Caspase-8 controls the gut response to microbial challenges by Tnf-α-dependent and independent pathways

Gut

Volumn 64, Issue 4, 2015, Pages 601-610

  Günther, Claudia ^a   Buchen, Barbara ^a   He, Gui Wei ^a   Hornef, Mathias ^b   Torow, Natalia ^b   Neumann, Helmut ^a   Wittkopf, Nadine ^a   Martini, Eva ^a   Basic, Marijana ^b   Bleich, André ^b   Watson, Alastair J M ^c   Neurath, Markus F ^a   Becker, Christoph ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

^c UNIVERSITY OF EAST ANGLIA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 8; INTERFERON; INTERFERON TYPE III; LIPOPOLYSACCHARIDE; POLYINOSINIC POLYCYTIDYLIC ACID; PROTEIN KINASE; PROTEIN RIP3; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BACTERIAL SHEDDING; BACTERIAL VIRULENCE; CELL SPECIFICITY; ENZYME ACTIVATION; ENZYME INHIBITION; IN VIVO STUDY; INTESTINE EPITHELIUM CELL; INTESTINE INJURY; MICROORGANISM; MOLECULAR PROBE; MORTALITY; MOUSE; NECROPTOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RNA VIRUS; SIGNAL TRANSDUCTION; ANIMAL; EPITHELIUM CELL; INTESTINE MUCOSA; MICROBIOLOGY; PHYSIOLOGY;

ANIMALS; CASPASE 8; EPITHELIAL CELLS; INTESTINAL MUCOSA; MICE; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84924405610     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2014-307226     Document Type: Article

References (26)

1. Kaser A, Zeissig S, Blumberg RS. Inflammatory bowel disease. Annu Rev Immunol 2010;28:573-621.
2. Jager S, Stange EF, Wehkamp J. Inflammatory bowel disease: an impaired barrier disease. Langenbecks Arch Surg 2013;398:1-12.
3. Gersemann M, Wehkamp J, Stange EF. Innate immune dysfunction in inflammatory bowel disease. J Intern Med 2012;271:421-8.
4. Hagiwara C, Tanaka M, Kudo H. Increase in colorectal epithelial apoptotic cells in patients with ulcerative colitis ultimately requiring surgery. J Gastroenterol Hepatol 2002;17:758-64.
5. Iwamoto M, Koji T, Makiyama K, et al. Apoptosis of crypt epithelial cells in ulcerative colitis. J Pathol 1996;180:152-9.
6. Zeissig S, Bojarski C, Buergel N, et al. Downregulation of epithelial apoptosis and barrier repair in active Crohn's disease by tumour necrosis factor alpha antibody treatment. Gut 2004;53:1295-302.
7. Watson AJ, Hughes KR. TNF-alpha-induced intestinal epithelial cell shedding: implications for intestinal barrier function. Ann N Y Acad Sci 2012;1258:1-8.
8. Kiesslich R, Goetz M, Angus EM, et al. Identification of epithelial gaps in human small and large intestine by confocal endomicroscopy. Gastroenterology 2007;133:1769-78.
9. Marchiando AM, Shen L, Graham WV, et al. The epithelial barrier is maintained by in vivo tight junction expansion during pathologic intestinal epithelial shedding. Gastroenterology 2011;140:1208-18 e1-2.
10. Williams JM, Duckworth CA, Watson AJ, et al. A mouse model of pathological small intestinal epithelial cell apoptosis and shedding induced by systemic administration of lipopolysaccharide. Dis Model Mech 2013;6:1388-99.
11. Kiesslich R, Duckworth CA, Moussata D, et al. Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease. Gut 2012;61:1146-53.
12. Gunther C, Martini E, Wittkopf N, et al. Caspase-8 regulates TNF-alpha-induced epithelial necroptosis and terminal ileitis. Nature 2011;477:335-9.
13. McAllister CS, Lakhdari O, Pineton de Chambrun G, et al. TLR3, TRIF, and caspase 8 determine double-stranded RNA-induced epithelial cell death and survival in vivo. J Immunol 2013;190:418-27.
14. Wittkopf N, Gunther C, Martini E, et al. Cellular FLICE-like inhibitory protein secures intestinal epithelial cell survival and immune homeostasis by regulating Caspase-8. Gastroenterology 2013;145:1369-79.
15. Hoebe K, Du X, Georgel P, et al. Identi fication of Lps2 as a key transducer of MyD88-independent TIR signalling. Nature 2003;424:743-8.
16. Sato T, Vries RG, Snippert HJ, et al. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature 2009;459:262-5.
17. Cario E. Toll-like receptors in in flammatory bowel diseases: a decade later. Inflamm Bowel Dis 2010;16:1583-97.
18. Pott J, Stockinger S, Torow N, et al. Age-dependent TLR3 expression of the intestinal epithelium contributes to rotavirus susceptibility. PLoS Pathog 2012;8: e1002670.
19. Ank N, Iversen MB, Bartholdy C, et al. An important role for type III interferon (IFN-lambda/IL-28) in TLR-induced antiviral activity. J Immunol 2008;180: 2474-85.
20. Pott J, Mahlakoiv T, Mordstein M, et al . IFN-lambda determines the intestinal epithelial antiviral host defense. Proc Natl Acad Sci USA 2011;108:7944-9.
21. Ioannidis I, Ye F, McNally B, et al. Toll-like receptor expression and induction of type I and type III interferons in primary airway epithelial cells. J Virol 2013;87:3261-70.
22. Su L, Shen L, Clayburgh DR, et al. Targeted epithelial tight junction dysfunction causes immune activation and contributes to development of experimental colitis. Gastroenterology 2009;136:551-63.
23. Wang Y, Han G, Chen Y, et al. Protective role of tumor necrosis factor (TNF) receptors in chronic intestinal inflammation: TNFR1 ablation boosts systemic inflammatory response. Lab Invest 2013;93:1024-35.
24. Young JA, He TH, Reizis B, et al. Commensal microbiota are required for systemic inflammation triggered by necrotic dendritic cells. Cell Rep 2013;3: 1932-44.
25. Feoktistova M, Geserick P, Kellert B, et al. cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms. Mol Cell 2011;43:449-63.
26. Becker C, Wirtz S, Blessing M, et al. Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells. J Clin Invest 2003;112:693-706.