , vol.113 , Issue.1 , pp. 58-65
    • Bosque, A.1    Planelles, V.2
  • 111
    • 84910624272 scopus 로고    scopus 로고
    • Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p65
    • Shinozaki S, et al. Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p65. Sci Signal. 2014;7(351):ra106.
    • (2014) Sci Signal. , vol.7 , Issue.351 , pp. 106
    • Shinozaki, S.1
  • 113
    • 0344980379 scopus 로고    scopus 로고
    • Nitric oxide modulates HIV-1 replication
    • Mannick JB, et al. Nitric oxide modulates HIV-1 replication. J Acquir Immune Defic Syndr. 1999;22(1):1-9.
    • (1999) J Acquir Immune Defic Syndr , vol.22 , Issue.1 , pp. 1-9
    • Mannick, J.B.1
  • 114
    • 84931265981 scopus 로고    scopus 로고
    • Apoptosisinduced activation of HIV-1 in latently infected cell lines
    • Khan SZ, Hand N, Zeichner SL. Apoptosisinduced activation of HIV-1 in latently infected cell lines. Retrovirology. 2015;12:42.
    • (2015) Retrovirology , vol.12 , pp. 42
    • Khan, S.Z.1    Hand, N.2    Zeichner, S.L.3
  • 115
    • 0142183455 scopus 로고    scopus 로고
    • B-cell-specific transcription factor BACH2 modifies the cytotoxic effects of anticancer drugs
    • Kamio T, et al. B-cell-specific transcription factor BACH2 modifies the cytotoxic effects of anticancer drugs. Blood. 2003;102(9):3317-3322.
    • (2003) Blood , vol.102 , Issue.9 , pp. 3317-3322
    • Kamio, T.1
  • 117
    • 34347268139 scopus 로고    scopus 로고
    • Involvement of reactive oxygen species in multidrug resistance of a vincristine-selected lymphoblastoma
    • Tsai SY, Sun NK, Lu HP, Cheng ML, Chao CC. Involvement of reactive oxygen species in multidrug resistance of a vincristine-selected lymphoblastoma. Cancer Sci. 2007;98(8):1206-1214.
    • (2007) Cancer Sci. , vol.98 , Issue.8 , pp. 1206-1214
    • Tsai, S.Y.1    Sun, N.K.2    Lu, H.P.3    Cheng, M.L.4    Chao, C.C.5
  • 118
    • 67649259174 scopus 로고    scopus 로고
    • Shock and kill effects of class I-selective histone deacetylase inhibitors in combination with the glutathione synthesis inhibitor buthionine sulfoximine in cell line models for HIV-1 quiescence
    • Savarino A, et al. "Shock and kill" effects of class I-selective histone deacetylase inhibitors in combination with the glutathione synthesis inhibitor buthionine sulfoximine in cell line models for HIV-1 quiescence. Retrovirology. 2009;6:52.
    • (2009) Retrovirology , vol.6 , pp. 52
    • Savarino, A.1
  • 119
    • 60549090253 scopus 로고    scopus 로고
    • Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation
    • Hütter G, et al. Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation. N Engl J Med. 2009;360(7):692-698.
    • (2009) N Engl J Med. , vol.360 , Issue.7 , pp. 692-698
    • Hütter, G.1
  • 120
    • 77954633050 scopus 로고    scopus 로고
    • HIV persistence and the prospect of long-term drug-free remissions forHIV-infected individuals
    • Trono D, et al. HIV persistence and the prospect of long-term drug-free remissions forHIV-infected individuals. Science. 2010;329(5988):174-180.
    • (2010) Science , vol.329 , Issue.5988 , pp. 174-180
    • Trono, D.1
  • 122
    • 84935914891 scopus 로고    scopus 로고
    • Chloroquine and beyond: Exploring anti-rheumatic drugs to reduce immune hyperactivation in HIV/AIDS
    • Savarino A, Shytaj IL. Chloroquine and beyond: exploring anti-rheumatic drugs to reduce immune hyperactivation in HIV/AIDS. Retrovirology. 2015;12:51.
    • (2015) Retrovirology , vol.12 , pp. 51
    • Savarino, A.1    Shytaj, I.L.2
  • 124
    • 33847258674 scopus 로고    scopus 로고
    • Discovery and development of SAHA as an anticancer agent
    • Marks PA. Discovery and development of SAHA as an anticancer agent. Oncogene. 2007;26(9):1351-1356.
    • (2007) Oncogene , vol.26 , Issue.9 , pp. 1351-1356
    • Marks, P.A.1
  • 125
    • 19044394312 scopus 로고    scopus 로고
    • Overview of ribonucleotide reductase inhibitors: An appealing target in anti-tumour therapy
    • Cerqueira NM, Pereira S, Fernandes PA, Ramos MJ. Overview of ribonucleotide reductase inhibitors: an appealing target in anti-tumour therapy. Curr Med Chem. 2005;12(11):1283-1294.
    • (2005) Curr Med Chem , vol.12 , Issue.11 , pp. 1283-1294
    • Cerqueira, N.M.1    Pereira, S.2    Fernandes, P.A.3    Ramos, M.J.4
  • 126
    • 0032785432 scopus 로고    scopus 로고
    • Effects of nitric oxide on the induction and differentiation of Th1 cells
    • Niedbala W, Wei XQ, Piedrafita D, Xu D, Liew FY. Effects of nitric oxide on the induction and differentiation of Th1 cells. Eur J Immunol. 1999;29(8):2498-2505.
    • (1999) Eur J Immunol , vol.29 , Issue.8 , pp. 2498-2505
    • Niedbala, W.1    Wei, X.Q.2    Piedrafita, D.3    Xu, D.4    Liew, F.Y.5
  • 127
    • 79959566034 scopus 로고    scopus 로고
    • + regulatory T cell differentiation and potentiate Th1 development
    • Lee SW, Choi H, Eun SY, Fukuyama S, Croft M. Nitric oxide modulates TGF-β-directive signals to suppress Foxp3+ regulatory T cell differentiation and potentiate Th1 development. J Immunol. 2011;186(12):6972-6980.
    • (2011) J Immunol , vol.186 , Issue.12 , pp. 6972-6980
    • Lee, S.W.1    Choi, H.2    Eun, S.Y.3    Fukuyama, S.4    Croft, M.5
  • 128
    • 4344625883 scopus 로고    scopus 로고
    • A critical role of glutathione in determining apoptosis sensitivity and resistance in leukemia cells
    • Friesen C, Kiess Y, Debatin KM. A critical role of glutathione in determining apoptosis sensitivity and resistance in leukemia cells. Cell Death Differ. 2004;11(suppl 1):S73-S85.
    • (2004) Cell Death Differ. , vol.11 , pp. S73-S85
    • Friesen, C.1    Kiess, Y.2    Debatin, K.M.3
  • 129
    • 84928718905 scopus 로고    scopus 로고
    • Post-treatment control of HIV infection
    • Conway JM, Perelson AS. Post-treatment control of HIV infection. Proc Natl Acad Sci U S A. 2015;112(17):5467-5472.
    • (2015) Proc Natl Acad Sci U S A , vol.112 , Issue.17 , pp. 5467-5472
    • Conway, J.M.1    Perelson, A.S.2
  • 130
    • 84942369533 scopus 로고    scopus 로고
    • Cell-mediated anti-Gag immunity in pharmacologically induced functional cure of simian AIDS: A 'bottleneck effect'?
    • Shytaj IL, Savarino A. Cell-mediated anti-Gag immunity in pharmacologically induced functional cure of simian AIDS: a 'bottleneck effect'? J Med Primatol. 2015;44(5):227-240.
    • (2015) J Med Primatol , vol.44 , Issue.5 , pp. 227-240
    • Shytaj, I.L.1    Savarino, A.2
  • 131
    • 84922764937 scopus 로고    scopus 로고
    • Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations
    • Deng K, et al. Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations. Nature. 2015;517(7534):381-385.
    • (2015) Nature , vol.517 , Issue.7534 , pp. 381-385
    • Deng, K.1
  • 132
    • 79953272280 scopus 로고    scopus 로고
    • Human immunodeficiency virus infection and hodgkin's Lymphoma in South Africa: An emerging problem
    • Patel M, Philip V, Fazel F. Human Immunodeficiency Virus Infection and Hodgkin's Lymphoma in South Africa: an emerging problem. Adv Hematol. 2011;2011:578163.
    • (2011) Adv Hematol , vol.2011 , pp. 578163
    • Patel, M.1    Philip, V.2    Fazel, F.3
  • 133
    • 84896701770 scopus 로고    scopus 로고
    • Malignancies in South African children with HIV
    • Davidson A, et al. Malignancies in South African children with HIV. J Pediatr Hematol Oncol. 2014;36(2):111-117.
    • (2014) J Pediatr Hematol Oncol , vol.36 , Issue.2 , pp. 111-117
    • Davidson, A.1
  • 134
    • 84864051807 scopus 로고    scopus 로고
    • A highly intensified ART regimen induces long-term viral suppression and restriction of the viral reservoir in a simian AIDS model
    • Shytaj IL, et al. A highly intensified ART regimen induces long-term viral suppression and restriction of the viral reservoir in a simian AIDS model. PLoS Pathog. 2012;8(6):e1002774.
    • (2012) PLoS Pathog , vol.8 , Issue.6 , pp. e1002774
    • Shytaj, I.L.1
  • 135
    • 84866150865 scopus 로고    scopus 로고
    • Nonhuman primate models for HIV cure research
    • Apetrei C, Pandrea I, Mellors JW. Nonhuman primate models for HIV cure research. PLoS Pathog. 2012;8(8):e1002892.
    • (2012) PLoS Pathog , vol.8 , Issue.8 , pp. e1002892
    • Apetrei, C.1    Pandrea, I.2    Mellors, J.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.