Redox mechanisms of cytoprotection by Bcl-2

Antioxidants and Redox Signaling

Volumn 7, Issue 3-4, 2005, Pages 508-514

  Kowaltowski, Alicia J ^a   Fiskum, Gary ^b  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALASE; CYTOCHROME C; GLUTATHIONE; GLUTATHIONE DISULFIDE; HYDROGEN PEROXIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; SUPEROXIDE; SUPEROXIDE DISMUTASE;

ANTIOXIDANT ACTIVITY; APOPTOSIS; CELL LEVEL; CELL PROTECTION; HUMAN; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL RESPIRATION; NECROSIS; NONHUMAN; OLIGOMERIZATION; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; CELL DEATH; CELL SURVIVAL; HUMANS; MITOCHONDRIA; OXIDATION-REDUCTION; OXIDATIVE STRESS; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES;

EID: 14044268132     PISSN: 15230864     EISSN: None     Source Type: Journal    
DOI: 10.1089/ars.2005.7.508     Document Type: Review

References (63)

1. Armstrong JS and Jones DP. Glutathione depletion enforces the mitochondrial permeability transition and causes cell death in Bcl-2 overexpressing HL60 cells. FASEB J 16: 1263-1265, 2002.
2. Bojes HK, Datta K, Xu J, Chin A, Simonian P, Nunez G, and Kehrer JP. Bcl-xL overexpression attenuates glutathione depletion in FL5.12 cells following interleukin-3 withdrawal. Biochem J 325: 315-319, 1997.
3. Bunn HF and Poyton RO. Oxygen sensing and molecular adaptation to hypoxia. Physiol Rev 76: 839-885, 1996.
4. Cadenas E, Boveris A, Ragan CI, and Stoppani AO. Production of superoxide radicals and hydrogen peroxide by NADH-ubiquinone reductase and ubiquinol-cytochrome c reductase from beef-heart mitochondria. Arch Biochem Biophys 180: 248-257, 1977.
5. Cai J and Jones DP. Superoxide in apoptosis. Mitochondrial generation triggered by cytochrome c loss. J Biol Chem 273: 11401-11404, 1998.
6. Chen SR, Dunigan DD, and Dickman MB. Bcl-2 family members inhibit oxidative stress-induced programmed cell death in Saccharomyces cerevisiae. Free Radic Biol Med 34: 1315-1325, 2003.
7. Colell A, Garcia-Ruiz C, Lluis JM, Coll O, Mari M, and Fernandez-Checa JC. Cholesterol impairs the adenine nucleotide translocator-mediated mitochondrial permeability transition through altered membrane fluidity. J Biol Chem 278: 33928-33935, 2003.
8. Crompton M. The mitochondrial permeability transition pore and its role in cell death. Biochem J 341: 233-249, 1999.
9. Demasi AP, Pereira GA, and Netto LES. Cytosolic thioredoxin peroxidase I is essential for the antioxidant defense of yeast with dysfunctional mitochondria. FEBS Lett 509: 430-434, 2001.
10. Ellerby LM, Ellerby HM, Park SM, Holleran AL, Murphy AN, Fiskum G, Kane DJ, Testa MP, Kayalar C, and Bredesen DE. Shift of the cellular oxidation-reduction potential in neural cells expressing Bcl-2. J Neurochem 67: 1259-1267, 1996.
11. Enari M, Hase A, and Nagata S. Apoptosis by a cytosolic extract from Fas-activated cells. EMBO J 14: 5201-5208, 1995.
12. Esposti MD, Hatzinisiriou T, McLennan H, and Ralph S. Bcl-2 and mitochondrial oxygen radicals. New approaches with reactive oxygen species-sensitive probes. J Biol Chem 274: 29831-29837, 1999.
13. 2 stimulon in Saccharomyces cerevisiae. J Biol Chem 273: 22480-22489, 1998.
14. Gouaze V, Andrieu-Abadie N, Cuvillier O, Malagarie-Cazenave S, Frisach MF, Mirault ME, and Levade T. Glutathione peroxidase-1 protects from CD95-induced apoptosis. J Biol Chem 277: 42867-42874, 2002.
15. Hochman A, Sternin H, Gorodin S, Korsmeyer S, Ziv I, Melamed E, and Offen D. Enhanced oxidative stress and altered antioxidants in brains of Bcl-2-deficient mice. J Neurochem 71: 741-748, 1998.
16. Hockenbery DM, Nunez G, Milliman C, Schreiber RD, and Korsmeyer SJ. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 348: 334-336, 1990.
17. Hockenbery DM, Oltvai ZN, Yin XM, Milliman CL, and Korsmeyer SJ. Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 75: 241-251, 1993.
18. Holmgren A. Antioxidant function of thioredoxin and glutaredoxin systems. Antioxid Redox Signal 2: 811-820, 2000.
19. Jacobson MD, Burne JF, King MP, Miyashita T, Reed JC, and Raff MC. Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA. Nature 361: 365-369, 1993.
20. Jacobsen MD, Weil M, and Raff MC. Role of Ced-3/ICE-family proteases in staurosporine-induced programmed cell death. J Cell Biol 133: 1041-1051, 1996.
21. Kane DJ, Sarafian TA, Anton R, Hahn H, Gralla EB, Valentine JS, Ord T, and Bredesen DE. Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species. Science 262: 1274-1277, 1993.
22. Kowaltowski AJ, Vercesi AE, and Fiskum G. Bcl-2 prevents mitochondrial permeability transition and cytochrome c release via maintenance of reduced pyridine nucleotides. Cell Death Differ 7: 903-910, 2000.
23. Kowaltowski AJ, Castilho RF, and Vercesi AE. Mitochondrial permeability transition and oxidative stress. FEBS Lett 495: 12-15, 2001.
24. Kowaltowski AJ, Cosso RG, Campos CB, and Fiskum G. Effect of Bcl-2 overexpression on mitochondrial structure and function. J Biol Chem 277: 42802-42807, 2002.
25. Kowaltowski AJ, Fenton RG, and Fiskum G. Bcl-2 family proteins regulate mitochondrial reactive oxygen production and protect against oxidative stress. Free Radic Biol Med 37: 1845-1853, 2004.
26. + oxidation-reduction state. Biochem J 368: 545-553, 2002.
27. Kwast KE, Burke PV, Staahl BT, and Poyton RO. Oxygen sensing in yeast: evidence for the involvement of the respiratory chain in regulating the transcription of a subset of hypoxic genes. Proc Natl Acad Sci U S A 96: 5446-5451, 1999.
28. 2+ fluxes. Proc Natl Acad Sci U S A 91: 6569-6573, 1994.
29. Lotem J and Sachs L. Regulation by bcl-2, c-myc, and p53 of susceptibility to induction of apoptosis by heat shock and cancer chemotherapy compounds in differentiation-competent and -defective myeloid leukemic cells. Cell Growth Differ 4: 41-47, 1993.
30. Luetjens CM, Lankiewicz S, Bui NT, Krohn AJ, Poppe M, and Prehn JH. Up-regulation of Bcl-xL in response to subtoxic beta-amyloid: role in neuronal resistance against apoptotic and oxidative injury. Neuroscience 102: 139-150, 2001.
31. Mahajan NP, Linder K, Berry G, Gordon GW, Heim R, and Herman B. Bcl-2 and Bax interactions in mitochondria probed with green fluorescent protein and fluorescence resonance energy transfer. Nat Biotechnol 16: 547-552, 1998.
32. Marchetti P, Castedo M, Susin SA, Zamzami N, Hirsch T, Macho A, Haeffner A, Hirsch F, Geuskens M, and Kroemer G. Mitochondrial permeability transition is a central coordinating event of apoptosis. J Exp Med 184: 1155-1160, 1996.
33. 2+. Oncogene 12: 2259-2266, 1996.
34. Meister A, and Anderson ME. Glutathione. Annu Rev Biochem 52: 711-760, 1983.
35. Meredith MJ, Cusick CL, Soltaninassab S, Sekhar KS, Lu S, and Freeman ML. Expression of Bcl-2 increases intracellular glutathione by inhibiting methionine-dependent GSH efflux. Biochem Biophys Res Commun 248: 458-463, 1998.
36. Mirkovic N, Voehringer DW, Story MD, McConkey DJ, McDonnell TJ, and Meyn RE. Resistance to radiation-induced apoptosis in Bcl-2-expressing cells is reversed by depleting cellular thiols. Oncogene 15: 1461-1470, 1997.
37. Miyashita T, Krajewski S, Krajewska M, Wang HG, Lin HK, Liebermann DA, Hoffman B, and Reed JC. Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene 9: 1799-1805, 1994.
38. Monaghan P, Robertson D, Amos TA, Dyer MJ, Mason DY, and Greaves MF. Ultrastructural localization of bcl-2 protein. J Histochem Cytochem 40: 1819-1825, 1992.
39. Murphy AN, Bredesen DE, Cortopassi G, Wang E, and Fiskum G. Bcl-2 potentiates the maximal calcium uptake capacity of neural cell mitochondria. Proc Natl Acad Sci U S A 93: 9893-9898, 1996.
40. Myers KM, Fiskum G, Liu Y, Simmens SJ, Bredesen DE, and Murphy AN. Bcl-2 protects neural cells from cyanide/aglycemia-induced lipid oxidation, mitochondrial injury, and loss of viability. J Neurochem 65: 2432-2440, 1995.
41. Nguyen M, Millar DG, Yong VW, Korsmeyer SJ, and Shore GC. Targeting of Bcl-2 to the mitochondrial outer membrane by a COOH-terminal signal anchor sequence. J Biol Chem 268: 25265-25268, 1993.
42. Pegoraro L, Palumbo A, Erikson J, Falda M, Giovanazzo B, Emanuel BS, Rovera G, Nowell PC, and Croce CM. A 14;18 and an 8;14 chromosome translocation in a cell line derived from an acute B-cell leukemia. Proc Natl Acad Sci U S A 81: 7166-7170, 1984.
43. Polster BM, Kinnally KW, and Fiskum G. BH3 death domain peptide induces cell type-selective mitochondrial outer membrane permeability. J Biol Chem 276: 37887-37894, 2001.
44. Polyak K, Xia Y, Zweier JL, Kinzler KW, and Vogelstein B. A model for p53-induced apoptosis. Nature 389: 300-305, 1997.
45. Reed JC, Cuddy M, Slabiak T, Croce CM, and Nowell PC. Oncogenic potential of bcl-2 demonstrated by gene transfer. Nature 336: 259-261, 1988.
46. Rudin CM, Yang Z, Schumaker LM, Vander Weele DJ, Newkirk K, Egorin MJ, Zuhowski EG, and Cullen KJ. Inhibition of glutathione synthesis reverses Bcl-2-mediated cisplatin resistance. Cancer Res 63: 312-318, 2003.
47. Schendel SL, Xie Z, Montal MO, Matsuyama S, Montal M, and Reed JC. Channel formation by antiapoptotic protein Bcl-2. Proc Natl Acad Sci U S A 94: 5113-5118, 1997.
48. Sentman CL, Shutter JR, Hockenbery D, Kanagawa O, and Korsmeyer SJ. bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell 67: 879-888, 1991.
49. Shimizu S, Eguchi Y, Kamiike W, Funahashi Y, Mignon A, Lacronique V, Matsuda H, and Tsujimoto Y. Bcl-2 prevents apoptotic mitochondrial dysfunction by regulating proton flux. Proc Natl Acad Sci U S A 95: 1455-1459, 1998.
50. 2 production by membrane potential and NAD(P)H redox state. J Neurochem 86: 1101-1107, 2003.
51. Starkov AA, Polster BM, and Fiskum G. Regulation of hydrogen peroxide production by brain mitochondria by calcium and Bax. J Neurochem 83: 220-228, 2002.
52. Strasser A, Harris AW, and Cory S. bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship. Cell 67: 889-899, 1991.
53. Tsujimoto Y, Finger LR, Yunis J, Nowell PC, and Croce CM. Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation. Science 226: 1097-1099, 1984.
54. Vaux DL, Cory S, and Adams JM. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature 335: 440-442, 1988.
55. Veis DJ, Sorenson CM, Shutter JR, and Korsmeyer SJ. Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair. Cell 75: 229-240, 1993.
56. Voehringer DW. BCL-2 and glutathione: alterations in cellular redox state that regulate apoptosis sensitivity. Free Radic Biol Med 27: 945-950, 1999.
57. Voehringer DW, McConkey DJ, McDonnell TJ, Brisbay S, and Meyn RE. Bcl-2 expression causes redistribution of glutathione to the nucleus. Proc Natl Acad Sci U S A 95: 2956-2960, 1998.
58. Zamzami N, Marchetti P, Castedo M, Decaudin D, Macho A, Hirsch T, Susin SA, Petit PX, Mignotte B, and Kroemer G. Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death. J Exp Med 182: 367-377, 1995.
59. Zamzami N, Marzo I, Susin SA, Brenner C, Larochette N, Marchetti P, Reed J, Kofler R, and Kroemer G. The thiol crosslinking agent diamide overcomes the apoptosis-inhibitory effect of Bcl-2 by enforcing mitochondrial permeability transition. Oncogene 16: 1055-1063, 1998.
60. Zhang P, Liu B, Kang SW, Seo MS, Rhee SG, and Obeid LM. Thioredoxin peroxidase is a novel inhibitor of apoptosis with a mechanism distinct from that of Bcl-2. J Biol Chem 272: 30615-30618, 1997.
61. Zhong LT, Sarafian T, Kane DJ, Charles AC, Mah SP, Edwards RH, and Bredesen DE. bcl-2 inhibits death of central neural cells induced by multiple agents. Proc Natl Acad Sci U S A 90: 4533-4537, 1993.
62. Zitomer RS and Lowry CV. Regulation of gene expression by oxygen in Saccharomyces cerevisiae. Microbiol Rev 56: 1-11, 1992.
63. Zoratti M and Szabo I. The mitochondrial permeability transition. Biochim Biophys Acta 1241: 139-176, 1995.