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Volumn 551, Issue 7680, 2017, Pages 333-339

A single-cell survey of the small intestinal epithelium

(21)  Haber, Adam L a   Biton, Moshe a,b   Rogel, Noga a   Herbst, Rebecca H a,c   Shekhar, Karthik a   Smillie, Christopher a   Burgin, Grace a   Delorey, Toni M a,d   Howitt, Michael R e   Katz, Yarden c   Tirosh, Itay a   Beyaz, Semir a,f,g   Dionne, Danielle a   Zhang, Mei b   Raychowdhury, Raktima a   Garrett, Wendy S a,e   Rozenblatt Rosen, Orit a   Shi, Hai Ning b   Yilmaz, Omer a,b   Xavier, Ramnik J a,b   more..


Author keywords

[No Author keywords available]

Indexed keywords

CD45 ANTIGEN; THYMIC STROMAL LYMPHOPOIETIN; CYTOKINE; PTPRC PROTEIN, MOUSE; RECEPTOR TYPE TYROSINE PROTEIN PHOSPHATASE C;

EID: 85034439213     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature24489     Document Type: Article
Times cited : (1088)

References (67)
  • 1
    • 35548974423 scopus 로고    scopus 로고
    • Identification of stem cells in small intestine and colon by marker gene Lgr5
    • Barker, N. et al. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 449, 1003-1007 (2007).
    • (2007) Nature , vol.449 , pp. 1003-1007
    • Barker, N.1
  • 2
    • 84954286513 scopus 로고    scopus 로고
    • Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit
    • von Moltke, J., Ji, M., Liang, H. E. & Locksley, R. M. Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit. Nature 529, 221-225 (2016).
    • (2016) Nature , vol.529 , pp. 221-225
    • Von Moltke, J.1    Ji, M.2    Liang, H.E.3    Locksley, R.M.4
  • 3
    • 85014726810 scopus 로고    scopus 로고
    • Mex3a marks a slowly dividing subpopulation of Lgr5+ intestinal stem cells
    • Barriga, F. M. et al. Mex3a marks a slowly dividing subpopulation of Lgr5+ intestinal stem cells. Cell Stem Cell 20, 801-816.e7 (2017).
    • (2017) Cell Stem Cell , vol.20 , pp. 801-801e7
    • Barriga, F.M.1
  • 4
    • 85008153076 scopus 로고    scopus 로고
    • Induced quiescence of Lgr5+ stem cells in intestinal organoids enables differentiation of hormone-producing enteroendocrine cells
    • Basak, O. et al. Induced quiescence of Lgr5+ stem cells in intestinal organoids enables differentiation of hormone-producing enteroendocrine cells. Cell Stem Cell 20, 177-190.e4 (2017).
    • (2017) Cell Stem Cell , vol.20 , pp. 177-177e4
    • Basak, O.1
  • 5
    • 84941201582 scopus 로고    scopus 로고
    • Single-cell messenger RNA sequencing reveals rare intestinal cell types
    • Grün, D. et al. Single-cell messenger RNA sequencing reveals rare intestinal cell types. Nature 525, 251-255 (2015).
    • (2015) Nature , vol.525 , pp. 251-255
    • Grün, D.1
  • 6
    • 85019174371 scopus 로고    scopus 로고
    • Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem-cell self-renewal
    • Yan, K. S. et al. Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem-cell self-renewal. Nature 545, 238-242 (2017).
    • (2017) Nature , vol.545 , pp. 238-242
    • Yan, K.S.1
  • 7
    • 85029219708 scopus 로고    scopus 로고
    • Intestinal enteroendocrine lineage cells possess homeostatic and injury-inducible stem cell activity
    • Yan, K. S. et al. Intestinal enteroendocrine lineage cells possess homeostatic and injury-inducible stem cell activity. Cell Stem Cell 21, 78-90.e6 (2017).
    • (2017) Cell Stem Cell , vol.21 , pp. 78-78e6
    • Yan, K.S.1
  • 8
    • 84960894307 scopus 로고    scopus 로고
    • Haplotyping germline and cancer genomes with highthroughput linked-read sequencing
    • Zheng, G. X. et al. Haplotyping germline and cancer genomes with highthroughput linked-read sequencing. Nat. Biotechnol. 34, 303-311 (2016).
    • (2016) Nat. Biotechnol , vol.34 , pp. 303-311
    • Zheng, G.X.1
  • 9
    • 39549086558 scopus 로고    scopus 로고
    • Maps of random walks on complex networks reveal community structure
    • Rosvall, M. & Bergstrom, C. T. Maps of random walks on complex networks reveal community structure. Proc. Natl Acad. Sci. USA 105, 1118-1123 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 1118-1123
    • Rosvall, M.1    Bergstrom, C.T.2
  • 10
    • 84983741021 scopus 로고    scopus 로고
    • Comprehensive classification of retinal bipolar neurons by single-cell transcriptomics
    • Shekhar, K. et al. Comprehensive classification of retinal bipolar neurons by single-cell transcriptomics. Cell 166, 1308-1323.e30 (2016).
    • (2016) Cell , vol.166 , pp. 1308-1308e30
    • Shekhar, K.1
  • 11
    • 84880280631 scopus 로고    scopus 로고
    • ViSNE enables visualization of high dimensional single-cell data and reveals phenotypic heterogeneity of leukemia
    • Amir, E.-a. D. et al. viSNE enables visualization of high dimensional single-cell data and reveals phenotypic heterogeneity of leukemia. Nat. Biotechnol. 31, 545-552 (2013).
    • (2013) Nat. Biotechnol , vol.31 , pp. 545-552
    • Amir, E.-A.D.1
  • 12
    • 84956599311 scopus 로고    scopus 로고
    • Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells
    • Kowalczyk, M. S. et al. Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells. Genome Res. 25, 1860-1872 (2015).
    • (2015) Genome Res , vol.25 , pp. 1860-1872
    • Kowalczyk, M.S.1
  • 13
    • 0030863618 scopus 로고    scopus 로고
    • Examining the role of Paneth cells in the small intestine by lineage ablation in transgenic mice
    • Garabedian, E. M., Roberts, L. J., McNevin, M. S. & Gordon, J. I. Examining the role of Paneth cells in the small intestine by lineage ablation in transgenic mice. J. Biol. Chem. 272, 23729-23740 (1997).
    • (1997) J. Biol. Chem , vol.272 , pp. 23729-23740
    • Garabedian, E.M.1    Roberts, L.J.2    McNevin, M.S.3    Gordon, J.I.4
  • 14
    • 84958620086 scopus 로고    scopus 로고
    • Enteroendocrine cells: Chemosensors in the intestinal epithelium
    • Gribble, F. M. & Reimann, F. Enteroendocrine cells: chemosensors in the intestinal epithelium. Annu. Rev. Physiol. 78, 277-299 (2016).
    • (2016) Annu. Rev. Physiol , vol.78 , pp. 277-299
    • Gribble, F.M.1    Reimann, F.2
  • 15
    • 84958767810 scopus 로고    scopus 로고
    • Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut
    • Howitt, M. R. et al. Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut. Science 351, 1329-1333 (2016).
    • (2016) Science , vol.351 , pp. 1329-1333
    • Howitt, M.R.1
  • 16
    • 84891677425 scopus 로고    scopus 로고
    • Full-length RNA-seq from single cells using Smart-seq2
    • Picelli, S. et al. Full-length RNA-seq from single cells using Smart-seq2. Nat. Protocols 9, 171-181 (2014).
    • (2014) Nat. Protocols , vol.9 , pp. 171-181
    • Picelli, S.1
  • 17
    • 38349026795 scopus 로고    scopus 로고
    • Dietary modulation and structure prediction of rat mucosal pentraxin (Mptx) protein and loss of function in humans
    • van der Meer-van Kraaij, C. et al. Dietary modulation and structure prediction of rat mucosal pentraxin (Mptx) protein and loss of function in humans. Genes Nutr. 2, 275-285 (2007).
    • (2007) Genes Nutr , vol.2 , pp. 275-285
    • Van Der Meer-Van Kraaij, C.1
  • 18
    • 84895513254 scopus 로고    scopus 로고
    • Structure, function, and role in inflammation
    • Du Clos, T. W. Pentraxins: structure, function, and role in inflammation. ISRN Inflamm. 2013, 379040 (2013).
    • (2013) ISRN Inflamm , vol.2013 , pp. 379040
    • Clos, D.1    Pentraxins, T.W.2
  • 19
    • 0036340041 scopus 로고    scopus 로고
    • The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon
    • Katz, J. P. et al. The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon. Development 129, 2619-2628 (2002).
    • (2002) Development , vol.129 , pp. 2619-2628
    • Katz, J.P.1
  • 20
    • 84895520482 scopus 로고    scopus 로고
    • The bile acid TGR5 membrane receptor: From basic research to clinical application
    • Duboc, H., Taché, Y. & Hofmann, A. F. The bile acid TGR5 membrane receptor: from basic research to clinical application. Dig. Liver Dis. 46, 302-312 (2014).
    • (2014) Dig. Liver Dis , vol.46 , pp. 302-312
    • Duboc, H.1    Taché, Y.2    Hofmann, A.F.3
  • 21
    • 40349114501 scopus 로고    scopus 로고
    • GPR119, a novel G protein-coupled receptor target for the treatment of type 2 diabetes and obesity
    • Overton, H. A., Fyfe, M. C. & Reynet, C. GPR119, a novel G protein-coupled receptor target for the treatment of type 2 diabetes and obesity. Br. J. Pharmacol. 153 (Suppl. 1), S76-S81 (2008).
    • (2008) Br. J. Pharmacol , vol.153 , pp. S76-S81
    • Overton, H.A.1    Fyfe, M.C.2    Reynet, C.3
  • 22
    • 19644394100 scopus 로고    scopus 로고
    • Geometric diffusions as a tool for harmonic analysis and structure definition of data: Diffusion maps
    • Coifman, R. R. et al. Geometric diffusions as a tool for harmonic analysis and structure definition of data: diffusion maps. Proc. Natl Acad. Sci. USA 102, 7426-7431 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 7426-7431
    • Coifman, R.R.1
  • 23
    • 84908191732 scopus 로고    scopus 로고
    • Mapping early fate determination in Lgr5+ crypt stem cells using a novel Ki67-RFP allele
    • Basak, O. et al. Mapping early fate determination in Lgr5+ crypt stem cells using a novel Ki67-RFP allele. EMBO J. 33, 2057-2068 (2014).
    • (2014) EMBO J , vol.33 , pp. 2057-2068
    • Basak, O.1
  • 24
    • 79953187258 scopus 로고    scopus 로고
    • GATA factors regulate proliferation, differentiation, and gene expression in small intestine of mature mice
    • Beuling, E. et al. GATA factors regulate proliferation, differentiation, and gene expression in small intestine of mature mice. Gastroenterology 140, 1219-1229.e2 (2011).
    • (2011) Gastroenterology , vol.140 , pp. 1219-1219e2
    • Beuling, E.1
  • 26
    • 85034455511 scopus 로고    scopus 로고
    • Enteroendocrine cells-sensory sentinels of the intestinal environment and orchestrators of mucosal immunity
    • Worthington, J. J., Reimann, F. & Gribble, F. M. Enteroendocrine cells-sensory sentinels of the intestinal environment and orchestrators of mucosal immunity. Mucosal Immunol. (2017).
    • (2017) Mucosal Immunol
    • Worthington, J.J.1    Reimann, F.2    Gribble, F.M.3
  • 27
    • 84877763148 scopus 로고    scopus 로고
    • Co-localisation and secretion of glucagon-like peptide 1 and peptide YY from primary cultured human L cells
    • Habib, A. M., Richards, P., Rogers, G. J., Reimann, F. & Gribble, F. M. Co-localisation and secretion of glucagon-like peptide 1 and peptide YY from primary cultured human L cells. Diabetologia 56, 1413-1416 (2013).
    • (2013) Diabetologia , vol.56 , pp. 1413-1416
    • Habib, A.M.1    Richards, P.2    Rogers, G.J.3    Reimann, F.4    Gribble, F.M.5
  • 28
    • 33846347644 scopus 로고    scopus 로고
    • The serotonin signaling system: From basic understanding to drug development for functional GI disorders
    • Gershon, M. D. & Tack, J. The serotonin signaling system: from basic understanding to drug development for functional GI disorders. Gastroenterology 132, 397-414 (2007).
    • (2007) Gastroenterology , vol.132 , pp. 397-414
    • Gershon, M.D.1    Tack, J.2
  • 29
    • 33845642664 scopus 로고    scopus 로고
    • The role of leptin and ghrelin in the regulation of food intake and body weight in humans: A review
    • Klok, M. D., Jakobsdottir, S. & Drent, M. L. The role of leptin and ghrelin in the regulation of food intake and body weight in humans: a review. Obes. Rev. 8, 21-34 (2007).
    • (2007) Obes. Rev , vol.8 , pp. 21-34
    • Klok, M.D.1    Jakobsdottir, S.2    Drent, M.L.3
  • 30
    • 58149295547 scopus 로고    scopus 로고
    • The role of peptide YY in appetite regulation and obesity
    • Karra, E., Chandarana, K. & Batterham, R. L. The role of peptide YY in appetite regulation and obesity. J. Physiol. 587, 19-25 (2009).
    • (2009) J. Physiol , vol.587 , pp. 19-25
    • Karra, E.1    Chandarana, K.2    Batterham, R.L.3
  • 31
    • 84991609080 scopus 로고    scopus 로고
    • Intestinal tuft cells: Epithelial sentinels linking luminal cues to the immune system
    • Gerbe, F. & Jay, P. Intestinal tuft cells: epithelial sentinels linking luminal cues to the immune system. Mucosal Immunol. 9, 1353-1359 (2016).
    • (2016) Mucosal Immunol , vol.9 , pp. 1353-1359
    • Gerbe, F.1    Jay, P.2
  • 32
    • 84954561117 scopus 로고    scopus 로고
    • Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites
    • Gerbe, F. et al. Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites. Nature 529, 226-230 (2016).
    • (2016) Nature , vol.529 , pp. 226-230
    • Gerbe, F.1
  • 33
    • 48249128056 scopus 로고    scopus 로고
    • Murine intestinal cells expressing Trpm5 are mostly brush cells and express markers of neuronal and inflammatory cells
    • Bezençon, C. et al. Murine intestinal cells expressing Trpm5 are mostly brush cells and express markers of neuronal and inflammatory cells. J. Comp. Neurol. 509, 514-525 (2008).
    • (2008) J. Comp. Neurol , vol.509 , pp. 514-525
    • Bezençon, C.1
  • 34
    • 79951598704 scopus 로고    scopus 로고
    • Epithelial microRNAs regulate gut mucosal immunity via epithelium-T cell crosstalk
    • Biton, M. et al. Epithelial microRNAs regulate gut mucosal immunity via epithelium-T cell crosstalk. Nat. Immunol. 12, 239-246 (2011).
    • (2011) Nat. Immunol , vol.12 , pp. 239-246
    • Biton, M.1
  • 35
    • 84866465328 scopus 로고    scopus 로고
    • Peyer's patch M cells derived from Lgr5+ stem cells require SpiB and are induced by RankL in cultured "miniguts
    • de Lau, W. et al. Peyer's patch M cells derived from Lgr5+ stem cells require SpiB and are induced by RankL in cultured "miniguts". Mol. Cell. Biol. 32, 3639-3647 (2012).
    • (2012) Mol. Cell. Biol , vol.32 , pp. 3639-3647
    • De Lau, W.1
  • 36
    • 84879336857 scopus 로고    scopus 로고
    • Microfold (M) cells: Important immunosurveillance posts in the intestinal epithelium
    • Mabbott, N. A., Donaldson, D. S., Ohno, H., Williams, I. R. & Mahajan, A. Microfold (M) cells: important immunosurveillance posts in the intestinal epithelium. Mucosal Immunol. 6, 666-677 (2013).
    • (2013) Mucosal Immunol , vol.6 , pp. 666-677
    • Mabbott, N.A.1    Donaldson, D.S.2    Ohno, H.3    Williams, I.R.4    Mahajan, A.5
  • 37
    • 50949083497 scopus 로고    scopus 로고
    • Comprehensive gene expression profiling of Peyer's patch M cells, villous M-like cells, and intestinal epithelial cells
    • Terahara, K. et al. Comprehensive gene expression profiling of Peyer's patch M cells, villous M-like cells, and intestinal epithelial cells. J. Immunol. 180, 7840-7846 (2008).
    • (2008) J. Immunol , vol.180 , pp. 7840-7846
    • Terahara, K.1
  • 38
    • 84896851032 scopus 로고    scopus 로고
    • Intestinal epithelial cells: Regulators of barrier function and immune homeostasis
    • Peterson, L. W. & Artis, D. Intestinal epithelial cells: regulators of barrier function and immune homeostasis. Nat. Rev. Immunol. 14, 141-153 (2014).
    • (2014) Nat. Rev. Immunol , vol.14 , pp. 141-153
    • Peterson, L.W.1    Artis, D.2
  • 39
    • 84902590860 scopus 로고    scopus 로고
    • REG3λ -deficient mice have altered mucus distribution and increased mucosal inflammatory responses to the microbiota and enteric pathogens in the ileum
    • Loonen, L. M. et al. REG3λ -deficient mice have altered mucus distribution and increased mucosal inflammatory responses to the microbiota and enteric pathogens in the ileum. Mucosal Immunol. 7, 939-947 (2014).
    • (2014) Mucosal Immunol , vol.7 , pp. 939-947
    • Loonen, L.M.1
  • 40
    • 78149236073 scopus 로고    scopus 로고
    • Intestinal epithelial serum amyloid A modulates bacterial growth in vitro and pro-inflammatory responses in mouse experimental colitis
    • Eckhardt, E. R. et al. Intestinal epithelial serum amyloid A modulates bacterial growth in vitro and pro-inflammatory responses in mouse experimental colitis. BMC Gastroenterol. 10, 133 (2010).
    • (2010) BMC Gastroenterol , vol.10 , pp. 133
    • Eckhardt, E.R.1
  • 41
    • 84857065857 scopus 로고    scopus 로고
    • Expansion of Paneth cell population in response to enteric Salmonella enterica serovar Typhimurium infection
    • Martinez Rodriguez, N. R. et al. Expansion of Paneth cell population in response to enteric Salmonella enterica serovar Typhimurium infection. Infect. Immun. 80, 266-275 (2012).
    • (2012) Infect. Immun , vol.80 , pp. 266-275
    • Martinez Rodriguez, N.R.1
  • 42
    • 4544300682 scopus 로고    scopus 로고
    • RELMbeta/FIZZ2 is a goblet cell-specific immune-effector molecule in the gastrointestinal tract
    • Artis, D. et al. RELMbeta/FIZZ2 is a goblet cell-specific immune-effector molecule in the gastrointestinal tract. Proc. Natl Acad. Sci. USA 101, 13596-13600 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 13596-13600
    • Artis, D.1
  • 43
    • 33947251378 scopus 로고    scopus 로고
    • Green fluorescent protein knock-in mice reveal a dynamic expression pattern of Gfi1b during hematopoiesis that is largely complementary to Gfi1
    • Vassen, L., Okayama, T. & Möröy, T. Gfi1b:green fluorescent protein knock-in mice reveal a dynamic expression pattern of Gfi1b during hematopoiesis that is largely complementary to Gfi1. Blood 109, 2356-2364 (2007).
    • (2007) Blood , vol.109 , pp. 2356-2364
    • Vassen, L.1    Okayama, T.2    Gfib, M.T.3
  • 44
    • 84906052539 scopus 로고    scopus 로고
    • Coinfection with an intestinal helminth impairs host innate immunity against Salmonella enterica serovar Typhimurium and exacerbates intestinal inflammation in mice
    • Su, L. et al. Coinfection with an intestinal helminth impairs host innate immunity against Salmonella enterica serovar Typhimurium and exacerbates intestinal inflammation in mice. Infect. Immun. 82, 3855-3866 (2014).
    • (2014) Infect. Immun , vol.82 , pp. 3855-3866
    • Su, L.1
  • 45
    • 84863205849 scopus 로고    scopus 로고
    • NIH Image to ImageJ: 25 years of image analysis
    • Schneider, C. A., Rasband, W. S. & Eliceiri, K. W. NIH Image to ImageJ: 25 years of image analysis. Nat. Methods 9, 671-675 (2012).
    • (2012) Nat. Methods , vol.9 , pp. 671-675
    • Schneider, C.A.1    Rasband, W.S.2    Eliceiri, K.W.3
  • 46
    • 33845432928 scopus 로고    scopus 로고
    • Adjusting batch effects in microarray expression data using empirical Bayes methods
    • Johnson, W. E., Li, C. & Rabinovic, A. Adjusting batch effects in microarray expression data using empirical Bayes methods. Biostatistics 8, 118-127 (2007).
    • (2007) Biostatistics , vol.8 , pp. 118-127
    • Johnson, W.E.1    Li, C.2    Rabinovic, A.3
  • 47
    • 84859098571 scopus 로고    scopus 로고
    • The sva package for removing batch effects and other unwanted variation in high-throughput experiments
    • Leek, J. T., Johnson, W. E., Parker, H. S., Jaffe, A. E. & Storey, J. D. The sva package for removing batch effects and other unwanted variation in high-throughput experiments. Bioinformatics 28, 882-883 (2012).
    • (2012) Bioinformatics , vol.28 , pp. 882-883
    • Leek, J.T.1    Johnson, W.E.2    Parker, H.S.3    Jaffe, A.E.4    Storey, J.D.5
  • 48
    • 84887109584 scopus 로고    scopus 로고
    • Accounting for technical noise in single-cell RNA-seq experiments
    • Brennecke, P. et al. Accounting for technical noise in single-cell RNA-seq experiments. Nat. Methods 10, 1093-1095 (2013).
    • (2013) Nat. Methods , vol.10 , pp. 1093-1095
    • Brennecke, P.1
  • 49
    • 62349130698 scopus 로고    scopus 로고
    • Ultrafast and memoryefficient alignment of short DNA sequences to the human genome
    • Langmead, B., Trapnell, C., Pop, M. & Salzberg, S. L. Ultrafast and memoryefficient alignment of short DNA sequences to the human genome. Genome Biol. 10, R25 (2009).
    • (2009) Genome Biol , vol.10 , pp. R25
    • Langmead, B.1    Trapnell, C.2    Pop, M.3    Salzberg, S.L.4
  • 50
    • 79961123152 scopus 로고    scopus 로고
    • RSEM: Accurate transcript quantification from RNA-seq data with or without a reference genome
    • Li, B. & Dewey, C. N. RSEM: accurate transcript quantification from RNA-seq data with or without a reference genome. BMC Bioinformatics 12, 323 (2011).
    • (2011) BMC Bioinformatics , vol.12 , pp. 323
    • Li, B.1    Dewey, C.N.2
  • 52
    • 84919775831 scopus 로고    scopus 로고
    • Accelerating t-SNE using tree-based algorithms
    • van der Maaten, L. Accelerating t-SNE using tree-based algorithms. J. Mach. Learn. Res. 15, 3221-3245 (2014).
    • (2014) J. Mach. Learn. Res , vol.15 , pp. 3221-3245
    • Van Der Maaten, L.1
  • 54
    • 84924565530 scopus 로고    scopus 로고
    • Brain structure. Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq
    • Zeisel, A. et al. Brain structure. Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq. Science 347, 1138-1142 (2015).
    • (2015) Science , vol.347 , pp. 1138-1142
    • Zeisel, A.1
  • 55
    • 84941753288 scopus 로고    scopus 로고
    • Diffusion maps for high-dimensional single-cell analysis of differentiation data
    • Haghverdi, L., Buettner, F. & Theis, F. J. Diffusion maps for high-dimensional single-cell analysis of differentiation data. Bioinformatics 31, 2989-2998 (2015).
    • (2015) Bioinformatics , vol.31 , pp. 2989-2998
    • Haghverdi, L.1    Buettner, F.2    Theis, F.J.3
  • 57
    • 84934442835 scopus 로고    scopus 로고
    • Data-driven phenotypic dissection of AML reveals progenitorlike cells that correlate with prognosis
    • Levine, J. H. et al. Data-driven phenotypic dissection of AML reveals progenitorlike cells that correlate with prognosis. Cell 162, 184-197 (2015).
    • (2015) Cell , vol.162 , pp. 184-197
    • Levine, J.H.1
  • 58
    • 84903289127 scopus 로고    scopus 로고
    • Machine learning. Clustering by fast search and find of density peaks
    • Rodriguez, A. & Laio, A. Machine learning. Clustering by fast search and find of density peaks. Science 344, 1492-1496 (2014).
    • (2014) Science , vol.344 , pp. 1492-1496
    • Rodriguez, A.1    Laio, A.2
  • 59
    • 84951574149 scopus 로고    scopus 로고
    • MAST: A flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data
    • Finak, G. et al. MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data. Genome Biol. 16, 278 (2015).
    • (2015) Genome Biol , vol.16 , pp. 278
    • Finak, G.1
  • 60
    • 0001677717 scopus 로고
    • Controlling the false discovery rate: A practical and powerful approach to multiple testing
    • Benjamini, Y. & Hochberg, Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J. R. Stat. Soc. B 57, 289-300 (1995).
    • (1995) J. R. Stat. Soc. B , vol.57 , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2
  • 61
    • 84862198697 scopus 로고    scopus 로고
    • AnimalTFDB: A comprehensive animal transcription factor database
    • Zhang, H.-M. et al. AnimalTFDB: a comprehensive animal transcription factor database. Nucleic Acids Res. 40, D144-D149 (2012).
    • (2012) Nucleic Acids Res , vol.40 , pp. D144-D149
    • Zhang, H.-M.1
  • 62
    • 79952742148 scopus 로고    scopus 로고
    • Human leucine-rich repeat proteins: A genome-wide bioinformatic categorization and functional analysis in innate immunity
    • Ng, A., Eisenberg, J. M. & Heath, R. Human leucine-rich repeat proteins: a genome-wide bioinformatic categorization and functional analysis in innate immunity. Proc. Natl Acad. Sci. 108, 4631-4638 (2011).
    • (2011) Proc. Natl Acad. Sci , vol.108 , pp. 4631-4638
    • Ng, A.1    Eisenberg, J.M.2    Heath, R.3
  • 63
    • 77953212372 scopus 로고    scopus 로고
    • Gene ontology analysis for RNA-seq: Accounting for selection bias
    • Young, M. D., Wakefield, M. J., Smyth, G. K. & Oshlack, A. Gene ontology analysis for RNA-seq: accounting for selection bias. Genome Biol. 11, R14 (2010).
    • (2010) Genome Biol , vol.11 , pp. R14
    • Young, M.D.1    Wakefield, M.J.2    Smyth, G.K.3    Oshlack, A.4
  • 64
  • 65
    • 0000135972 scopus 로고
    • The Bayesian bootstrap
    • Rubin, D. B. The Bayesian bootstrap. Ann. Stat. 9, 130-134 (1981).
    • (1981) Ann. Stat , vol.9 , pp. 130-134
    • Rubin, D.B.1
  • 66
    • 84867724554 scopus 로고    scopus 로고
    • Identification of novel genes selectively expressed in the follicle-associated epithelium from the meta-analysis of transcriptomics data from multiple mouse cell and tissue populations
    • Kobayashi, A. et al. Identification of novel genes selectively expressed in the follicle-associated epithelium from the meta-analysis of transcriptomics data from multiple mouse cell and tissue populations. DNA Res. 19, 407-422 (2012).
    • (2012) DNA Res , vol.19 , pp. 407-422
    • Kobayashi, A.1
  • 67
    • 21544454393 scopus 로고    scopus 로고
    • Identification of novel genes in intestinal tissue that are regulated after infection with an intestinal nematode parasite
    • Datta, R. et al. Identification of novel genes in intestinal tissue that are regulated after infection with an intestinal nematode parasite. Infect. Immun. 73, 4025-4033 (2005).
    • (2005) Infect. Immun , vol.73 , pp. 4025-4033
    • Datta, R.1


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