Potential for diet to prevent and remediate cognitive deficits in neurological disorders

Nutrition Reviews

Volumn 76, Issue 3, 2018, Pages 204-217

  Francis, Heather M ^a   Stevenson, Richard J ^a  

^a MACQUARIE UNIVERSITY   (Australia)

Author keywords

Caloric restriction; Cognition; Fasting; Ketogenic; Mediterranean; Polyphenol

Indexed keywords

AGED; CHILD; COGNITION; COGNITIVE DEFECT; DIET; EATING; FEMALE; HUMAN; INFLAMMATION; MALE; MIDDLE AGED; MITOCHONDRION; NEUROLOGIC DISEASE; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PHYSIOLOGY; PROCEDURES; PSYCHOLOGY;

AGED; CHILD; COGNITION; COGNITION DISORDERS; DIET; EATING; FEMALE; HUMANS; INFLAMMATION; MALE; MIDDLE AGED; MITOCHONDRIA; NERVOUS SYSTEM DISEASES; OXIDATIVE STRESS;

EID: 85044676117     PISSN: 00296643     EISSN: 17534887     Source Type: Journal    
DOI: 10.1093/nutrit/nux073     Document Type: Article

References (159)

1. Francis HM, Mirzaei M, Pardey MC, et al. Proteomic analysis of the dorsal and ventral hippocampus of rats maintained on a high fat and refined sugar diet. Proteomics. 2013;13:3076-3091
2. Pistell PJ, Morrison CD, Gupta S, et al. Cognitive impairment following high fat diet consumption is associated with brain inflammation. J Neuroimmunol. 2010;219:25-32
3. Yoon J-H, Baek SJ. Molecular targets of dietary polyphenols with antiinflammatory properties. Yonsei Med J. 2005;46:585-596
4. Estruch R. Anti-inflammatory effects of the Mediterranean diet: the experience of the PREDIMED study. Proc Nutr Soc. 2010;69:333-340
5. Halaris A. Neurological disorders, depression and inflammation: is there a common link? Future Neurol. 2015;10:327-343
6. Mattson MP, Gleichmann M, Cheng A. Mitochondria in neuroplasticity and neurological disorders. Neuron. 2008;60:748-766
7. Mitchell AJ, Kemp S, Benito-Leon J, Reuber M. The influence of cognitive impairment on health-related quality of life in neurological disease. Acta Neuropsychiatr. 2010;22:2-13
8. Friedman DB, Becofsky K, Anderson LA, et al. Public perceptions about risk and protective factors for cognitive health and impairment: a review of the literature. Int Psychogeriatr. 2015;27:1263-1275
9. Leong EM, Semple SJ, AngleyM, et al. Complementary and alternative medicines and dietary interventions in multiple sclerosis:what is being used in South Australia and why? Complement Ther Med. 2009;17:216-223
10. Baranano KW, Hartman AL. The ketogenic diet: uses in epilepsy and other neurological illnesses. Curr Treat Options Neurol. 2008;10:410-419
11. Maalouf M, Rho JM, Mattson MP. The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies. Brain Res Rev. 2009;59:293-315
12. Macready AL, Kennedy OB, Ellis JA, et al. Flavonoids and cognitive function: a review of human randomized controlled trial studies and recommendations for future studies. Genes Nutr. 2009;4:227-242
13. Strafstrom CE, Rho JM. The ketogenic diet as a treatment paradigm for diverse neurological disorders. Front Pharmacol. 2012;3:1-8
14. Lamport DJ, Dye JD, Wightman JD, et al. The effects of flavonoid and other polyphenol consumption on cognitive performance: a systematic research review of human experimental and epidemiological studies. Nutr Aging. 2012;1:5-25
15. Hallböök T, Ji S, Maudsley S, Martin B. The effects of the ketogenic diet on behavior and cognition. Epilepsy Res. 2012;100:304-309
16. Hardman RJ, Kennedy H, Macpherson AB, et al. Adeherenence to a Mediterranean-style diet and effects on cognition in adults: a qualitative evaluation and systematic review of longitudinal and prospective trials. Front Nutr. 2016;2:22
17. Wahl D, Cogger VC, Solon-Biet SM, et al. Nutritional strategies to optimise cognitive function in the aging brain. Ageing Res Rev. 2016;31:80-92
18. Bhullar KS, Rupasinghe HP. Polyphenols: multipotent therapeutic agents in neurodegenerative diseases. Oxid Med Cell Longev. 2013;2013:891748
19. Grosso C, Valentao P, Ferreres F, et al. The use of flavonoids in central nervous system disorders. Curr Med Chem. 2013;20:4694-4719
20. Lourida I, Soni M, Thompson-Coon J, et al. Mediterranean diet, cognitive function, and dementia: a systematic review. Epidemiology. 2013;24:479-489
21. Pathak L, Agrawal Y, Dhir A. Natural polyphenols in the management of major depression. Expert Opin Investig Drugs. 2013;22:863-880
22. Riccio P. The molecular basis of nutritional intervention in multiple sclerosis:a narrative review. Complement Ther Med. 2011;19:228-237
23. Lai JS, Hiles S, Bisquera A, et al. A systematic review and meta-analysis of dietary patterns and depression in community-dwelling adults. Am J Clin Nutr. 2014;99:181-197
24. Psaltopoulou T, Sergentanis TN, Panagiotakos DB, et al. Mediterranean diet, stroke, cognitive impairment, and depression: a meta-analysis. Ann Neurol. 2013;74:580-591
25. Tangney CC. DASH and Mediterranean-type dietary patterns to maintain cognitive health. Curr Nutr Rep. 2014;3:51-61
26. Trebaticka J, Durackova Z. Psychiatric disorders and polyphenols: can they be helpful in therapy? Oxid Med Cell Longev. 2015;2015:248529
27. Zainuddin MSA, Thuret S. Nutrition, adult hippocampal neurogenesis andmental health. Brit Med Bull. 2012;103:89-114
28. Van Cauwenberghe C, Vandendriessche C, Libert C, et al. Caloric restriction: beneficial effects on brain aging and Alzheimer's disease. Mamm Genome. 2016;27:300-319
29. Lamport DJ, Pal D, Moutsiana C, et al. The effect of flavanol-rich cocoa on cerebral perfusion in healthy older adults during conscious resting state: a placebo controlled, crossover, acute trial. Psychopharmacology (Berlin). 2015;232:3227-323
30. Masana MF, Koyanagi A, Haro JM, et al. n-3 Fatty acids, Mediterranean diet and cognitive function in normal aging: a systematic review. Exp Gerontol. 2017;91:39-50
31. Strafstrom CE. Dietary approaches to epilepsy treatment: old and new options on the menu. Epilepsy Curr. 2004;4:215-222
32. Gano LB, Patel M, Rho JM. Ketogenic diets, mitochondria, and neurological diseases. J Lipid Res. 2014;55:2211-2228
33. Gasior M, Rogawski MA, Hartman AL. Neuroprotective and disease-modifying effects of the ketogenic diet. Behav Pharmacol. 2006;17:431-439
34. Wilder RM. The effects of ketonemia on the course of epilepsy. Mayo Clin Proc. 1921;2:307-308
35. Neal EG, Chaffe H, Schwartz RH, et al. The ketogenic diet for the treatment of childhood epilepsy: a randomised controlled trial. Lancet Neurol. 2008;7:500-506
36. Su SW, Cilio MR, Sogawa Y, et al. Timing of ketogenic diet initiation in an experimental epilepsy model. Brain Res Dev Brain Res. 2000;125:131-138
37. Zhao Q, Stafstrom CE, Fu DD, et al. Detrimental effects of the ketogenic diet on cognitive function in rats. Pediatr Res. 2004;55:498-506
38. Hori A, Tandon P, Holmes GL, Stafstrom CE. Ketogenic diet: effects on expression of kindled seizures and behavior in adult rats. Epilepsia. 1997;38:750-758
39. Ni H, Zhao DJ, Tian T. Ketogenic diet change cPLA2/clusterin and autophagy related gene expression and correlate with cognitive deficits and hippocampal MFs sprouting following neonatal seizures. Epilepsy Res. 2016;120:13-18
40. Kim do Y, Simeone KA, Simeone TA, et al. Ketone bodies mediate antiseizure effects through mitochondrial permeability transition. Ann Neurol. 2015;78:77-87
41. Nikanorova M, Miranda MJ, Atkins M, et al. Ketogenic diet in the treatment of refractory continuous spikes and waves during slow sleep. Epilepsia. 2009;50:1127-1131
42. Ito Y, Oguni H, Ito S, et al. A modified Atkins diet is promising as a treatment for glucose transporter type 1 deficiency syndrome. Dev Med Child Neurol. 2011;53:658-663
43. Roulet-Perez E, Ballhausen D, Bonafe L, et al. Glut-1 deficiency syndrome masquerading as idiopathic generalized epilepsy. Epilepsia. 2008;49:1955-1958
44. Haberlandt E, Karall D, Jud V, et al. Glucose transporter type 1 deficiency syndrome effectively treated with modified Atkins diet. Neuropediatrics. 2014;45:117-119
45. Kang HC, Kim HD, Lee YM, et al. Landau-Kleffner syndrome with mitochondrial respiratory chain-complex I deficiency. Pediatr Neurol. 2006;35:158-161
46. Farasat S, Kossoff EH, Pillas DJ, et al. The importance of parental expectations of cognitive improvement for their children with epilepsy prior to starting the ketogenic diet. Epilepsy Behav. 2006;8:406-410
47. Wu YJ, Zhang LM, Chai YM, et al. Six-month efficacy of the ketogenic diet is predicted after 3 months and is unrelated to clinical variables. Epilepsy Behav. 2016;55:165-169
48. Pulsifer MB, Gordon JM, Brandt J, et al. Effects of ketogenic diet on development and behavior: preliminary report of a prospective study. Dev Med Child Neurol. 2001;43:301-306
49. Hallböök T, Lundgren J, Rosen I. Ketogenic diet improves sleep quality in children with therapy-resistant epilepsy. Epilepsia. 2007;48:59-65
50. Leen WG, Mewasingh L, Verbeek MM, et al. Movement disorders in GLUT1 deficiency syndrome respond to the modified Atkins diet. Mov Disord. 2013;28:1439-1442
51. Lambrechts DA, Bovens MJ, de la Parra NM, et al. Ketogenic diet effects on cognition, mood, and psychosocial adjustment in children. Acta Neurol Scand. 2013;127:103-108
52. Ramm-Pettersen A, Stabell KE, Nakken KO, et al. Does ketogenic diet improve cognitive function in patients with GLUT1-DS? A 6-to 17-month follow-up study. Epilepsy Behav. 2014;39:111-115
53. Caraballo R, Noli D, Cachia P. Epilepsy of infancy with migrating focal seizures: three patients treated with the ketogenic diet. Epileptic Disord. 2015;17:194-197
54. Lambrechts DA, de Kinderen RJ, Vles JS, et al. A randomized controlled trial of the ketogenic diet in refractory childhood epilepsy. Acta Neurol Scand. 2017;135:231-239
55. DM IJ, Postulart D, Lambrechts DA, et al. Cognitive and behavioral impact of the ketogenic diet in children and adolescents with refractory epilepsy: a randomized controlled trial. Epilepsy Behav. 2016;60:153-157
56. Sirven J, Whedon B, Caplan D, et al. The ketogenic diet for intractable epilepsy in adults: preliminary results. Epilepsia. 1999;40:1721-1726
57. Mosek A, Natour H, Neufeld MY, et al. Ketogenic diet treatment in adults with refractory epilepsy: a prospective pilot study. Seizure-Eur J Epilep. 2009;18:30-33
58. Lambrechts DA, Wielders LH, Aldenkamp AP, et al. The ketogenic diet as a treatment option in adults with chronic refractory epilepsy: efficacy and tolerability in clinical practice. Epilepsy Behav. 2012;23:310-314
59. Veggiotti P, Teutonico F, Alfei E, et al. Glucose transporter type 1 deficiency: ketogenic diet in three patients with atypical phenotype. Brain Dev. 2010;32:404-408
60. Sullivan PG, Rippy NA, Dorenbos K, et al. The ketogenic diet increases mitochondrial uncoupling protein levels and activity. Ann Neurol. 2004;55:576-580
61. Milder JB, Liang LP, Patel M. Acute oxidative stress and systemic Nrf2 activation by the ketogenic diet. Neurobiol Dis. 2010;40:238-244
62. Bough KJ, Wetherington J, Hassel B, et al. Mitochondrial biogenesis in the anticonvulsant mechanismof the ketogenic diet. Ann Neurol. 2006;60:223-235
63. Kim do Y, Hao J, Liu R, et al. Inflammation-mediated memory dysfunction and effects of a ketogenic diet in a murine model of multiple sclerosis. PLoS One. 2012;7:e35476
64. Marklund N, Clausen F, Lewander T, et al. Monitoring of reactive oxygen species production after traumatic brain injury in rats with microdialysis and the 4-hydroxybenzoic acid trapping method. J Neurotrauma. 2001;18:1217-1227
65. Gilgun-Sherki Y, Melamed E, Offen D. The role of oxidative stress in the pathogenesis of multiple sclerosis: the need for effective antioxidant therapy. J Neurol. 2004;251:261-268
66. Markesbery WR. Oxidative stress hypothesis in Alzheimer's disease. Free Radic Biol Med. 1997;23:134-147
67. Kumar A, Loane DJ. Neuroinflammation after traumatic brain injury: opportunities for therapeutic intervention. Brain Behav Immun. 2012;26:1191-1201
68. Grigoriadis N, Grigoriadis S, Polyzoidou E, et al. Neuroinflammation in multiple sclerosis: evidence for autoimmune dysregulation, not simple autoimmune reaction. Clin Neurol Neurosurg. 2006;108:241-244
69. Hensley K. Neuroinflammation in Alzheimer's disease: mechanisms, pathologic consequences, and potential for therapeutic manipulation. JAD. 2010;21:1-14
70. Mosconi L, Mistur R, Switalski R, et al. FDG-PET changes in brain glucose metabolism from normal cognition to pathologically verified Alzheimer's disease. Eur J Nucl Med Mol Imaging. 2009;36:811-822
71. Roelcke U, Kappos L, LechnerScott J, et al. Reduced glucose metabolism in the frontal cortex and basal ganglia of multiple sclerosis patients with fatigue: a F-18-fluorodeoxyglucose positron emission tomography study. Neurology. 1997;48:1566-1571
72. Yoshino A, Hovda DA, Kawamata T, et al. Dynamic changes in local cerebral glucose-utilization following cerebral concussion in rats-evidence of a hypermetabolic and subsequent hypometabolic state. Brain Res. 1991;561:106-119
73. Evangeliou A, Vlachonikolis I, Mihailidou H, et al. Application of a ketogenic diet in children with autistic behavior: pilot study. J Child Neurol. 2003;18:113-118
74. Appelberg KS, Hovda DA, Prins ML. The effects of a ketogenic diet on behavioral outcome after controlled cortical impact injury in the juvenile and adult rat. J Neurotrauma. 2009;26:497-506
75. Deng-Bryant Y, Prins ML, Hovda DA, et al. Ketogenic diet prevents alterations in brain metabolism in young but not adult rats after traumatic brain injury. J Neurotrauma. 2011;28:1813-1825
76. Hu ZG, Wang HD, Qiao L, et al. The protective effect of the ketogenic diet on traumatic brain injury-induced cell death in juvenile rats. Brain Inj. 2009;23:459-465
77. Prins ML, Fujima LS, Hovda DA. Age-dependent reduction of cortical contusion volume by ketones after traumatic brain injury. J Neurosci Res. 2005;82:413-420
78. Choi IY, Piccio L, Childress P, et al. A diet mimicking fasting promotes regeneration and reduces autoimmunity and multiple sclerosis symptoms. Cell Rep. 2016;15:2136-2146
79. Xu K, Sun XY, Eroku BO, et al. Diet-induced ketosis improves cognitive performance in aged rats. Oxygen Transport to Tissue Xxxi 2010;662:71-75
80. Reger MA, Henderson ST, Hale C, et al. Effects of beta-hydroxybutyrate on cognition in memory-impaired adults. Neurobiol Aging. 2004;25:311-314
81. Krikorian R, Shidler MD, Dangelo K, et al. Dietary ketosis enhances memory in mild cognitive impairment. Neurobiol Aging. 2012;33:425
82. Henderson ST, Vogel JL, Barr LJ, et al. Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer's disease:a randomized, double-blind, placebo-controlled, multicenter trial. Nutr Metab (London). 2009;6:31
83. Bordone L, Guarente L. Calorie restriction, SIRT1 and metabolism:understanding longevity. Nat Rev Mol Cell Biol. 2005;6:298-305
84. Means LW, Higgins JL, Fernandez TJ. Mid-life onset of dietary restriction extends life and prolongs cognitive functioning. Physiol Behav. 1993;54:503-508
85. Mattson MP. The impact of dietary energy intake on cognitive aging. Front Aging Neurosci. 2010;2:5
86. Mattson MP. Gene-diet interactions in brain aging and neurodegenerative disorders. Ann Intern Med. 2003;139:441-444
87. Marie C, Bralet AM, Gueldry S, et al. Fasting prior to transient cerebral ischemia reduces delayed neuronal necrosis. Metab Brain Dis. 1990;5:65-75
88. Mattson MP, Chan SL, Duan W. Modification of brain aging and neurodegenerative disorders by genes, diet, and behavior. Physiol Rev. 2002;82:637-672
89. Ingram DK, Weindruch R, Spangler EL, et al. Dietary restriction benefits learning andmotor performance of aged mice. J Gerontol. 1987;42:78-81
90. Pitsikas N, Algeri S. Deterioration of spatial and nonspatial reference and working memory in aged rats: protective effect of life-long calorie restriction. Neurobiol Aging. 1992;13:369-373
91. Pitsikas N, Carli M, Fidecka S, et al. Effect of life-long hypocaloric diet on agerelated changes in motor and cognitive behavior in a rat population. Neurobiol Aging. 1990;11:417-423
92. Singh R, Lakhanpal D, Kumar S, et al. Late-onset intermittent fasting dietary restriction as a potential intervention to retard age-associated brain function impairments in male rats. Age (Dordr). 2012;34:917-933
93. Witte AV, Fobker M, Gellner R, et al. Caloric restriction improves memory in elderly humans. Proc Natl Acad Sci U S A. 2009;106:1255-1260
94. Horie NC, Serrao VT, Simon SS, et al. Cognitive effects of intentional weight loss in elderly obese individuals with mild cognitive impairment. J Clin Endocrinol Metab. 2016;101:1104-1112
95. Davis LM, Pauly JR, Readnower RD, et al. Fasting is neuroprotective following traumatic brain injury. J Neurosci Res. 2008;86:1812-1822
96. Rich NJ, VanLandingham JW, Figueiroa S, et al. Chronic caloric restriction reduces tissue damage and improves spatial memory in a rat model of traumatic brain injury. J Neurosci Res. 2010;88:2933-2939
97. Rainey-Smith SR, Brown BM, Sohrabi HR, et al. Curcumin and cognition: a randomised, placebo-controlled, double-blind study of community-dwelling older adults. Br J Nutr. 2016;115:2106-2113
98. Witte AV, Kerti L, Margulies DS, et al. Effects of resveratrol on memory performance, hippocampal functional connectivity, and glucose metabolism in healthy older adults. J Neurosci. 2014;34:7862-7870
99. Rabassa M, Cherubini A, Zamora-Ros R, et al. Low levels of a urinary biomarker of dietary polyphenol are associated with substantial cognitive decline over a 3-year period in older adults: the Invecchiare in Chianti Study. J Am Geriatr Soc. 2015;63:938-946
100. Llorach R, Garcia-Aloy M, Tulipani S, et al. Nutrimetabolomic strategies to develop new biomarkers of intake and health effects. J Agric Food Chem. 2012;60:8797-8808
101. Lian QW, Nie YS, Zhang XY, et al. Effects of grape seed proanthocyanidin on Alzheimer's disease in vitro and in vivo. Exp Ther Med. 2016;12:1681-1692
102. Hoppe JB, Coradini K, Frozza RL, et al. Free and nanoencapsulated curcumin suppress beta-amyloid-induced cognitive impairments in rats: involvement of BDNF and Akt/GSK-3 beta signaling pathway. Neurobiol Learn Memory. 2013;106:134-144
103. Sakurai T, Kitadate K, Nishioka H, et al. Oligomerised lychee fruit-derived polyphenol attenuates cognitive impairment in senescence-accelerated mice and endoplasmic reticulum stress in neuronal cells. Br J Nutr. 2013;110:1549-1558
104. Madhavadas S, Kapgal VK, Kutty BM, et al. The neuroprotective effect of dark chocolate in monosodium glutamate-induced nontransgenic Alzheimer disease model rats: biochemical, behavioral, and histological studies. J Diet Suppl. 2016;13:449-460
105. Haque AM, Hashimoto M, Katakura M, et al. Green tea catechins prevent cognitive deficits caused by A beta(1-40) in rats. J Nutr Biochem. 2008;19:619-626
106. Wang J, Ho L, Zhao Z, et al. Moderate consumption of cabernet sauvignon attenuates A beta neuropathology in a mouse model of Alzheimer's disease. FASEB J. 2006;20:2313-2320
107. Frydman-Marom A, Levin A, Farfara D, et al. Orally administrated cinnamon extract reduces beta-amyloid oligomerization and corrects cognitive impairment in Alzheimer's disease animal models. PLoS One. 2011;6:e16564
108. Valls-Pedret C, Lamuela-Raventos RM, Medina-Remon A, et al. Polyphenolrich foods in the Mediterranean diet are associated with better cognitive function in elderly subjects at high cardiovascular risk. J Alzheimers Dis. 2012;29:773-782
109. Kesse-Guyot E, Fezeu L, Andreeva VA, et al. Total and specific polyphenol intakes in midlife are associated with cognitive function measured 13 years later. J Nutr. 2012;142:76-83
110. Lazarus SA, Hammerstone JF, Schmitz HH. Chocolate contains additional flavonoids not found in tea. Lancet. 1999;354:1825
111. Pase MP, Scholey AB, Pipingas A, et al. Cocoa polyphenols enhance positive mood states but not cognitive performance: a randomized, placebo-controlled trial. J Psychopharmacol. 2013;27:451-458
112. Brickman AM, Khan UA, Provenzano FA, et al. Enhancing dentate gyrus function with dietary flavanols improves cognition in older adults. Nat Neurosci. 2014;17:1798-1803
113. Stalmach A, Edwards CA, Wightman JD, et al. Identification of (poly)phenolic compounds in concord grape juice and their metabolites in human plasma and urine after juice consumption. J Agric Food Chem. 2011;59:9512-9522
114. Lamport DJ, Lawton CL, Merat N, et al. Concord grape juice, cognitive function, and driving performance:a 12-wk, placebo-controlled, randomized crossover trial in mothers of preteen children. Am J Clin Nutr. 2016;103:775-783
115. Krikorian R, Boespflug EL, Fleck DE, et al. Concord grape juice supplementation and neurocognitive function in human aging. J Agric Food Chem. 2012;60:5736-5742
116. Liu D, Zhang Q, Gu J, et al. Resveratrol prevents impaired cognition induced by chronic unpredictable mild stress in rats. Prog Neuropsychopharmacol Biol Psychiatry. 2014;49:21-29
117. Schmatz R, Mazzanti CM, Spanevello R, et al. Resveratrol prevents memory deficits and the increase in acetylcholinesterase activity in streptozotocin-induced diabetic rats. Eur J Pharmacol. 2009;610:42-48
118. Sonmez U, Sonmez A, Erbil G, et al. Neuroprotective effects of resveratrol against traumatic brain injury in immature rats. Neurosci Lett. 2007;420:133-137
119. Li Z, Fang F, Wang YY, et al. Resveratrol protects CA1 neurons against focal cerebral ischemic reperfusion-induced damage via the ERK-CREB signaling pathway in rats. Pharmacol Biochem Behav. 2016;146:21-27
120. Kaur H, Patro I, Tikoo K, et al. Curcumin attenuates inflammatory response and cognitive deficits in experimental model of chronic epilepsy. Neurochem Int. 2015;89:40-50
121. Kaur H, Bal A, Sandhir R. Curcumin supplementation improves mitochondrial and behavioral deficits in experimental model of chronic epilepsy. Pharmacol Biochem Behav. 2014;125:55-64
122. Jiang Z, Guo M, Shi C, et al. Protection against cognitive impairment and modification of epileptogenesis with curcumin in a post-status epilepticus model of temporal lobe epilepsy. Neuroscience. 2015;310:362-371
123. Ahmad M. Protective effects of curcumin against lithium-pilocarpine induced status epilepticus, cognitive dysfunction and oxidative stress in young rats. Saudi J Biol Sci. 2013;20:155-162
124. Reeta KH, Mehla J, Pahuja M, et al. Pharmacokinetic and pharmacodynamic interactions of valproate, phenytoin, phenobarbitone and carbamazepine with curcumin in experimental models of epilepsy in rats. Pharmacol Biochem Behav. 2011;99:399-407
125. Choudhary KM, Mishra A, Poroikov VV, et al. Ameliorative effect of curcumin on seizure severity, depression like behavior, learning and memory deficit in postpentylenetetrazole-kindled mice. Eur J Pharmacol. 2013;704:33-40
126. Mehla J, Reeta KH, Gupta P, et al. Protective effect of curcumin against seizures and cognitive impairment in a pentylenetetrazole-kindled epileptic rat model. Life Sci. 2010;87:596-603
127. Wu A, Ying Z, Gomez-Pinilla F. Dietary curcumin counteracts the outcome of traumatic brain injury on oxidative stress, synaptic plasticity, and cognition. Exp Neurol. 2006;197:309-317
128. Sharma S, Ying Z, Gomez-Pinilla F. A pyrazole curcumin derivative restores membrane homeostasis disrupted after brain trauma. Exp Neurol. 2010;226:191-199
129. Sharma S, Zhuang Y, Ying Z, et al. Dietary curcumin supplementation counteracts reduction in levels of molecules involved in energy homeostasis after brain trauma. Neuroscience. 2009;161:1037-1044
130. Wu A, Ying Z, Schubert D, et al. Brain and spinal cord interaction: a dietary curcumin derivative counteracts locomotor and cognitive deficits after brain trauma. Neurorehabil Neural Repair. 2011;25:332-342
131. Wu A, Ying Z, Gomez-Pinilla F. Dietary strategy to repair plasma membrane after brain trauma: implications for plasticity. Neurorehabil Neural Repair. 2014;28:75-84
132. Kuhad A, Chopra K. Curcumin attenuates diabetic encephalopathy in rats: behavioral and biochemical evidences. Eur J Pharmacol. 2007;576:34-42
133. Tang H, Lu D, Pan R, et al. Curcumin improves spatial memory impairment induced by human immunodeficiency virus type 1 glycoprotein 120 V3 loop peptide in rats. Life Sci. 2009;85:1-10
134. Xu Y, Lin D, Li S, et al. Curcumin reverses impaired cognition and neuronal plasticity induced by chronic stress. Neuropharmacology. 2009;57:463-471
135. Jaques JA, Doleski PH, Castilhos LG, et al. Free and nanoencapsulated curcumin prevents cigarette smoke-induced cognitive impairment and redox imbalance. Neurobiol Learn Mem. 2013;100:98-107
136. Jaques JA, Rezer JF, Carvalho FB, et al. Curcumin protects against cigarette smoke-induced cognitive impairment and increased acetylcholinesterase activity in rats. Physiol Behav. 2012;106:664-669
137. Xie L, Li XK, Funeshima-Fuji N, et al. Amelioration of experimental autoimmune encephalomyelitis by curcumin treatment through inhibition of IL-17 production. Int Immunopharmacol. 2009;9:575-581
138. Natarajan C, Bright J. Curcumin inhibits experimental allergic encephalomyelitis by blocking IL-12 signaling through Janus kinase-STAT pathway in T lymphocytes. J Immunol. 2002;168:6506-6513
139. Banji D, Banji OJ, Abbagoni S, et al. Amelioration of behavioral aberrations and oxidative markers by green tea extract in valproate induced autism in animals. Brain Res. 2011;1410:141-151
140. Gao L, Taha R, Gauvin D, et al. Postoperative cognitive dysfunction after cardiac surgery. Chest. 2005;128:3664-3670
141. Ropacki SA, Patel SM, Hartman RE. Pomegranate supplementation protects against memory dysfunction after heart surgery: a pilot study. Evid Based Complement Alternat Med. 2013;2013:932401
142. Willett WC. Diet and health: what should we eat? Science. 1994;264:532-537
143. Keys A, Menotti A, Karvonen MJ, et al. The diet and 15-year death rate in the seven countries study. Am J Epidemiol. 1986;124:903-915
144. Serra-Majem L, Roman B, Estruch R. Scientific evidence of interventions using the Mediterranean diet: a systematic review. Nutr Rev. 2006;64:S27-S47
145. Petersson SD, Philippou E. Mediterranean diet, cognitive function, and dementia: a systematic review of the evidence. Adv Nutr. 2016;7:889-904
146. Cao L, Tan L, Wang HF, et al. Dietary patterns and risk of dementia: a systematic review and meta-analysis of cohort studies. Mol Neurobiol. 2016;53:6144-6154
147. Wu L, Sun D. Adherence to Mediterranean diet and risk of developing cognitive disorders: an updated systematic review and meta-analysis of prospective cohort studies. Sci Rep. 2017;7:41317
148. Wardle J, Rogers P, Judd P, et al. Randomized trial of the effects of cholesterollowering dietary treatment on psychological function. Am J Med. 2000;108: 547-553
149. Martinez-Lapiscina EH, Clavero P, Toledo E, et al. Mediterranean diet improves cognition:the PREDIMED-NAVARRA randomised trial. J Neurol Neurosurg Psychiatry. 2013;84:1318-1325
150. Martinez-Lapiscina EH, Galbete C, Corella D, et al. Genotype patterns at CLU, CR1, PICALM and APOE, cognition and Mediterranean diet: the PREDIMEDNAVARRA trial. Genes Nutr. 2014;9:393
151. Assmann KE, Adjibade M, Andreeva VA, et al. Association between adherence to the Mediterranean Diet at midlife and healthy aging in a cohort of French adults. J Gerontol A Biol Sci Med Sci. 2017; doi: 10.1093/gerona/glx066. [Epub ahead of print]
152. Hernandez-Galiot A, Goni I. Adherence to the Mediterranean diet pattern, cognitive status and depressive symptoms in an elderly non-institutionalized population. Nutr Hosp. 2017;34:338-344
153. McEvoy CT, Guyer H, Langa KM, et al. Neuroprotective diets are associated with better cognitive function:the health and retirement study. J Am Geriatr Soc. 2017;65:1857-1862
154. Frisardi V, Panza F, Seripa D, et al. Nutraceutical properties of Mediterranean diet and cognitive decline: possible underlying mechanisms. JAD. 2010;22:715-740
155. Jahromi SR, Toghae M, Jahromi MJ, et al. Dietary pattern and risk of multiple sclerosis. Iran J Neurol. 2012;11:47-53
156. Sedaghat F, Jessri M, Behrooz M, et al. Mediterranean diet adherence and risk of multiple sclerosis:a case-control study. Asia Pac J Clin Nutr. 2016;25:377-384
157. Hadgkiss EJ, Jelinek GA, Weiland TJ, et al. The association of diet with quality of life, disability, and relapse rate in an international sample of people with multiple sclerosis. Nutr Neurosci. 2015;18:125-136
158. Francis H, Stevenson R. The longer-term impacts of Western diet on human cognition and the brain. Appetite. 2013;63:119-128
159. Atkins RC. Dr Atkins' Diet Revolution: The High Calorie Way to Stay Thin Forever. New York: D McKay; 1972