Targeting ALDH1A1 by disulfiram/copper complex inhibits non-small cell lung cancer recurrence driven by ALDH-positive cancer stem cells

Oncotarget

Volumn 7, Issue 36, 2016, Pages 58516-58530

  Liu, Xinwei ^a   Wang, Lihui ^a   Cui, Wei ^a   Yuan, Xiangzhong ^a   Lin, Lulu ^a   Cao, Qi ^a   Wang, Nannan ^a   Li, Yi ^a   Guo, Wei ^a   Zhang, Xun ^a   Wu, Chunfu ^a   Yang, Jingyu ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

ALDH1A1; Cancer stem cell; Disulfiram copper; NSCLC; Recurrence

Indexed keywords

ALDEHYDE DEHYDROGENASE; ALDEHYDE DEHYDROGENASE ISOENZYME 1; ALDEHYDE DEHYDROGENASE ISOENZYME 1 A1; ALDEHYDE DEHYDROGENASE ISOENZYME 1 A3; COPPER; DISULFIRAM; OCTAMER TRANSCRIPTION FACTOR 4; PACLITAXEL; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX2; UNCLASSIFIED DRUG; ALDH1A1 PROTEIN, HUMAN; ISOENZYME;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER INHIBITION; CANCER RECURRENCE; CANCER STEM CELL; CELL DIFFERENTIATION; CELL RENEWAL; COMPLEX FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; DRUG TARGETING; ENZYME ACTIVITY; IN VITRO STUDY; IN VIVO STUDY; MALE; MONOTHERAPY; MOUSE; NOD SCID MOUSE; NON SMALL CELL LUNG CANCER; NONHUMAN; ONCOLOGICAL PARAMETERS; PROTEIN EXPRESSION; RNA INTERFERENCE; TUMOR INVASION; TUMOR REGROWTH; TUMOR VOLUME; TUMOR XENOGRAFT; ANIMAL; CANCER TRANSPLANTATION; CELL PROLIFERATION; CELL SEPARATION; CHEMISTRY; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GENETICS; HUMAN; INCIDENCE; LUNG TUMOR; METABOLISM; NONOBESE DIABETIC MOUSE; SCID MOUSE; TUMOR CELL LINE; TUMOR RECURRENCE;

ALDEHYDE DEHYDROGENASE; ANIMALS; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SEPARATION; COPPER; DISULFIRAM; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INCIDENCE; ISOENZYMES; LUNG NEOPLASMS; MALE; MICE; MICE, INBRED NOD; MICE, SCID; NEOPLASM RECURRENCE, LOCAL; NEOPLASM TRANSPLANTATION; NEOPLASTIC STEM CELLS; RNA INTERFERENCE;

EID: 84988355081     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.11305     Document Type: Article

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