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Volumn 108, Issue 3, 2006, Pages 241-244

Neuroinflammation in multiple sclerosis: Evidence for autoimmune dysregulation, not simple autoimmune reaction

Author keywords

Inflammation; Multiple sclerosis; Regulatory cells

Indexed keywords

TRANSCRIPTION FACTOR FOXP3;

EID: 33644624531     PISSN: 03038467     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clineuro.2005.11.006     Document Type: Conference Paper
Times cited : (48)

References (40)
  • 1
    • 0031914989 scopus 로고    scopus 로고
    • The specificity of the antibody response in multiple sclerosis
    • H. Garren, L. Steinman, and C. Lock The specificity of the antibody response in multiple sclerosis Ann Neurol 43 1998 4 6
    • (1998) Ann Neurol , vol.43 , pp. 4-6
    • Garren, H.1    Steinman, L.2    Lock, C.3
  • 2
    • 0035554898 scopus 로고    scopus 로고
    • Multiple sclerosis: A two-stage disease
    • L. Steinman Multiple sclerosis: a two-stage disease Nat Immunol 2 2001 762 764
    • (2001) Nat Immunol , vol.2 , pp. 762-764
    • Steinman, L.1
  • 3
    • 2642587969 scopus 로고    scopus 로고
    • Axonal damage in multiple sclerosis: A complex issue in a complex disease
    • N. Grigoriadis, T. Ben-Hur, and D. Karussis Axonal damage in multiple sclerosis: a complex issue in a complex disease Clin Neurol Neurosurg 106 2004 211 217
    • (2004) Clin Neurol Neurosurg , vol.106 , pp. 211-217
    • Grigoriadis, N.1    Ben-Hur, T.2    Karussis, D.3
  • 4
    • 0036074812 scopus 로고    scopus 로고
    • Interferon-ß treatment in relapsing-/remitting multiple sclerosis. a review
    • N. Grigoriadis Interferon-ß treatment in relapsing-/remitting multiple sclerosis. A review Clin Neurol Neurosurg 104 2002 251 258
    • (2002) Clin Neurol Neurosurg , vol.104 , pp. 251-258
    • Grigoriadis, N.1
  • 5
    • 0026645658 scopus 로고
    • Immunological aspects of demyelinating diseases
    • R. Martin, H. McFarland, and D. McFarlin Immunological aspects of demyelinating diseases Ann Rev Immunol 10 1992 153 187
    • (1992) Ann Rev Immunol , vol.10 , pp. 153-187
    • Martin, R.1    McFarland, H.2    McFarlin, D.3
  • 6
    • 17644396349 scopus 로고    scopus 로고
    • Immunology of multiple sclerosis
    • M. Sospedra, and R. Martin Immunology of multiple sclerosis Ann Rev Immunol 23 2005 683 747
    • (2005) Ann Rev Immunol , vol.23 , pp. 683-747
    • Sospedra, M.1    Martin, R.2
  • 7
    • 2142662186 scopus 로고    scopus 로고
    • Multiple sclerosis
    • D. Hafler Multiple sclerosis J Clin Invest 113 2004 788 794
    • (2004) J Clin Invest , vol.113 , pp. 788-794
    • Hafler, D.1
  • 8
    • 0029847368 scopus 로고    scopus 로고
    • Functional diversity of helper lymphocytes
    • A. Abbas, K. Murphy, and A. Sher Functional diversity of helper lymphocytes Nature 383 1996 787 793
    • (1996) Nature , vol.383 , pp. 787-793
    • Abbas, A.1    Murphy, K.2    Sher, A.3
  • 9
    • 0028288179 scopus 로고
    • Lymphokine production by human T cells in disease states
    • S. Romagnani Lymphokine production by human T cells in disease states Ann Rev Immunol 12 1994 227 257
    • (1994) Ann Rev Immunol , vol.12 , pp. 227-257
    • Romagnani, S.1
  • 10
    • 0032741665 scopus 로고    scopus 로고
    • The paradigm of Th1 and Th2 cytokines: Its relevance to autoimmunity and allergy
    • V. Singh, S. Mehrotra, and S. Agarwal The paradigm of Th1 and Th2 cytokines: its relevance to autoimmunity and allergy Immunol Res 20 1999 147 161
    • (1999) Immunol Res , vol.20 , pp. 147-161
    • Singh, V.1    Mehrotra, S.2    Agarwal, S.3
  • 11
    • 0030739650 scopus 로고    scopus 로고
    • Myelin basic protein-specific T helper 2 (Th2) cells cause experimental autoimmune encephalomyelitis in immunodeficient hosts rather than protect them from the disease
    • J. Lafaille, F. Van de Keere, and A. Hsu Myelin basic protein-specific T helper 2 (Th2) cells cause experimental autoimmune encephalomyelitis in immunodeficient hosts rather than protect them from the disease J Exp Med 186 1997 307 312
    • (1997) J Exp Med , vol.186 , pp. 307-312
    • Lafaille, J.1    Van De Keere, F.2    Hsu, A.3
  • 12
    • 0032213831 scopus 로고    scopus 로고
    • Balancing the TH1/TH2 concept in multiple sclerosis
    • J. Laman, E. Thompson, and L. Kappos Balancing the TH1/TH2 concept in multiple sclerosis Immunol Today 19 1998 489 490
    • (1998) Immunol Today , vol.19 , pp. 489-490
    • Laman, J.1    Thompson, E.2    Kappos, L.3
  • 13
    • 0028941871 scopus 로고
    • The adhesion molecule and cytokine profile of multiple sclerosis lesions
    • B. Cannella, and C. Raine The adhesion molecule and cytokine profile of multiple sclerosis lesions Ann Neurol 37 1995 423 424
    • (1995) Ann Neurol , vol.37 , pp. 423-424
    • Cannella, B.1    Raine, C.2
  • 14
    • 0032476640 scopus 로고    scopus 로고
    • Cytokine secretion of myelin basic protein reactive T cells in patients with multiple sclerosis
    • A. Windhagen, D. Anderson, and A. Carrizosa Cytokine secretion of myelin basic protein reactive T cells in patients with multiple sclerosis J Neuroimmunol 91 1998 1 9
    • (1998) J Neuroimmunol , vol.91 , pp. 1-9
    • Windhagen, A.1    Anderson, D.2    Carrizosa, A.3
  • 15
    • 0032126914 scopus 로고    scopus 로고
    • Elevated serum levels of IFN-gamma, IL-4 and TNFalpha/unelevated serum levels of IL-10 in patients with demyelinating diseases during the acute stage
    • K. Hohnoki, A. Inoue, and C. Koh Elevated serum levels of IFN-gamma, IL-4 and TNFalpha/unelevated serum levels of IL-10 in patients with demyelinating diseases during the acute stage J Neuroimmunol 87 1998 27 32
    • (1998) J Neuroimmunol , vol.87 , pp. 27-32
    • Hohnoki, K.1    Inoue, A.2    Koh, C.3
  • 16
    • 0034548707 scopus 로고    scopus 로고
    • Transcriptional analysis of multiple sclerosis brain lesions reveals a complex pattern of cytokine expression
    • S. Baranzini, C. Elfstrom, and S. Chang Transcriptional analysis of multiple sclerosis brain lesions reveals a complex pattern of cytokine expression J Immunol 165 2000 6576 6582
    • (2000) J Immunol , vol.165 , pp. 6576-6582
    • Baranzini, S.1    Elfstrom, C.2    Chang, S.3
  • 17
    • 0034517626 scopus 로고    scopus 로고
    • Interferon-gamma and interleukin-4 producing T cells in peripheral blood of multiple sclerosis patients
    • D. Franciotta, E. Zardini, and R. Bergamaschi Interferon-gamma and interleukin-4 producing T cells in peripheral blood of multiple sclerosis patients Eur Cytokine Netw 11 2000 677 681
    • (2000) Eur Cytokine Netw , vol.11 , pp. 677-681
    • Franciotta, D.1    Zardini, E.2    Bergamaschi, R.3
  • 18
    • 0032950794 scopus 로고    scopus 로고
    • Identification of autoantibodies associated with myelin damage in multiple sclerosis
    • C. Genain, B. Cannella, and S. Hauser Identification of autoantibodies associated with myelin damage in multiple sclerosis Nat Med 5 1999 170 175
    • (1999) Nat Med , vol.5 , pp. 170-175
    • Genain, C.1    Cannella, B.2    Hauser, S.3
  • 19
    • 0034333057 scopus 로고    scopus 로고
    • Significant correlation between IL-10 levels and IgG indices in the cerebrospinal fluid of patients with multiple sclerosis
    • I. Nakashima, K. Fujihara, and T. Misu Significant correlation between IL-10 levels and IgG indices in the cerebrospinal fluid of patients with multiple sclerosis J Neuroimmunol 111 2000 64 67
    • (2000) J Neuroimmunol , vol.111 , pp. 64-67
    • Nakashima, I.1    Fujihara, K.2    Misu, T.3
  • 20
    • 0032917298 scopus 로고    scopus 로고
    • Autoimmunity in multiple sclerosis: Study of a wide spectrum of autoantibodies
    • M. Spadaro, M. Amendolea, and M. Mazzucconi Autoimmunity in multiple sclerosis: study of a wide spectrum of autoantibodies Multiple Sclerosis 5 1999 121 125
    • (1999) Multiple Sclerosis , vol.5 , pp. 121-125
    • Spadaro, M.1    Amendolea, M.2    Mazzucconi, M.3
  • 22
    • 0036717722 scopus 로고    scopus 로고
    • Pathogen-specific regulatory T cells provoke a shift in the Th1/Th2 paradigm in immunity to infectious diseases
    • P. McGuirk, and K. Mills Pathogen-specific regulatory T cells provoke a shift in the Th1/Th2 paradigm in immunity to infectious diseases Trends Immunol 23 2002 450 455
    • (2002) Trends Immunol , vol.23 , pp. 450-455
    • McGuirk, P.1    Mills, K.2
  • 23
    • 0026708718 scopus 로고
    • Regulation of immunity to parasites by T cells and T cell-derived cytokines
    • A. Sher, and R. Coffman Regulation of immunity to parasites by T cells and T cell-derived cytokines Ann Rev Immunol 10 1992 385 409
    • (1992) Ann Rev Immunol , vol.10 , pp. 385-409
    • Sher, A.1    Coffman, R.2
  • 24
    • 4043052238 scopus 로고    scopus 로고
    • Regulatory T cells and mechanisms of immune system control
    • A. O'Garra, and P. Vieira Regulatory T cells and mechanisms of immune system control Nat Med 10 2004 801 805
    • (2004) Nat Med , vol.10 , pp. 801-805
    • O'Garra, A.1    Vieira, P.2
  • 25
    • 0035806290 scopus 로고    scopus 로고
    • + cells with regulatory properties isolated from peripheral blood
    • + cells with regulatory properties isolated from peripheral blood J Exp Med 193 2001 1285 1294
    • (2001) J Exp Med , vol.193 , pp. 1285-1294
    • Jonuleit, H.1    Schmitt, E.2    Stassen, M.3
  • 27
    • 0034084162 scopus 로고    scopus 로고
    • Regulatory T cells in autoimmmunity
    • E. Shevach Regulatory T cells in autoimmmunity Ann Rev Immunol 18 2000 423 449
    • (2000) Ann Rev Immunol , vol.18 , pp. 423-449
    • Shevach, E.1
  • 30
    • 1842607712 scopus 로고    scopus 로고
    • + T regulatory cells are not altered in multiple sclerosis and unaffected by disease-modulating drugs
    • + T regulatory cells are not altered in multiple sclerosis and unaffected by disease-modulating drugs J Clin Immunol 24 2004 155 161
    • (2004) J Clin Immunol , vol.24 , pp. 155-161
    • Putheti, P.1    Pettersson, A.2    Soderstrom, M.3
  • 31
    • 1542605341 scopus 로고    scopus 로고
    • CD4 T cell activation and disease activity at onset of multiple sclerosis
    • J. Jensen, A. Langkilde, and C. Fenst CD4 T cell activation and disease activity at onset of multiple sclerosis J Neuroimmunol 149 2004 202 209
    • (2004) J Neuroimmunol , vol.149 , pp. 202-209
    • Jensen, J.1    Langkilde, A.2    Fenst, C.3
  • 32
    • 0036229882 scopus 로고    scopus 로고
    • Immunological disturbances in the central nervous system linked to MRI findings in multiple sclerosis
    • H. Wang, M. Matsui, and T. Saida Immunological disturbances in the central nervous system linked to MRI findings in multiple sclerosis J Neuroimmunol 125 2002 149 154
    • (2002) J Neuroimmunol , vol.125 , pp. 149-154
    • Wang, H.1    Matsui, M.2    Saida, T.3
  • 33
    • 0142119367 scopus 로고    scopus 로고
    • Multiple sclerosis: A study of chemokine receptors and regulatory T cells in relation to MRI variables
    • P. Putheti, M. Morris, and L. Stawiarz Multiple sclerosis: a study of chemokine receptors and regulatory T cells in relation to MRI variables Eur J Neurol 10 2003 529 535
    • (2003) Eur J Neurol , vol.10 , pp. 529-535
    • Putheti, P.1    Morris, M.2    Stawiarz, L.3
  • 35
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • S. Hori, T. Nomura, and S. Sakaguchi Control of regulatory T cell development by the transcription factor Foxp3 Science 299 2003 1057 1061
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 36
    • 0038434099 scopus 로고    scopus 로고
    • T-immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis
    • E. Gambineri, T. Torgerson, and H. Ochs T-immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis Curr Opin Rheumatol 15 2003 430 435
    • (2003) Curr Opin Rheumatol , vol.15 , pp. 430-435
    • Gambineri, E.1    Torgerson, T.2    Ochs, H.3
  • 37
    • 18144387626 scopus 로고    scopus 로고
    • + regulatory T cells by copolymer-I through activation of transcription factor Foxp3
    • + regulatory T cells by copolymer-I through activation of transcription factor Foxp3 Proc Natl Acad Sci USA 102 2005 6449 6454
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 6449-6454
    • Hong, J.1    Li, N.2    Zhang, X.3
  • 38
    • 23744515175 scopus 로고    scopus 로고
    • Decreased FOXP3 levels in multiple sclerosis patients
    • J. Huan, N. Culbertson, and L. Spencer Decreased FOXP3 levels in multiple sclerosis patients J Neurosci Res 81 2005 45 52
    • (2005) J Neurosci Res , vol.81 , pp. 45-52
    • Huan, J.1    Culbertson, N.2    Spencer, L.3
  • 39
    • 0142195835 scopus 로고    scopus 로고
    • + high T regulatory cells and their IL-10 production in multiple sclerosis
    • + high T regulatory cells and their IL-10 production in multiple sclerosis J Neuroimmunol 144 2003 125 131
    • (2003) J Neuroimmunol , vol.144 , pp. 125-131
    • Putheti, P.1    Soderstrom, M.2    Link, H.3
  • 40
    • 85047690488 scopus 로고    scopus 로고
    • An integrated view of suppressor T cell subsets in immunoregulation
    • H. Jiang, and L. Chess An integrated view of suppressor T cell subsets in immunoregulation J Clin Invest 114 2004 1198 1208
    • (2004) J Clin Invest , vol.114 , pp. 1198-1208
    • Jiang, H.1    Chess, L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.