메뉴 건너뛰기




Volumn 163, Issue 1, 2011, Pages 65-76

Interfering with interferon-γ signalling in intestinal epithelial cells: Selective inhibition of apoptosis-maintained secretion of anti-inflammatory interleukin-18 binding protein

Author keywords

Apoptosis; Inflammatory bowel disease; Interferon ; Interleukin 18; Intestinal epithelial cell

Indexed keywords

CASPASE 3; GAMMA INTERFERON; INTERLEUKIN 18; INTERLEUKIN 18 BINDING PROTEIN; JANUS KINASE; LACTATE DEHYDROGENASE; MITOGEN ACTIVATED PROTEIN KINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHATIDYLSERINE;

EID: 78649748394     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2010.04250.x     Document Type: Article
Times cited : (19)

References (46)
  • 1
    • 38649115342 scopus 로고    scopus 로고
    • Microbial influences in inflammatory bowel diseases
    • Sartor RB. Microbial influences in inflammatory bowel diseases. Gastroenterology 2008; 134:577-94.
    • (2008) Gastroenterology , vol.134 , pp. 577-94
    • Sartor, R.B.1
  • 2
    • 0035895992 scopus 로고    scopus 로고
    • Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB
    • Ogura Y, Inohara N, Benito A, Chen FF, Yamaoka S, Nunez G. Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB. J Biol Chem 2001; 276:4812-18.
    • (2001) J Biol Chem , vol.276 , pp. 4812-18
    • Ogura, Y.1    Inohara, N.2    Benito, A.3    Chen, F.F.4    Yamaoka, S.5    Nunez, G.6
  • 3
    • 58849084704 scopus 로고    scopus 로고
    • Defensins and inflammation: the role of defensins in inflammatory bowel disease
    • Ramasundara M, Leach ST, Lemberg DA, Day AS. Defensins and inflammation: the role of defensins in inflammatory bowel disease. J Gastroenterol Hepatol 2009; 24:202-8.
    • (2009) J Gastroenterol Hepatol , vol.24 , pp. 202-8
    • Ramasundara, M.1    Leach, S.T.2    Lemberg, D.A.3    Day, A.S.4
  • 4
    • 0027464093 scopus 로고
    • Neutrophil migration across cultured intestinal epithelial monolayers is modulated by epithelial exposure to IFN-gamma in a highly polarized fashion
    • Colgan SP, Parkos CA, Delp C, Arnaout MA, Madara JL. Neutrophil migration across cultured intestinal epithelial monolayers is modulated by epithelial exposure to IFN-gamma in a highly polarized fashion. J Cell Biol 1993; 120:785-98.
    • (1993) J Cell Biol , vol.120 , pp. 785-98
    • Colgan, S.P.1    Parkos, C.A.2    Delp, C.3    Arnaout, M.A.4    Madara, J.L.5
  • 6
    • 0027441514 scopus 로고
    • Interleukin-2- and interferon-gamma-secreting T cells in normal and diseased human intestinal mucosa
    • Breese E, Braegger CP, Corrigan CJ, Walker-Smith JA, MacDonald TT. Interleukin-2- and interferon-gamma-secreting T cells in normal and diseased human intestinal mucosa. Immunology 1993; 78:127-31.
    • (1993) Immunology , vol.78 , pp. 127-31
    • Breese, E.1    Braegger, C.P.2    Corrigan, C.J.3    Walker-Smith, J.A.4    MacDonald, T.T.5
  • 7
    • 0030209985 scopus 로고    scopus 로고
    • Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5
    • Fuss IJ, Neurath M, Boirivant M et al. Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5. J Immunol 1996; 157:1261-70.
    • (1996) J Immunol , vol.157 , pp. 1261-70
    • Fuss, I.J.1    Neurath, M.2    Boirivant, M.3
  • 8
    • 0029130042 scopus 로고
    • Altered Th1/Th2 cytokine profiles in the intestinal mucosa of patients with inflammatory bowel disease as assessed by quantitative reversed transcribed polymerase chain reaction (RT-PCR)
    • Niessner M, Volk BA. Altered Th1/Th2 cytokine profiles in the intestinal mucosa of patients with inflammatory bowel disease as assessed by quantitative reversed transcribed polymerase chain reaction (RT-PCR). Clin Exp Immunol 1995; 101:428-35.
    • (1995) Clin Exp Immunol , vol.101 , pp. 428-35
    • Niessner, M.1    Volk, B.A.2
  • 9
    • 0028845730 scopus 로고
    • Cloning of a new cytokine that induces IFN-gamma production by T cells
    • Okamura H, Tsutsi H, Komatsu T et al. Cloning of a new cytokine that induces IFN-gamma production by T cells. Nature 1995; 378:88-91.
    • (1995) Nature , vol.378 , pp. 88-91
    • Okamura, H.1    Tsutsi, H.2    Komatsu, T.3
  • 10
    • 15844367093 scopus 로고    scopus 로고
    • Cloning of the cDNA for human IFN-gamma-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein
    • Ushio S, Namba M, Okura T et al. Cloning of the cDNA for human IFN-gamma-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein. J Immunol 1996; 156:4274-9.
    • (1996) J Immunol , vol.156 , pp. 4274-9
    • Ushio, S.1    Namba, M.2    Okura, T.3
  • 11
    • 0031705349 scopus 로고    scopus 로고
    • Production of functional IL-18 by different subtypes of murine and human dendritic cells (DC): DC-derived IL-18 enhances IL-12-dependent Th1 development
    • Stoll S, Jonuleit H, Schmitt E et al. Production of functional IL-18 by different subtypes of murine and human dendritic cells (DC): DC-derived IL-18 enhances IL-12-dependent Th1 development. Eur J Immunol 1998; 28:3231-9.
    • (1998) Eur J Immunol , vol.28 , pp. 3231-9
    • Stoll, S.1    Jonuleit, H.2    Schmitt, E.3
  • 12
    • 0033152023 scopus 로고    scopus 로고
    • IL-18, a novel immunoregulatory cytokine, is up-regulated in Crohn's disease: expression and localization in intestinal mucosal cells
    • Pizarro TT, Michie MH, Bentz M et al. IL-18, a novel immunoregulatory cytokine, is up-regulated in Crohn's disease: expression and localization in intestinal mucosal cells. J Immunol 1999; 162:6829-35.
    • (1999) J Immunol , vol.162 , pp. 6829-35
    • Pizarro, T.T.1    Michie, M.H.2    Bentz, M.3
  • 13
    • 0029080727 scopus 로고
    • A novel costimulatory factor for gamma interferon induction found in the livers of mice causes endotoxic shock
    • Okamura H, Nagata K, Komatsu T et al. A novel costimulatory factor for gamma interferon induction found in the livers of mice causes endotoxic shock. Infect Immun 1995; 63:3966-72.
    • (1995) Infect Immun , vol.63 , pp. 3966-72
    • Okamura, H.1    Nagata, K.2    Komatsu, T.3
  • 14
    • 8944226108 scopus 로고    scopus 로고
    • Interferon-gamma-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin-12 for interferon-gamma production
    • Micallef MJ, Ohtsuki T, Kohno K et al. Interferon-gamma-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin-12 for interferon-gamma production. Eur J Immunol 1996; 26:1647-51.
    • (1996) Eur J Immunol , vol.26 , pp. 1647-51
    • Micallef, M.J.1    Ohtsuki, T.2    Kohno, K.3
  • 15
    • 0031568526 scopus 로고    scopus 로고
    • IFN-gamma-inducing factor (IGIF) is a costimulatory factor on the activation of Th1 but not Th2 cells and exerts its effect independently of IL-12
    • Kohno K, Kataoka J, Ohtsuki T et al. IFN-gamma-inducing factor (IGIF) is a costimulatory factor on the activation of Th1 but not Th2 cells and exerts its effect independently of IL-12. J Immunol 1997; 158:1541-50.
    • (1997) J Immunol , vol.158 , pp. 1541-50
    • Kohno, K.1    Kataoka, J.2    Ohtsuki, T.3
  • 16
    • 0037262797 scopus 로고    scopus 로고
    • Anti-interleukin-18 therapy in murine models of inflammatory bowel disease
    • Lochner M, Forster I. Anti-interleukin-18 therapy in murine models of inflammatory bowel disease. Pathobiology 2002; 70:164-9.
    • (2002) Pathobiology , vol.70 , pp. 164-9
    • Lochner, M.1    Forster, I.2
  • 17
    • 0033168120 scopus 로고    scopus 로고
    • Bioactive IL-18 expression is up-regulated in Crohn's disease
    • Monteleone G, Trapasso F, Parrello T et al. Bioactive IL-18 expression is up-regulated in Crohn's disease. J Immunol 1999; 163:143-7.
    • (1999) J Immunol , vol.163 , pp. 143-7
    • Monteleone, G.1    Trapasso, F.2    Parrello, T.3
  • 19
    • 0031759714 scopus 로고    scopus 로고
    • Differential expression of interleukin 1 receptor antagonist isoforms in human intestinal epithelial cells
    • Böcker U, Damiao A, Holt L et al. Differential expression of interleukin 1 receptor antagonist isoforms in human intestinal epithelial cells. Gastroenterology 1998; 115:1426-38.
    • (1998) Gastroenterology , vol.115 , pp. 1426-38
    • Böcker, U.1    Damiao, A.2    Holt, L.3
  • 20
    • 0036737806 scopus 로고    scopus 로고
    • Enhanced production of IL-18 in butyrate-treated intestinal epithelium by stimulation of the proximal promoter region
    • Kalina U, Koyama N, Hosoda T et al. Enhanced production of IL-18 in butyrate-treated intestinal epithelium by stimulation of the proximal promoter region. Eur J Immunol 2002; 32:2635-43.
    • (2002) Eur J Immunol , vol.32 , pp. 2635-43
    • Kalina, U.1    Koyama, N.2    Hosoda, T.3
  • 21
    • 0039179478 scopus 로고    scopus 로고
    • Cellular differentiation causes a selective down-regulation of interleukin (IL)-1beta-mediated NF-kappaB activation and IL-8 gene expression in intestinal epithelial cells
    • Böcker U, Schottelius A, Watson JM et al. Cellular differentiation causes a selective down-regulation of interleukin (IL)-1beta-mediated NF-kappaB activation and IL-8 gene expression in intestinal epithelial cells. J Biol Chem 2000; 275:12207-13.
    • (2000) J Biol Chem , vol.275 , pp. 12207-13
    • Böcker, U.1    Schottelius, A.2    Watson, J.M.3
  • 22
    • 0034528911 scopus 로고    scopus 로고
    • Lipopolysaccharide/endotoxin induces IL-18 via CD14 in human peripheral blood mononuclear cells in vitro
    • Manigold T, Böcker U, Traber P et al. Lipopolysaccharide/endotoxin induces IL-18 via CD14 in human peripheral blood mononuclear cells in vitro. Cytokine 2000; 12:1788-92.
    • (2000) Cytokine , vol.12 , pp. 1788-92
    • Manigold, T.1    Böcker, U.2    Traber, P.3
  • 23
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
    • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001; 25:402-8.
    • (2001) Methods , vol.25 , pp. 402-8
    • Livak, K.J.1    Schmittgen, T.D.2
  • 24
    • 0035892991 scopus 로고    scopus 로고
    • Expression and release of IL-18 binding protein in response to IFN-gamma
    • Paulukat J, Bosmann M, Nold M et al. Expression and release of IL-18 binding protein in response to IFN-gamma. J Immunol 2001; 167:7038-43.
    • (2001) J Immunol , vol.167 , pp. 7038-43
    • Paulukat, J.1    Bosmann, M.2    Nold, M.3
  • 25
    • 0033974776 scopus 로고    scopus 로고
    • Structural requirements of six naturally occurring isoforms of the IL-18 binding protein to inhibit IL-18
    • Kim SH, Eisenstein M, Reznikov L et al. Structural requirements of six naturally occurring isoforms of the IL-18 binding protein to inhibit IL-18. Proc Natl Acad Sci USA 2000; 97:1190-5.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 1190-5
    • Kim, S.H.1    Eisenstein, M.2    Reznikov, L.3
  • 26
    • 0031036872 scopus 로고    scopus 로고
    • Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked
    • Yang J, Liu X, Bhalla K et al. Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science 1997; 275:1129-32.
    • (1997) Science , vol.275 , pp. 1129-32
    • Yang, J.1    Liu, X.2    Bhalla, K.3
  • 27
    • 0031037897 scopus 로고    scopus 로고
    • The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis
    • Kluck RM, Bossy-Wetzel E, Green DR, Newmeyer DD. The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science 1997; 275:1132-6.
    • (1997) Science , vol.275 , pp. 1132-6
    • Kluck, R.M.1    Bossy-Wetzel, E.2    Green, D.R.3    Newmeyer, D.D.4
  • 28
    • 0040056864 scopus 로고    scopus 로고
    • p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis
    • Schurmann A, Mooney AF, Sanders LC et al. p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis. Mol Cell Biol 2000; 20:453-61.
    • (2000) Mol Cell Biol , vol.20 , pp. 453-61
    • Schurmann, A.1    Mooney, A.F.2    Sanders, L.C.3
  • 29
    • 0025835716 scopus 로고
    • BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death
    • Hockenbery DM, Zutter M, Hickey W, Nahm M, Korsmeyer SJ. BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proc Natl Acad Sci USA 1991; 88:6961-5.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 6961-5
    • Hockenbery, D.M.1    Zutter, M.2    Hickey, W.3    Nahm, M.4    Korsmeyer, S.J.5
  • 30
    • 0028036895 scopus 로고
    • Immunohistochemical determination of in vivo distribution of Bax, a dominant inhibitor of Bcl-2
    • Krajewski S, Krajewska M, Shabaik A, Miyashita T, Wang HG, Reed JC. Immunohistochemical determination of in vivo distribution of Bax, a dominant inhibitor of Bcl-2. Am J Pathol 1994; 145:1323-36.
    • (1994) Am J Pathol , vol.145 , pp. 1323-36
    • Krajewski, S.1    Krajewska, M.2    Shabaik, A.3    Miyashita, T.4    Wang, H.G.5    Reed, J.C.6
  • 31
    • 33746146891 scopus 로고    scopus 로고
    • Interfering with interferons in inflammatory bowel disease
    • Ghosh S, Chaudhary R, Carpani M, Playford R. Interfering with interferons in inflammatory bowel disease. Gut 2006; 55:1071-3.
    • (2006) Gut , vol.55 , pp. 1071-3
    • Ghosh, S.1    Chaudhary, R.2    Carpani, M.3    Playford, R.4
  • 32
    • 58049129497 scopus 로고    scopus 로고
    • AG490, a Jak2-specific inhibitor, induces osteoclast survival by activating the akt and ERK signaling pathway
    • Kwak HB, Sun HM, Ha H, Lee JH, Kim HN, Lee ZH. AG490, a Jak2-specific inhibitor, induces osteoclast survival by activating the akt and ERK signaling pathway. Mol Cell 2008; 26:436-42.
    • (2008) Mol Cell , vol.26 , pp. 436-42
    • Kwak, H.B.1    Sun, H.M.2    Ha, H.3    Lee, J.H.4    Kim, H.N.5    Lee, Z.H.6
  • 33
    • 34648835016 scopus 로고    scopus 로고
    • AG490 influences UCN-01-induced cytotoxicity in glioma cells in a p53-dependent fashion, correlating with effects on BAX cleavage and BAD phosphorylation
    • Jane EP, Premkumar DR, Pollack IF. AG490 influences UCN-01-induced cytotoxicity in glioma cells in a p53-dependent fashion, correlating with effects on BAX cleavage and BAD phosphorylation. Cancer Lett 2007; 257:36-46.
    • (2007) Cancer Lett , vol.257 , pp. 36-46
    • Jane, E.P.1    Premkumar, D.R.2    Pollack, I.F.3
  • 34
    • 34347207939 scopus 로고    scopus 로고
    • STAT5 signaling in normal and pathologic hematopoiesis
    • Bunting KD. STAT5 signaling in normal and pathologic hematopoiesis. Front Biosci 2007; 12:2807-20.
    • (2007) Front Biosci , vol.12 , pp. 2807-20
    • Bunting, K.D.1
  • 35
    • 0034327770 scopus 로고    scopus 로고
    • Functional uncoupling of the Janus kinase 3-Stat5 pathway in malignant growth of human T cell leukemia virus type 1-transformed human T cells
    • Kirken RA, Erwin RA, Wang L, Wang Y, Rui H, Farrar WL. Functional uncoupling of the Janus kinase 3-Stat5 pathway in malignant growth of human T cell leukemia virus type 1-transformed human T cells. J Immunol 2000; 165:5097-104.
    • (2000) J Immunol , vol.165 , pp. 5097-104
    • Kirken, R.A.1    Erwin, R.A.2    Wang, L.3    Wang, Y.4    Rui, H.5    Farrar, W.L.6
  • 36
    • 0034102695 scopus 로고    scopus 로고
    • Apoptosis in the intestinal epithelium: its relevance in normal and pathophysiological conditions
    • Ramachandran A, Madesh M, Balasubramanian KA. Apoptosis in the intestinal epithelium: its relevance in normal and pathophysiological conditions. J Gastroenterol Hepatol 2000; 15:109-20.
    • (2000) J Gastroenterol Hepatol , vol.15 , pp. 109-20
    • Ramachandran, A.1    Madesh, M.2    Balasubramanian, K.A.3
  • 37
    • 52949092696 scopus 로고    scopus 로고
    • Caspase inhibition augmented oridonin-induced cell death in murine fibrosarcoma l929 by enhancing reactive oxygen species generation
    • Wu JN, Huang J, Yang J, Tashiro S, Onodera S, Ikejima T. Caspase inhibition augmented oridonin-induced cell death in murine fibrosarcoma l929 by enhancing reactive oxygen species generation. J Pharmacol Sci 2008; 108:32-9.
    • (2008) J Pharmacol Sci , vol.108 , pp. 32-9
    • Wu, J.N.1    Huang, J.2    Yang, J.3    Tashiro, S.4    Onodera, S.5    Ikejima, T.6
  • 38
    • 23244455992 scopus 로고    scopus 로고
    • Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution
    • Heller F, Florian P, Bojarski C et al. Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution. Gastroenterology 2005; 129:550-64.
    • (2005) Gastroenterology , vol.129 , pp. 550-64
    • Heller, F.1    Florian, P.2    Bojarski, C.3
  • 39
    • 0028057613 scopus 로고
    • Disruption of epithelial cell-matrix interactions induces apoptosis
    • Frisch SM, Francis H. Disruption of epithelial cell-matrix interactions induces apoptosis. J Cell Biol 1994; 124:619-26.
    • (1994) J Cell Biol , vol.124 , pp. 619-26
    • Frisch, S.M.1    Francis, H.2
  • 40
    • 0036883937 scopus 로고    scopus 로고
    • Nuclear factor kappaB inhibitors induce adhesion-dependent colon cancer apoptosis: implications for metastasis
    • Scaife CL, Kuang J, Wills JC et al. Nuclear factor kappaB inhibitors induce adhesion-dependent colon cancer apoptosis: implications for metastasis. Cancer Res 2002; 62:6870-8.
    • (2002) Cancer Res , vol.62 , pp. 6870-8
    • Scaife, C.L.1    Kuang, J.2    Wills, J.C.3
  • 41
    • 0035805563 scopus 로고    scopus 로고
    • Constitutive ERK1/2 activation in esophagogastric rib bone marrow micrometastatic cells is MEK-independent
    • Barry OP, Mullan B, Sheehan D et al. Constitutive ERK1/2 activation in esophagogastric rib bone marrow micrometastatic cells is MEK-independent. J Biol Chem 2001; 276:15537-46.
    • (2001) J Biol Chem , vol.276 , pp. 15537-46
    • Barry, O.P.1    Mullan, B.2    Sheehan, D.3
  • 42
    • 0037445952 scopus 로고    scopus 로고
    • Alpha2beta1-integrin signaling by itself controls G1/S transition in a human adenocarcinoma cell line (Caco-2): implication of NADPH oxidase-dependent production of ROS
    • Honore S, Kovacic H, Pichard V, Briand C, Rognoni JB. Alpha2beta1-integrin signaling by itself controls G1/S transition in a human adenocarcinoma cell line (Caco-2): implication of NADPH oxidase-dependent production of ROS. Exp Cell Res 2003; 285:59-71.
    • (2003) Exp Cell Res , vol.285 , pp. 59-71
    • Honore, S.1    Kovacic, H.2    Pichard, V.3    Briand, C.4    Rognoni, J.B.5
  • 43
    • 33750058573 scopus 로고    scopus 로고
    • Oxidative stress-induced intestinal epithelial cell apoptosis is mediated by p38 MAPK
    • Zhou Y, Wang Q, Mark Evers B, Chung DH. Oxidative stress-induced intestinal epithelial cell apoptosis is mediated by p38 MAPK. Biochem Biophys Res Commun 2006; 350:860-5.
    • (2006) Biochem Biophys Res Commun , vol.350 , pp. 860-5
    • Zhou, Y.1    Wang, Q.2    Mark Evers, B.3    Chung, D.H.4
  • 44
    • 35348994840 scopus 로고    scopus 로고
    • PGE2 inhibits apoptosis in human adenocarcinoma Caco-2 cell line through Ras-PI3K association and cAMP-dependent kinase A activation
    • Leone V, Di Palma A, Ricchi P et al. PGE2 inhibits apoptosis in human adenocarcinoma Caco-2 cell line through Ras-PI3K association and cAMP-dependent kinase A activation. Am J Physiol Gastrointest Liver Physiol 2007; 293:G673-81.
    • (2007) Am J Physiol Gastrointest Liver Physiol , vol.293
    • Leone, V.1    Di Palma, A.2    Ricchi, P.3
  • 45
    • 33645828828 scopus 로고    scopus 로고
    • The specific JNK inhibitor SP600125 targets tumour necrosis factor-alpha production and epithelial cell apoptosis in acute murine colitis
    • Assi K, Pillai R, Gomez-Munoz A, Owen D, Salh B. The specific JNK inhibitor SP600125 targets tumour necrosis factor-alpha production and epithelial cell apoptosis in acute murine colitis. Immunology 2006; 118:112-21.
    • (2006) Immunology , vol.118 , pp. 112-21
    • Assi, K.1    Pillai, R.2    Gomez-Munoz, A.3    Owen, D.4    Salh, B.5
  • 46
    • 33644756429 scopus 로고    scopus 로고
    • Oral p38 mitogen-activated protein kinase inhibition with BIRB 796 for active Crohn's disease: a randomized, double-blind, placebo-controlled trial
    • Schreiber S, Feagan B, D'Haens G et al. Oral p38 mitogen-activated protein kinase inhibition with BIRB 796 for active Crohn's disease: a randomized, double-blind, placebo-controlled trial. Clin Gastroenterol Hepatol 2006; 4:325-34.
    • (2006) Clin Gastroenterol Hepatol , vol.4 , pp. 325-34
    • Schreiber, S.1    Feagan, B.2    D'Haens, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.