Mediterranean diet, cognitive function, and dementia: A systematic review of the evidence

Advances in Nutrition

Volumn 7, Issue 5, 2016, Pages 889-904

  Petersson, Sara Danuta ^a   Philippou, Elena ^a,b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF NICOSIA   (Cyprus)

Author keywords

Alzheimer disease; Cognitive function; Cognitive impairment; Dementia; Dietary patterns; Mediterranean diet; Systematic review

Indexed keywords

ALZHEIMER DISEASE; COGNITION; COGNITION DISORDERS; DEMENTIA; FEEDING BEHAVIOR; HUMAN; MEDITERRANEAN DIET;

ALZHEIMER DISEASE; COGNITION; COGNITION DISORDERS; DEMENTIA; DIET, MEDITERRANEAN; FEEDING BEHAVIOR; HUMANS;

EID: 84992724064     PISSN: 21618313     EISSN: 21565376     Source Type: Journal    
DOI: 10.3945/an.116.012138     Document Type: Review

References (85)

1. Daviglus ML, Bell CC, Berrettini W, Bowen PE, Connolly ES, Cox NJ, Dunbar-Jacob JM, Granieri EC, Hunt G, McGarry K, et al. National Institutes of Health state-of-the-science conference statement: preventing Alzheimer disease and cognitive decline. Ann Intern Med 2010; 153:176-81.
2. Alzheimer's SocietyAlzheimer's Society online information-About dementia-What is dementia? Leading the fight against Dementia [Internet]. 2014 [cited 2016 Mar 30]. Available from: http://www.alzheimers. org.uk/site/scripts/documents.php?categoryID=200360.
3. Tricco AC, Soobiah C, Berliner S, Ho JM, Ng CH, Ashoor HM, Chen MH, Hemmelgarn BSS. Efficacy and safety of cognitive enhancers for patients with mild cognitive impairment: a systematic review and meta-analysis. CMAJ 2013;185:1393-401.
4. Tan CC, Yu JT, Wang HF, Tan MS, Meng XF, Wang C, Jiang T, Zhu XC, Tan L. Efficacy and safety of donepezil, galantamine, rivastigmine, and memantine for the treatment of Alzheimer's disease: a systematic review and meta-analysis. J Alzheimers Dis 2014;41:615-31.
5. Srisuwan P. Primary prevention of dementia: focus on modifiable risk factors. J Med Assoc Thai 2013;96:251-8.
6. Gill SS, Seitz D. Lifestyles and cognitive health. What older individuals can do to optimize cognitive outcomes. JAMA 2015;314:774-5.
7. Yankner BA, Lu T, Loerch P. The aging brain. Annu Rev Pathol 2008;3: 41-66.
8. Riddle DR, Sonntag WE, Lichtenwalner RJ. Microvascular plasticity in aging. Ageing Res Rev 2003;2:149-68.
9. Wallace DC. Mitochondrial genetics: a paradigm for aging and degenerative diseases? Science 1992;256:628-32.
10. Bach-Faig A, Berry EM, Lairon D, Reguant J, Trichopoulou A, Dernini S, Medina FX, Battino M, Belahsen R, Miranda G, et al. Mediterranean diet pyramid today. Science and cultural updates. Public Health Nutr 2011;14 12A:2274-84.
11. Schwingshackl L, Hoffmann G. Adherence to Mediterranean diet and risk of cancer: a systematic review and meta-analysis of observational studies. Int J Cancer 2014;135:1884-97.
12. Keys A, Menotti A, Aravanis C, Blackburn H, Djordevic BS, Buzina R, Dontas AS, Fidanza F, Karvonen MJ, Kimura N. The seven countries study: 2, 289 deaths in 15 years. Prev Med 1984;13:141-54.
13. Trichopoulou A, Costacou T, Bamia C, Trichopoulos D. Adherence to a Mediterranean diet and survival in a Greek population. N Engl J Med 2003;348:2599-608.
14. Solfrizzi V, Colacicco AM, D'Introno A, Capurso C, Torres F, Rizzo C, Capurso A, Panza F. Dietary intake of unsaturated fatty acids and agerelated cognitive decline: a 8.5-year follow-up of the Italian Longitudinal Study on Aging. Neurobiol Aging 2006;27:1694-704.
15. Engelhart MJ, Geerlings MI, Ruitenberg A, van Swieten JC, Hofman A, Witteman JCM, Breteler MMB. Dietary intake of antioxidants and risk of Alzheimer disease. JAMA 2002;287:3223-9.
16. Li FJ, Shen L, Ji HF. Dietary intakes of vitamin E, vitamin C, and betacarotene and risk of Alzheimer's disease: a meta-analysis. J Alzheimers Dis 2012;31:253-8.
17. Letenneur L, Proust-Lima C, Le Gouge A, Dartigues JF, Barberger-Gateau P. Flavonoid intake and cognitive decline over a 10-year period. Am J Epidemiol 2007;165:1364-71.
18. Jacobs DR, Gross MD, Tapsell LC. Food synergy: an operational concept for understanding nutrition. Am J Clin Nutr 2009;89:1543S-8S.
19. Dai J, Jones DP, Goldberg J, Ziegler TR, Bostick RM, Wilson PW, Manatunga AK, Shallenberger L, Jones L, Vaccarino V. Association between adherence to the Mediterranean diet and oxidative stress. Am J Clin Nutr 2008;88:1364-70.
20. Chrysohoou C, Panagiotakos DB, Pitsavos C, Das UN, Stefanadis C. Adherence to the Mediterranean diet attenuates inflammation and coagulation process in healthy adults: the ATTICA study. J Am Coll Cardiol 2004;44:152-8.
21. Kuo H-K, Yen C-J, Chang C-H, Kuo C-K, Chen J-H, Sorond F. Relation of C-reactive protein to stroke, cognitive disorders, and depression in the general population: systematic review and meta-analysis. Lancet Neurol 2005;4:371-80.
22. Grimm A, Friedland K, Eckert A. Mitochondrial dysfunction: the missing link between aging and sporadic Alzheimer's disease. Biogerontology 2016;17:281-96.
23. Féart C, Samieri C, Allès B, Barberger-Gateau P. Potential benefits of adherence to the Mediterranean diet on cognitive health. Proc Nutr Soc 2013;72:140-52.
24. Panza F, Solfrizzi V, Colacicco AM, D'Introno A, Capurso C, Torres F, Del Parigi A, Capurso S, Capurso A. Mediterranean diet and cognitive decline. Public Health Nutr 2004;7:959-63.
25. Lourida I, Soni M, Thompson-Coon J, Purandare N, Lang IA, Ukoumunne OC, Llewellyn DJ. Mediterranean diet, cognitive function, and dementia: a systematic review. Epidemiology 2013;24:479-89.
26. Psaltopoulou T, Sergentanis TN, Panagiotakos DB, Sergentanis IN, Kosti R, Scarmeas N. Mediterranean diet, stroke, cognitive impairment, and depression: a meta-analysis. Ann Neurol 2013;74:580-91.
27. Moher D, Liberati A, Tetzlaff J, Altman DG, The PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA Statement. BMJ 2009;339:b2535.
28. Viswanathan M, Berkman ND. Development of the RTI item bank on risk of bias and precision of observational studies. J Clin Epidemiol 2012;65:163-78.
29. Chan R, Chan D, Woo J. A cross sectional study to examine the association between dietary patterns and cognitive impairment in older Chinese people in Hong Kong. J Nutr Health Aging 2013;17: 757-65.
30. Crichton GE, Bryan J, Hodgson JM, Murphy KJ. Mediterranean diet adherence and self-reported psychological functioning in an Australian sample. Appetite 2013;70:53-9.
31. Gardener S, Gu Y, Rainey-Smith SR, Keogh JB, Clifton PM, Mathieson SL, Taddei K, Mondal A, Ward VK, Scarmeas N, et al. Adherence to a Mediterranean diet and Alzheimer's disease risk in an Australian population. Transl Psychiatry 2012;2:e164.
32. Katsiardanis K, Diamantaras A-A, Dessypris N, Michelakos T, Anastasiou A, Katsiardani K-P, Kanavidis P, Papadopoulos FC, Stefanadis C, Panagiotakos DB, et al. Cognitive impairment and dietary habits among elders: the Velestino study. J Med Food 2013;16:343-50.
33. Ye X, Scott T, Gao X, Maras JE, Bakun PJ, Tucker KL. Mediterranean diet, Healthy Eating Index 2005, and cognitive function in middle-aged and older Puerto Rican adults. J Acad Nutr Diet 2013;113:276-81.e1-3.
34. Scarmeas N, Stern Y, Mayeux R, Luchsinger JA. Mediterranean diet, Alzheimer disease, and vascular mediation. Arch Neurol 2006;63:1709-17.
35. Cherbuin N, Anstey KJ. The Mediterranean diet is not related to cognitive change in a large prospective investigation: the PATH Through Life study. Am J Geriatr Psychiatry 2012;20:635-9.
36. Corley J, Starr JM, McNeill G, Deary IJ. Do dietary patterns influence cognitive function in old age? Int Psychogeriatr 2013;25:1393-407.
37. Féart C, Samieri C, Rondeau V, Amieva H, Portet F, Dartigues J-F, Scarmeas N, Barberger-Gateau P. Adherence to a Mediterranean diet, cognitive decline, and risk of dementia. JAMA 2009;302:638-48.
38. Kesse-Guyot E, Andreeva VA, Lassale C, Ferry M, Jeandel C, Hercberg S, Galan P. Mediterranean diet and cognitive function: a French study. Am J Clin Nutr 2013;97:369-76.
39. Koyama A, Houston DK, Simonsick EM, Lee JS, Ayonayon HN, Shahar DR, Rosano C, Satterfield S, Yaffe K. Association between the Mediterranean diet and cognitive decline in a biracial population. J Gerontol A Biol Sci Med Sci 2015;70:354-9.
40. Olsson E, Karlstroma B, Kilanderb L, Bybergc L, Cederholma TSP. Dietary patterns and cognitive dysfunction in a 12-year follow-up study of 70 year old men. J Alzheimers Dis 2015;43:109-19.
41. Psaltopoulou T, Kyrozis A, Stathopoulos P, Trichopoulos D, Vassilopoulos D, Trichopoulou A. Diet, physical activity and cognitive impairment among elders: the EPIC-Greece cohort (European Prospective Investigation into Cancer and Nutrition). Public Health Nutr 2008;11:1054-62.
42. Samieri C, Sun Q, Townsend MK, Chiuve SE, Okereke OI, Willett WC, Stampfer M, Grodstein F. The association between dietary patterns at midlife and health in aging: an observational study. Ann Intern Med 2013;159:584-91.
43. Samieri C, Okereke OIE, Devore E, Grodstein F. Long-term adherence to the Mediterranean diet is associated with overall cognitive status, but not cognitive decline, in women. J Nutr 2013;143:493-9.
44. Samieri C, Grodstein F, Rosner BA, Kang JH, Cook NR, Manson JE, Buring JE, Willett WC, Okereke OI. Mediterranean diet and cognitive function in older age. Epidemiology 2013;24:490-9.
45. Scarmeas N, Luchsinger JA, Schupf N, Brickman AM, Cosentino S, Tang MX, Stern Y. Physical activity, diet, and risk of Alzheimer disease. JAMA 2009;302:627-37.
46. Scarmeas N, Stern Y, Mayeux R, Manly JJ, Schupf N, Luchsinger JA. Mediterranean diet and mild cognitive impairment. Arch Neurol 2009;66:216-25.
47. Scarmeas N, Stern Y, Tang M-X, Mayeux R, Luchsinger JA. Mediterranean diet and risk for Alzheimer's disease. Ann Neurol 2006;59:912-21.
48. Tangney CC, Li H, Wang Y, Barnes L, Schneider JA, Bennett DA, Morris MC. Relation of DASH-and Mediterranean-like dietary patterns to cognitive decline in older persons. Neurology 2014;83:1410-6.
49. Titova OE, Ax E, Brooks SJ, Sjögren P, Cederholm T, Kilander L, Kullberg J, Larsson EM, Johansson L, Åhlström H, et al. Mediterranean diet habits in older individuals: associations with cognitive functioning and brain volumes. Exp Gerontol 2013;48:1443-8.
50. Tsivgoulis G, Judd S, Letter AJ, Alexandrov AV, Howard G, Nahab F, Unverzagt FW, Moy C, Howard VJ, Kissela B, et al. Adherence to a Mediterranean diet and risk of incident cognitive impairment. Neurology 2013;80:1684-92.
51. Vercambre M-N, Grodstein F, Berr C, Kang JH. Mediterranean diet and cognitive decline in women with cardiovascular disease or risk factors. J Acad Nutr Diet 2012;112:816-23.
52. Wengreen H, Munger RG, Cutler A, Quach A, Bowles A, Corcoran C, Tschanz JT, Norton MC, Welsh-Bohmer KA. Prospective study of Dietary Approaches to Stop Hypertension-and Mediterranean-style dietary patterns and age-related cognitive change: the Cache County Study on Memory, Health and Aging. Am J Clin Nutr 2013;98:1263-71.
53. Gu Y, Luchsinger JA, Stern Y, Scarmeas N. Mediterranean diet, inflammatory and metabolic biomarkers, and risk of Alzheimer's disease. J Alzheimers Dis 2010;22:483-92.
54. Roberts RO, Geda YE, Cerhan JR, Knopman DS, Cha RH, Christianson TJH, Pankratz VS, Ivnik RJ, Boeve BF, O'Connor HM, et al. Vegetables, unsaturated fats, moderate alcohol intake, and mild cognitive impairment. Dement Geriatr Cogn Disord 2010;29:413-23.
55. Tangney CC, Kwasny MJ, Li H, Wilson RS, Evans DA, Morris MC. Adherence to a Mediterranean-type dietary pattern and cognitive decline in a community population. Am J Clin Nutr 2011;93:601-7.
56. Martínez-Lapiscina EH, Clavero P, Toledo E, Estruch R, Salas-Salvadó J, San Julián B, Sanchez-Tainta A, Ros E, Valls-Pedret C, Martinez-Gonzalez Má. Mediterranean diet improves cognition: the PREDIMED-NAVARRA randomised trial. J Neurol Neurosurg Psychiatry 2013;84:1318-25.
57. Martínez-Lapiscina EH, Clavero P, Toledo E, San Julian B, Sanchez-Tainta A, Corella D, Lamuela-Raventos RM, Martinez JA, Martinez-Gonzalez MA. Virgin olive oil supplementation and long-term cognition: the PREDIMED-NAVARRA randomized, trial. J Nutr Health Aging 2013; 17:544-52.
58. Martínez-Lapiscina EH, Galbete C, Corella D, Toledo E, Buil-Cosiales P, Salas-Salvado J, Ros E, Martinez-Gonzalez Má. Genotype patterns at CLU, CR1, PICALM and APOE, cognition and Mediterranean diet: the PREDIMED-NAVARRA trial. Genes Nutr 2014;9:393.
59. McMillan L, Owen L, Kras M, Scholey A. Behavioural effects of a 10-day Mediterranean diet. Results from a pilot study evaluating mood and cognitive performance. Appetite 2011;56:143-7.
60. Wardle J, Rogers P, Judd P, Taylor MA, Rapoport L, Green M, Nicholson Perry K. Randomized trial of the effects of cholesterol-lowering dietary treatment on psychological function. Am J Med 2000;108:547-53.
61. Panagiotakos DB, Pitsavos C, Stefanadis C. Dietary patterns: a Mediterranean diet score and its relation to clinical and biological markers of cardiovascular disease risk. Nutr Metab Cardiovasc Dis 2006;16:559-68.
62. Valls-Pedret C, Sala-Vila A, Serra-MirM, Corella D, de la Torre R, Martínez-González Má, Martínez-Lapiscina EH, Fitó M, Pérez-Heras A, Salas-Salvadó J, et al. Mediterranean diet and age-related cognitive decline: a randomized clinical trial. JAMA Intern Med 2015;175:1094-103.
63. Estruch R, Ros E, Salas-Salvadó J, Covas M-I, Corella D, Arós F, Gómez-Gracia E, Ruiz-Gutiérrez V, FiolM, Lapetra J, et al. Primary prevention of cardiovascular disease with a Mediterranean diet. N Engl J Med 2013;368:1279-90.
64. Stampfer MJ. Cardiovascular disease and Alzheimer's disease: common links. J Intern Med 2006;260:211-23.
65. Scarmeas N, Luchsinger J, Mayeux R. Mediterranean diet and Alzheimer disease mortality. Neurology 2007;69:1084-93.
66. Navarro A, Gómez C, Sánchez-Pino M-J, González H, Bández MJ, Boveris AD, Boveris A. Vitamin E at high doses improves survival, neurological performance, and brain mitochondrial function in aging male mice. Am J Physiol Regul Integr Comp Physiol 2005;289:R1392-9.
67. Gemma C, Vila J, Bachstetter A, Bickford PC. Chapter 15 oxidative stress and the aging brain: from theory to prevention. Prevention. In: Riddle DR, editor. Brain Aging: Models, methods, and mechanisms. Boca Raton (FL): CRC Press/Taylor & Francis 2007;(15)1-19.
68. Petersen RC, Thomas RG, Grundman M, Bennett D, Doody R, Ferris S, Galasko D, Jin S, Kaye J, Levey A, et al. Vitamin E and donepezil for the treatment of mild cognitive impairment. N Engl J Med 2005;352:2379-88.
69. Araújo JR, Martel F, Borges N, Araújo JM, Keating E. Folates and ageing: role in mild cognitive impairment, dementia and depression. Ageing Res Rev 2015;22:9-19.
70. Masaki KH, Losonczy KG, Izmirlian G, Foley DJ, Ross GW, Petrovitch H, Havlik R, White LR. Association of vitamin E and C supplement use with cognitive function and dementia in elderly men. Neurology 2000; 54:1265-72.
71. Blazer DG, Yaffe K, Karlawish J. Cognitive aging: A report from the institute of medicine. JAMA 2015;313:2121-2.
72. García-Fernández E, Rico-Cabanas L, Rosgaard N, Estruch R, Bach-Faig A. Mediterranean diet and cardiodiabesity: a review. Nutrients 2014;6:3474-500.
73. Whitmer RA, Gunderson EP, Barrett-Connor E, Quesenberry CP, Yaffe K. Obesity in middle age and future risk of dementia: a 27 year longitudinal population based study. BMJ 2005;330:1360.
74. Rizzi L, Rosset I, Roriz-Cruz M. Global epidemiology of dementia: Alzheimer's and vascular types. BioMed Res Int 2014;2014:908915.
75. Cooper C, Sommerlad A, Lyketsos CG, Livingston G. Modifiable predictors of dementia in mild cognitive impairment: a systematic review and meta-analysis. Am J Psychiatry 2015;172:323-34.
76. Grosso G, Pajak A, Mistretta A, Marventano S, Raciti T, Buscemi S, Drago F, Scalfi L, Galvano F. Protective role of the Mediterranean diet on several cardiovascular risk factors: evidence from Sicily, southern Italy. Nutr Metab Cardiovasc Dis 2014;24:370-7.
77. Rodríguez-Rejón AI, Castro-Quezada I, Ruano-Rodríguez C, Ruiz-López MD, Sánchez-Villegas A, Toledo E, Artacho R, Estruch R, Salas-Salvadó J, Covas MI, et al. Effect of a Mediterranean diet intervention on dietary glycemic load and dietary glycemic index: the PREDIMED study. J Nutr Metab 2014;2014:985373
78. Philippou E, ConstantinouM. The influence of glycemic index on cognitive functioning: a systematic review of the evidence. Adv Nutr 2014;5:119-30.
79. Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, Roses AD, Haines JL, Pericak-Vance MA. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 1993;261:921-3.
80. Gluhm S, Goldstein J, Loc K, Colt A, Van Liew C, Corey-Bloom J. Cognitive performance on the mini-mental state examination and the Montreal cognitive assessment across the healthy adult lifespan. Cogn Behav Neurol 2013;26:1-5.
81. Uhlmann RF, Larson EB. Effect of education on the mini-mental state examination as a screening test for dementia. J Am Geriatr Soc 1991;39: 876-80.
82. Allès B, Samieri C, Féart C, Jutand M-a, Laurin D, Barberger-Gateau P. Dietary patterns: a novel approach to examine the link between nutrition and cognitive function in older individuals. Nutr Res Rev 2012;25: 207-22.
83. Viswanathan M, Ansari MT, Berkman ND, Chang S, Hartling L, McPheeters M, Santaguida PL, Shamliyan T, Singh K, Tsertsvadze ATJ. Methods guide for comparative effectiveness reviews-assessing the risk of bias of individual studies in systematic reviews of health care interventions [Internet]. Agency Healthc Res Qual Methods. 2012; AHRQ Publication No. 12-EHC047-EF [cited 2016 Mar 30]. Available from: www.effectivehealthcare.ahrq.gov/.
84. Scarmeas N, Luchsinger JA, Stern Y, Gu Y, He J, Decarli C, Brown T, Brickman AM. Mediterranean diet and magnetic resonance imagingassessed cerebrovascular disease. Ann Neurol 2011;69:257-68.
85. Woodford HJ, George J. Cognitive assessment in the elderly: a review of clinical methods. QJM 2007;100:469-84.