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Volumn 232, Issue 17, 2015, Pages 3227-3234

The effect of flavanol-rich cocoa on cerebral perfusion in healthy older adults during conscious resting state: A placebo controlled, crossover, acute trial

Author keywords

Arterial spin labelling; Cerebral blood flow; Cocoa; Cognition; Flavanol; Flavonoid; fMRI; Imaging; Regional perfusion

Indexed keywords

CAFFEINE; FLAVANOL DERIVATIVE; THEOBROMINE; FLAVONOL DERIVATIVE; POLYPHENOL;

EID: 84939255866     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-015-3972-4     Document Type: Article
Times cited : (98)

References (45)
  • 2
    • 0030842112 scopus 로고    scopus 로고
    • Relationship between flavonoid structure and inhibition of phosphatidylinositol 3-kinase: A comparison with tyrosine kinase and protein kinase C inhibition
    • 1:CAS:528:DyaK2sXlt1Snsr0%3D 9264317
    • Agullo G, Gamet-Payrastre L, Manenti S, Viala C, Rémésy C, Chap H, Payrastre B (1997) Relationship between flavonoid structure and inhibition of phosphatidylinositol 3-kinase: a comparison with tyrosine kinase and protein kinase C inhibition. Biochem Pharmacol 53:1649-1657
    • (1997) Biochem Pharmacol , vol.53 , pp. 1649-1657
    • Agullo, G.1    Gamet-Payrastre, L.2    Manenti, S.3    Viala, C.4    Rémésy, C.5    Chap, H.6    Payrastre, B.7
  • 3
    • 77958531915 scopus 로고    scopus 로고
    • Protective action of resveratrol in human skin: Possible involvement of specific receptor binding sites
    • Bastianetto S, Dumont Y, Duranton A, Vercauteren F, Breton L, Quirion R (2010) Protective action of resveratrol in human skin: possible involvement of specific receptor binding sites. PLoS One 5:129-135
    • (2010) PLoS One , vol.5 , pp. 129-135
    • Bastianetto, S.1    Dumont, Y.2    Duranton, A.3    Vercauteren, F.4    Breton, L.5    Quirion, R.6
  • 6
    • 0034212432 scopus 로고    scopus 로고
    • Cognitive and emotional influences in anterior cingulate cortex
    • Bush G, Luu P, Posner MI (2000) Cognitive and emotional influences in anterior cingulate cortex. Trends Cog Sci 4:215-222
    • (2000) Trends Cog Sci , vol.4 , pp. 215-222
    • Bush, G.1    Luu, P.2    Posner, M.I.3
  • 8
    • 84865458738 scopus 로고    scopus 로고
    • Benefits in cognitive function, blood pressure, and insulin resistance through cocoa flavanol consumption in elderly subjects with mild cognitive impairment: The cocoa cognition and ageing (CoCoA) study
    • 1:CAS:528:DC%2BC38Xht1Siur7L
    • Desideri G, Kwik-Uribe C, Grassi D, Necozione S, Ghiadoni L, Mastroiacovo D, Raffaele A, Ferri L, Bocale R, Carmela L, Marini C, Reffi C (2012) Benefits in cognitive function, blood pressure, and insulin resistance through cocoa flavanol consumption in elderly subjects with mild cognitive impairment: the cocoa cognition and ageing (CoCoA) study. Hyperten 60:794-801
    • (2012) Hyperten , vol.60 , pp. 794-801
    • Desideri, G.1    Kwik-Uribe, C.2    Grassi, D.3    Necozione, S.4    Ghiadoni, L.5    Mastroiacovo, D.6    Raffaele, A.7    Ferri, L.8    Bocale, R.9    Carmela, L.10    Marini, C.11    Reffi, C.12
  • 9
    • 47249091864 scopus 로고    scopus 로고
    • Acute dark chocolate and cocoa ingestion and endothelial function: A randomized controlled crossover trial
    • 1:CAS:528:DC%2BD1cXoslylsLw%3D 18614724
    • Faridi Z, Njike VY, Dutta S, Ali A, Katz DL (2008) Acute dark chocolate and cocoa ingestion and endothelial function: a randomized controlled crossover trial. Am J Clin Nutr 88:58-63
    • (2008) Am J Clin Nutr , vol.88 , pp. 58-63
    • Faridi, Z.1    Njike, V.Y.2    Dutta, S.3    Ali, A.4    Katz, D.L.5
  • 10
    • 50949103149 scopus 로고    scopus 로고
    • Flavan-3-ol derivatives are positive modulators of GABA(A) receptors with higher efficacy for the alpha(2) subtype and anxiolytic action in mice
    • 1:CAS:528:DC%2BD1cXhtFajurzO
    • Fernandez SP, Mewett KN, Hanrahan JR, Chebib M, Johnston GA (2008) Flavan-3-ol derivatives are positive modulators of GABA(A) receptors with higher efficacy for the alpha(2) subtype and anxiolytic action in mice. Neuropharmacol 55:900-907
    • (2008) Neuropharmacol , vol.55 , pp. 900-907
    • Fernandez, S.P.1    Mewett, K.N.2    Hanrahan, J.R.3    Chebib, M.4    Johnston, G.A.5
  • 11
    • 79952578169 scopus 로고    scopus 로고
    • Consumption of cocoa flavanols results in an acute improvement in visual and cognitive functions
    • 1:CAS:528:DC%2BC3MXltFyisLc%3D 21324330
    • Field DT, Williams CM, Butler LT (2011) Consumption of cocoa flavanols results in an acute improvement in visual and cognitive functions. Physiol Behav 103:255-260
    • (2011) Physiol Behav , vol.103 , pp. 255-260
    • Field, D.T.1    Williams, C.M.2    Butler, L.T.3
  • 12
    • 33746753353 scopus 로고    scopus 로고
    • Aging and vascular responses to flavanol-rich cocoa
    • 1:CAS:528:DC%2BD28XnsVOltLY%3D 16877960
    • Fisher ND, Hollenberg NK (2006) Aging and vascular responses to flavanol-rich cocoa. J Hypertens 24:1575-1580
    • (2006) J Hypertens , vol.24 , pp. 1575-1580
    • Fisher, N.D.1    Hollenberg, N.K.2
  • 13
    • 1442274617 scopus 로고    scopus 로고
    • Flavanol-rich cocoa induces nitric-oxide-dependent vasodilation in healthy humans
    • 1:CAS:528:DC%2BD3sXpsVGhs7k%3D 14654748
    • Fisher ND, Hughes M, Gerhard-Herman M, Hollenberg NK (2003) Flavanol-rich cocoa induces nitric-oxide-dependent vasodilation in healthy humans. J Hypertens 21:2281-2286
    • (2003) J Hypertens , vol.21 , pp. 2281-2286
    • Fisher, N.D.1    Hughes, M.2    Gerhard-Herman, M.3    Hollenberg, N.K.4
  • 14
    • 33750305274 scopus 로고    scopus 로고
    • The effect of flavanol-rich cocoa on the fMRI response to a cognitive task in healthy young people
    • Francis ST, Head K, Morris PG, Macdonald IA (2006) The effect of flavanol-rich cocoa on the fMRI response to a cognitive task in healthy young people. J Cardiovasc Pharmacol 47:215-220
    • (2006) J Cardiovasc Pharmacol , vol.47 , pp. 215-220
    • Francis, S.T.1    Head, K.2    Morris, P.G.3    Macdonald, I.A.4
  • 16
    • 23244468093 scopus 로고    scopus 로고
    • Cocoa reduces blood pressure and insulin resistance and improves endothelium-dependent vasodilation in hypertensives
    • 1:CAS:528:DC%2BD2MXmtlSisrg%3D 16027246
    • Grassi D, Necozione S, Lippi C, Croce G, Valeri L, Pasqualetti P, Desideri G, Blumberg JB, Ferri C (2005) Cocoa reduces blood pressure and insulin resistance and improves endothelium-dependent vasodilation in hypertensives. Hypertension 46:398-405
    • (2005) Hypertension , vol.46 , pp. 398-405
    • Grassi, D.1    Necozione, S.2    Lippi, C.3    Croce, G.4    Valeri, L.5    Pasqualetti, P.6    Desideri, G.7    Blumberg, J.B.8    Ferri, C.9
  • 18
    • 27744449813 scopus 로고    scopus 로고
    • Acute consumption of flavanol-rich cocoa and the reversal of endothelial dysfunction in smokers
    • 1:CAS:528:DC%2BD2MXhtlarsr%2FN 16198843
    • Heiss C, Kleinbongard P, Dejam A, Perre S, Schroeter H, Sies H, Kelm M (2005) Acute consumption of flavanol-rich cocoa and the reversal of endothelial dysfunction in smokers. J Am Coll Cardiol 46:1276-1283
    • (2005) J Am Coll Cardiol , vol.46 , pp. 1276-1283
    • Heiss, C.1    Kleinbongard, P.2    Dejam, A.3    Perre, S.4    Schroeter, H.5    Sies, H.6    Kelm, M.7
  • 20
    • 0035989543 scopus 로고    scopus 로고
    • Interactions of flavones and other phytochemicals with adenosine receptors
    • 3429336 1:CAS:528:DC%2BD38Xms1ahu7k%3D 12083460
    • Jacobson KA, Moro S, Manthey JA, West PL, Ji XD (2002) Interactions of flavones and other phytochemicals with adenosine receptors. Adv Exp Med Biol 505:163-171
    • (2002) Adv Exp Med Biol , vol.505 , pp. 163-171
    • Jacobson, K.A.1    Moro, S.2    Manthey, J.A.3    West, P.L.4    Ji, X.D.5
  • 22
    • 20044396748 scopus 로고    scopus 로고
    • GABA (A) receptor channel pharmacology
    • 1:CAS:528:DC%2BD2MXkvFCru7c%3D
    • Johnston GA (2005) GABA (A) receptor channel pharmacology. Curr Pharma Des 11:1867-1885
    • (2005) Curr Pharma des , vol.11 , pp. 1867-1885
    • Johnston, G.A.1
  • 23
    • 0033862093 scopus 로고    scopus 로고
    • Effects of cocoa extracts on endothelium-dependent relaxation
    • Karim M, McCormick K, Kappagoda CT (2000) Effects of cocoa extracts on endothelium-dependent relaxation. J Nutr 130:2105-2108
    • (2000) J Nutr , vol.130 , pp. 2105-2108
    • Karim, M.1    McCormick, K.2    Kappagoda, C.T.3
  • 24
    • 34548620863 scopus 로고    scopus 로고
    • Flavonoids as opioid receptor ligands: Identification and preliminary structure-activity relationships
    • 2265593 1:CAS:528:DC%2BD2sXos1Kksrw%3D 17685652
    • Katavic PL, Lamb K, Navarro H, Prisinzano TE (2007) Flavonoids as opioid receptor ligands: identification and preliminary structure-activity relationships. J Nat Prod 70:1278-1282
    • (2007) J Nat Prod , vol.70 , pp. 1278-1282
    • Katavic, P.L.1    Lamb, K.2    Navarro, H.3    Prisinzano, T.E.4
  • 25
    • 0036950704 scopus 로고    scopus 로고
    • Mapping cortical columnar structures using fMRI
    • 1:CAS:528:DC%2BD3sXivVKrug%3D%3D 12527012
    • Kim SG, Duong TQ (2002) Mapping cortical columnar structures using fMRI. Physiol Behav 77:641-644
    • (2002) Physiol Behav , vol.77 , pp. 641-644
    • Kim, S.G.1    Duong, T.Q.2
  • 26
    • 85013590603 scopus 로고    scopus 로고
    • The effects of flavonoid and other polyphenol consumption on cognitive performance: A systematic research review of human experimental and epidemiological studies
    • Lamport DJ, Dye L, Wightman JD, Lawton CL (2012) The effects of flavonoid and other polyphenol consumption on cognitive performance: a systematic research review of human experimental and epidemiological studies. Nutr Aging 1:5-25
    • (2012) Nutr Aging , vol.1 , pp. 5-25
    • Lamport, D.J.1    Dye, L.2    Wightman, J.D.3    Lawton, C.L.4
  • 27
    • 78049318379 scopus 로고    scopus 로고
    • Quercetin enhances human alpha7 nicotinic acetylcholine receptor-mediated ion current through interactions with Ca(2+) binding sites
    • 1:CAS:528:DC%2BC3cXht1Wgs73J 20803082
    • Lee BH, Choi SH, Shin TJ, Pyo MK, Hwang SH, Kim BR, Lee SM, Lee JH, Kim HC, Park HY (2010) Quercetin enhances human alpha7 nicotinic acetylcholine receptor-mediated ion current through interactions with Ca(2+) binding sites. Mol Cells 30:245-253
    • (2010) Mol Cells , vol.30 , pp. 245-253
    • Lee, B.H.1    Choi, S.H.2    Shin, T.J.3    Pyo, M.K.4    Hwang, S.H.5    Kim, B.R.6    Lee, S.M.7    Lee, J.H.8    Kim, H.C.9    Park, H.Y.10
  • 29
    • 0033937960 scopus 로고    scopus 로고
    • Comparison of simultaneously measured perfusion and BOLD signal increases during brain activation with T (1)-based tissue identification
    • 1:STN:280:DC%2BD3cvntl2isA%3D%3D 10893532
    • Luh WM, Wong EC, Bandettini PA, Ward BD, Hyde JS (2000) Comparison of simultaneously measured perfusion and BOLD signal increases during brain activation with T (1)-based tissue identification. Magn Reson Med 44:137-143
    • (2000) Magn Reson Med , vol.44 , pp. 137-143
    • Luh, W.M.1    Wong, E.C.2    Bandettini, P.A.3    Ward, B.D.4    Hyde, J.S.5
  • 30
    • 71949083731 scopus 로고    scopus 로고
    • Flavonoids and cognitive function: A review of human randomized controlled trial studies and recommendations for future studies
    • 2775887 1:CAS:528:DC%2BD1MXhtl2ks77K 19680703
    • Macready AL, Kennedy OB, Ellis JA, Williams CM, Spencer JPE, Butler LT (2009) Flavonoids and cognitive function: a review of human randomized controlled trial studies and recommendations for future studies. Genes Nutr 4:227-242
    • (2009) Genes Nutr , vol.4 , pp. 227-242
    • Macready, A.L.1    Kennedy, O.B.2    Ellis, J.A.3    Williams, C.M.4    Spencer, J.P.E.5    Butler, L.T.6
  • 33
    • 84873479600 scopus 로고    scopus 로고
    • The neuroprotective effects of cocoa flavanol and its influence on cognitive performance
    • Nehlig A (2012) The neuroprotective effects of cocoa flavanol and its influence on cognitive performance. Br J Clin Pharm 75:716-727
    • (2012) Br J Clin Pharm , vol.75 , pp. 716-727
    • Nehlig, A.1
  • 35
    • 84876556632 scopus 로고    scopus 로고
    • Cocoa polyphenols enhance positive mood states but not cognitive performance. A randomized, placebo-controlled trial
    • 1:CAS:528:DC%2BC2cXhs1OltrfN
    • Pase MP, Scholey AB, Pipingas A, Kras M, Nolidin K, Gibbs A, Wesnes K, Stough CK (2013) Cocoa polyphenols enhance positive mood states but not cognitive performance. A randomized, placebo-controlled trial. J Psychopharm 27:451-458
    • (2013) J Psychopharm , vol.27 , pp. 451-458
    • Pase, M.P.1    Scholey, A.B.2    Pipingas, A.3    Kras, M.4    Nolidin, K.5    Gibbs, A.6    Wesnes, K.7    Stough, C.K.8
  • 36
    • 84971494022 scopus 로고    scopus 로고
    • The effects of dark chocolate and cocoa products on endothelial function: A meta analysis
    • 1:CAS:528:DC%2BC3sXhslWlsLfF
    • Petrone AB, Gaziano JM, Djousse L (2013) The effects of dark chocolate and cocoa products on endothelial function: a meta analysis. Curr Nutr Rep 2:267-273
    • (2013) Curr Nutr Rep , vol.2 , pp. 267-273
    • Petrone, A.B.1    Gaziano, J.M.2    Djousse, L.3
  • 38
    • 84885466602 scopus 로고    scopus 로고
    • Effects of chocolate on cognitive function and mood: A systematic review
    • 24117885
    • Scholey A, Owen L (2013) Effects of chocolate on cognitive function and mood: a systematic review. Nutr Rev 71:665-681
    • (2013) Nutr Rev , vol.71 , pp. 665-681
    • Scholey, A.1    Owen, L.2
  • 39
    • 77955571972 scopus 로고    scopus 로고
    • Consumption of cocoa flavanols results in acute improvements in mood and cognitive performance during sustained mental effort
    • 1:CAS:528:DC%2BC3cXhsFCnsr3E 19942640
    • Scholey A, French SJ, Morris PJ, Kennedy DO, Milne AL, Haskell CF (2010) Consumption of cocoa flavanols results in acute improvements in mood and cognitive performance during sustained mental effort. J Psychopharmacol 24:1505-1514
    • (2010) J Psychopharmacol , vol.24 , pp. 1505-1514
    • Scholey, A.1    French, S.J.2    Morris, P.J.3    Kennedy, D.O.4    Milne, A.L.5    Haskell, C.F.6
  • 41
    • 71949107443 scopus 로고    scopus 로고
    • Flavonoids and brain health: Multiple effects underpinned by common mechanisms
    • 2775888 1:CAS:528:DC%2BD1MXhtl2ks77N 19685255
    • Spencer JPE (2009) Flavonoids and brain health: multiple effects underpinned by common mechanisms. Genes Nutr 4:243-250
    • (2009) Genes Nutr , vol.4 , pp. 243-250
    • Spencer, J.P.E.1
  • 42
    • 34347404130 scopus 로고    scopus 로고
    • Effects of low habitual cocoa intake on blood pressure and bioactive nitric oxide. A randomized controlled trial
    • 1:CAS:528:DC%2BD2sXovF2rsrc%3D 17609490
    • Taubert D, Roesen R, Lehmann C, Jung N, Schömig E (2007) Effects of low habitual cocoa intake on blood pressure and bioactive nitric oxide. A randomized controlled trial. JAMA 298:49-60
    • (2007) JAMA , vol.298 , pp. 49-60
    • Taubert, D.1    Roesen, R.2    Lehmann, C.3    Jung, N.4    Schömig, E.5
  • 43
    • 23044502323 scopus 로고    scopus 로고
    • Quantitative assessment of the reproducibility of functional activation measured with BOLD and MR perfusion imaging: Implications for clinical trial design
    • 15921936
    • Tjandra T, Brooks JC, Figueiredo P, Wise R, Matthews PM, Tracey I (2005) Quantitative assessment of the reproducibility of functional activation measured with BOLD and MR perfusion imaging: implications for clinical trial design. Neuroimage 27:393-401
    • (2005) Neuroimage , vol.27 , pp. 393-401
    • Tjandra, T.1    Brooks, J.C.2    Figueiredo, P.3    Wise, R.4    Matthews, P.M.5    Tracey, I.6


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