Influence of glutathione levels and activity of glutathione-related enzymes in the brains of tumor-bearing mice

BioScience Trends

Volumn 5, Issue 1, 2011, Pages 30-37

  Shen, Kaikai ^a   Ji, Lili ^a,b   Chen, Ying ^a   Yu, Qianming ^a   Wang, Zhengtao ^a,b  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b Shanghai R and D Centre for Standardization of Chinese Medicines   (China)

Author keywords

Brain; Glutamate cysteine ligase (GCL); Glutathione peroxidase (GPx); Glutathione reductase (GR); Glutathione stransferase (GST); Reduced glutathione; Tumor

Indexed keywords

MUS;

FLUOROURACIL; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE;

ANALYSIS OF VARIANCE; ANIMAL; ARTICLE; BRAIN; BRAIN TUMOR; DRUG EFFECT; ENZYMOLOGY; METABOLISM; MOUSE; OXIDATIVE STRESS;

ANALYSIS OF VARIANCE; ANIMALS; BRAIN; BRAIN NEOPLASMS; FLUOROURACIL; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; MICE; OXIDATIVE STRESS;

EID: 79959429865     PISSN: 18817815     EISSN: 18817823     Source Type: Journal    
DOI: 10.5582/bst.2011.v5.1.30     Document Type: Article

References (35)

1. Schafer FQ, Buettner GR. Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. Free Radic Biol Med. 2001; 30:1191-1212.
2. Winterbourn CC, Metodiewa D. The reaction of superoxide with reduced glutathione. Arch Biochem Biophys. 1994; 314:284-290.
3. DeWvs WD. Pathophysiology of cancer cachexia: Current understanding and areas for future research. Cancer Res. 1982; 42:721s-726s.
4. Szatrowski TP, Nathan CF. Production of large amounts of hydrogen peroxide by human tumor cells. Cancer Res. 1991; 51:794-798.
5. Commandeur JN, Stijntjes GJ, Vermeulen NP. Enzymes and transport systems involved in the formation and disposition of glutathione-s-conjugates. Role in bioactivation and detoxication mechanisms of xenobiotics. Pharmacol Rev. 1995; 47:271-330.
6. Dringen R. Metabolism and functions of glutathione in brain. Prog Neurobiol. 2000; 62:649-671.
7. Aovama K, Watabe M, Nakaki T. Regulation of neuronal glutathione synthesis. J Pharmacol Sci. 2008; 108:227-238.
8. Sies H, Akerboom TP. Glutathione disulfide (GSSG) efflux from cells and tissues. Methods Enzymol. 1984; 105:445-451.
9. Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG, Hoekstra WG. Selenium: Biochemical role as a component of glutathione peroxidase. Science. 1973; 179:588-590.
10. Habig WH, Pabst MJ, Jakoby WB. Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J Biol Chem. 1974; 249:7130-7139.
11. Carlberg I, Mannervik B. Glutathione reductase. Methods Enzymol. 1985; 113:484-490.
12. Zheng S, Yumei F, Chen A. De novo synthesis of glutathione is a prerequisite for curcumin to inhibit hepatic stellate cell (HSC) activation. Free Radic Biol Med. 2007; 43:444-453.
13. Li XJ, Mao YX, Zhang HL, Wang JX, Liu FY. Study on effects of anticancer and immunoregulation of Fuganchun 6 on hepatoma of mouse. Zhongguo Zhong Yao Za Zhi. 2006; 31:1622-1625. (in Chinese)
14. Yu ZH, Wei PK, Xu L, Qin ZF, Shi J. Anticancer effect of jinlongshe granules on in situ-transplanted human MKN-45 gastric cancer in nude mice and xenografted sarcoma 180 in Kunming mice and its mechanism. World J Gastroenterol. 2006; 12:2890-2894.
15. DeLeve LD, Kaplowitz N. Glutathione metabolism and its role in hepatotoxicity. Pharmacol Ther. 1991; 52:287-305.
16. Lei XG. In vivo antioxidant role of glutathione peroxidase: Evidence from knockout mice. Methods Enzymol. 2002; 347:213-225.
17. Strange RC, Spiteri MA, Ramachandran S, Fryer A. Glutathione-S-transferase family of enzymes. Mutat Res. 2001; 482:21-26.
18. Longlev DB, Harkin DP, Johnston PG. 5-fluorouracil: Mechanisms of action and clinical strategies. Nat Rev Cancer. 2003; 3:330-338.
19. Muqqia FM, Peters GJ, Landolph JR J r. XIII International Charles Heidelberger Symposium and 50 Years of fluoropyrimidines in cancer therapy held on September 6 to 8, 2007 at New York University Cancer Institute, Smilow Conference Center. Mol Cancer Ther. 2009; 8:992-999.
20. Wang XB, Liu QH, Wang P, Zhang K, Tang W, Wang BL. Enhancement of apoptosis by sonodynamic therapy with protoporphyrin IX in isolate sarcoma 180 cells. Cancer Biother Radiopharm. 2008; 23:238-246.
21. Yuan F, Zhang ZR, Yang YX, Huang Y. In vitro release study, in vivo evaluation of biodistribution and antitumor activity of HPMA copolymer-5-fluorouracil conjugates. Yao Xue Xue Bao. 2008; 43:1152-1156. (in Chinese)
22. Choi BH. Oxygen, antioxidants and brain dysfunction. Yonsei Med J. 1993; 34:1-10.
23. Halli well B. Role of free radicals in the neurodegenerative diseases: Therapeutic implications for antioxidant treatment. Drugs Aging. 2001; 18:685-716.
24. Olanow CW. A radical hypothesis for neurodegeneration. Trends Neurosci. 1993; 16: 439-444.
25. Briqelius-Flohe R, Kipp A. Glutathione peroxidases in different stages of carcinogenesis. Biochim Biophys Acta. 2009; 1790:1555-1568.
26. Dourado DF, Fernandes PA, Ramos MJ. Mammalian cytosolic glutathione transferases. Curr Protein Pept Sci. 2008; 9:325-337.
27. McIlwain CC, Townsend DM, Tew KD. Glutathione s-transferase polymorphisms: Cancer incidence and therapy. Oncogene. 2006; 25:1639-1648.
28. Ricci G, Caccuri AM, Lo Bello M, Parker MW, Nuccetelli M, Turella P, Stella L, Di lorio EE, Federici G. Glutathione transferase P1-1: Self-preservation of an anti-cancer enzyme. Biochem J. 2003; 376(Pt 1):71-76.
29. Griffith OW. Biologic and pharmacologic regulation of mammalian glutathione synthesis. Free Radic Biol Med. 1999; 27: 922-935.
30. Banheqvi G, Mandl J, Csala M. Redox-based endoplasmic reticulum dysfunction in neurological diseases. J Neurochem. 2008; 107:20-34.
31. Devi PU, Manocha A, Vohora D. Seizures, antiepileptics, antioxidants and oxidative stress: An insight for researchers. Expert Opin Pharmacother. 2008; 9:3169-3177.
32. Kaur C, Ling EA. Antioxidants and neuroprotection in the adult and developing central nervous system. Curr Med Chem. 2008; 15:3068-3080.
33. Maier CM, Chan PH. Role of superoxide dismutases in oxidative damage and neurodegenerative disorders. Neuroscientist. 2002; 8:323-334.
34. Napoli C, Palinski W. Neurodegenerative diseases: I n s i g h t s i n t o p a t h o g e n i c mechanisms f r o m atherosclerosis. Neurobiol Aging. 2005; 26:293-302.
35. Hyslop PA, Zhang Z, Pearson DV, Phebus LA. Measurement of striatal H2O2 by microdialysis following global forebrain ischemia and reperfusion in the rat: Correlation with the cytotoxic potential of H2O2 in vitro. Brain Res. 1995; 671:181-186.