PABA/NO as an anticancer lead: Analogue synthesis, structure revision, solution chemistry, reactivity toward glutathione, and in vitro activity

Journal of Medicinal Chemistry

Volumn 49, Issue 3, 2006, Pages 1157-1164

  Saavedra, Joseph E ^a   Srinivasan, Aloka ^a   Buzard, Gregory S ^a   Davies, Keith M ^b   Waterhouse, David J ^a   Inami, Keiko ^a   Wilde, Thomas C ^a   Citro, Michael L ^a   Cuellar, Matthew ^a   Deschamps, Jeffrey R ^c   Parrish, Damon ^c   Shami, Paul J ^d   Findlay, Victoria J ^e   Townsend, Danyelle M ^e   Tew, Kenneth D ^e   Singh, Shivendra ^f   Jia, Lee ^g   Ji, Xinhua ^a   Keefer, Larry K ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b GEORGE MASON UNIVERSITY   (United States)

^c NAVAL RESEARCH LABORATORY   (United States)

^d UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^e MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^f UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^g NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 O [2,4 DINITRO 5 (3 CARBOXYLATOPHENYL)AMINO]PHENYL 1 (N,N DIMETHYLAMINO)DIAZEN 1 IUM 1,2 DIOLATE; 2 O [2,4 DINITRO 5 (4 CARBOXYLATOPHENYL)AMINO]PHENYL 1 (N,N DIMETHYLAMINO)DIAZEN 1 IUM 1,2 DIOLATE; 2 O [2,4 DINITRO 5 [N (3 CARBOXYLATOPHENYL) N METHYL]AMINO]PHENYL 1 (N,N DIMETHYLAMINO)DIAZEN 1 IUM 1,2 DIOLATE; 2,4 DINITROPHENOL; 4 AMINOBENZOIC ACID DERIVATIVE; ANILINE; ANTINEOPLASTIC AGENT; CARBOXYL GROUP; CISPLATIN; GLUTATHIONE; METHYL GROUP; NITRIC OXIDE; NITROBENZENE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; AQUEOUS SOLUTION; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SOLUBILITY; DRUG STABILITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; PHYSICAL CHEMISTRY; STRUCTURE ACTIVITY RELATION; TUMOR XENOGRAFT; X RAY CRYSTALLOGRAPHY; X RAY DIFFRACTION;

4-AMINOBENZOIC ACID; ANIMALS; ANTINEOPLASTIC AGENTS; AZO COMPOUNDS; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; DRUG SCREENING ASSAYS, ANTITUMOR; DRUG STABILITY; GLUTATHIONE; HUMANS; HYDROLYSIS; MICE; MICE, INBRED NOD; MICE, SCID; NITRIC OXIDE; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSPLANTATION, HETEROLOGOUS;

EID: 31044449239     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm050700k     Document Type: Article

References (12)

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