Cytokine tuning of intestinal epithelial function

Frontiers in Immunology

Volumn 9, Issue JUN, 2018, Pages

  Andrews, Caroline ^a   McLean, Mairi H ^b   Durum, Scott K ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

Chemokine; Cytokine; Epithelium; Intestine; Mucosal immunology

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERFERON; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 22; INTERLEUKIN 28A; INTERLEUKIN 33; INTERLEUKIN 36; INTERLEUKIN 4; INTERLEUKIN 6; STEM CELL FACTOR; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CARCINOGENESIS; CELL DIFFERENTIATION; CELL PROLIFERATION; COMMENSAL; CYTOKINE PRODUCTION; HOST PATHOGEN INTERACTION; HUMAN; IMMUNOCOMPETENT CELL; INTESTINE EPITHELIUM; INTESTINE FUNCTION; INTESTINE MUCOSA PERMEABILITY; MEDIATOR RELEASE; MUCOSAL IMMUNITY; NONHUMAN; PERMEABILITY BARRIER;

EID: 85048135365     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2018.01270     Document Type: Article

References (108)

1. Peterson LW, Artis D. Intestinal epithelial cells: regulators of barrier function and immune homeostasis. Nat Rev Immunol (2014) 14(3):141-53. doi:10.1038/nri3608
2. Mowat AM, Agace WW. Regional specialization within the intestinal immune system. Nat Rev Immunol (2014) 14(10):667-85. doi:10.1038/nri3738
3. Carding SR, Davis N, Hoyles L. Review article: the human intestinal virome in health and disease. Aliment Pharmacol Ther (2017) 46(9):800-15. doi:10.1111/apt.14280
4. Woo PCY, Chang MW, Chai LYA. The fungal mycobiome and its interaction with gut bacteria in the host. Int J Mol Sci (2017) 18(2):330. doi:10.3390/ijms18020330
5. Blander JM. Death in the intestinal epithelium-basic biology and implications for inflammatory bowel disease. FEBS J (2016) 283(14):2720-30. doi:10.1111/febs.13771
6. Haber AL, Biton M, Rogel N, Herbst RH, Shekhar K, Smillie C, et al. A single-cell survey of the small intestinal epithelium. Nature (2017) 551(7680):333-9. doi:10.1038/nature24489
7. von Moltke J, Ji M, Liang H, Locksley RM. Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit. Nature (2016) 529(7585):221-5. doi:10.1038/nature16161
8. Howitt MR, Lavoie S, Michaud M, Blum AM, Tran SV, Weinstock JV, et al. Tuft cells, taste chemosensory cells, orchestrate parasite type 2 immunity in the gut. Science (2016) 351(6279):1329-33. doi:10.1126/science.aaf1648
9. Takahashi Y, Sato S, Kurashima Y, Yamamoto T, Kurokawa S, Yuki Y, et al. A refined culture system for human induced pluripotent stem cell-derived intestinal epithelial organoids. Stem Cell Reports (2018) 10(1):314-28. doi:10.1016/j.stemcr.2017.11.004
10. Neurath MF. Cytokines in inflammatory bowel disease. Nat Rev Immunol (2014) 14(5):329-42. doi:10.1038/nri3661
11. Mittal R, Coopersmith CM. Redefining the gut as the motor of critical illness. Trends Mol Med (2014) 20(4):214-23. doi:10.1016/j.molmed.2013.08.004
12. Groschwitz KR, Hogan SP. Intestinal barrier function: molecular regulation and disease pathogenesis. J Allergy Clin Immunol (2009) 124(1):3-22. doi:10.1016/j.jaci.2009.05.038
13. Dinarello CA. Historical review of cytokines. Eur J Immunol (2007) 37(Suppl 1):S34-45. doi:10.1002/eji.200737772
14. Targan SR, Feagan BG, Vermeire S, Panaccione R, Melmed GY, Blosch C. M02083 a randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability and efficacy of AMG 827 in subjects with moderate to severe Crohn's disease. Gastroenterology (2012) 143(3):e26. doi:10.1053/j.gastro.2012.07.084
15. Andrews C, McLean MH, Durum SK. Interleukin-27 as a novel therapy for inflammatory bowel disease: a critical review of the literature. Inflamm Bowel Dis (2016) 22(9):2255-64. doi:10.1097/MIB.0000000000000818
16. Bradford EM, Ryu SH, Singh AP, Lee G, Goretsky T, Sinh P, et al. Epithelial TNF receptor signaling promotes mucosal repair in inflammatory bowel disease. J Immunol (2017) 199:1886-97. doi:10.4049/jimmunol.1601066
17. Waddell A, Vallance JE, Moore PD, Hummel AT, Wu D, Shanmukhappa SK, et al. IL-33 signaling protects from murine oxazolone colitis by supporting intestinal epithelial function. Inflamm Bowel Dis (2015) 21(12):2737-46. doi:10.1097/MIB.0000000000000532
18. Jeffery V, Goldson AJ, Dainty JR, Chieppa M, Sobolewski A. IL-6 signaling regulates small intestinal crypt homeostasis. J Immunol (2017) 199:304-11. doi:10.4049/jimmunol.1600960
19. Judd LM, Chalinor HV, Walduck A, Pavlic DI, Däbritz J, Dubeykovskaya Z, et al. TFF2 deficiency exacerbates weight loss and alters immune cell and cytokine profiles in DSS colitis, and this cannot be rescued by wild-type bone marrow. Am J Physiol Gastrointest Liver Physiol (2015) 308(1):G12-24. doi:10.1152/ajpgi.00172.2014
20. Hyun J, Romero L, Riveron R, Flores C, Kanagavelu S, Chung KD, et al. Human intestinal epithelial cells express IL-10 through toll-like receptor 4 (TLR4)-mediated epithelial-macrophage crosstalk. J Innate Immun (2015) 7(1):87-101. doi:10.1159/000365417
21. McLean MH, Neurath MF, Durum SK. Targeting interleukins for the treatment of inflammatory bowel disease-what lies beyond anti-TNF therapy? Inflamm Bowel Dis (2014) 20(2):389-97. doi:10.1097/01.MIB.0000437616.37000.41
22. Grabinger T, Bode KJ, Demgenski J, Seitz C, Delgado ME, Kostadinova F, et al. Inhibitor of apoptosis protein-1 regulates tumor necrosis factor-mediated destruction of intestinal epithelial cells. Gastroenterology (2017) 152:867-79. doi:10.1053/j.gastro.2016.11.019
23. Tinico-Veras CM, Santos AAQA, Stipursky J, Meloni M, Bergamo Araujo AP, Foshetti DA, et al. Transforming growth factor ß1/SMAD signaling pathway activation protects the intestinal epithelium from Clostridium difficile toxin A-induced damage. Infect Immun (2017) 85(10):e00430-17. doi:10.1128/IAI.00430-17
24. Nava P, Koch S, Kaukoetter MG, Lee WY, KolegraffK, Capaldo CT, et al. Interferon-? regulates intestinal epithelial homeostasis through converging ß-catenin signaling pathways. Immunity (2010) 32(3):392-402. doi:10.1016/j.immuni.2010.03.001
25. Tang R, Yang G, Zhang S, Wu C, Chen M. Opposite effects of interferon regulatory factor 1 and osteopontin on the apoptosis of epithelial cells induced by TNF-a in inflammatory bowel disease. Inflamm Bowel Dis (2014) 20(11):1950-61. doi:10.1097/MIB.0000000000000192
26. Takahashi N, Vereecke L, Bertrand MJM, Duprez L, Berger SB, Divert T, et al. RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis. Nature (2014) 513(7516):95-9. doi:10.1038/nature13706
27. Lee JS, Tato CM, Joyce-Shaikh B, Gulen MF, Cayatte C, Chen Y, et al. Interleukin-23-independent IL-17 production regulates intestinal epithelial permeability. Immunity (2015) 43(4):727-38. doi:10.1016/j.immuni.2015.09.003
28. Ma TY, Iwamoto GK, Hoa NT, Akotia V, Pedram A, Boivin MA, et al. TNF-alpha-induced increase in intestinal epithelial tight junction permeability requires NF-kappa B activation. Am J Physiol Gastrointest Liver Physiol (2004) 286(3):G367-76. doi:10.1152/ajpgi.00173.2003
29. Ye X, Sun M. AGR2 ameliorates tumor necrosis factor-a-induced epithelial barrier dysfunction via suppression of NF-KB p65-mediated MLCK/p-MLC pathway activation. Int J Mol Med (2017) 39(5):1206-14. doi:10.3892/ijmm.2017.2928
30. Watari A, Sakamoto Y, Hisaie K, Iwamoto K, Fueta M, Yagi K, et al. Rebeccamycin attenuates TNF-a-induced intestinal epithelial barrier dysfunction by inhibiting myosin light chain kinase production. Cell Physiol Biochem (2017) 41(5):1924-34. doi:10.1159/000472367
31. Regan T, Nally K, Carmody R, Houston A, Shanahan F, MacSharry J, et al. Identification of TLR10 as a key mediator of the inflammatory response to Listeria monocytogenes in intestinal epithelial cells and macrophages. J Immunol (2013) 191(12):6084-92. doi:10.4049/jimmunol.1203245
32. Triner D, Xue X, Schwartz AJ, Jung I, Colacino JA, Shah YM. Epithelial hypoxia-inducible factor 2a facilitates the progression of colon tumors through recruiting neutrophils. Mol Cell Biol (2017) 37(5):e00481-16. doi:10.1128/MCB.00481-16
33. Dent G, Loweth SC, Hasan AM, Leslie FM. Synergic production of neutrophil chemotactic activity by colonic epithelial cells and eosinophils. Immunobiology (2014) 219(10):793-7. doi:10.1016/j.imbio.2014.06.008
34. Franzè E, Marafini I, De Simone V, Monteleone I, Caprioli F, Colantoni A, et al. Interleukin-34 induces Cc-chemokine ligand 20 in gut epithelial cells. J Crohns Colitis (2016) 10(1):87-94. doi:10.1093/ecco-jcc/jjv181
35. Sedger LM, McDermott MF. TNF and TNF-receptors: from mediators of cell death and inflammation to therapeutic giants-past, present, and future. Cytokine Growth Factor Rev (2014) 25(4):453-72. doi:10.1016/j.cytogfr.2014.07.016
36. Blouin CM, Lamaze C. Interferon gamma receptor: the beginning of the journey. Front Immunol (2013) 4:267. doi:10.3389/fimmu.2013.00267
37. Huang F, Chen Y. Regulation of TGF-ß receptor activity. Cell Biosci (2012) 2:9. doi:10.1186/2045-3701-2-9
38. Sabat R, Ouyang W, Wolk K. Therapeutic opportunities of the IL-22-IL-22R1 system. Nat Rev Drug Discov (2014) 13(1):21-38. doi:10.1038/nrd4176
39. Chiriac MT, Buchen B, Wandersee A, Hundorfean G, Gunther C, Bourjau Y, et al. Activation of epithelial signal transducer and activator of transcription 1 by interleukin 28 controls mucosal healing in mice with colitis and is increased in mucosa of patients with inflammatory bowel disease. Gastroenterology (2017) 153:123-38. doi:10.1053/j.gastro.2017.03.015
40. Griesenauer B, Paczesny S. The ST2/IL-33 axis in immune cells during inflammatory diseases. Front Immunol (2017) 8:475. doi:10.3389/fimmu.2017.00475
41. Guanghui Y, Ybe JA, Saha SS, Caviness G, Raymond E, Ganesan R, et al. Structural and functional attributes of the interleukin-36 receptor. J Biol Chem (2016) 291(32):16597-609. doi:10.1074/jbc. M116.723064
42. Kominsky DJ, Campbell EL, Ehrentraut SF, Wilson KE, Kelly CJ, Glover LE, et al. IFN-?-mediated induction of an apical IL-10 receptor on polarized intestinal epithelia. J Immunol (2014) 192(3):1267-76. doi:10.4049/jimmunol.1301757
43. Gandhi NA, Bennett BL, Graham NM, Pirozzi G, Stahl N, Yancopoulos GD. Targeting key proximal drivers of type 2 inflammation in disease. Nat Rev Drug Discov (2016) 15(1):35-50. doi:10.1038/nrd4624
44. Song X, Dai D, He X, Zhu S, Yao Y, Gao H, et al. Growth factor FGF2 cooperates with interleukin-17 to repair intestinal epithelial damage. Immunity (2015) 43:488-501. doi:10.1016/j.immuni.2015.06.024
45. Kuhn KA, Manieri NA, Liu T, Stappenbeck TS. IL-6 stimulates intestinal epithelial proliferation and repair after injury. PLoS One (2014) 9(12):e114195. doi:10.1371/journal.pone.0114195
46. Lindemans CA, Calafiore M, Mertelsmann AM, O'Connor MH, Dudakov JA, Jenq RR, et al. Interleukin-22 promotes intestinal stem cell-mediated epithelial regeneration. Nature (2015) 528(7583):560-4. doi:10.1038/nature16460
47. Scheibe K, Backert I, Wirtz S, Hueber A, Schett G, Vieth M, et al. IL-36R signalling activates intestinal epithelial cells and fibroblasts and promotes mucosal healing in vivo. Gut (2017) 66:823-38. doi:10.1136/gutjnl-2015-310374
48. Quiros M, Nishio H, Neumann PA, Siuda D, Brazil JC, Azcutia V, et al. Macrophage-derived IL-10 mediates mucosal repair by epithelial WISP-1 signaling. J Clin Invest (2017) 127(9):3510-20. doi:10.1172/JCI90229
49. Gerbe F, Sidot E, Smyth DJ, Ohmoto M, Matsumoto I, Dardalhon V, et al. Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites. Nature (2016) 529(7585):226-30. doi:10.1038/nature16527
50. Mahapatro M, Foersch S, Hefele M, He G, Giner-Ventura E, Mchedlidze T, et al. Programming of intestinal epithelial differentiation by IL-33 derived from pericryptal fibroblasts in response to systemic infection. Cell Rep (2016) 15(8):1743-56. doi:10.1016/j.celrep.2016.04.049
51. Waetzig GH, Rosenstiel P, Arlt A, Till A, Brautigam K, Schafer H, et al. Soluble tumor necrosis factor (TNF) receptor-1 induces apoptosis via reverse TNF signaling and autocrine transforming growth factor-beta1. FASEB J (2005) 19(1):91-3. doi:10.1096/fj.04-2073fje
52. Sandborn WJ, Hanauer SB, Katz S, Safdi M, Wolf DG, Baerg RD, et al. Etanercept for active Crohn's disease: a randomized, double-blind, placebo-controlled trial. Gastroenterology (2001) 121(5):1088-94. doi:10.1053/gast.2001.28674
53. Elphick DA, Mahida YR. Paneth cells: their role in innate immunity and inflammatory disease. Gut (2005) 54(12):1802-9. doi:10.1136/gut.2005.068601
54. Aparicio-Domingo P, Romera-Hernandez M, Karrich JJ, Cornelissen F, Papazian N, Lindenbergh-Kortleve DJ, et al. Type 3 innate lymphoid cells maintain intestinal epithelial stem cells after tissue damage. J Exp Med (2015) 212(11):1783-91. doi:10.1084/jem.20150318
55. Bergstrom KSB, Morampudi V, Chan JM, Bhinder G, Lau J, Yang H, et al. Goblet cell derived RELM-ß recruits CD4+ T cells during infectious colitis to promote protective intestinal epithelial cell proliferation. PLoS Pathog (2015) 11(8):e1005108. doi:10.1371/journal.ppat.1005108
56. Wang K, Kim MK, Di Caro G, Wong J, Shalapour S, Wan J, et al. Interleukin-17 receptor A signaling in transformed enterocytes promotes early colorectal tumorigenesis. Immunity (2014) 41(6):1052-63. doi:10.1016/j.immuni.2014.11.009
57. De Simone V, Franze E, Ronchetti G, Colantoni A, Fantini MC, Di Fusco D, et al. Th17-type cytokines, IL-6 and TNF-a synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth. Oncogene (2015) 34:3493-503. doi:10.1038/onc.2014.286
58. Kirchberger S, Royston DJ, Boulard O, Thornton E, Franchini F, Szabady RL, et al. Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model. J Exp Med (2013) 210(5):917-31. doi:10.1084/jem.20122308
59. Kryczek I, Lin Y, Nagarsheth N, Peng D, Zhao L, Zhao E, et al. IL-22+CD4+ T cell promote colorectal cancer stemness via STAT3 transcription factor activation and induction of the methyltransferase DOT1L. Immunity (2014) 40(5):772-84. doi:10.1016/j.immuni.2014.03.010
60. Liu H, Antony S, Roy K, Juhasz A, Wu Y, Lu J, et al. Interleukin-4 and interleukin-13 increase NADPH oxidase 1-related proliferation of human colon cancer cells. Oncotarget (2017) 8(24):38113-35. doi:10.18632/oncotarget.17494
61. Martini E, Schneider E, Neufert C, Neurath MF, Becker C. Survivin is a guardian of the intestinal stem cell niche and its expression is regulated by TGF-ß. Cell Cycle (2016) 15(21):2875-81. doi:10.1080/15384101.2016.1231286
62. Oshima H, Nakayama M, Han TS, Naoi K, Ju X, Maeda Y, et al. Suppressing TGFß signaling in regenerating epithelia in an inflammatory microenvironment is sufficient to cause invasive intestinal cancer. Cancer Res (2015) 75(4):766-76. doi:10.1158/0008-5472.CAN-14-2036
63. Katlinskaya YV, Katlinski KV, Lasri A, Li N, Beiting DP, Durham AC, et al. Type I interferons control proliferation and function of the intestinal epithelium. Mol Cell Biol (2016) 36(7):1124-35. doi:10.1128/MCB.00988-15
64. Tschurtschenthaler M, Wang J, Fricke C, Fritz TMJ, Niederreiter L, Adolph TE, et al. Type I interferon signaling in the intestinal epithelium affects Paneth cells, microbial ecology, and epithelial regeneration. Gut (2014) 63:1921-31. doi:10.1136/gutjnl-2013-305863
65. Jarry A, Malard F, Bou-Hanna C, Meurette G, Mohty M, Mosnier J, et al. Interferon-alpha promotes Th1 response and epithelial apoptosis via inflammasome activation in human intestinal mucosa. Cell Mol Gastroenterol Hepatol (2016) 3(1):72-81. doi:10.1016/j.jcmgh.2016.09.007
66. Schuhmann D, Godoy P, Weiss C, GerloffA, Singer MV, Dooley S, et al. Interfering with interferon-? signaling in intestinal epithelial cells: selective inhibition of apoptosis-maintained secretion of anti-inflammatory interleukin-18 binding protein. Clin Exp Immunol (2011) 163(1):65-76. doi:10.1111/j.1365-2249.2010.04250.x
67. Leppkes M, Roulis M, Neurath MF, Kollias G, Becker C. Pleiotropic functions of TNF-a in the regulation of the intestinal epithelial response to inflammation. Int Immunol (2014) 26(9):509-15. doi:10.1093/intimm/dxu051
68. Sarhan M, Land WG, Tonnus W, Hugo CP, Linkermann A. Origin and consequences of necroinflammation. Physiol Rev (2018) 98(2):727-80. doi:10.1152/physrev.00041.2016
69. Günther C, Buchen B, He G, Hornef M, Torow N, Neumann H, et al. Caspase-8 controls the gut response to microbial challenges by TNF-a-dependent and independent pathways. Gut (2015) 64(4):601-10. doi:10.1136/gutjnl-2014-307226
70. Maxwell JR, Zhang Y, Brown WA, Smith CL, Byrne FR, Fiorino M, et al. Differential roles for interleukin-23 and interleukin-17 in intestinal immunoregulation. Immunity (2015) 43(4):739-50. doi:10.1016/j.immuni.2015.08.019
71. Kuhn KA, Schulz HM, Regner EH, Severs EL, Hendrickson JD, Mehta G, et al. Bacteroidales recruit IL-6-producing intraepithelial lymphocytes in the colon to promote barrier integrity. Mucosal Immunol (2018) 11(2):357-68. doi:10.1038/mi.2017.55
72. Wang Y, Sun T, Sun H, Yang S, Li D, Zhou D. SCF/c-kit/JNK/AP-1 signaling pathway promotes claudin-3 expression in colonic epithelium and colorectal carcinoma. Int J Mol Sci (2017) 18(4):765. doi:10.3390/ijms18040765
73. Zheng L, Kelly CJ, Battista KD, Schaefer R, Lanis JM, Alexeev EE, et al. Microbial-derived butyrate promotes epithelial barrier function through IL-10 receptor-dependent repression of claudin-2. J Immunol (2017) 199(8):2976-84. doi:10.4049/jimmunol.1700105
74. Lorén V, Cabré E, Ojanguren I, Domènech E, Pedrosa E, Garcia-Jaraquemada A, et al. Interleukin-10 enhances the intestinal epithelial barrier in the presence of corticosteroids through p38 MAPK activity in Caco-2 monolayers: a possible mechanism for steroid responsiveness in ulcerative colitis. PLoS One (2015) 10(6):e0130921. doi:10.1371/journal.pone.0130921
75. Machiels K, Joossens M, Sabino J, De Preter V, Arijs I, Eeckhaut V, et al. A decrease of the butyrate producing species Roseburia hominis and Faecalibacterium prausnitzii defines dysbiosis in patients with ulcerative colitis. Gut (2014) 63(8):1275-83. doi:10.1136/gutjnl-2013-304833
76. Ryu W, Lee H, Bae HC, Jeon J, Ryu HJ, Kim J, et al. IL-33 down-regulates CLDN1 expression through the ERK/STAT3 pathway in keratinocytes. J Dermatol Sci (2018) 90(3):313-22. doi:10.1016/j.jdermsci.2018.02.017
77. Sedhom MAK, Pichery M, Murdoch JR, Foligne B, Ortega N, Normand S, et al. Neutralisation of the interleukin-33/ST2 pathway ameliorates experimental colitis through enhancement of mucosal healing in mice. Gut (2013) 62(12):1714-23. doi:10.1136/gutjnl-2011-301785
78. Sattler S, Ling G, Xu D, Hussaarts L, Romaine A, Zhao H, et al. IL-10-producing regulatory B cells induced by IL-33 (BregIL-33) effectively attenuate mucosal inflammatory responses in the gut. J Autoimmun (2014) 50(100):107-22. doi:10.1016/j.jaut.2014.01.032
79. Wang Y, Mumm JB, Herbst R, Kolbeck R, Wang Y. IL-22 increases permeability of intestinal tight junctions by enhancing claudin-2 expression. J Immunol (2017) 199(9):3316-25. doi:10.4049/jimmunol.1700152
80. Sumagin R, Robin AZ, Nusrat A, Parkos CA. Transmigrated neutrophils in the intestinal lumen engage ICAM-1 to regulate the epithelial barrier and neutrophil recruitment. Mucosal Immunol (2014) 7(4):905-15. doi:10.1038/mi.2013.106
81. Khan MR, Uwada J, Yazawa T, Islam MT, Krug SM, Fromm M, et al. Activation of muscarinic cholinoceptor ameliorates tumor necrosis factor-a-induced barrier dysfunction in intestinal epithelial cells. FEBS Lett (2015) 589(23):3640-7. doi:10.1016/j.febslet.2015.10.029
82. Saxena K, Simon LM, Zeng X, Blutt SE, Crawford SE, Sastri NP, et al. A paradox of transcriptional and functional innate interferon responses of human intestinal enteroids to enteric virus infection. Proc Natl Acad Sci U S A (2017) 114(4):E570-9. doi:10.1073/pnas.1615422114
83. Pott J, Mahlakõiv T, Mordstein M, Duerr CU, Michiels T, Stockinger S, et al. IFN-? determines the intestinal epithelial antiviral host defense. Proc Natl Acad Sci U S A (2011) 108(19):7944-9. doi:10.1073/pnas.1100552108
84. Mahlakõiv T, Hernandez P, Gronke K, Diefenbach A, Staeheli P. Leukocyte-derived IFN-a/ß and epithelial IFN-? constitute a compartmentalized mucosal defense system that restricts enteric virus infections. PLoS Pathog (2015) 11(4):e1004782. doi:10.1371/journal.ppat.1004782
85. Zindl CL, Lai J, Lee YK, Maynard CL, Harbour SN, Ouyang W, et al. IL-22-producing neutrophils contribute to antimicrobial defense and restitution of colonic epithelial integrity during colitis. Proc Natl Acad Sci U S A (2013) 110(31):12768-73. doi:10.1073/pnas.1300318110
86. Kumar P, Monin L, Castillo P, Elsegeiny W, Horne W, Eddens T, et al. Intestinal interleukin-17 receptor signaling mediates reciprocal control of the gut microbiota and autoimmune inflammation. Immunity (2016) 44(3):659-71. doi:10.1016/j.immuni.2016.02.007
87. Kumar A, Chatterjee I, Gujral T, Alakkam A, Coffing H, Anbazhagan AN, et al. Activation of nuclear factor-?B by tumor necrosis factor in intestinal epithelial cells and mouse intestinal epithelia reduces expression of the chloride transporter SLC26A3. Gastroenterology (2017) 153(5):1338-50.e3. doi:10.1053/j.gastro.2017.08.024
88. Wood MB, Rios D, Williams IR. TNF-a augments RANKL-dependent intestinal M cell differentiation in enteroid cultures. Am J Physiol Cell Physiol (2016) 311(3):C498-507. doi:10.1152/ajpcell.00108.2016
89. Takahashi Y, Sato S, Kurashima Y, Lai C, Otsu M, Hayashi M, et al. Reciprocal inflammatory signaling between intestinal epithelial cells and adipocytes in the absence of immune cells. EBioMedicine (2017) 23:34-45. doi:10.1016/j.ebiom.2017.07.027
90. Scarpa M, Kessler S, Sadler T, West G, Homer C, McDonald C, et al. The epithelial danger signal IL-1a is a potent activator of fibroblasts and reactivator of intestinal inflammation. Am J Pathol (2015) 185(6):1624-37. doi:10.1016/j.ajpath.2015.02.018
91. Bersudsky M, Luski L, Fishman D, White RM, Ziv-Sokolovskaya N, Dotan S, et al. Non-redundant properties of IL-1a and IL-1ß during acute colon inflammation in mice. Gut (2014) 63(4):598-609. doi:10.1136/gutjnl-2012-303329
92. He Z, Chen L, Souto FO, Canasto-Chibuque C, Bongers G, Deshpande M, et al. Epithelial-derived IL-33 promotes intestinal tumorigenesis in ApcMin/+ mice. Sci Rep (2017) 7:5520. doi:10.1038/s41598-017-05716-z
93. Maywald RL, Doerner SK, Pastorelli L, De Salvo C, Benton SM, Dawson EP. IL-33 activates tumor stroma to promote intestinal polyposis. Proc Natl Acad Sci U S A (2015) 112(19):E2487-96. doi:10.1073/pnas.1422445112
94. Islam MS, Horiguchi K, Iino S, Kaji N, Mikawa S, Hori M, et al. Epidermal growth factor is a critical regulator of the cytokine IL-33 in intestinal epithelial cells. Br J Pharmacol (2016) 173(16):2532-42. doi:10.1111/bph.13535
95. O'Donnell C, Mahmoud A, Keane J, Murphy C, White D, Carey S, et al. An antitumorigenic role for the IL-33 receptor, ST2L, in colon cancer. Br J Cancer (2016) 114(1):37-43. doi:10.1038/bjc.2015.433
96. Griffith JW, Sokol CL, Luster AD. Chemokines and chemokine receptors: positioning cells for host defense and immunity. Annu Rev Immunol (2014) 32:659-702. doi:10.1146/annurev-immunol-032713-120145
97. Rossi O, Karczewski J, Stolte EH, Brummer RJM, van Nieuwenhoven MA, Meijerink M, et al. Vectorial secretion of interleukin-8 mediates autocrine signalling in intestinal epithelial cells via apically located CXCR1. BMC Res Notes (2013) 6:431. doi:10.1186/1756-0500-6-431
98. Wang H, Rogers TJ, Paton JC, Paton AW. Differential effects of Escherichia coli subtilase cytotoxin and Shiga toxin 2 on chemokine and proinflammatory cytokine expression in human macrophage, colonic epithelial, and brain microvascular endothelial cell lines. Infect Immun (2014) 82(9):3567-79. doi:10.1128/IAI.02120-14
99. Fiorentino M, Levine MM, Sztein MB, Fasano A. Effect of wild-type Shigella species and attenuated Shigella vaccine candidates on small intestinal barrier function, antigen trafficking, and cytokine release. PLoS One (2014) 9(1):e85211. doi:10.1371/journal.pone.0085211
100. Knodler LA, Crowley SM, Sham HP, Yang H, Wrande M, Ma C, et al. Non-canonical inflammasome activation of caspase-4/caspase-11 mediates epithelial defenses against enteric bacterial pathogens. Cell Host Microbe (2014) 16(2):249-56. doi:10.1016/j.chom.2014.07.002
101. Zeuthen LH, Fink LN, Frokiaer H. Epithelial cells prime the immune response to an array of gut-derived commensals towards a tolerogenic phenotype through distinct actions of thymic stromal lymphopoietin and transforming growth factor-ß. Immunology (2008) 123:197-208. doi:10.1111/j.1365-2567.2007.02687.x
102. Kainulainen V, Tang Y, Spillmann T, Kilpinen S, Reunanen J, Saris PEJ, et al. The canine isolate Lactobacillus acidophilus LAB20 adheres to intestinal epithelium and attenuates LPS-induced IL-8 secretion of enterocytes in vitro. BMC Microbiol (2015) 15:4. doi:10.1186/s12866-014-0337-9
103. Tian Z, Liu X, Dai R, Xiao Y, Wang X, Bi D, et al. Enterococcus faecium HDRsEf1 protects the intestinal epithelium and attenuates ETEC-induced IL-8 secretion in enterocytes. Mediators Inflamm (2016) 2016:7474306. doi:10.1155/2016/7474306
104. Hirao LA, Grishina I, Bourry O, Hu WK, Somrit M, Sankaran-Walters S, et al. Early mucosal sensing of SIV infection by Paneth cells induces IL-1ß production and initiates gut epithelial disruption. PLoS Pathog (2014) 10(8):e1004311. doi:10.1371/journal.ppat.1004311
105. Hernández PP, Mahlakoiv T, Yang I, Schwierzeck V, Nguyen N, Guendel F, et al. Interferon-? and interleukin-22 cooperate for the induction of interferon-stimulated genes and control of rotavirus infection. Nat Immunol (2015) 16(7):698-707. doi:10.1038/ni.3180
106. Knight-Sepulveda K, Kais S, Santaolalla R, Abreu MT. Diet and inflammatory bowel disease. Gastroenterol Hepatol (N Y) (2015) 11(8):511-20
107. Ferrari D, Cimino F, Fratantonio D, Molonia MS, Bashllari R, Busà R, et al. Cyanidin-3-O-glucoside modulates the in vitro inflammatory crosstalk between intestinal epithelial and endothelial cells. Mediators Inflamm (2017) 2017:3454023. doi:10.1155/2017/3454023
108. Hung TV, Suzuki T. Guar gum fiber increases suppressor of cytokine signaling-1 expression via toll-like receptor 2 and dectin-1 pathways, regulating inflammatory response in small intestinal epithelial cells. Mol Nutr Food Res (2017) 61(10). doi:10.1002/mnfr.201700048