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Volumn 199, Issue 9, 2017, Pages 3316-3325

IL-22 increases permeability of intestinal epithelial tight junctions by enhancing claudin-2 expression

Author keywords

[No Author keywords available]

Indexed keywords

CLAUDIN 2; INTERLEUKIN 22; JANUS KINASE; JANUS KINASE INHIBITOR; SMALL INTERFERING RNA; STAT PROTEIN; CLAUDIN; CLDN2 PROTEIN, HUMAN; CLDN2 PROTEIN, MOUSE; INTERLEUKIN DERIVATIVE; INTERLEUKIN-22;

EID: 85032004783     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1700152     Document Type: Article
Times cited : (96)

References (68)
  • 1
    • 84976444297 scopus 로고    scopus 로고
    • Tight junctions: From simple barriers to multifunctional molecular gates
    • Zihni, C., C. Mills, K. Matter, and M. S. Balda. 2016. Tight junctions: from simple barriers to multifunctional molecular gates. Nat. Rev. Mol. Cell Biol. 17: 564-580.
    • (2016) Nat. Rev. Mol. Cell Biol. , vol.17 , pp. 564-580
    • Zihni, C.1    Mills, C.2    Matter, K.3    Balda, M.S.4
  • 2
    • 84878506887 scopus 로고    scopus 로고
    • Claudins and the modulation of tight junction permeability
    • Gunzel, D., and A. S. Yu. 2013. Claudins and the modulation of tight junction permeability. Physiol. Rev. 93: 525-569.
    • (2013) Physiol. Rev. , vol.93 , pp. 525-569
    • Gunzel, D.1    Yu, A.S.2
  • 3
    • 84896851032 scopus 로고    scopus 로고
    • Intestinal epithelial cells: Regulators of barrier function and immune homeostasis
    • Peterson, L. W., and D. Artis. 2014. Intestinal epithelial cells: regulators of barrier function and immune homeostasis. Nat. Rev. Immunol. 14: 141-153.
    • (2014) Nat. Rev. Immunol. , vol.14 , pp. 141-153
    • Peterson, L.W.1    Artis, D.2
  • 4
    • 84937524388 scopus 로고    scopus 로고
    • Intestinal permeability regulation by tight junction: Implication on inflammatory bowel diseases
    • Lee, S. H. 2015. Intestinal permeability regulation by tight junction: implication on inflammatory bowel diseases. Intest. Res. 13: 11-18.
    • (2015) Intest. Res. , vol.13 , pp. 11-18
    • Lee, S.H.1
  • 6
    • 84883437538 scopus 로고    scopus 로고
    • Claudins in intestines: Distribution and functional significance in health and diseases
    • Lu, Z., L. Ding, Q. Lu, and Y. H. Chen. 2013. Claudins in intestines: distribution and functional significance in health and diseases. Tissue Barriers 1: e24978.
    • (2013) Tissue Barriers , vol.1 , pp. e24978
    • Lu, Z.1    Ding, L.2    Lu, Q.3    Chen, Y.H.4
  • 8
    • 35348841509 scopus 로고    scopus 로고
    • Tight junctions/adherens junctions: Basic structure and function
    • Niessen, C. M. 2007. Tight junctions/adherens junctions: basic structure and function. J. Invest. Dermatol. 127: 2525-2532.
    • (2007) J. Invest. Dermatol. , vol.127 , pp. 2525-2532
    • Niessen, C.M.1
  • 10
    • 60549090106 scopus 로고    scopus 로고
    • Molecular basis for cation selectivity in claudin-2-based paracellular pores: Identification of an electrostatic interaction site
    • Yu, A. S., M. H. Cheng, S. Angelow, D. Gunzel, S. A. Kanzawa, E. E. Schneeberger, M. Fromm, and R. D. Coalson. 2009. Molecular basis for cation selectivity in claudin-2-based paracellular pores: identification of an electrostatic interaction site. J. Gen. Physiol. 133: 111-127.
    • (2009) J. Gen. Physiol. , vol.133 , pp. 111-127
    • Yu, A.S.1    Cheng, M.H.2    Angelow, S.3    Gunzel, D.4    Kanzawa, S.A.5    Schneeberger, E.E.6    Fromm, M.7    Coalson, R.D.8
  • 13
  • 14
    • 33845995125 scopus 로고    scopus 로고
    • Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease
    • Zeissig, S., N. Burgel, D. Gunzel, J. Richter, J. Mankertz, U. Wahnschaffe, A. J. Kroesen, M. Zeitz, M. Fromm, and J. D. Schulzke. 2007. Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease. Gut 56: 61-72.
    • (2007) Gut , vol.56 , pp. 61-72
    • Zeissig, S.1    Burgel, N.2    Gunzel, D.3    Richter, J.4    Mankertz, J.5    Wahnschaffe, U.6    Kroesen, A.J.7    Zeitz, M.8    Fromm, M.9    Schulzke, J.D.10
  • 15
    • 57449095650 scopus 로고    scopus 로고
    • Changes in the expression of claudins in active ulcerative colitis
    • Oshima, T., H. Miwa, and T. Joh. 2008. Changes in the expression of claudins in active ulcerative colitis. J. Gastroenterol. Hepatol. 23(Suppl. 2): S146-S150.
    • (2008) J. Gastroenterol. Hepatol. , vol.23 , pp. S146-S150
    • Oshima, T.1    Miwa, H.2    Joh, T.3
  • 16
    • 52649123158 scopus 로고    scopus 로고
    • Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformation
    • Weber, C. R., S. C. Nalle, M. Tretiakova, D. T. Rubin, and J. R. Turner. 2008. Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformation. Lab. Invest. 88: 1110-1120.
    • (2008) Lab. Invest. , vol.88 , pp. 1110-1120
    • Weber, C.R.1    Nalle, S.C.2    Tretiakova, M.3    Rubin, D.T.4    Turner, J.R.5
  • 21
    • 77949720519 scopus 로고    scopus 로고
    • Mucosal expression of claudins 2, 3 and 4 in proximal and distal part of duodenum in children with coeliac disease
    • Szakal, D. N., H. Gyorffy, A. Arato, A. Cseh, K. Molnar, M. Papp, A. Dezsofi, and G. Veres. 2010. Mucosal expression of claudins 2, 3 and 4 in proximal and distal part of duodenum in children with coeliac disease. Virchows Arch. 456: 245-250.
    • (2010) Virchows Arch. , vol.456 , pp. 245-250
    • Szakal, D.N.1    Gyorffy, H.2    Arato, A.3    Cseh, A.4    Molnar, K.5    Papp, M.6    Dezsofi, A.7    Veres, G.8
  • 24
    • 67651154105 scopus 로고    scopus 로고
    • Production of interleukin 22 but not interleukin 17 by a subset of human skinhoming memory T cells
    • Duhen, T., R. Geiger, D. Jarrossay, A. Lanzavecchia, and F. Sallusto. 2009. Production of interleukin 22 but not interleukin 17 by a subset of human skinhoming memory T cells. Nat. Immunol. 10: 857-863.
    • (2009) Nat. Immunol. , vol.10 , pp. 857-863
    • Duhen, T.1    Geiger, R.2    Jarrossay, D.3    Lanzavecchia, A.4    Sallusto, F.5
  • 25
    • 67651171182 scopus 로고    scopus 로고
    • Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from T(H)-17, T(H)1 and T(H)2 cells
    • Trifari, S., C. D. Kaplan, E. H. Tran, N. K. Crellin, and H. Spits. 2009. Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from T(H)-17, T(H)1 and T(H)2 cells. Nat. Immunol. 10: 864-871.
    • (2009) Nat. Immunol. , vol.10 , pp. 864-871
    • Trifari, S.1    Kaplan, C.D.2    Tran, E.H.3    Crellin, N.K.4    Spits, H.5
  • 26
    • 68649126866 scopus 로고    scopus 로고
    • Interleukin-17-producing gammadelta T cells selectively expand in response to pathogen products and environmental signals
    • Martin, B., K. Hirota, D. J. Cua, B. Stockinger, and M. Veldhoen. 2009. Interleukin-17-producing gammadelta T cells selectively expand in response to pathogen products and environmental signals. Immunity 31: 321-330.
    • (2009) Immunity , vol.31 , pp. 321-330
    • Martin, B.1    Hirota, K.2    Cua, D.J.3    Stockinger, B.4    Veldhoen, M.5
  • 27
    • 68649088121 scopus 로고    scopus 로고
    • Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity
    • Sutton, C. E., S. J. Lalor, C. M. Sweeney, C. F. Brereton, E. C. Lavelle, and K. H. Mills. 2009. Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity. Immunity 31: 331-341.
    • (2009) Immunity , vol.31 , pp. 331-341
    • Sutton, C.E.1    Lalor, S.J.2    Sweeney, C.M.3    Brereton, C.F.4    Lavelle, E.C.5    Mills, K.H.6
  • 31
    • 0034613201 scopus 로고    scopus 로고
    • Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R
    • Xie, M. H., S. Aggarwal, W. H. Ho, J. Foster, Z. Zhang, J. Stinson, W. I. Wood, A. D. Goddard, and A. L. Gurney. 2000. Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R. J. Biol. Chem. 275: 31335-31339.
    • (2000) J. Biol. Chem. , vol.275 , pp. 31335-31339
    • Xie, M.H.1    Aggarwal, S.2    Ho, W.H.3    Foster, J.4    Zhang, Z.5    Stinson, J.6    Wood, W.I.7    Goddard, A.D.8    Gurney, A.L.9
  • 32
    • 0035951795 scopus 로고    scopus 로고
    • Identification of the functional interleukin-22 (IL-22) receptor complex: The IL-10R2 chain (IL-10Rbeta ) is a common chain of both the IL-10 and IL-22 (IL-10-related T cell-derived inducible factor, IL-TIF) receptor complexes
    • Kotenko, S. V., L. S. Izotova, O. V. Mirochnitchenko, E. Esterova, H. Dickensheets, R. P. Donnelly, and S. Pestka. 2001. Identification of the functional interleukin-22 (IL-22) receptor complex: the IL-10R2 chain (IL-10Rbeta ) is a common chain of both the IL-10 and IL-22 (IL-10-related T cell-derived inducible factor, IL-TIF) receptor complexes. J. Biol. Chem. 276: 2725-2732.
    • (2001) J. Biol. Chem. , vol.276 , pp. 2725-2732
    • Kotenko, S.V.1    Izotova, L.S.2    Mirochnitchenko, O.V.3    Esterova, E.4    Dickensheets, H.5    Donnelly, R.P.6    Pestka, S.7
  • 36
    • 84891702406 scopus 로고    scopus 로고
    • Therapeutic opportunities of the IL-22-IL-22R1 system
    • Sabat, R., W. Ouyang, and K. Wolk. 2014. Therapeutic opportunities of the IL-22-IL-22R1 system. Nat. Rev. Drug Discov. 13: 21-38.
    • (2014) Nat. Rev. Drug Discov. , vol.13 , pp. 21-38
    • Sabat, R.1    Ouyang, W.2    Wolk, K.3
  • 38
    • 0026244776 scopus 로고
    • Caco-2 cells cultured in serum-free medium as a model for the study of enterocytic differentiation in vitro
    • Jumarie, C., and C. Malo. 1991. Caco-2 cells cultured in serum-free medium as a model for the study of enterocytic differentiation in vitro. J. Cell. Physiol. 149: 24-33.
    • (1991) J. Cell. Physiol. , vol.149 , pp. 24-33
    • Jumarie, C.1    Malo, C.2
  • 39
    • 84879114381 scopus 로고    scopus 로고
    • Mechanism of IL-1b modulation of intestinal epithelial barrier involves p38 kinase and activating transcription factor-2 activation
    • Al-Sadi, R., S. Guo, D. Ye, K. Dokladny, T. Alhmoud, L. Ereifej, H. M. Said, and T. Y. Ma. 2013. Mechanism of IL-1b modulation of intestinal epithelial barrier involves p38 kinase and activating transcription factor-2 activation. J. Immunol. 190: 6596-6606.
    • (2013) J. Immunol. , vol.190 , pp. 6596-6606
    • Al-Sadi, R.1    Guo, S.2    Ye, D.3    Dokladny, K.4    Alhmoud, T.5    Ereifej, L.6    Said, H.M.7    Ma, T.Y.8
  • 40
    • 84861837990 scopus 로고    scopus 로고
    • Identification, isolation, and culture of intestinal epithelial stem cells from murine intestine
    • Gracz, A. D., B. J. Puthoff, and S. T. Magness. 2012. Identification, isolation, and culture of intestinal epithelial stem cells from murine intestine. Methods Mol. Biol. 879: 89-107.
    • (2012) Methods Mol. Biol. , vol.879 , pp. 89-107
    • Gracz, A.D.1    Puthoff, B.J.2    Magness, S.T.3
  • 41
    • 84908075358 scopus 로고    scopus 로고
    • Epithelial IL-22RA1-mediated fucosylation promotes intestinal colonization resistance to an opportunistic pathogen
    • Sanger Mouse Genetics Project
    • Pham, T. A., S. Clare, D. Goulding, J. M. Arasteh, M. D. Stares, H. P. Browne, J. A. Keane, A. J. Page, N. Kumasaka, L. Kane, et al; Sanger Mouse Genetics Project. 2014. Epithelial IL-22RA1-mediated fucosylation promotes intestinal colonization resistance to an opportunistic pathogen. Cell Host Microbe 16: 504-516.
    • (2014) Cell Host Microbe , vol.16 , pp. 504-516
    • Pham, T.A.1    Clare, S.2    Goulding, D.3    Arasteh, J.M.4    Stares, M.D.5    Browne, H.P.6    Keane, J.A.7    Page, A.J.8    Kumasaka, N.9    Kane, L.10
  • 43
    • 0035877222 scopus 로고    scopus 로고
    • Cloning and characterization of IL-22 binding protein, a natural antagonist of IL-10-related T cell-derived inducible factor/IL-22
    • Dumoutier, L., D. Lejeune, D. Colau, and J. C. Renauld. 2001. Cloning and characterization of IL-22 binding protein, a natural antagonist of IL-10-related T cell-derived inducible factor/IL-22. J. Immunol. 166: 7090-7095.
    • (2001) J. Immunol. , vol.166 , pp. 7090-7095
    • Dumoutier, L.1    Lejeune, D.2    Colau, D.3    Renauld, J.C.4
  • 45
    • 0035877120 scopus 로고    scopus 로고
    • Identification, cloning, and characterization of a novel soluble receptor that binds IL-22 and neutralizes its activity
    • Kotenko, S. V., L. S. Izotova, O. V. Mirochnitchenko, E. Esterova, H. Dickensheets, R. P. Donnelly, and S. Pestka. 2001. Identification, cloning, and characterization of a novel soluble receptor that binds IL-22 and neutralizes its activity. J. Immunol. 166: 7096-7103.
    • (2001) J. Immunol. , vol.166 , pp. 7096-7103
    • Kotenko, S.V.1    Izotova, L.S.2    Mirochnitchenko, O.V.3    Esterova, E.4    Dickensheets, H.5    Donnelly, R.P.6    Pestka, S.7
  • 48
    • 80052400212 scopus 로고    scopus 로고
    • Interleukin-6 (IL-6) regulates claudin-2 expression and tight junction permeability in intestinal epithelium
    • Suzuki, T., N. Yoshinaga, and S. Tanabe. 2011. Interleukin-6 (IL-6) regulates claudin-2 expression and tight junction permeability in intestinal epithelium. J. Biol. Chem. 286: 31263-31271.
    • (2011) J. Biol. Chem. , vol.286 , pp. 31263-31271
    • Suzuki, T.1    Yoshinaga, N.2    Tanabe, S.3
  • 49
    • 84899722895 scopus 로고    scopus 로고
    • Interleukin-6 modulation of intestinal epithelial tight junction permeability is mediated by JNK pathway activation of claudin-2 gene
    • Al-Sadi, R., D. Ye, M. Boivin, S. Guo, M. Hashimi, L. Ereifej, and T. Y. Ma. 2014. Interleukin-6 modulation of intestinal epithelial tight junction permeability is mediated by JNK pathway activation of claudin-2 gene. PLoS One 9: e85345.
    • (2014) PLoS One , vol.9 , pp. e85345
    • Al-Sadi, R.1    Ye, D.2    Boivin, M.3    Guo, S.4    Hashimi, M.5    Ereifej, L.6    Ma, T.Y.7
  • 50
    • 77950588683 scopus 로고    scopus 로고
    • Epithelial myosin light chain kinase activation induces mucosal interleukin-13 expression to alter tight junction ion selectivity
    • Weber, C. R., D. R. Raleigh, L. Su, L. Shen, E. A. Sullivan, Y. Wang, and J. R. Turner. 2010. Epithelial myosin light chain kinase activation induces mucosal interleukin-13 expression to alter tight junction ion selectivity. J. Biol. Chem. 285: 12037-12046.
    • (2010) J. Biol. Chem. , vol.285 , pp. 12037-12046
    • Weber, C.R.1    Raleigh, D.R.2    Su, L.3    Shen, L.4    Sullivan, E.A.5    Wang, Y.6    Turner, J.R.7
  • 51
    • 0034128634 scopus 로고    scopus 로고
    • Claudins regulate the intestinal barrier in response to immune mediators
    • Kinugasa, T., T. Sakaguchi, X. Gu, and H. C. Reinecker. 2000. Claudins regulate the intestinal barrier in response to immune mediators. Gastroenterology 118: 1001-1011.
    • (2000) Gastroenterology , vol.118 , pp. 1001-1011
    • Kinugasa, T.1    Sakaguchi, T.2    Gu, X.3    Reinecker, H.C.4
  • 52
    • 84935438223 scopus 로고    scopus 로고
    • Tumor necrosis factor-A induces a biphasic change in claudin-2 expression in tubular epithelial cells: Role in barrier functions
    • Amoozadeh, Y., Q. Dan, J. Xiao, F. Waheed, and K. Szászi. 2015. Tumor necrosis factor-A induces a biphasic change in claudin-2 expression in tubular epithelial cells: role in barrier functions. Am. J. Physiol. Cell Physiol. 309: C38-C50.
    • (2015) Am. J. Physiol. Cell Physiol. , vol.309 , pp. C38-C50
    • Amoozadeh, Y.1    Dan, Q.2    Xiao, J.3    Waheed, F.4    Szászi, K.5
  • 55
    • 33750298971 scopus 로고    scopus 로고
    • Pyridone 6, a pan-Janus-activated kinase inhibitor, induces growth inhibition of multiple myeloma cells
    • Pedranzini, L., T. Dechow, M. Berishaj, R. Comenzo, P. Zhou, J. Azare, W. Bornmann, and J. Bromberg. 2006. Pyridone 6, a pan-Janus-activated kinase inhibitor, induces growth inhibition of multiple myeloma cells. Cancer Res. 66: 9714-9721.
    • (2006) Cancer Res. , vol.66 , pp. 9714-9721
    • Pedranzini, L.1    Dechow, T.2    Berishaj, M.3    Comenzo, R.4    Zhou, P.5    Azare, J.6    Bornmann, W.7    Bromberg, J.8
  • 57
    • 84922479625 scopus 로고    scopus 로고
    • The IL-20 subfamily of cytokines-from host defence to tissue homeostasis
    • Rutz, S., X. Wang, and W. Ouyang. 2014. The IL-20 subfamily of cytokines-from host defence to tissue homeostasis. Nat. Rev. Immunol. 14: 783-795.
    • (2014) Nat. Rev. Immunol. , vol.14 , pp. 783-795
    • Rutz, S.1    Wang, X.2    Ouyang, W.3
  • 59
    • 84860340266 scopus 로고    scopus 로고
    • Comparative tight junction protein expressions in colonic Crohn's disease, ulcerative colitis, and tuberculosis: A new perspective
    • Das, P., P. Goswami, T. K. Das, T. Nag, V. Sreenivas, V. Ahuja, S. K. Panda, S. D. Gupta, and G. K. Makharia. 2012. Comparative tight junction protein expressions in colonic Crohn's disease, ulcerative colitis, and tuberculosis: a new perspective. Virchows Arch. 460: 261-270.
    • (2012) Virchows Arch. , vol.460 , pp. 261-270
    • Das, P.1    Goswami, P.2    Das, T.K.3    Nag, T.4    Sreenivas, V.5    Ahuja, V.6    Panda, S.K.7    Gupta, S.D.8    Makharia, G.K.9
  • 61
  • 62
    • 84865409069 scopus 로고    scopus 로고
    • IL-22 induced cell proliferation is regulated by PI3K/Akt/mTOR signaling cascade
    • Mitra, A., S. K. Raychaudhuri, and S. P. Raychaudhuri. 2012. IL-22 induced cell proliferation is regulated by PI3K/Akt/mTOR signaling cascade. Cytokine 60: 38-42.
    • (2012) Cytokine , vol.60 , pp. 38-42
    • Mitra, A.1    Raychaudhuri, S.K.2    Raychaudhuri, S.P.3
  • 63
    • 17244381180 scopus 로고    scopus 로고
    • Expression of interleukin-22 in rheumatoid arthritis: Potential role as a proinflammatory cytokine
    • Ikeuchi, H., T. Kuroiwa, N. Hiramatsu, Y. Kaneko, K. Hiromura, K. Ueki, and Y. Nojima. 2005. Expression of interleukin-22 in rheumatoid arthritis: potential role as a proinflammatory cytokine. Arthritis Rheum. 52: 1037-1046.
    • (2005) Arthritis Rheum. , vol.52 , pp. 1037-1046
    • Ikeuchi, H.1    Kuroiwa, T.2    Hiramatsu, N.3    Kaneko, Y.4    Hiromura, K.5    Ueki, K.6    Nojima, Y.7
  • 67
    • 84990855013 scopus 로고    scopus 로고
    • Impaired tight junctions in atopic dermatitis skin and in a skin-equivalent model treated with interleukin-17
    • Yuki, T., M. Tobiishi, A. Kusaka-Kikushima, Y. Ota, and Y. Tokura. 2016. Impaired tight junctions in atopic dermatitis skin and in a skin-equivalent model treated with interleukin-17. PLoS One 11: e0161759.
    • (2016) PLoS One , vol.11 , pp. e0161759
    • Yuki, T.1    Tobiishi, M.2    Kusaka-Kikushima, A.3    Ota, Y.4    Tokura, Y.5
  • 68
    • 85020929772 scopus 로고    scopus 로고
    • Efficacy and safety of MEDI2070, an antibody against interleukin 23, in patients with moderate to severe Crohn's disease: A phase 2a study
    • Sands, B. E., J. Chen, B. G. Feagan, M. Penney, W. A. Rees, S. Danese, P. D. R. Higgins, P. Newbold, R. Faggioni, K. Patra, et al.2017. Efficacy and safety of MEDI2070, an antibody against interleukin 23, in patients with moderate to severe Crohn's disease: a phase 2a study. Gastroenterology 153: 77-86.e76.
    • (2017) Gastroenterology , vol.153 , pp. 77e76-86e76
    • Sands, B.E.1    Chen, J.2    Feagan, B.G.3    Penney, M.4    Rees, W.A.5    Danese, S.6    Higgins, P.D.R.7    Newbold, P.8    Faggioni, R.9    Patra, K.10


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