Transforming growth factor β1/SMAD signaling pathway activation protects the intestinal epithelium from Clostridium difficile toxin A-induced damage

Infection and Immunity

Volumn 85, Issue 10, 2017, Pages

  Tinoco Veras, Christianne Maria ^a,b,c   Santos, Ana Angélica Q A ^a   Stipursky, Joice ^b   Meloni, Marcelo ^b   Araujo, Ana Paula Bérgamo ^b   Foschetti, Danielle Abreu ^a   López Ureña, Diana ^d   Quesada Gómez, Carlos ^d   Leitão, Renata F C ^a   Gomes, Flávia Carvalho Alcantara ^b   Brito, Gerly Anne de Castro ^a  

^a FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

^b FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^c FEDERAL UNIVERSITY OF PIAUÍ   (Brazil)

^d UNIVERSIDAD DE COSTA RICA   (Costa Rica)

Author keywords

Clostridium difficile; SMAD; SMAD transcription factors; TGF ; Toxin A

Indexed keywords

CLOSTRIDIUM DIFFICILE TOXIN A; KI 67 ANTIGEN; MESSENGER RNA; SMAD PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; BACTERIAL PROTEIN; BACTERIAL TOXIN; ENTEROTOXIN; TCDA PROTEIN, CLOSTRIDIUM DIFFICILE;

ANIMAL CELL; ANIMAL TISSUE; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CELL MIGRATION; CELL PROLIFERATION; CELL PROTECTION; CELL REGENERATION; CLOSTRIDIUM DIFFICILE INFECTION; CONTROLLED STUDY; FLOW CYTOMETRY; IEC-6 CELL LINE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; INTESTINE CRYPT; INTESTINE EPITHELIUM; INTESTINE EPITHELIUM CELL; LAMINA PROPRIA; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; CELL DEATH; CELL LINE; CELL SURVIVAL; DRUG EFFECTS; GENETICS; ILEUM; IMMUNOLOGY; INTESTINE; INTESTINE MUCOSA; METABOLISM; MICROBIOLOGY; PATHOGENICITY; PATHOLOGY; PEPTOCLOSTRIDIUM DIFFICILE;

ANIMALS; BACTERIAL PROTEINS; BACTERIAL TOXINS; CELL DEATH; CELL LINE; CELL SURVIVAL; CLOSTRIDIUM DIFFICILE; ENTEROTOXINS; ILEUM; INTESTINAL MUCOSA; INTESTINES; MICE; SIGNAL TRANSDUCTION; SMAD PROTEINS; TRANSFORMING GROWTH FACTOR BETA1;

EID: 85029743101     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.00430-17     Document Type: Article

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