Brain and spinal cord interaction: A dietary curcumin derivative counteracts locomotor and cognitive deficits after brain trauma

Neurorehabilitation and Neural Repair

Volumn 25, Issue 4, 2011, Pages 332-342

  Wu, Aiguo ^a   Ying, Zhe ^a   Schubert, David ^b   Gomez Pinilla, Fernando ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

BDNF; Curcumin derivative; Hippocampus; Learning; Traumatic brain injury

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CNB 001; CURCUMIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; SILENT INFORMATION REGULATOR PROTEIN 2; SUPEROXIDE DISMUTASE; SYNAPSIN I; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR DISORDER; BIOLOGICAL ACTIVITY; BRAIN; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; DEGENERATIVE DISEASE; DIET SUPPLEMENTATION; DRUG ABSORPTION; HIPPOCAMPUS; LEARNING; LOCOMOTION; MALE; MOTOR PERFORMANCE; NERVE CELL PLASTICITY; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; RAT; SPINAL CORD; TRAUMATIC BRAIN INJURY;

ANIMALS; BRAIN INJURIES; COGNITION DISORDERS; CURCUMIN; DISEASE MODELS, ANIMAL; GAIT DISORDERS, NEUROLOGIC; MALE; NEUROPROTECTIVE AGENTS; PARESIS; PYRAZOLES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 79954580263     PISSN: 15459683     EISSN: 15526844     Source Type: Journal    
DOI: 10.1177/1545968310397706     Document Type: Article

References (50)

1. Langlois JA, Rutland-Brown W, Thomas KE. The incidence of traumatic brain injury among children in the United States: differences by race. J Head Trauma Rehabil. 2005;20:229-238. (Pubitemid 40695718)
2. Ashman TA, Gordon WA, Cantor JB, Hibbard MR. Neurobehavioral consequences of traumatic brain injury. Mt Sinai J Med. 2006;73:999-1005. (Pubitemid 46040398)
3. Levin HS. Prediction of recovery from traumatic brain injury. J Neurotrauma. 1995;12:913-922.
4. Kim YH, Yoo WK, Ko MH, Park CH, Kim STY, Na DL. Plasticity of the attentional network after brain injury and cognitive rehabilitation. Neurorehabil Neural Repair. 2009;23:468-477.
5. Piot-Grosjean O, Wahl F, Gobbo O, Stutzmann JM. Assessment of sensorimotor and cognitive deficits induced by a moderate traumatic injury in the right parietal cortex of the rat. Neurobiol Dis. 2001;8:1082-1093. (Pubitemid 34017101)
6. Fox GB, Fan L, Levasseur RA, Faden AI. Sustained sensory/motor and cognitive deficits with neuronal apoptosis following controlled cortical impact brain injury in the mouse. J Neurotrauma. 1998;15:599-614. (Pubitemid 28413053)
7. Smith DH, Soares HD, Pierce JS, et al. A model of parasagittal controlled cortical impact in the mouse: cognitive and histopathologic effects. J Neurotrauma. 1995;12:169-178.
8. Wu A, Molteni R, Ying Z, Gomez-Pinilla F. A saturated-fat diet aggravates the outcome of traumatic brain injury on hippocampal plasticity and cognitive function by reducing brainderived neurotrophic factor. Neuroscience. 2003;119:365-375. (Pubitemid 36588816)
9. Jöhnk K, Kuhtz-Buschbeck JP, Stolze H, et al. Assessment of sensorimotor functions after traumatic brain injury (TBI) in childhood-methodological aspects. Restor Neurol Neurosci. 1999;14:143-152. (Pubitemid 29173195)
10. Williams G, Morris ME, Schache A, McCrory PR. People preferentially increase hip joint power generation to walk faster following traumatic brain injury. Neurorehabil Neural Repair. 2010;24:550-558.
11. Niechwiej-Szwedo E, Inness EL, Howe JA, Jaglal S, McIlroy WE, Verrier MC. Changes in gait variability during different challenges to mobility in patients with traumatic brain injury. Gait Posture. 2007;25:70-77. (Pubitemid 44750658)
12. Venturi L, Miranda M, Selmi V, et al. Systemic sepsis exacerbates mild post-traumatic brain injury in the rat. J Neurotrauma. 2009; 26:1547-1556.
13. Exo JL, Shellington DK, Bayir H, et al. Resuscitation of traumatic brain injury and hemorrhagic shock with polynitroxylated albumin, hextend, hypertonic saline, and lactated Ringer's: effects on acute hemodynamics, survival, and neuronal death in mice. J Neurotrauma. 2009;26:2403-2408.
14. Clough RW, Neese SL, Sherill LK, et al. Cortical edema in moderate fluid percussion brain injury is attenuated by vagus nerve stimulation. Neuroscience. 2007;147:286-293. (Pubitemid 46907461)
15. Wu A, Ying Z, Gomez-Pinilla F. Dietary omega-3 fatty acids normalize BDNF levels, reduce oxidative damage, and counteract learning disability after traumatic brain injury in rats. J Neurotrauma. 2004;21:1457-1467. (Pubitemid 39435321)
16. Griesbach GS, Hovda DA, Gomez-Pinilla F. Exercise-induced improvement in cognitive performance after traumatic brain injury in rats is dependent on BDNF activation. Brain Res. 2009;1288:105-115.
17. Ying Z, Roy RR, Edgerton VR, Gómez-Pinilla F. Exercise restores levels of neurotrophins and synaptic plasticity following spinal cord injury. Exp Neurol. 2005;193:411-419. (Pubitemid 40626768)
18. Ying Z, Roy RR, Zhong H, Zdunowski S, Edgerton VR, Gomez-Pinilla F. BDNF-exercise interactions in the recovery of symmetrical stepping after a cervical hemisection in rats. Neuroscience. 2008;155:1070-1078.
19. Kang H, Schuman EM. A requirement for local protein synthesis in neurotrophin-induced hippocampal synaptic plasticity. Science. 1996;273:1402-1406. (Pubitemid 26296531)
20. Levine ES, Crozier RA, Black IB, Plummer MR. Brainderived neurotrophic factor modulates hippocampal synaptic transmission by increasing N-methyl-D-aspartic acid receptor activity. Proc Natl Acad Sci U S A. 1998;95:10235-10239. (Pubitemid 28415324)
21. Sherwood NT, Lo DC. Long-term enhancement of central synaptic transmission by chronic brain-derived neurotrophic factor treatment. J Neurosci. 1999;19:7025-7036. (Pubitemid 29380128)
22. Tyler WJ, Pozzo-Miller LD. BDNF enhances quantal neurotransmitter release and increases the number of docked vesicles at the active zones of hippocampal excitatory synapses. J Neurosci. 2001;21:4249-4258. (Pubitemid 32538550)
23. Jovanovic JN, Benfenati F, Siow YL, et al. Neurotrophins stimulate phosphorylation of synapsin I by MAP kinase and regulate synapsin I-actin interactions. Proc Natl Acad Sci U S A. 1996;93:3679-3683. (Pubitemid 26127596)
24. Brock TO, O'Callaghan JP. Quantitative changes in the synaptic vesicle proteins synapsin I and p38 and the astrocytespecific protein glial fibrillary acidic protein are associated with chemical-induced injury to the rat central nervous system. J Neurosci. 1987;7:931-942. (Pubitemid 17055338)
25. Wang T, Xie K, Lu B. Neurotrophins promote maturation of developing neuromuscular synapses. J Neurosci. 1995;15:4796-4805.
26. Finkbeiner S. CREB couples neurotrophin signals to survival messages. Neuron. 2000;25:11-14. (Pubitemid 30316505)
27. Vaynman S, Ying Z, Gomez-Pinilla F. The select action of hippocampal calcium calmodulin protein kinase II in mediating exercise-enhanced cognitive function. Neuroscience. 2007; 144:825-833. (Pubitemid 46013982)
28. Aggarwal BB, Sundaram C, Malani N, Ichikawa H. Curcumin: the Indian solid gold. Adv Exp Med Biol. 2007;595:1-75.
29. Wu A, Ying Z, Gomez-Pinilla F. Dietary curcumin counteracts the outcome of traumatic brain injury on oxidative stress, synaptic plasticity, and cognition. Exp Neurol. 2006;197:309-317. (Pubitemid 43077138)
30. Liu Y, Dargusch R, Maher P, Schubert D. A broadly neuroprotective derivative of curcumin. J Neurochem. 2008;105: 1336-1345. (Pubitemid 351590797)
31. Wu A, Ying Z, Gomez-Pinilla F. Oxidative stress modulates Sir2alpha in rat hippocampus and cerebral cortex. Eur J Neurosci. 2006;23:2573-2580. (Pubitemid 43801449)
32. Wu A, Ying Z, Gomez-Pinilla F. Omega-3 fatty acids supplementation restores mechanisms that maintain brain homeostasis in traumatic brain injury. J Neurotrauma. 2007;24:1587-1595. (Pubitemid 350035841)
33. Wu A, Ying Z, Gomez-Pinilla F. Docosahexaenoic acid dietary supplementation enhances the effects of exercise on synaptic plasticity and cognition. Neuroscience. 2008;155:751-759.
34. Loane DJ, Pocivavsek A, Moussa CE, et al. Amyloid precursor protein secretases as therapeutic targets for traumatic brain injury. Nat Med. 2009;15:377-379.
35. Gómez-Pinilla F, Ying Z, Opazo P, Roy RR, Edgerton VR. Differential regulation by exercise of BDNF and NT-3 in rat spinal cord and skeletal muscle. Eur J Neurosci. 2001;13:1078-1084. (Pubitemid 32275744)
36. Molteni R, Barnard RJ, Ying Z, Roberts CK, Gómez-Pinilla F. A high-fat, refined sugar diet reduces hippocampal brain-derived neurotrophic factor, neuronal plasticity, and learning. Neuroscience. 2002;112:803-814. (Pubitemid 34667045)
37. Ying SW, Futter M, Rosenblum K, et al. Brain-derived neurotrophic factor induces long-term potentiation in intact adult hippocampus: requirement for ERK activation coupled to CREB and upregulation of Arc synthesis. J Neurosci. 2002;22:1532-1540. (Pubitemid 35386272)
38. Walker WC, Pickett TC. Motor impairment after severe traumatic brain injury: a longitudinal multicenter study. J Rehabil Res Dev. 2007;44:975-982.
39. Vaynman S, Gomez-Pinilla F. License to run: exercise impacts functional plasticity in the intact and injured central nervous system by using neurotrophins. Neurorehabil Neural Repair. 2005;19:283-295. (Pubitemid 41705657)
40. Bregman BS, McAtee M, Dai HN, Kuhn PL. Neurotrophic factors increase axonal growth after spinal cord injury and transplantation in the adult rat. Exp Neurol. 1997;148:475-494. (Pubitemid 28068843)
41. Jakeman LB, Wei P, Guan Z, Stokes BT. Brain-derived neurotrophic factor stimulates hindlimb stepping and sprouting of cholinergic fibers after spinal cord injury. Exp Neurol. 1998; 154:170-184. (Pubitemid 28553577)
42. Gómez-Pinilla F, Huie JR, Ying Z, et al. BDNF and learning: evidence that instrumental training promotes learning within the spinal cord by up-regulating BDNF expression. Neuroscience. 2007;148:893-906. (Pubitemid 47419189)
43. Colicos MA, Dash PK. Apoptotic morphology of dentate gyrus granule cells following experimental cortical impact injury in rats: possible role in spatial memory deficits. Brain Res. 1996; 739:120-131. (Pubitemid 26387370)
44. Arciniegas D, Adler L, Topkoff J, Cawthra E, Filley CM, Reite M. Attention and memory dysfunction after traumatic brain injury: cholinergic mechanisms, sensory gating, and a hypothesis for further investigation. Brain Inj. 1999;13:1-13. (Pubitemid 29043314)
45. Levin HS, Goldstein FC, High WM Jr, Eisenberg HM. Disproportionately severe memory deficit in relation to normal intellectual functioning after closed head injury. J Neurol Neurosurg Psychiatry. 1988;51:1294-1301.
46. Dash PK, Mach SA, Moore AN. The role of extracellular signalregulated kinase in cognitive and motor deficits following experimental traumatic brain injury. Neuroscience. 2002;114:755-767. (Pubitemid 35247661)
47. Bolton MM, Lo DC, Sherwood NT. Long-term regulation of excitatory and inhibitory synaptic transmission in hippocampal cultures by brain-derived neurotrophic factor. Prog Brain Res. 2000;128:203-218. (Pubitemid 35461237)
48. Hariri AR, Goldberg TE, Mattay VS, et al. Brain-derived neurotrophic factor val66met polymorphism affects human memoryrelated hippocampal activity and predicts memory performance. J Neurosci. 2003;23:6690-6694. (Pubitemid 36951196)
49. Mu JS, Li WP, Yao ZB, Zhou XF. Deprivation of endogenous brain-derived neurotrophic factor results in impairment of spatial learning and memory in adult rats. Brain Res. 1999;835:259-265.
50. Daitoku H, Hatta M, Matsuzaki H, et al. Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity. Proc Natl Acad Sci U S A. 2004;101:10042-10047. (Pubitemid 38891191)