High expression of GCLC is associated with malignant melanoma of low oxidative phenotype and predicts a better prognosis

Journal of Molecular Medicine

Volumn 90, Issue 8, 2012, Pages 935-944

  Mougiakakos, Dimitrios ^a,b   Okita, Riki ^a   Ando, Takashi ^c   Dürr, Christoph ^d   Gadiot, Jules ^e   Ichikawa, Jiro ^f   Zeiser, Robert ^d   Blank, Christian ^e   Johansson, C Christian ^a   Kiessling, Rolf ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c UNIVERSITY OF YAMANASHI   (Japan)

^d UNIVERSITY OF FREIBURG   (Germany)

^e ANTONI VAN LEEUWENHOEK HOSPITAL   (Netherlands)

^f VANDERBILT UNIVERSITY   (United States)

Author keywords

GCLC; Melanoma; Oxidative stress; Prognosis

Indexed keywords

ACETYLCYSTEINE; GLUTAMATE CYSTEINE LIGASE; NERVE CELL ADHESION MOLECULE; RAG2 PROTEIN; REACTIVE OXYGEN METABOLITE; UVOMORULIN;

ADULT; ADVANCED CANCER; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CANCER INVASION; CANCER SURVIVAL; CELL INVASION; CELL PROLIFERATION; CELL SURVIVAL; CLINICAL ARTICLE; ENZYME SUBUNIT; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MELANOMA; MOUSE; NONHUMAN; OVERALL SURVIVAL; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PHENOTYPE; PROGNOSIS; PROTEIN EXPRESSION;

ACETYLCYSTEINE; ADULT; AGED; AGED, 80 AND OVER; ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, NEOPLASTIC; GLUTAMATE-CYSTEINE LIGASE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MELANOMA; MICE; MICE, KNOCKOUT; MIDDLE AGED; OXIDATION-REDUCTION; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION; YOUNG ADULT;

EID: 84865134141     PISSN: 09462716     EISSN: 14321440     Source Type: Journal    
DOI: 10.1007/s00109-012-0857-4     Document Type: Article

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