Curcumin inhibits experimental allergic encephalomyelitis by blocking IL-12 signaling through Janus kinase-STAT pathway in T lymphocytes

Journal of Immunology

Volumn 168, Issue 12, 2002, Pages 6506-6513

  Natarajan, Chandramohan ^a   Bright, John J ^a  

^a Vanderbilt Stallworth Rehabilitation Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CURCUMA LONGA EXTRACT; CURCUMIN; INTERLEUKIN 12; JANUS KINASE; PROTEIN TYROSINE KINASE; STAT PROTEIN; STAT3 PROTEIN; STAT4 PROTEIN;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; CELL DIFFERENTIATION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DEMYELINATING DISEASE; DISEASE SEVERITY; DRUG ACTIVITY; DRUG EFFECT; DRUG ISOLATION; DRUG MECHANISM; ENZYME INHIBITION; ENZYME MECHANISM; FEMALE; MOUSE; MULTIPLE SCLEROSIS; NONHUMAN; PASSIVE IMMUNIZATION; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TH1 CELL;

EID: 0037097660     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.168.12.6506     Document Type: Article

References (72)

1. How many people in the world have MS?
2. Immunomodulatory drugs for multiple sclerosis: A systematic review of clinical and cost effectiveness
3. Drugs in development for the treatment of multiple sclerosis: Antigen non-specific therapies, an update
4. Multiple sclerosis: Current pathophysiological concepts
5. Immunology of demyelinating disease
6. The neuroimmunology of multiple sclerosis: Possible roles of T and B lymphocytes in immunopathogenesis
7. Immunological markers in multiple sclerosis
8. Animal models for autoimmune demyelinating disorders of the nervous system
9. The immunology of multiple sclerosis and its animal model, experimental allergic encephalomyclitis
10. Antigen-specific T cells in autoimmune diseases with a focus on multiple sclerosis and experimental allergic encephalomyelitis
11. The role of cytokines in experimental autoimmune encephalomyelitis
12. Interleukin 12: A pro-inflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen specific adaptive immunity
13. The role of IL-12 in the induction of organ-specific autoimmune diseases
14. Interleukin-12: Amiss in MS
15. Elevated serum levels of interleukin-12 in chronic progressive multiple sclerosis
16. IL-12 is detectable in sera of patients with multiple sclerosis: Association with chronic progressive disease course?
17. Increased release of interleukin-12p40 in MS: Association with intracerebral inflammation
18. Serum interleukin-12 levels in patients with multiple sclerosis
19. Elevated interleukin-12 in progressive multiple sclerosis correlates with disease activity and is normalized by pulse cyclophosphamide therapy
20. + T cells via CD40 ligand
21. Expression of IL-12 in CNS and lymphoid organs of mice with experimental allergic encephalomyelitis
22. Interleukin-12 induces relapse in experimental allergic encephalomyelitis in the Lewis rat
23. Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin-12
24. Molecular mechanisms of NF-κB activation induced by bacterial lipopolysaccharide through Toll-like receptors
25. Regulation of interleukin 12 p40 expression through an NF-κB half-site
26. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
27. Interleukin-12 signaling in T helper type I (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4
28. Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes
29. Differential influence of interleukin-12 in the pathogenesis of autoimmune and virus-induced CNS demyelination
30. Prevention of experimental allergic encephalomyelitis via inhibition of IL-12 signaling and IL-12-mediated Th1 differentiation: An effect of the novel anti-inflammatory drug lisofylline
31. Tyrphostin B42 inhibits IL-12-induced tyrosine phosphorylation and activation of Janus kinase-2 and prevents experimental allergic encephalomyelitis
32. Traditional Indian systems of medicine
33. Pharmacology of diferuloyl methane (curcumin), a non-steroidal anti-inflammatory agent
34. Biological activities of Curcuma longa L
35. The importance of using scientific principles in the development of medicinal agents from plants
36. Three non-phenolic diarylheptanoids with anti-inflammatory activity from Curcuma xanthorrhiza
37. Anti-inflammatory and irritant activities of curcumin analogues in rats
38. Anti-inflammatory studies on Curcuma longa (turmeric)
39. Anti-inflammatory and anti-arthritic activity of volatile oil of Curcuma longa (Haldi)
40. Sodium curcuminate as an effective anti-inflammatory agent
41. Molecular mechanisms of chemopreventive effects of selected dietary and medicinal phenolic substances
42. Curcumin, an anti-tumour promoter and anti-inflammatory agent, inhibits induction of nitric oxide synthase in activated macrophages
43. Curcuminoids as potent inhibitors of lipid peroxidation
44. In vivo inhibition of nitric oxide synthase gene expression by curcumin, a cancer preventive natural product with anti-inflammatory properties
45. Curcumin inhibits TPA induced expression of c-fos, c-jun and c-myc proto-oncogenes messenger RNAs in mouse skin
46. Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: Down-regulation of COX-2 and iNOS through suppression of NF-κB activation
47. Inhibition of interleukin-12 production in lipopolysaccharide-activated macrophages by curcumin
48. + T cells by suppressing interleukin-12 production in macrophages
49. TGF-β inhibits IL-12-induced activation of Jak-STAT pathway in T lymphocytes
50. TGF-β inhibits IL-2-induced tyrosine phosphorylation and activation of Jak1 and Stat5 in T lymphocytes
51. Inhibition of CD40 signaling pathway by tyrphostin A1 reduces secretion of IL-12 in macrophage Th1 cell development and experimental allergic encephalomyelitis in SJL/J mice
52. + T cells
53. Oral administration of a turmeric extract inhibits LDL oxidation and has hypocholesterolemic effects in rabbits with experimental atherosclerosis
54. The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse
55. 1-42 insult
56. Presence of an acidic glycoprotein in the serum of arthritic rats: Modulation by capsaicin and curcumin
57. Preliminary study on antirheumatic activity of curcumin (diferuloyl methane)
58. Contingent genetic regulatory events in T lymphocyte activation
59. Regulation of human lymphocyte proliferation by a heterodimeric cytokine, IL-12 (cytotoxic lymphocyte maturation factor)
60. IL-12 augments antigen-dependent proliferation of activated T lymphocytes
61. Second signal activity of IL-12 on the proliferation and IL-2R expression of T helper cell-1 clone
62. IL-12 enhances IL-2 function by inducing CD25 expression through a p38 mitogen-activated protein kinase pathway
63. Interleukin-12 regulates the proliferation of Th1, but not Th2 or Th0, clones
64. Curcumin blocks cyclosporine A-resistant CD28 costimulatory pathway of human T-cell proliferation
65. Oncostatin M-induced matrix metalloproteinase and tissue inhibitor of metalloproteinase-3 genes expression in chondrocytes requires Janus kinase/STAT signaling pathway
66. A signal transducer and activator of transcription (Stat)4-independent pathway for the development of T helper type 1 cells
67. Type I IFNs inhibit human dendritic cell IL-12 production and Th1 cell development
68. IFN-β differentially regulates CD40-induced cytokine secretion by human dendritic cells
69. An interleukin (IL)-10/IL-12 immunoregulatory circuit controls susceptibility to autoimmune disease
70. Modulation of the IL-10/IL-12 cytokine circuit by interferon-β inhibits the development of epitope spreading and disease progression in murine autoimmune encephalomyelitis
71. Interferon β in multiple sclerosis: Is IL-12 suppression the key?