Nutrition, adult hippocampal neurogenesis and mental health

British Medical Bulletin

Volumn 103, Issue 1, 2012, Pages 89-114

  Zainuddin, Muhammad Syahrul Anwar ^a   Thuret, Sandrine ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

adult hippocampal neurogenesis; diet; learning and memory; mood; neural stem cells; nutrition

Indexed keywords

ALCOHOL; ALPHA TOCOPHEROL; CAFFEINE; CAPSAICIN; CURCUMIN; FAT; FLAVONOID; FOLIC ACID; FRUCTOSE; HOMOCYSTEINE; OMEGA 3 FATTY ACID; POLYPHENOL; RESVERATROL; RETINOIC ACID; RETINOL; THIAMINE; ZINC;

AGING; ALPHA TOCOPHEROL DEFICIENCY; ALZHEIMER DISEASE; BLUEBERRY; CALORIC INTAKE; CELL PROLIFERATION; CELL SURVIVAL; CENTRAL NERVOUS SYSTEM DISEASE; COGNITION; COGNITIVE DEFECT; DENTATE GYRUS; DIET; DIET RESTRICTION; ENTORHINAL CORTEX; EPILEPSY; EXERCISE; FOLIC ACID DEFICIENCY; FUNCTIONAL ASSESSMENT; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL CA3 REGION; HIPPOCAMPUS; HUMAN; HUNTINGTON CHOREA; LEARNING; LIPID DIET; MEAL; MEMORY; MENTAL HEALTH; MOOD; NEOCORTEX; NERVE CELL; NERVE CELL PLASTICITY; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; NUTRITION; PARKINSON DISEASE; PRIORITY JOURNAL; RETINOL DEFICIENCY; REVIEW; SPATIAL MEMORY; STRESS; STROKE; THIAMINE DEFICIENCY; ZINC DEFICIENCY;

ADULT; ANIMALS; CAFFEINE; CARBOHYDRATES; FATTY ACIDS, OMEGA-3; FOOD; HIPPOCAMPUS; HUMANS; LEARNING; MEMORY; MENTAL DISORDERS; MICE; MINERALS; NEUROGENESIS; NEURONS; NUTRITIONAL STATUS; POLYPHENOLS; RATS; VITAMINS;

EID: 84865802076     PISSN: 00071420     EISSN: 14718391     Source Type: Journal    
DOI: 10.1093/bmb/lds021     Document Type: Review

References (206)

1. Gomez-Pinilla F. Brain foods: the effects of nutrients on brain function. Nat Rev Neurosci 2008;9:568-78.
2. Jacka FN, Kremer PJ, Berk M et al. A prospective study of diet quality and mental health in adolescents. PLoS One 2011;6:e24805.
3. Jacka FN, Pasco JA, Mykletun A et al. Association of Western and traditional diets with depression and anxiety in women. Am J Psychiatry 2010;167:305-11.
4. Nanri A, Kimura Y, Matsushita Y et al. Dietary patterns and depressive symptoms among Japanese men and women. Eur J Clin Nutr 2010;64:832-9.
5. Sanchez-Villegas A, Delgado-Rodriguez M, Alonso A et al. Association of the Mediterranean dietary pattern with the incidence of depression: the Seguimiento Universidad de Navarra/University of Navarra follow-up (SUN) cohort. Arch Gen Psychiatry 2009;66:1090-8.
6. Akbaraly TN, Brunner EJ, Ferrie JE et al. Dietary pattern and depressive symptoms in middle age. Br J Psychiatry 2009;195:408-13.
7. Solfrizzi V, Frisardi V, Seripa D et al. Mediterranean diet in predementia and dementia syndromes. Curr Alzheimer Res 2011;8:520-42.
8. Kanoski SE, Davidson TL. Western diet consumption and cognitive impairment: links to hippocampal dysfunction and obesity. Physiol Behav 2011;103:59-68.
9. Gu Y, Scarmeas N. Dietary patterns in Alzheimer's disease and cognitive aging. Curr Alzheimer Res 2011;8:510-9.
10. Zhao C, Deng W, Gage FH. Mechanisms and functional implications of adult neurogenesis. Cell 2008;132:645-60.
11. Kempermann G, Gage FH. Neurogenesis in the adult hippocampus. Novartis Found Symp 2000;231:220-35; discussion 235-41, 302-6.
12. Alvarez-Buylla A, Seri B, Doetsch F. Identification of neural stem cells in the adult vertebrate brain. Brain Res Bull 2002;57:751-8.
13. Eriksson PS, Perfilieva E, Bjork-Eriksson T et al. Neurogenesis in the adult human hippocampus. Nat Med 1998;4:1313-7.
14. Kempermann G, Gast D, Kronenberg G et al. Early determination and long-term persistence of adult-generated new neurons in the hippocampus of mice. Development 2003;130:391-9.
15. Toni N, Laplagne DA, Zhao C et al. Neurons born in the adult dentate gyrus form functional synapses with target cells. Nat Neurosci 2008;11:901-7.
16. van Praag H, Schinder AF, Christie BR et al. Functional neurogenesis in the adult hippocampus. Nature 2002;415:1030-4.
17. Mu Y, Lee SW, Gage FH. Signaling in adult neurogenesis. Curr Opin Neurobiol 2010;20:416-23.
18. Sun J, Sun J, Ming GL et al. Epigenetic regulation of neurogenesis in the adult mammalian brain. Eur J Neurosci 2011;33:1087-93.
19. Koehl M, Abrous DN. A new chapter in the field of memory: adult hippocampal neurogenesis. Eur J Neurosci 2011;33:1101-14.
20. Aimone JB, Gage FH. Modeling new neuron function: a history of using computational neuroscience to study adult neurogenesis. Eur J Neurosci 2011;33:1160-9.
21. Kempermann G, Gast D, Gage FH. Neuroplasticity in old age: sustained fivefold induction of hippocampal neurogenesis by long-term environmental enrichment. Ann Neurol 2002;52:135-43.
22. Thuret S, Toni N, Aigner S et al. Hippocampus-dependent learning is associated with adult neurogenesis in MRL/MpJ mice. Hippocampus 2009;19:658-69.
23. Deng W, Aimone JB, Gage FH. New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? Nat Rev Neurosci 2010;11:339-50.
24. Clelland CD, Choi M, Romberg C et al. A functional role for adult hippocampal neurogenesis in spatial pattern separation. Science 2009;325:210-3.
25. Tronel S, Belnoue L, Grosjean N et al. Adult-born neurons are necessary for extended contextual discrimination. Hippocampus 2010;22:292-8.
26. Aimone JB, Wiles J, Gage FH. Computational influence of adult neurogenesis on memory encoding. Neuron 2009;61:187-202.
27. Ge S, Yang CH, Hsu KS et al. A critical period for enhanced synaptic plasticity in newly generated neurons of the adult brain. Neuron 2007;54:559-66.
28. Kesner RP. A behavioral analysis of dentate gyrus function. Prog Brain Res 2007;163:567-76.
29. Manganas LN, Zhang X, Li Y et al. Magnetic resonance spectroscopy identifies neural progenitor cells in the live human brain. Science 2007;318:980-5.
30. Becker S, Wojtowicz JM. A model of hippocampal neurogenesis in memory and mood disorders. Trends Cogn Sci 2007;11:70-6.
31. Vollmayr B, Mahlstedt MM, Henn FA. Neurogenesis and depression: what animal models tell us about the link. Eur Arch Psychiatry Clin Neurosci 2007;257:300-3.
32. Dranovsky A, Hen R. Hippocampal neurogenesis: regulation by stress and antidepressants. Biol Psychiatry 2006;59:1136-43.
33. Scott BW, Wojtowicz JM, Burnham WM. Neurogenesis in the dentate gyrus of the rat following electroconvulsive shock seizures. Exp Neurol 2000;165:231-6.
34. Malberg JE, Eisch AJ, Nestler EJ et al. Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. J Neurosci 2000;20:9104-10.
35. Boldrini M, Underwood MD, Hen R et al. Antidepressants increase neural progenitor cells in the human hippocampus. Neuropsychopharmacology 2009;34:2376-89.
36. Encinas JM, Vaahtokari A, Enikolopov G. Fluoxetine targets early progenitor cells in the adult brain. Proc Natl Acad Sci USA 2006;103:8233-8.
37. Samuels BA, Hen R. Neurogenesis and affective disorders. Eur J Neurosci 2011;33:1152-9.
38. Mirescu C, Gould E. Stress and adult neurogenesis. Hippocampus 2006;16:233-8.
39. Schloesser RJ, Manji HK, Martinowich K. Suppression of adult neurogenesis leads to an increased hypothalamo-pituitary-adrenal axis response. Neuroreport 2009;20:553-7.
40. Anacker C, Zunszain PA, Cattaneo A et al. Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor. Mol Psychiatry 2011;16:738-50.
41. Dunn JD, Orr SE. Differential plasma corticosterone responses to hippocampal stimulation. Exp Brain Res 1984;54:1-6.
42. Mu Y, Gage FH. Adult hippocampal neurogenesis and its role in Alzheimer's disease. Mol Neurodegener 2011;6:85.
43. Thompson A, Boekhoorn K, Van Dam AM et al. Changes in adult neurogenesis in neurodegenerative diseases: cause or consequence? Genes Brain Behav 2008;7(Suppl. 1):28-42.
44. Winner B, Kohl Z, Gage FH. Neurodegenerative disease and adult neurogenesis. Eur J Neurosci 2011;33:1139-51.
45. Jessberger S, Nakashima K, Clemenson GD Jr et al. Epigenetic modulation of seizure-induced neurogenesis and cognitive decline. J Neurosci 2007;27:5967-75.
46. Urbach A, Redecker C, Witte OW. Induction of neurogenesis in the adult dentate gyrus by cortical spreading depression. Stroke 2008;39:3064-72.
47. Okamoto S, Kang YJ, Brechtel CW et al. HIV/gp120 decreases adult neural progenitor cell proliferation via checkpoint kinase-mediated cell-cycle withdrawal and G1 arrest. Cell Stem Cell 2007;1:230-6.
48. Jakubs K, Bonde S, Iosif RE et al. Inflammation regulates functional integration of neurons born in adult brain. J Neurosci 2008;28:12477-88.
49. Klempin F, Kempermann G. Adult hippocampal neurogenesis and aging. Eur Arch Psychiatry Clin Neurosci 2007;257:271-80.
50. Villeda SA, Luo J, Mosher KI et al. The ageing systemic milieu negatively regulates neurogenesis and cognitive function. Nature 2011;477:90-4.
51. Lu L, Bao G, Chen H et al. Modification of hippocampal neurogenesis and neuroplasticity by social environments. Exp Neurol 2003;183:600-9.
52. Meerlo P, Mistlberger RE, Jacobs BL et al. New neurons in the adult brain: the role of sleep and consequences of sleep loss. Sleep Med Rev 2009;13:187-94.
53. Mueller AD, Mear RJ, Mistlberger RE. Inhibition of hippocampal neurogenesis by sleep deprivation is independent of circadian disruption and melatonin suppression. Neuroscience 2011;193:170-81.
54. Stickgold R. Sleep-dependent memory consolidation. Nature 2005;437:1272-8.
55. Grassi Zucconi G, Cipriani S, Balgkouranidou I et al. 'One night' sleep deprivation stimulates hippocampal neurogenesis. Brain Res Bull 2006;69:375-81.
56. Wu JC, Bunney WE. The biological basis of an antidepressant response to sleep deprivation and relapse: review and hypothesis. Am J Psychiatry 1990;147:14-21.
57. Junek A, Rusak B, Semba K. Short-term sleep deprivation may alter the dynamics of hippocampal cell proliferation in adult rats. Neuroscience 2010;170:1140-52.
58. Sportiche N, Suntsova N, Methippara M et al. Sustained sleep fragmentation results in delayed changes in hippocampal-dependent cognitive function associated with reduced dentate gyrus neurogenesis. Neuroscience 2010;170:247-58.
59. Rolls A, Schori H, London A et al. Decrease in hippocampal neurogenesis during pregnancy: a link to immunity. Mol Psychiatry 2008;13:468-9.
60. Leuner B, Mirescu C, Noiman L et al. Maternal experience inhibits the production of immature neurons in the hippocampus during the postpartum period through elevations in adrenal steroids. Hippocampus 2007;17:434-42.
61. van Praag H, Kempermann G, Gage FH. Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nat Neurosci 1999;2:266-70.
62. Kempermann G, Kuhn HG, Gage FH. More hippocampal neurons in adult mice living in an enriched environment. Nature 1997;386:493-5.
63. Tashiro A, Makino H, Gage FH. Experience-specific functional modification of the dentate gyrus through adult neurogenesis: a critical period during an immature stage. J Neurosci 2007;27:3252-9.
64. Olson AK, Eadie BD, Ernst C et al. Environmental enrichment and voluntary exercise massively increase neurogenesis in the adult hippocampus via dissociable pathways. Hippocampus 2006;16:250-60.
65. Leuner B, Gould E, Shors TJ. Is there a link between adult neurogenesis and learning? Hippocampus 2006;16:216-24.
66. Brene S, Bjornebekk A, Aberg E et al. Running is rewarding and antidepressive. Physiol Behav 2007;92:136-40.
67. Mattson MP. Neuroprotective signaling and the aging brain: take away my food and let me run. Brain Res 2000;886:47-53.
68. Lee J, Seroogy KB, Mattson MP. Dietary restriction enhances neurotrophin expression and neurogenesis in the hippocampus of adult mice. J Neurochem 2002;80:539-47.
69. Park HR, Lee J. Neurogenic contributions made by dietary regulation to hippocampal neurogenesis. Ann N Y Acad Sci 2011;1229:23-8.
70. Qiu G, Liu S, So KF. Dietary restriction and brain health. Neurosci Bull 2010;26:55-65.
71. Witte AV, Fobker M, Gellner R et al. Caloric restriction improves memory in elderly humans. Proc Natl Acad Sci USA 2009;106:1255-60.
72. Stangl D, Thuret S. Impact of diet on adult hippocampal neurogenesis. Genes Nutr 2009;4:271-82.
73. Aoki H, Kimoto K, Hori N et al. Cell proliferation in the dentate gyrus of rat hippocampus is inhibited by soft diet feeding. Gerontology 2005;51:369-74.
74. Kushida S, Kimoto K, Hori N et al. Soft-diet feeding decreases dopamine release and impairs aversion learning in Alzheimer model rats. Neurosci Lett 2008;439:208-11.
75. Tsutsui K, Kaku M, Motokawa M et al. Influences of reduced masticatory sensory input from soft-diet feeding upon spatial memory/learning ability in mice. Biomed Res 2007;28:1-7.
76. Yamamoto T, Hirayama A, Hosoe N et al. Soft-diet feeding inhibits adult neurogenesis in hippocampus of mice. Bull Tokyo Dent Coll 2009;50:117-24.
77. Dyall SC, Michael GJ, Michael-Titus AT. Omega-3 fatty acids reverse age-related decreases in nuclear receptors and increase neurogenesis in old rats. J Neurosci Res 2010;88:2091-102.
78. Morris MC, Evans DA, Bienias JL et al. Dietary fats and the risk of incident Alzheimer disease. Arch Neurol 2003;60:194-200.
79. Kalmijn S, Launer LJ, Ott A et al. Dietary fat intake and the risk of incident dementia in the Rotterdam Study. Ann Neurol 1997;42:776-82.
80. van Gelder BM, Tijhuis M, Kalmijn S et al. Fish consumption, n-3 fatty acids, and subsequent 5-y cognitive decline in elderly men: the Zutphen Elderly Study. Am J Clin Nutr 2007;85:1142-7.
81. Freemantle E, Vandal M, Tremblay-Mercier J et al. Omega-3 fatty acids, energy substrates, and brain function during aging. Prostaglandins Leukot Essent Fatty Acids 2006;75:213-20.
82. Fedorova I, Salem N Jr. Omega-3 fatty acids and rodent behavior. Prostaglandins Leukot Essent Fatty Acids 2006;75:271-89.
83. Su HM. Mechanisms of n-3 fatty acid-mediated development and maintenance of learning memory performance. J Nutr Biochem 2010;21:364-73.
84. Logan AC. Omega-3 fatty acids and 6 major depression: a primer for the mental health professional. Lipids Health Dis 2004;3:25.
85. Frangou S, Lewis M, McCrone P. Efficacy of ethyl-eicosapentaenoic acid in bipolar depression: randomised double-blind placebo-controlled study. Br J Psychiatry 2006;188:46-50.
86. Jazayeri S, Tehrani-Doost M, Keshavarz SA et al. Comparison of therapeutic effects of omega-3 fatty acid eicosapentaenoic acid and fluoxetine, separately and in combination, in major depressive disorder. Aust N Z J Psychiatry 2008;42:192-8.
87. Schipper P, Kiliaan AJ, Homberg JR. A mixed polyunsaturated fatty acid diet normalizes hippocampal neurogenesis and reduces anxiety in serotonin transporter knockout rats. Behav Pharmacol 2011;22:324-34.
88. An L, Zhang YZ, Yu NJ et al. The total flavonoids extracted from Xiaobuxin-Tang up-regulate the decreased hippocampal neurogenesis and neurotrophic molecules expression in chronically stressed rats. Prog Neuropsychopharmacol Biol Psychiatry 2008;32:1484-90.
89. Dimpfel W. Rat electropharmacograms of the flavonoids rutin and quercetin in comparison to those of moclobemide and clinically used reference drugs suggest antidepressive and/or neuroprotective action. Phytomedicine 2009;16:287-94.
90. Williams CM, El Mohsen MA, Vauzour D et al. Blueberry-induced changes in spatial working memory correlate with changes in hippocampal CREB phosphorylation and brainderived neurotrophic factor (BDNF) levels. Free Radic Biol Med 2008;45:295-305.
91. Kim SJ, Son TG, Park HR et al. Curcumin stimulates proliferation of embryonic neural progenitor cells and neurogenesis in the adult hippocampus. J Biol Chem 2008;283:14497-505.
92. Ng TP, Chiam PC, Lee T et al. Curry consumption and cognitive function in the elderly. Am J Epidemiol 2006;164:898-906.
93. Dong S, Zeng Q, Mitchell ES et al. Curcumin enhances neurogenesis and cognition in aged rats: implications for transcriptional interactions related to growth and synaptic plasticity. PLoS One 2012;7:e31211.
94. Xu Y, Lin D, Li S et al. Curcumin reverses impaired cognition and neuronal plasticity induced by chronic stress. Neuropharmacology 2009;57:463-71.
95. Xu Y, Ku B, Cui L et al. Curcumin reverses impaired hippocampal neurogenesis and increases serotonin receptor 1A mRNA and brain-derived neurotrophic factor expression in chronically stressed rats. Brain Res 2007;1162:9-18.
96. Li YC, Wang FM, Pan Y et al. Antidepressant-like effects of curcumin on serotonergic receptor-coupled AC-cAMP pathway in chronic unpredictable mild stress of rats. Prog Neuropsychopharmacol Biol Psychiatry 2009;33:435-49.
97. Moriya J, Chen R, Yamakawa J et al. Resveratrol improves hippocampal atrophy in chronic fatigue mice by enhancing neurogenesis and inhibiting apoptosis of granular cells. Biol Pharm Bull 2011;34:354-9.
98. Harada N, Zhao J, Kurihara H et al. Resveratrol improves cognitive function in mice by increasing production of insulin-like growth factor-I in the hippocampus. J Nutr Biochem 2011;22:1150-9.
99. Xu Y, Wang Z, You W et al. Antidepressant-like effect of trans-resveratrol: involvement of serotonin and noradrenaline system. Eur Neuropsychopharmacol 2010;20:405-13.
100. Corniola RS, Tassabehji NM, Hare J et al. Zinc deficiency impairs neuronal precursor cell proliferation and induces apoptosis via p53-mediated mechanisms. Brain Res 2008;1237:52-61.
101. Tassabehji NM, Corniola RS, Alshingiti A et al. Zinc deficiency induces depression-like symptoms in adult rats. Physiol Behav 2008;95:365-9.
102. Szewczyk B, Poleszak E, Sowa-Kucma M et al. Antidepressant activity of zinc and magnesium in view of the current hypotheses of antidepressant action. Pharmacol Rep 2008;60:588-9.
103. Gao HL, Zheng W, Xin N et al. Zinc deficiency reduces neurogenesis accompanied by neuronal apoptosis through caspase-dependent and-independent signaling pathways. Neurotox Res 2009;16:416-25.
104. Levenson CW, Morris D. Zinc and neurogenesis: making new neurons from development to adulthood. Adv Nutr 2011;2:96-100.
105. Nuttall JR, Oteiza PI. Zinc and the ERK kinases in the developing brain. Neurotox Res 2012;21:128-41.
106. Crandall J, Sakai Y, Zhang J et al. 13-cis-retinoic acid suppresses hippocampal cell division and hippocampal-dependent learning in mice. Proc Natl Acad Sci USA 2004;101:5111-6.
107. O'Reilly KC, Shumake J, Bailey SJ et al. Chronic 13-cis-retinoic acid administration disrupts network interactions between the raphe nuclei and the hippocampal system in young adult mice. Eur J Pharmacol 2009;605:68-77.
108. Bonnet E, Touyarot K, Alfos S et al. Retinoic acid restores adult hippocampal neurogenesis and reverses spatial memory deficit in vitamin A deprived rats. PLoS One 2008;3:e3487.
109. Fragoso YD, Shearer KD, Sementilli A et al. High expression of retinoic acid receptors and synthetic enzymes in the human hippocampus. Brain Struct Funct 2012;217:473-83.
110. Kotasova H, Vesela I, Kucera J et al. Phosphoinositide 3-kinase inhibition enables retinoic acid-induced neurogenesis in monolayer culture of embryonic stem cells. J Cell Biochem 2012;113:563-70.
111. Engberg N, Kahn M, Petersen DR et al. Retinoic acid synthesis promotes development of neural progenitors from mouse embryonic stem cells by suppressing endogenous, Wnt-dependent nodal signaling. Stem Cells 2010;28:1498-509.
112. Jacobs S, Lie DC, DeCicco KL et al. Retinoic acid is required early during adult neurogenesis in the dentate gyrus. Proc Natl Acad Sci USA 2006;103:3902-7.
113. Han ME, Park KH, Baek SY et al. Inhibitory effects of caffeine on hippocampal neurogenesis and function. Biochem Biophys Res Commun 2007;356:976-80.
114. Wentz CT, Magavi SS. Caffeine alters proliferation of neuronal precursors in the adult hippocampus. Neuropharmacology 2009;56:994-1000.
115. Lindqvist A, Mohapel P, Bouter B et al. High-fat diet impairs hippocampal neurogenesis in male rats. Eur J Neurol 2006;13:1385-8.
116. Park HR, Park M, Choi J et al. A high-fat diet impairs neurogenesis: involvement of lipid peroxidation and brain-derived neurotrophic factor. Neurosci Lett 2010;482:235-9.
117. van der Borght K, Kohnke R, Goransson N et al. Reduced neurogenesis in the rat hippocampus following high fructose consumption. Regul Pept 2011;167:26-30.
118. Molteni R, Barnard RJ, Ying Z et al. A high-fat, refined sugar diet reduces hippocampal brain-derived neurotrophic factor, neuronal plasticity, and learning. Neuroscience 2002;112:803-14.
119. Palmer TD, Willhoite AR, Gage FH. Vascular niche for adult hippocampal neurogenesis. J Comp Neurol 2000;425:479-94.
120. Song H, Stevens CF, Gage FH. Astroglia induce neurogenesis from adult neural stem cells. Nature 2002;417:39-44.
121. Fisher ND, Sorond FA, Hollenberg NK. Cocoa flavanols and brain perfusion. J Cardiovasc Pharmacol 2006;47(Suppl. 2):S210-4.
122. Francis ST, Head K, Morris PG et al. The effect of flavanol-rich cocoa on the fMRI response to a cognitive task in healthy young people. J Cardiovasc Pharmacol 2006;47(Suppl. 2):S215-20.
123. Bahia PK, Rattray M, Williams RJ. Dietary flavonoid (-)epicatechin stimulates phosphatidylinositol 3-kinase-dependent anti-oxidant response element activity and up-regulates glutathione in cortical astrocytes. J Neurochem 2008;106:2194-204.
124. Mathers JC. Nutritional modulation of ageing: genomic and epigenetic approaches. Mech Ageing Dev 2006;127:584-9.
125. Bondolfi L, Ermini F, Long JM et al. Impact of age and caloric restriction on neurogenesis in the dentate gyrus of C57BL/6 mice. Neurobiol Aging 2004;25:333-40.
126. Kitamura T, Mishina M, Sugiyama H. Dietary restriction increases hippocampal neurogenesis by molecular mechanisms independent of NMDA receptors. Neurosci Lett 2006;393:94-6.
127. Lee J, Duan W, Mattson MP. Evidence that brain-derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice. J Neurochem 2002;82:1367-75.
128. Kawakita E, Hashimoto M, Shido O. Docosahexaenoic acid promotes neurogenesis in vitro and in vivo. Neuroscience 2006;139:991-7.
129. Crupi R, Cambiaghi M, Deckelbaum R et al. n-3 fatty acids prevent impairment of neurogenesis and synaptic plasticity in B-cell activating factor (BAFF) transgenic mice. Prev Med 2011;54:S103-8.
130. Valente T, Hidalgo J, Bolea I et al. A diet enriched in polyphenols and polyunsaturated fatty acids, LMN diet, induces neurogenesis in the subventricular zone and hippocampus of adult mouse brain. J Alzheimers Dis 2009;18:849-65.
131. Yoo KY, Choi JH, Hwang IK et al. (-)-Epigallocatechin-3-gallate increases cell proliferation and neuroblasts in the subgranular zone of the dentate gyrus in adult mice. Phytother Res 2010;24:1065-70.
132. Lee S, Kim DH, Lee DH et al. Oroxylin A, a flavonoid, stimulates adult neurogenesis in the hippocampal dentate gyrus region of mice. Neurochem Res 2010;35:1725-32.
133. Casadesus G, Shukitt-Hale B, Stellwagen HM et al. Modulation of hippocampal plasticity and cognitive behavior by short-term blueberry supplementation in aged rats. Nutr Neurosci 2004;7:309-16.
134. Zhao N, Zhong C, Wang Y et al. Impaired hippocampal neurogenesis is involved in cognitive dysfunction induced by thiamine deficiency at early pre-pathological lesion stage. Neurobiol Dis 2008;29:176-85.
135. Zhao Y, Pan X, Zhao J et al. Decreased transketolase activity contributes to impaired hippocampal neurogenesis induced by thiamine deficiency. J Neurochem 2009;111:537-46.
136. Suh SW, Won SJ, Hamby AM et al. Decreased brain zinc availability reduces hippocampal neurogenesis in mice and rats. J Cereb Blood Flow Metab 2009;29:1579-88.
137. Xumei Z, Guowei H, Huan L et al. Folic acid enhances Notch signaling, hippocampal neurogenesis, and cognitive function in a rat model of cerebral ischemia. Nutr Neurosci 2012;15:55-61.
138. Kronenberg G, Harms C, Sobol RW et al. Folate deficiency induces neurodegeneration and brain dysfunction in mice lacking uracil DNA glycosylase. J Neurosci 2008;28:7219-30.
139. Kruman II, Mouton PR, Emokpae R Jr et al. Folate deficiency inhibits proliferation of adult hippocampal progenitors. Neuroreport 2005;16:1055-9.
140. Rabaneda LG, Carrasco M, Lopez-Toledano MA et al. Homocysteine inhibits proliferation of neuronal precursors in the mouse adult brain by impairing the basic fibroblast growth factor signaling cascade and reducing extracellular regulated kinase 1/2-dependent cyclin E expression. FASEB J 2008;22:3823-35.
141. He J, Nixon K, Shetty AK et al. Chronic alcohol exposure reduces hippocampal neurogenesis and dendritic growth of newborn neurons. Eur J Neurosci 2005;21:2711-20.
142. Nixon K, Crews FT. Binge ethanol exposure decreases neurogenesis in adult rat hippocampus. J Neurochem 2002;83:1087-93.
143. Stevenson JR, Schroeder JP, Nixon K et al. Abstinence following alcohol drinking produces depression-like behavior and reduced hippocampal neurogenesis in mice. Neuropsychopharmacology 2008;34:1209-22.
144. Kong KH, Kim HK, Song KS et al. Capsaicin impairs proliferation of neural progenitor cells and hippocampal neurogenesis in young mice. J Toxicol Environ Health A 2010;73:1490-501.
145. Cecchini T, Ciaroni S, Ferri P et al. Alpha-tocopherol, an exogenous factor of adult hippocampal neurogenesis regulation. J Neurosci Res 2003;73:447-55.
146. Ciaroni S, Cecchini T, Ferri P et al. Neural precursor proliferation and newborn cell survival in the adult rat dentate gyrus are affected by vitamin E deficiency. Neurosci Res 2002;44:369-77.
147. Ciaroni S, Cuppini R, Cecchini T et al. Neurogenesis in the adult rat dentate gyrus is enhanced by vitamin E deficiency. J Comp Neurol 1999;411:495-502.
148. Cuppini R, Ciaroni S, Cecchini T et al. Tocopherols enhance neurogenesis in dentate gyrus of adult rats. Int J Vitam Nutr Res 2002;72:170-6.
149. Stewart J, Mitchell J, Kalant N. The effects of life-long food restriction on spatial memory in young and aged Fischer 344 rats measured in the eight-arm radial and the Morris water mazes. Neurobiol Aging 1989;10:669-75.
150. Ingram DK, Weindruch R, Spangler EL et al. Dietary restriction benefits learning and motor performance of aged mice. J Gerontol 1987;42:78-81.
151. Fontan-Lozano A, Saez-Cassanelli JL, Inda MC et al. Caloric restriction increases learning consolidation and facilitates synaptic plasticity through mechanisms dependent on NR2B subunits of the NMDA receptor. J Neurosci 2007;27:10185-95.
152. Rich NJ, Van Landingham JW, Figueiroa S et al. Chronic caloric restriction reduces tissue damage and improves spatial memory in a rat model of traumatic brain injury. J Neurosci Res 2010;88:2933-9.
153. Lutter M, Krishnan V, Russo SJ et al. Orexin signaling mediates the antidepressant-like effect of calorie restriction. J Neurosci 2008;28:3071-5.
154. Stoll AL, Severus WE, Freeman MP et al. Omega 3 fatty acids in bipolar disorder: a preliminary double-blind, placebo-controlled trial. Arch Gen Psychiatry 1999;56:407-12.
155. Osher Y, Bersudsky Y, Belmaker RH. Omega-3 eicosapentaenoic acid in bipolar depression: report of a small open-label study. J Clin Psychiatry 2005;66:726-9.
156. Keck PE Jr, Mintz J, McElroy SL et al. Double-blind, randomized, placebo-controlled trials of ethyl-eicosapentanoate in the treatment of bipolar depression and rapid cycling bipolar disorder. Biol Psychiatry 2006;60:1020-2.
157. Hooijmans CR, Van der Zee CEEM, Dederen PJ et al. DHA and cholesterol containing diets influence Alzheimer-like pathology, cognition and cerebral vasculature in APPswe/PS1dE9 mice. Neurobiol Dis 2009;33:482-98.
158. Petursdottir AL, Farr SA, Morley JE et al. Effect of dietary n-3 polyunsaturated fatty acids on brain lipid fatty acid composition, learning ability, and memory of senescence-accelerated mouse. J Gerontol Ser A Biol Sci Med Sci 2008;63:1153-60.
159. Yang RH, Wang F, Hou XH et al. Dietary Omega-3 polyunsaturated fatty acids improves learning performance of diabetic rats by regulating the neuron excitability. Neuroscience 2012;212:93-103.
160. Antypa N, Smelt AH, Strengholt A et al. Effects of omega-3 fatty acid supplementation on mood and emotional information processing in recovered depressed individuals. J Psychopharmacol 2011;26:738-43.
161. Spencer JP. Flavonoids and brain health: multiple effects underpinned by common mechanisms. Genes Nutr 2009;4:243-50.
162. Spencer JP. The impact of fruit flavonoids on memory and cognition. Br J Nutr 2010;104(Suppl. 3):S40-7.
163. Rendeiro C, Guerreiro JD, Williams CM et al. Flavonoids as modulators of memory and learning: molecular interactions resulting in behavioural effects. Proc Nutr Soc 2012;71:246-62.
164. Rendeiro C, Spencer JP, Vauzour D et al. The impact of flavonoids on spatial memory in rodents: from behaviour to underlying hippocampal mechanisms. Genes Nutr 2009; 4:251-70.
165. Zhang PH, Tang HQ, Zheng MZ et al. Effect of total flavonoids from Chrysanthemun morifolium on learning and memory in aging mice. Zhongguo Ying Yong Sheng Li Xue Za Zhi 2011;27:368-71.
166. Wang W, Wang F, Yang YJ et al. The flavonoid baicalein promotes NMDA receptordependent long-term potentiation and enhances memory. Br J Pharmacol 2011;162:1364-79.
167. Ding BJ, Ma WW, He LL et al. Soybean isoflavone alleviates beta-amyloid 1-42 induced inflammatory response to improve learning and memory ability by down regulation of Toll-like receptor 4 expression and nuclear factor-kappaB activity in rats. Int J Dev Neurosci 2011;29:537-42.
168. Baluchnejadmojarad T, Roghani M. Chronic epigallocatechin-3-gallate ameliorates learning and memory deficits in diabetic rats via modulation of nitric oxide and oxidative stress. Behav Brain Res 2011;224:305-10.
169. Li F, Gong QH, Wu Q et al. Icariin isolated from Epimedium brevicornum Maxim attenuates learning and memory deficits induced by d-galactose in rats. Pharmacol Biochem Behav 2010;96:301-5.
170. Krikorian R, Shidler MD, Nash TA et al. Blueberry supplementation improves memory in older adults. J Agric Food Chem 2010;58:3996-4000.
171. Papandreou MA, Dimakopoulou A, Linardaki ZI et al. Effect of a polyphenol-rich wild blueberry extract on cognitive performance of mice, brain antioxidant markers and acetylcholinesterase activity. Behav Brain Res 2009;198:352-8.
172. Reeta KH, Mehla J, Gupta YK. Curcumin ameliorates cognitive dysfunction and oxidative damage in phenobarbitone and carbamazepine administered rats. Eur J Pharmacol 2010;644:106-12.
173. Tang H, Lu D, Pan R et al. Curcumin improves spatial memory impairment induced by human immunodeficiency virus type 1 glycoprotein 120 V3 loop peptide in rats. Life Sci 2009;85:1-10.
174. Dong J, Lu DX, Pan R et al. Effect and mechanism of curcumin on learning and memory dysfunction induced by gp120 in rats. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2008;24:328-31.
175. Sun CY, Qi SS, Sun SH. Effect of curcumin on the learning, memory and hippocampal Ca +CaMK II level in senescence-accelerated mice. Zhongguo Zhong Xi Yi Jie He Za Zhi 2011;31:376-80.
176. Pan R, Qiu S, Lu DX et al. Curcumin improves learning and memory ability and its neuroprotective mechanism in mice. Chin Med J (Engl) 2008;121:832-9.
177. Ahmed T, Enam SA, Gilani AH. Curcuminoids enhance memory in an amyloid-infused rat model of Alzheimer's disease. Neuroscience 2010;169:1296-306.
178. Huang Z, Zhong XM, Li ZY et al. Curcumin reverses corticosterone-induced depressive-like behavior and decrease in brain BDNF levels in rats. Neurosci Lett 2011;493:145-8.
179. Xu Y, Ku B, Tie L et al. Curcumin reverses the effects of chronic stress on behavior, the HPA axis, BDNF expression and phosphorylation of CREB. Brain Res 2006;1122:56-64.
180. Xu Y, Ku BS, Yao HY et al. Antidepressant effects of curcumin in the forced swim test and olfactory bulbectomy models of depression in rats. Pharmacol Biochem Behav 2005;82:200-6.
181. Xu Y, Ku BS, Yao HY et al. The effects of curcumin on depressive-like behaviors in mice. Eur J Pharmacol 2005;518:40-6.
182. Cocco S, Diaz G, Stancampiano R et al. Vitamin A deficiency produces spatial learning and memory impairment in rats. Neuroscience 2002;115:475-82.
183. Etchamendy N, Enderlin V, Marighetto A et al. Vitamin A deficiency and relational memory deficit in adult mice: relationships with changes in brain retinoid signalling. Behav Brain Res 2003;145:37-49.
184. Winocur G, Greenwood CE. Studies of the effects of high fat diets on cognitive function in a rat model. Neurobiol Aging 2005;26(Suppl. 1):46-9.
185. Valladolid-Acebes I, Stucchi P, Cano V et al. High-fat diets impair spatial learning in the radial-arm maze in mice. Neurobiol Learn Mem 2011;95:80-5.
186. Abildgaard A, Solskov L, Volke V et al. A high-fat diet exacerbates depressive-like behavior in the Flinders Sensitive Line (FSL) rat, a genetic model of depression. Psychoneuroendocrinology 2011;36:623-33.
187. Alzoubi KH, Abdul-Razzak KK, Khabour OF et al. Adverse effect of combination of chronic psychosocial stress and high fat diet on hippocampus-dependent memory in rats. Behav Brain Res 2009;204:117-23.
188. Goldbart AD, Row BW, Kheirandish-Gozal L et al. High fat/refined carbohydrate diet enhances the susceptibility to spatial learning deficits in rats exposed to intermittent hypoxia. Brain Res 2006;1090:190-6.
189. Granholm AC, Bimonte-Nelson HA, Moore AB et al. Effects of a saturated fat and high cholesterol diet on memory and hippocampal morphology in the middle-aged rat. J Alzheimers Dis 2008;14:133-45.
190. Stranahan AM, Norman ED, Lee K et al. Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats. Hippocampus 2008;18:1085-8.
191. Ross AP, Bartness TJ, Mielke JG et al. A high fructose diet impairs spatial memory in male rats. Neurobiol Learn Mem 2009;92:410-6.
192. Kanoski SE, Zhang Y, Zheng W et al. The effects of a high-energy diet on hippocampal function and blood-brain barrier integrity in the rat. J Alzheimers Dis 2010;21:207-19.
193. Gold PE. Glucose and age-related changes in memory. Neurobiol Aging 2005;26:60-4.
194. Kubo KY, Ichihashi Y, Kurata C et al. Masticatory function and cognitive function. Okajimas Folia Anat Jpn 2010;87:135-40.
195. de Almeida MN, Mendes FC, Felicio AP et al. Spatial memory decline after masticatory deprivation and aging is associated with altered laminar distribution of CA1 astrocytes. BMC Neurosci 2012;13:23.
196. Costa MS, Botton PH, Mioranzza S et al. Caffeine improves adult mice performance in the object recognition task and increases BDNF and TrkB independent on phospho-CREB immunocontent in the hippocampus. Neurochem Int 2008;53:89-94.
197. Smith AP. Caffeine, cognitive failures and health in a non-working community sample. Hum Psychopharmacol 2009;24:29-34.
198. Lucas M, Mirzaei F, Pan A et al. Coffee, caffeine, and risk of depression among women. Arch Intern Med 2011;171:1571-8.
199. Abreu RV, Silva-Oliveira EM, Moraes MF et al. Chronic coffee and caffeine ingestion effects on the cognitive function and antioxidant system of rat brains. Pharmacol Biochem Behav 2011;99:659-64.
200. Robles N, Sabria J. Effects of moderate chronic ethanol consumption on hippocampal nicotinic receptors and associative learning. Neurobiol Learn Mem 2008;89:497-503.
201. Parsons OA. Neurocognitive deficits in alcoholics and social drinkers: a continuum? Alcohol Clin Exp Res 1998;22:954-61.
202. Hauser SR, Getachew B, Taylor RE et al. Alcohol induced depressive-like behavior is associated with a reduction in hippocampal BDNF. Pharmacol Biochem Behav 2011;100:253-8.
203. Delwing D, Bavaresco CS, Monteiro SC et al. alpha-Tocopherol and ascorbic acid prevent memory deficits provoked by chronic hyperprolinemia in rats. Behav Brain Res 2006;168:185-9.
204. Lockrow J, Prakasam A, Huang P et al. Cholinergic degeneration and memory loss delayed by vitamin E in a Down syndrome mouse model. Exp Neurol 2009;216:278-89.
205. Monteiro SC, Matte C, Bavaresco CS et al. Vitamins E and C pretreatment prevents ovariectomy-induced memory deficits in water maze. Neurobiol Learn Mem 2005;84:192-9.
206. Mills JD, Hadley K, Bailes JE. Dietary supplementation with the omega-3 fatty acid docosahexaenoic acid in traumatic brain injury. Neurosurgery 2011;68:474-81; discussion 481.