Dithiocarbamate toxicity toward thymocytes involves their copper- catalyzed conversion to thiuram disulfides, which oxidize glutathione in a redox cycle without the release of reactive oxygen species

Archives of Biochemistry and Biophysics

Volumn 353, Issue 1, 1998, Pages 73-84

  Burkitt, Mark J ^a   Bishop, Hugh S ^a   Milne, Lesley ^a   Tsang, Shui Ying ^a   Provan, Gordon J ^a   Nobel, C Stefan I ^b   Orrenius, Sten ^b   Slater, Andrew F G ^b  

^a ROWETT RESEARCH INSTITUTE   (United Kingdom)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Apoptosis; Copper; Dithiocarbamate; Glutathione; Reactive oxygen species

Indexed keywords

COPPER ION; DISULFIDE; DISULFIRAM; DITHIOCARBAMIC ACID; DNA FRAGMENT; GLUTATHIONE; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CATALYSIS; CELL KILLING; CHEMICAL REACTION; COPPER METABOLISM; ENZYME ACTIVITY; NONHUMAN; OXIDATION; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; RAT; THYMOCYTE;

EID: 0031825806     PISSN: 00039861     EISSN: None     Source Type: Journal    
DOI: 10.1006/abbi.1998.0618     Document Type: Article

References (60)

1. Thorn G. D., Ludwig R. A. The Dithiocarbamates and Related Compounds. 1962;Elsevier, Amsterdam.
2. Sunderman F. W. J. New Drugs. 4:1964;154-161.
3. Lang J.-M., Trepo C., Kirstetter M., Herviou L., Retornz G., Renoux G., Mussett M., Tourainem J.-L., Choutet P., Falkenrod A., Liverozet J.-M., Touraine M., Caraux J. Lancet. 1988;702-706.
4. Izumi Y., Ogino K., Murata T., Kobayashi H., Hobara T. Pharmacol. Toxicol. 74:1994;280-286.
5. Bartoli G. M., Müller A., Cadenas E., Sies H. FEBS Lett. 164:1983;371-374.
6. Heikkila R. E., Cabbat F. S., Cohen G. J. Biol. Chem. 251:1976;2182-2185.
7. Schreck R., Meier B., Männel D. N., Dröge W., Baeuerle P. A. J. Exp. Med. 175:1992;1181-1194.
8. Wolfe J. T., Ross D., Cohen G. M. FEBS Lett. 352:1994;58-62.
9. Bessho R., Matsubara K., Kubota M., Kuwakado K., Hirota H., Wakazono Y., Wei Lin Y., Okuda A., Kawai M., Nishikomri R., Heike T. Biochem. Pharmacol. 48:1994;1883-1889.
10. Verhaegen S., McGowan A. J., Brophy A. R., Fernandes R. S., Cotter T. G. Biochem. Pharmacol. 50:1995;1021-1029.
11. Albrecht H., Tschopp J., Jongeneel C. V. FEBS Lett. 351:1994;45-48.
12. Buttke T. M., Sandstrom P. A. Immunol. Today. 15:1994;7-10.
13. Slater A. F. G., Nobel C. S. I., Maellaro E., Bustamante J., Kimland M., Orrenius S. Biochem. J. 306:1995;771-778.
14. Slater A. F. G., Nobel C. S. I., Orrenius S. Biochim. Biophys. Acta. 1271:1995;59-62.
15. Nobel C. S. I., Kimland M., Lind B., Orrenius S., Slater A. F. G. J. Biol. Chem. 270:1995;26202-26208.
16. Nagele A. Biochem. Pharmacol. 49:1995;147-155.
17. Nagele A., Felix K., Lengfelder E. Biochem. Pharmacol. 47:1994;555-562.
18. Duracková Z., Labudová O., Andrezálová L., Feníková L., Labuda J., Kollárová M., Weser U. Int. J. Biochem. Cell. Biol. 27:1995;1341-1347.
19. Labudová O., Labuda J., Feníková L., Kollárová M., Duracková Z. J. Inorg. Biochem. 61:1996;227-231.
20. Burkitt M. J., Milne L., Nicotera P., Orrenius S. Biochem. J. 313:1996;163-169.
21. Tsang S. Y., Tam S. C., Bremner I., Burkitt M. J. Biochem. J. 317:1996;13-16.
22. Brennan P., O'Neill L. A. J. Biochem. J. 320:1996;975-981.
23. Misra H. P. J. Biol. Chem. 249:1974;2151-2155.
24. Wood J. L., Graham A. FEBS Lett. 366:1995;75-80.
25. Saez G., Thornalley P. J., Hill H. A. O., Bannister J. V. Biochim. Biophys. Acta. 719:1982;24-31.
26. Nyberg G. K., Granberg G. P. D., Carlsson J. Appl. Environ. Microbiol. 38:1979;29-34.
27. Spear N., Aust S. D. Arch. Biochem. Biophys. 317:1995;142-148.
28. Milne L., Nicotera P., Orrenius S., Burkitt M. J. Arch. Biochem. Biophys. 304:1993;102-109.
29. Freedman J. H., Ciriolo M. R., Peisach J. J. Biol. Chem. 264:1989;5598-5605.
30. von Sonntag C. The Chemical Basis of Radiation Biology. 1987;Taylor & Francis, London.
31. Mankhetkorn S., Abedinzadeth Z., Houee-Levin C. Free Radical Biol. Med. 17:1994;517-527.
32. Zanocco A. L., Pavez L. A., Videla L. A., Lissi E. A. Free Radical Biol. Med. 7:1989;151-156.
33. Dimitrijevic N. M., Micic O. I. J. Serb. Chem. Soc. 54:1989;465-471.
34. Sree Kumar K., Sancho A. M., Weiss J. F. Int. J. Radiat. Oncol. Biol. Phys. 12:1986;1463-1467.
35. Hosni M., Meskini N., Prigent A.-F., Anker G., Joulain C., El Habib R., Lagarde M. Biochem. Pharmacol. 43:1992;1319-1329.
36. Buettner G. R. J. Biochem. Biophys. Methods. 16:1988;27-40.
37. Freedman J. H., Band Horwitz S., Peisach J. Biochemistry. 21:1982;2203-2210.
38. Burkitt M. J., Mason R. P. Proc. Natl. Acad. Sci. USA. 88:1991;8440-8444.
39. Burkitt M. J., Tsang S. Y., Tam S. C., Bremner I. Arch. Biochem. Biophys. 323:1995;63-70.
40. Mason R. P. Methods Enzymol. 105:1984;416-422.
41. Burkitt M. J. Methods Enzymol. 234:1994;66-79.
42. Davis F. J., Gilbert B. C., Norman R. O. C., Symons M. C. R. J. Chem. Soc. Perkin Trans. II. 1983;1763-1711.
43. Choi J., Min Yoon N. J. Org. Chem. 60:1995;3266-3267.
44. Abeninzadeh Z., Gardes-Albert M., Ferradini C. Can. J. Chem. 67:1989;1247-1255.
45. Laurie S. H., Lund T., Raynor J. B. J. Chem. Soc. Dalton Trans. 1975;1389-1394.
46. Hanna P. M., Mason R. P. Arch. Biochem. Biophys. 295:1992;205-213.
47. Rowley D. A., Halliwell B. J. Inorg. Biochem. 23:1985;103-108.
48. Gatlin C. L., Turecek F., Vaisar T. Anal. Chem. 66:1994;3950-3958.
49. Bond A., Colton R., D'Agostino A., Downard A. J., Traeger J. C. Anal. Chem. 67:1995;1691-1695.
50. Gilbert B. C., Laue H. A. H., Norman R. O. C., Sealy R. C. J. Chem. Soc. Perkin Trans. II. 1975;892-900.
51. Scrivens G., Gilbert B. C., Lee T. C. P. J. Chem. Soc. Perkin Trans. 2:1995;955-963.
52. Kroneck P. J. Am. Chem. Soc. 97:1975;3839-3841.
53. Bond A. M., Martin R. L. Coordination Chem. Rev. 54:1984;23-98.
54. Nichols P. J., Grant M. W. Aust. J. Chem. 36:1983;1379-1386.
55. Asmus K.-D. Methods Enzymol. 186:1990;168-180.
56. Mason R. P., Rao D. N. R. Methods Enzymol. 186:1990;318-330.
57. Lash L. H., Jones D. P., Orrenius S. Biochim. Biophys. Acta. 779:1984;191-200.
58. Orrenius S. Phil Trans. R. Soc. Lond. B. 311:1985;673-677.
59. Wardman P., Clarke E. D. Br. J. Cancer. 55:1987;172-177.
60. Nobel C. S. I., Burgess D. H., Zhivotovsky B., Burkitt M. J., Orrenius S., Slater A. F. G. Chem. Res. Toxicol. 10:1997;636-643.