Pharmacokinetic and pharmacodynamic interactions of valproate, phenytoin, phenobarbitone and carbamazepine with curcumin in experimental models of epilepsy in rats

Pharmacology Biochemistry and Behavior

Volumn 99, Issue 3, 2011, Pages 399-407

  Reeta, K H ^a   Mehla, Jogender ^a   Pahuja, Monika ^a   Gupta, Yogendra Kumar ^a  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Antiepileptic drugs; Cognitive impairment; Curcumin; Interaction; Maximal electroshock (MES); Oxidative stress; Pentylenetetrazole (PTZ)

Indexed keywords

CARBAMAZEPINE; CURCUMIN; PENTETRAZOLE; PHENOBARBITAL; PHENYTOIN; VALPROIC ACID;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG EFFECT; LEARNING DISORDER; MALE; MAZE TEST; MEMORY DISORDER; NONHUMAN; OXIDATIVE STRESS; PASSIVE AVOIDANCE; PRIORITY JOURNAL; RAT; SEIZURE;

ANIMALS; ANTICONVULSANTS; CARBAMAZEPINE; CURCUMIN; DISEASE MODELS, ANIMAL; DRUG INTERACTIONS; DRUG THERAPY, COMBINATION; EPILEPSY; MALE; MAZE LEARNING; PHENOBARBITAL; PHENYTOIN; RANDOM ALLOCATION; RATS; RATS, WISTAR; VALPROIC ACID;

RATTUS; RATTUS NORVEGICUS;

EID: 79958088768     PISSN: 00913057     EISSN: 18735177     Source Type: Journal    
DOI: 10.1016/j.pbb.2011.05.011     Document Type: Article

References (55)

1. Aggarwal BB, Harikumar KB. Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. Int J Biochem Cell Biol 2009;41:40-59.
2. Aggarwal BB, Sung B. Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets. Trends Pharmacol Sci 2009;30:85-94.
3. Ammon HP, Wahl MA. Pharmacology of Curcuma longa. Planta Med 1991;57:1-7.
4. Barnes PM. Complementary and alternative medicine use among adults: United States 2002. Adv Data 2004;343:1-19.
5. Bharal N, Sahaya K, Jain S, Mediratta PK, Sharma KK. Curcumin has anticonvulsant activity on increasing current electroshock seizures in mice. Phytother Res 2008;22:1660-4.
6. Biswas SK, McClure D, Jimenez LA, Megson IL, Rahman I. Curcumin induces glutathione biosynthesis and inhibits NF-kappaB activation and interleukin-8 release in alveolar epithelial cells: mechanism of free radical scavenging activity. Antioxid Redox Signal 2005;7:32-41. (Pubitemid 40187923)
7. Black LC, Schefft BK, Howe SR, Szaflarski JP, Yeh HS, Privitera MD. The effect of seizures on working memory and executive functioning performance. Epilepsy Behav 2010;17:412-29.
8. Blatt SL, Takahashi RN. Memory-impairing effects of local anesthetics in an elevated plus-maze test in mice. Braz J Med Biol Res 1998;31:555-9. (Pubitemid 28223710)
9. Chen LC, Chen YF, Yang LL, Chou MH, Lin MF. Drug utilization pattern of antiepileptic drugs and traditional Chinese medicines in a general hospital in Taiwan - a pharmaco-epidemiologic study. J Clin Pharm Ther 2000;25:125-9. (Pubitemid 30326412)
10. Cheng AL, Hsu CH, Lin JK, Hsu MM, Ho YF, Shen TS, et al. Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high risk or pre-malignant lesions. Anticancer Res 2001;21:2895-900.
11. Choi BH. Oxygen, antioxidant and brain dysfunction. Yonsei Med J 1993;34:1-10.
12. Da Cunha IC, José RF, Orlandi Pereira L, Pimenta JA, de Souza IA Oliveira, Reiser R, et al. The role of nitric oxide in the emotional learning of rats in the plus-maze. Physiol Behav 2005;84:351-8. (Pubitemid 40342588)
13. Du P, Li X, Lin HJ, Peng WF, Liu JY, Ma Y, et al. Curcumin inhibits amygdaloid kindled seizures in rats. Chin Med J 2009;122:1435-8.
14. Eisenberg DM, Davis RB, Ettner SL, Appel S, Wilkey S, Van Rompay M, et al. Trends in alternative medicine use in the United States, 1990-1997: results of a follow-up national survey. JAMA 1998;280:1569-75.
15. Eisenberg DM, Kessler RC, Van Rompay MI, Kaptchuk TJ, Wilkey SA, Appel S, et al. Perceptions about complementary therapies relative to conventional therapies among adults who use both: results from a national survey. Ann InternMed 2001;135:344-51. (Pubitemid 32823241)
16. Ellman GL. Tissue sulfhydryl groups. Arch Biochem Biophys 1959;82:70-7.
17. Endermann M. A time-limited residential unit for young adults with epilepsy and mild cognitive impairment: results of a prospective pre-post-study. Seizure 2010;19:178-84.
18. Epstein J, Sanderson IR, Macdonald TT. Curcumin as a therapeutic agent: the evidence from in vitro, animal and human studies. Br J Nutr 2010;103:1545-57.
19. Fukui K, Omoi NO, Hayasaka T, Shinnkai T, Suzuki S, Abe K, et al. Cognitive impairment of rats caused by oxidative stress and aging and its prevention by vitamin E. Ann N Y Acad Sci 2002;959:275-84. (Pubitemid 34457568)
20. Gessner PK. Isobolographic analysis of interactions: an update on applications and utility. Toxicology 1995;105:161-79. (Pubitemid 26038237)
21. Gupta YK, Briyal S, Sharma M. Protective effect of curcumin against kainic acid induced seizures and oxidative stress in rats. Indian J Physiol Pharmacol 2009;53:39-46.
22. Hamed SA, Abdellah MM, EI-Melegy N. Blood levels of trace elements, electrolytes and oxidative stress/antioxidant systems in epileptic patients. J Pharmacol Sci 2004;96:465-73. (Pubitemid 40144068)
23. Hernandez R, Pernandez Mde L, Miranda G, Suastegin R. Decrease of folic acid and cognitive alterations in patients with epilepsy treated with phenytoin or carbamazepine, pilot study. Rev Invest Clin 2005;57:522-31. (Pubitemid 41644841)
24. Isik AT, Celik T, Ulusoy G, Ongoru O, Elibol B, Doruk H, et al. Curcumin ameliorates impaired insulin/IGF signalling and memory deficit in a streptozotocin-treated rat model. Age 2009;31:39-49.
25. Itoh J, Nabeshima T, Kameyama T. Utility of an elevated plus-maze for the evaluation of memory in mice: effects of nootropics, scopolamine and electroconvulsive shock. Psychopharmacology (Berl) 1990;101:27-33. (Pubitemid 20124737)
26. Jokeit H, Kramer G, Ebner A. Do antiepileptic drugs accelerate forgetting? Epilepsy Behav 2005;6:430-2.
27. Keller JN, Schmitt FA, Scheff SW, Ding Q, Chen Q, Butterfield DA, et al. Evidence of increased oxidative damage in subjects with mild cognitive impairment. Neurology 2005;64:1152-6.
28. Kwan P, Brodie MJ. Early identification of refractory epilepsy. N Engl J Med 2000;342: 314-9. (Pubitemid 30075244)
29. Leppik IE. Epilepsy foundation of America. Choosing an antiepileptic. Selecting drugs for older patients with epilepsy. Geriatrics 2005;60:42-7.
30. Liu CS, Wu HM, Kao SH, Wei YH. Phenytoin-mediated oxidative stress in serum of female epileptics: a possible pathogenesis in the fetal hydantoin syndrome. Human Exp Toxicol 1997;16:177-81.
31. Luszczki JJ, Wu JZ, Raszewski G, Czuczwar SJ. Isobolographic characterization of interactions of retigabine with carbamazepine, lamotrigine, and valproate in the mouse maximal electroshock-induced seizure model. Naunyn Schmiedebergs Arch Pharmacol 2009;379:163-79.
32. Malhotra J, Gupta YK. Effect of adenosine receptors modulation on pentylenetetrazole-induced seizures in rats. Br J Pharmacol 1997;120:282-8. (Pubitemid 27039278)
33. Mc Namara JO. Pharmacotherapy of the epilepsies. In: Bruton LL, Lazo JS, Parker KJ, editors. Goodman and Gilman's The Pharmacological Basis of Therapeutics, 11th edition. New York: Mc Graw-Hill; 2006. p. 501-25.
34. Mehla J, Reeta KH, Gupta P, Gupta YK. Protective effect of curcumin against seizures and cognitive impairment in a pentylenetetrazole-kindled epileptic rat model. Life Sci 2010;87:596-603.
35. Naidech AM, Kreiter KT, Janjua N, Ostapkovich N, Parra A, Commichau C, et al. Phenytoin exposure is associated with functional and cognitive disability after subarachnoid haemorrhage. Stroke 2005;36:583-7. (Pubitemid 40352567)
36. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animals tissues by thiobarbituric acid reaction. Anal Biochem 1979;95:351-8. (Pubitemid 9194347)
37. Ono H, Sakamoto A, Sakura N. Plasma total glutathione concentrations in epileptic patients taking anti-convulsants. Clin Chim Acta 2000;298:135-43. (Pubitemid 30392461)
38. Pan R, Qiu S, Lu DX, Dong J. Curcumin improves learning and memory ability and its neuroprotective mechanism in mice. Chin Med J 2008;121:832-9.
39. Patsalos PN, Perucca E. Clinically important drug interactions in epilepsy: interactions between antiepileptic drugs and other drugs. Lancet Neurol 2003;2:473-81. (Pubitemid 36876104)
40. Patsalos PN, Fröscher W, Pisani F, van Rijn CM. The importance of drug interactions in epilepsy therapy. Epilepsia 2002;43:365-85. (Pubitemid 34297175)
41. Reeta KH, Mehla J, Gupta YK. Curcumin is protective against phenytoin-induced cognitive impairment and oxidative stress in rats. Brain Res 2009;1301:52-60.
42. Reeta KH, Mehla J, Gupta YK. Curcumin ameliorates cognitive dysfunction and oxidative damage in phenobarbitone and carbamazepine administered rats. Eur J Pharmacol 2010;644:106-12.
43. Shannon HE, Love PL. Effects of antiepileptic drugs on attention as assessed by a five choice strial reaction time task in rats. Epilepsy Behav 2005;7:620-8.
44. + ATPase and protein kinase C in adult and old rat brain regions. Biogerontology 2009;10:489-502.
45. Shin HJ, Lee JY, Son E, Lee DH, Kim HJ, Kang SS, et al. Curcumin attenuates the kainic acid-induced hippocampal cell death in the mice. Neurosci Lett 2007;416:49-54. (Pubitemid 46437284)
46. Stafstrom CE, Sutula TP. Models of epilepsy in the developing and adult brain: implications for neuroprotection. Epilepsy Behav 2005;7:S18-24.
47. Stephen LJ, Brodie MJ. Seizure-freedom on more than one antiepileptic drug. Seizure 2002;11:349-51. (Pubitemid 35154146)
48. Sudha K, Rao AV, Rao A. Oxidative stress and antioxidants in epilepsy. Clin Chim Acta 2001;303:19-24. (Pubitemid 32121801)
49. Taylor J, Kolamunnage-Dona R, Marson AG, Smith PE, Aldenkamp AP. SANAD study group. Patients with epilepsy: cognitively compromised before the start of antiepileptic drug treatment? Epilepsia 2010;51:48-56.
50. Thome-Souza S, Kuczynski E, Assumpção FJr, Rzezak P, Fuentes D, Fiore L, et al. Which factors may play a pivotal role on determining the type of psychiatric disorder in children and adolescents with epilepsy? Epilepsy Behav 2004;5:988-94.
51. Vingerhoets G. Cognitive effects of seizures. Seizure 2006;15:221-6.
52. Wang Q, Sun AY, Simonyi A, Jensen MD, Shelat phenobarbitone, Rottinghaus GE, et al. Neuroprotective mechanisms of curcumin against cerebral ischemia-induced neuronal apoptosis and behavioral deficits. J Neurosci Res 2005;82:138-48. (Pubitemid 41604805)
53. World Health Organization. Traditional Medicine Strategy 2002-2005. Geneva: World Health Organization; 2002.
54. Xu K, Stringer JL. Antioxidants and free radical scavengers do not consistently delay seizure onset in animal models of acute seizures. Epilepsy Behav 2008;13:77-82.
55. Zhao J, Zhao Y, Zheng W, Lu Y, Feng G, Yu S. Neuroprotective effect of curcumin on transient focal cerebral ischemia in rats. Brain Res 2008;1229:224-32.