A randomized controlled trial of the ketogenic diet in refractory childhood epilepsy

Acta Neurologica Scandinavica

Volumn 135, Issue 2, 2017, Pages 231-239

  Lambrechts, D A J E ^a   de Kinderen, R J A ^a,b   Vles, J S H ^a,b   de Louw, A J A ^a,c   Aldenkamp, A P ^a,b,c   Majoie, H J M ^a,b,d  

^a MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^b MAASTRICHT UNIVERSITY   (Netherlands)

^c EINDHOVEN UNIVERSITY OF TECHNOLOGY   (Netherlands)

^d MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

children; ketogenic diet; RCT; refractory epilepsy; seizure severity

Indexed keywords

3 HYDROXYBUTYRIC ACID; ANTICONVULSIVE AGENT; CHOLESTEROL; KETONE BODY; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ADOLESCENT; ADULT; ANTICONVULSANT THERAPY; ARTICLE; BENIGN CHILDHOOD EPILEPSY; CHILD; CHILDHOOD ABSENCE EPILEPSY; CHOLESTEROL BLOOD LEVEL; CLINICAL EFFECTIVENESS; CLINICAL EVALUATION; CONTROLLED STUDY; DISEASE SEVERITY; DRUG RESISTANT EPILEPSY; ECG ABNORMALITY; EVIDENCE BASED MEDICINE; FEMALE; FOCAL EPILEPSY; GASTROINTESTINAL SYMPTOM; GENERALIZED EPILEPSY; HUMAN; INFANTILE SPASM; INTENTION TO TREAT ANALYSIS; KETOACIDOSIS; KETOGENIC DIET; KETONURIA; LENNOX GASTAUT SYNDROME; MAJOR CLINICAL STUDY; MALE; MORBIDITY; MYOCLONIC ASTATIC EPILEPSY; NEPHROLITHIASIS; PATIENT DROPOUT; PATIENT SATISFACTION; QT PROLONGATION; RANDOMIZED CONTROLLED TRIAL; SEIZURE; SEVERE MYOCLONIC EPILEPSY IN INFANCY; TREATMENT OUTCOME; TREATMENT RESPONSE; DIET THERAPY; INFANT; MEDICAL RECORD; NETHERLANDS; PRESCHOOL CHILD; PROCEDURES;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; DRUG RESISTANT EPILEPSY; FEMALE; HUMANS; INFANT; KETOGENIC DIET; MALE; MEDICAL RECORDS; NETHERLANDS; TREATMENT OUTCOME;

EID: 84962821708     PISSN: 00016314     EISSN: 16000404     Source Type: Journal    
DOI: 10.1111/ane.12592     Document Type: Article

References (24)

1. Kossoff EH, Zupec-Kania BA, Amark PE et al. Optimal clinical management of children receiving the ketogenic diet: recommendations of the International Ketogenic Diet Study Group. Epilepsia 2009;50:304–17.
2. Neal EG, Chaffe H, Schwartz RH et al. A randomized trial of classical and medium-chain triglyceride ketogenic diets in the treatment of childhood epilepsy. Epilepsia 2009;50:1109–17.
3. Levy RG, Cooper PN, Giri P. Ketogenic diet and other dietary treatments for epilepsy. Cochrane Database Syst Rev 2012;3:CD001903.
4. Neal EG, Chaffe H, Schwartz RH et al. The ketogenic diet for the treatment of childhood epilepsy: a randomised controlled trial. Lancet Neurol 2008;7:500–6.
5. Sharma S, Sankhyan N, Gulati S, Agarwala A. Use of the modified Atkins diet for treatment of refractory childhood epilepsy: a randomized controlled trial. Epilepsia 2013;54:481–6.
6. de Kinderen RJ, Lambrechts DA, Postulart D et al. Research into the (Cost-) effectiveness of the ketogenic diet among children and adolescents with intractable epilepsy: design of a randomized controlled trial. BMC Neurol 2011;11:10.
7. Kwan P, Brodie MJ. Early identification of refractory epilepsy. N Engl J Med 2000;342:314–9.
8. van den Hurk TAM, van der Louw EJTM. Dieetbehandelingsrichtlijn ketogeen dieet voor kinderen (0–18 jaar) met refractaire epilepsie. Evidence-Based Handleiding Voor een Multidisciplinaire Behandeling. Utrecht: UMC Utrecht, 2008.
9. O'Donoghue MF, Duncan JS, Sander JW. The National Hospital Seizure Severity Scale: a further development of the Chalfont Seizure Severity Scale. Epilepsia 1996;37:563–71.
10. Uijl SG, Uiterwaal CS, Aldenkamp AP et al. A cross-sectional study of subjective complaints in patients with epilepsy who seem to be well-controlled with anti-epileptic drugs. Seizure 2006;15:242–8.
11. Miranda MJ, Mortensen M, Povlsen JH, Nielsen H, Beniczky S. Danish study of a modified Atkins diet for medically intractable epilepsy in children: can we achieve the same results as with the classical ketogenic diet? Seizure 2011;20:151–5.
12. Hallbook T, Lundgren J, Rosen I. Ketogenic diet improves sleep quality in children with therapy-resistant epilepsy. Epilepsia 2007;48:59–65.
13. Neal EG, Chaffe HM, Edwards N, Lawson MS, Schwartz RH, Cross JH. Growth of children on classical and medium-chain triglyceride ketogenic diets. Pediatrics 2008;122:e334–40.
14. Nordli DR Jr, Kuroda MM, Carroll J et al. Experience with the ketogenic diet in infants. Pediatrics 2001;108:129–33.
15. Sampath A, Kossoff EH, Furth SL, Pyzik PL, Vining EP. Kidney stones and the ketogenic diet: risk factors and prevention. J Child Neurol 2007;22:375–8.
16. Paul E, Conant KD, Dunne IE et al. Urolithiasis on the ketogenic diet with concurrent topiramate or zonisamide therapy. Epilepsy Res 2010;90:151–6.
17. McNally MA, Pyzik PL, Rubenstein JE, Hamdy RF, Kossoff EH. Empiric use of potassium citrate reduces kidney-stone incidence with the ketogenic diet. Pediatrics 2009;124:e300–4.
18. Best TH, Franz DN, Gilbert DL, Nelson DP, Epstein MR. Cardiac complications in pediatric patients on the ketogenic diet. Neurology 2000;54:2328–30.
19. Doksoz O, Guzel O, Yilmaz U, Isguder R, Celegen K, Mese T. Dispersion durations of P-wave and QT interval in children treated with a ketogenic diet. Pediatr Neurol 2014;50:343–6.
20. Sharma S, Gulati S. The ketogenic diet and the QT interval. J Clin Neurosci 2012;19:181–2.
21. Nizamuddin J, Turner Z, Rubenstein JE, Pyzik PL, Kossoff EH. Management and risk factors for dyslipidemia with the ketogenic diet. J Child Neurol 2008;23:758–61.
22. van Delft R, Lambrechts D, Verschuure P, Hulsman J, Majoie M. Blood beta-hydroxybutyrate correlates better with seizure reduction due to ketogenic diet than do ketones in the urine. Seizure 2010;19:36–9.
23. Kverneland M, Tauboll M, Selmer KK, Iversen PO, Nakke KO. Modified Atkins diet may reduce serum concentrations of antiepileptic drugs. Acta Neurol Scand 2015;131:187–90.
24. Fisher RS, Blum DE, DiVentura B et al. Seizure diaries for clinical research and practice: limitations and future prospects. Epilepsy Behav 2012;24:304–10.