Activation of Epithelial Signal Transducer and Activator of Transcription 1 by Interleukin 28 Controls Mucosal Healing in Mice With Colitis and Is Increased in Mucosa of Patients With Inflammatory Bowel Disease

Gastroenterology

Volumn 153, Issue 1, 2017, Pages 123-138.e8

  Chiriac, Mircea T ^a   Buchen, Barbara ^a   Wandersee, Alexandra ^a   Hundorfean, Gheorghe ^a   Günther, Claudia ^a   Bourjau, Yvonne ^a   Doyle, Sean E ^b   Frey, Benjamin ^a   Ekici, Arif B ^a   Büttner, Christian ^a   Weigmann, Benno ^a   Atreya, Raja ^a,c   Wirtz, Stefan ^a   Becker, Christoph ^a   Siebler, Jürgen ^a   Neurath, Markus F ^a,c  

^a UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^b ZYMOGENETICS INC   (United States)

^c UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

Crohn's Disease; Interferon ; Ulcerative Colitis; Wound Healing

Indexed keywords

CYTOKINE; DEXTRAN SULFATE; INTERFERON REGULATORY FACTOR 3; INTERFERON REGULATORY FACTOR 7; INTERLEUKIN 28; INTERLEUKIN 28 RECEPTOR ALPHA; INTERLEUKIN 28A; OXAZOLONE; STAT1 PROTEIN; UNCLASSIFIED DRUG; CYTOKINE RECEPTOR; IFNLR1 PROTEIN, HUMAN; IFNLR1 PROTEIN, MOUSE; IL28A PROTEIN, HUMAN; IL28A PROTEIN, MOUSE; INTERFERON RECEPTOR; INTERLEUKIN DERIVATIVE; IRF3 PROTEIN, MOUSE; IRF7 PROTEIN, MOUSE; STAT1 PROTEIN, HUMAN; STAT1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CACO-2 CELL LINE; CELL PROLIFERATION; COLON BIOPSY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOPLASM; DISEASE COURSE; DRUG EFFECT; ENDOSCOPY; EXPERIMENTAL COLITIS; GENE EXPRESSION; GENE ONTOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; IN VIVO STUDY; INFLAMMATORY BOWEL DISEASE; INTESTINE CRYPT; INTESTINE EPITHELIUM CELL; INTESTINE MUCOSA; LAMINA PROPRIA; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; REGULATORY MECHANISM; RNA SEQUENCE; SIGNAL TRANSDUCTION; SMALL INTESTINE; STATISTICAL ANALYSIS; WOUND HEALING; WOUND HEALING ASSAY; ADOLESCENT; ADULT; AGED; ANIMAL; CHEMICALLY INDUCED; COLITIS; DENDRITIC CELL; DISEASE MODEL; EPITHELIUM CELL; FEMALE; GENETICS; KNOCKOUT MOUSE; MALE; METABOLISM; MIDDLE AGED; ORGANOID; PATHOLOGY; PHOSPHORYLATION; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANIMALS; CACO-2 CELLS; CELL PROLIFERATION; COLITIS; DENDRITIC CELLS; DEXTRAN SULFATE; DISEASE MODELS, ANIMAL; EPITHELIAL CELLS; FEMALE; GENE EXPRESSION; HUMANS; INFLAMMATORY BOWEL DISEASES; INTERFERON REGULATORY FACTOR-3; INTERFERON REGULATORY FACTOR-7; INTERLEUKINS; INTESTINAL MUCOSA; MALE; MICE; MICE, KNOCKOUT; MIDDLE AGED; ORGANOIDS; PHOSPHORYLATION; RECEPTORS, CYTOKINE; RECEPTORS, INTERFERON; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; WOUND HEALING; YOUNG ADULT;

EID: 85020884025     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2017.03.015     Document Type: Article

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