메뉴 건너뛰기




Volumn 172, Issue 1-2, 2018, Pages 14-21

Single-Cell Genomics: A Stepping Stone for Future Immunology Discoveries

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; CELL AGGREGATION; CELL CLONE; CELL COMPOSITION; CELL FUNCTION; CELL HETEROGENEITY; CELLS BY BODY ANATOMY; CELLULAR DISTRIBUTION; CLASSIFICATION; DEGENERATIVE DISEASE; DYNAMICS; GENOMICS; HUMAN; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; IMMUNOLOGY; IMMUNOMODULATION; IMMUNOPATHOLOGY; IMMUNOSTIMULATION; IMMUNOTHERAPY; MEDICAL RESEARCH; MEDICAL TECHNOLOGY; NONHUMAN; PRIORITY JOURNAL; REVIEW; RNA SEQUENCE; SAMPLING; TRANSLATIONAL RESEARCH; ANIMAL; IMMUNOLOGICAL TECHNIQUE; PROCEDURES; SINGLE CELL ANALYSIS; TRENDS;

EID: 85041115553     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2017.11.011     Document Type: Review
Times cited : (134)

References (96)
  • 3
    • 82255175259 scopus 로고    scopus 로고
    • Strategies to discover regulatory circuits of the mammalian immune system
    • Amit, I., Regev, A., Hacohen, N., Strategies to discover regulatory circuits of the mammalian immune system. Nat. Rev. Immunol. 11 (2011), 873–880.
    • (2011) Nat. Rev. Immunol. , vol.11 , pp. 873-880
    • Amit, I.1    Regev, A.2    Hacohen, N.3
  • 8
    • 84939600854 scopus 로고    scopus 로고
    • Single-cell transcriptome analysis reveals coordinated ectopic gene-expression patterns in medullary thymic epithelial cells
    • Brennecke, P., Reyes, A., Pinto, S., Rattay, K., Nguyen, M., Kuchler, R., Huber, W., Kyewski, B., Steinmetz, L.M., Single-cell transcriptome analysis reveals coordinated ectopic gene-expression patterns in medullary thymic epithelial cells. Nat Immunol 16 (2015), 933–941.
    • (2015) Nat Immunol , vol.16 , pp. 933-941
    • Brennecke, P.1    Reyes, A.2    Pinto, S.3    Rattay, K.4    Nguyen, M.5    Kuchler, R.6    Huber, W.7    Kyewski, B.8    Steinmetz, L.M.9
  • 9
    • 84925873107 scopus 로고    scopus 로고
    • Immune regulation of metabolic homeostasis in health and disease
    • Brestoff, J.R., Artis, D., Immune regulation of metabolic homeostasis in health and disease. Cell 161 (2015), 146–160.
    • (2015) Cell , vol.161 , pp. 146-160
    • Brestoff, J.R.1    Artis, D.2
  • 12
    • 85041108250 scopus 로고    scopus 로고
    • Integrated analysis of single cell transcriptomic data across conditions, technologies, and species
    • Butler, A., Satija, R., Integrated analysis of single cell transcriptomic data across conditions, technologies, and species. bioRxiv, 2017, 10.1101/164889.
    • (2017) bioRxiv
    • Butler, A.1    Satija, R.2
  • 17
    • 84892179132 scopus 로고    scopus 로고
    • Single-cell RNA-seq reveals dynamic, random monoallelic gene expression in mammalian cells
    • Deng, Q., Ramskold, D., Reinius, B., Sandberg, R., Single-cell RNA-seq reveals dynamic, random monoallelic gene expression in mammalian cells. Science 343 (2014), 193–196.
    • (2014) Science , vol.343 , pp. 193-196
    • Deng, Q.1    Ramskold, D.2    Reinius, B.3    Sandberg, R.4
  • 18
    • 80052365841 scopus 로고    scopus 로고
    • The innate immune system and the clearance of apoptotic cells
    • Devitt, A., Marshall, L.J., The innate immune system and the clearance of apoptotic cells. J. Leukoc. Biol. 90 (2011), 447–457.
    • (2011) J. Leukoc. Biol. , vol.90 , pp. 447-457
    • Devitt, A.1    Marshall, L.J.2
  • 21
    • 0001406390 scopus 로고
    • Electronic separation of biological cells by volume
    • Fulwyler, M., Electronic separation of biological cells by volume. Science 150 (1965), 910–911.
    • (1965) Science , vol.150 , pp. 910-911
    • Fulwyler, M.1
  • 24
    • 0015151267 scopus 로고
    • [Cytostatic effect of daunomycin in impulsecytophotometric test]
    • Göhde, W., Dittrich, W., [Cytostatic effect of daunomycin in impulsecytophotometric test]. Arzneimittelforschung 21 (1971), 1656–1658.
    • (1971) Arzneimittelforschung , vol.21 , pp. 1656-1658
    • Göhde, W.1    Dittrich, W.2
  • 25
    • 28544446111 scopus 로고    scopus 로고
    • Monocyte and macrophage heterogeneity
    • Gordon, S., Taylor, P.R., Monocyte and macrophage heterogeneity. Nat. Rev. Immunol. 5 (2005), 953–964.
    • (2005) Nat. Rev. Immunol. , vol.5 , pp. 953-964
    • Gordon, S.1    Taylor, P.R.2
  • 30
    • 84941753288 scopus 로고    scopus 로고
    • Diffusion maps for high-dimensional single-cell analysis of differentiation data
    • Haghverdi, L., Buettner, F., Theis, F.J., Diffusion maps for high-dimensional single-cell analysis of differentiation data. Bioinformatics 31 (2015), 2989–2998.
    • (2015) Bioinformatics , vol.31 , pp. 2989-2998
    • Haghverdi, L.1    Buettner, F.2    Theis, F.J.3
  • 32
    • 84903993800 scopus 로고    scopus 로고
    • Linking T-cell receptor sequence to functional phenotype at the single-cell level
    • Han, A., Glanville, J., Hansmann, L., Davis, M.M., Linking T-cell receptor sequence to functional phenotype at the single-cell level. Nat. Biotechnol. 32 (2014), 684–692.
    • (2014) Nat. Biotechnol. , vol.32 , pp. 684-692
    • Han, A.1    Glanville, J.2    Hansmann, L.3    Davis, M.M.4
  • 33
    • 84866953427 scopus 로고    scopus 로고
    • CEL-Seq: Single-Cell RNA-Seq by Multiplexed Linear Amplification
    • Hashimshony, T., Wagner, F., Sher, N., Yanai, I., CEL-Seq: Single-Cell RNA-Seq by Multiplexed Linear Amplification. Cell Reports 2 (2012), 666–673.
    • (2012) Cell Reports , vol.2 , pp. 666-673
    • Hashimshony, T.1    Wagner, F.2    Sher, N.3    Yanai, I.4
  • 34
    • 84967215049 scopus 로고    scopus 로고
    • Low Dimensionality in Gene Expression Data Enables the Accurate Extraction of Transcriptional Programs from Shallow Sequencing
    • Heimberg, G., Bhatnagar, R., El-Samad, H., Thomson, M., Low Dimensionality in Gene Expression Data Enables the Accurate Extraction of Transcriptional Programs from Shallow Sequencing. Cell Syst 2 (2016), 239–250.
    • (2016) Cell Syst , vol.2 , pp. 239-250
    • Heimberg, G.1    Bhatnagar, R.2    El-Samad, H.3    Thomson, M.4
  • 35
    • 84922012748 scopus 로고    scopus 로고
    • Single-cell technologies sharpen up mammalian stem cell research
    • Hoppe, P.S., Coutu, D.L., Schroeder, T., Single-cell technologies sharpen up mammalian stem cell research. Nat. Cell Biol. 16 (2014), 919–927.
    • (2014) Nat. Cell Biol. , vol.16 , pp. 919-927
    • Hoppe, P.S.1    Coutu, D.L.2    Schroeder, T.3
  • 36
    • 54449093241 scopus 로고    scopus 로고
    • Differentiation and heterogeneity in the mononuclear phagocyte system
    • Hume, D.A., Differentiation and heterogeneity in the mononuclear phagocyte system. Mucosal Immunol. 1 (2008), 432–441.
    • (2008) Mucosal Immunol. , vol.1 , pp. 432-441
    • Hume, D.A.1
  • 42
    • 84903574951 scopus 로고    scopus 로고
    • Bayesian approach to single-cell differential expression analysis
    • Kharchenko, P.V., Silberstein, L., Scadden, D.T., Bayesian approach to single-cell differential expression analysis. Nat. Methods 11 (2014), 740–742.
    • (2014) Nat. Methods , vol.11 , pp. 740-742
    • Kharchenko, P.V.1    Silberstein, L.2    Scadden, D.T.3
  • 44
    • 0016756272 scopus 로고
    • Continuous cultures of fused cells secreting antibody of predefined specificity
    • Köhler, G., Milstein, C., Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256 (1975), 495–497.
    • (1975) Nature , vol.256 , pp. 495-497
    • Köhler, G.1    Milstein, C.2
  • 45
    • 84949627236 scopus 로고    scopus 로고
    • Regulation of metabolism by the innate immune system
    • Lackey, D.E., Olefsky, J.M., Regulation of metabolism by the innate immune system. Nat. Rev. Endocrinol. 12 (2016), 15–28.
    • (2016) Nat. Rev. Endocrinol. , vol.12 , pp. 15-28
    • Lackey, D.E.1    Olefsky, J.M.2
  • 46
    • 84920724791 scopus 로고    scopus 로고
    • Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment
    • Lavin, Y., Winter, D., Blecher-Gonen, R., David, E., Keren-Shaul, H., Merad, M., Jung, S., Amit, I., Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment. Cell 159 (2014), 1312–1326.
    • (2014) Cell , vol.159 , pp. 1312-1326
    • Lavin, Y.1    Winter, D.2    Blecher-Gonen, R.3    David, E.4    Keren-Shaul, H.5    Merad, M.6    Jung, S.7    Amit, I.8
  • 52
  • 54
    • 84939622896 scopus 로고    scopus 로고
    • Aire controls gene expression in the thymic epithelium with ordered stochasticity
    • Meredith, M., Zemmour, D., Mathis, D., Benoist, C., Aire controls gene expression in the thymic epithelium with ordered stochasticity. Nat. Immunol. 16 (2015), 942–949.
    • (2015) Nat. Immunol. , vol.16 , pp. 942-949
    • Meredith, M.1    Zemmour, D.2    Mathis, D.3    Benoist, C.4
  • 55
    • 84981312051 scopus 로고    scopus 로고
    • Single-cell 5hmC sequencing reveals chromosome-wide cell-to-cell variability and enables lineage reconstruction
    • Mooijman, D., Dey, S.S., Boisset, J.-C., Crosetto, N., van Oudenaarden, A., Single-cell 5hmC sequencing reveals chromosome-wide cell-to-cell variability and enables lineage reconstruction. Nat. Biotechnol 34 (2016), 852–856.
    • (2016) Nat. Biotechnol , vol.34 , pp. 852-856
    • Mooijman, D.1    Dey, S.S.2    Boisset, J.-C.3    Crosetto, N.4    van Oudenaarden, A.5
  • 59
    • 85039047649 scopus 로고    scopus 로고
    • Single-cell RNA sequencing to explore immune cell heterogeneity
    • Published online August 7 2017.
    • Papalexi, E., Satija, R., Single-cell RNA sequencing to explore immune cell heterogeneity. Nat. Rev. Immunol., 2017 Published online August 7, 2017 https://doi.org/10.1038/nri.2017.76.
    • (2017) Nat. Rev. Immunol.
    • Papalexi, E.1    Satija, R.2
  • 60
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • Pardoll, D.M., The blockade of immune checkpoints in cancer immunotherapy. Nat. Rev. Cancer 12 (2012), 252–264.
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 252-264
    • Pardoll, D.M.1
  • 62
    • 84950283224 scopus 로고    scopus 로고
    • The Branching Point in Erythro-Myeloid Differentiation
    • Perié L., Duffy, K.R., Kok, L., de Boer, R.J., Schumacher, T.N., The Branching Point in Erythro-Myeloid Differentiation. Cell 163 (2015), 1655–1662.
    • (2015) Cell , vol.163 , pp. 1655-1662
    • Perié, L.1    Duffy, K.R.2    Kok, L.3    de Boer, R.J.4    Schumacher, T.N.5
  • 63
    • 85015591616 scopus 로고    scopus 로고
    • Continuous genetic recording with self-targeting CRISPR-Cas in human cells
    • Perli, S.D., Cui, C.H., Lu, T.K., Continuous genetic recording with self-targeting CRISPR-Cas in human cells. Science 353 (2016), 339–342.
    • (2016) Science , vol.353 , pp. 339-342
    • Perli, S.D.1    Cui, C.H.2    Lu, T.K.3
  • 66
    • 84975122314 scopus 로고    scopus 로고
    • Computational flow cytometry: helping to make sense of high-dimensional immunology data
    • Saeys, Y., Gassen, S.V., Lambrecht, B.N., Computational flow cytometry: helping to make sense of high-dimensional immunology data. Nat. Rev. Immunol. 16 (2016), 449–462.
    • (2016) Nat. Rev. Immunol. , vol.16 , pp. 449-462
    • Saeys, Y.1    Gassen, S.V.2    Lambrecht, B.N.3
  • 68
    • 84931394611 scopus 로고    scopus 로고
    • Identification of cDC1- and cDC2-committed DC progenitors reveals early lineage priming at the common DC progenitor stage in the bone marrow
    • Schlitzer, A., Sivakamasundari, V., Chen, J., Sumatoh, H.R., Schreuder, J., Lum, J., Malleret, B., Zhang, S., Larbi, A., Zolezzi, F., et al. Identification of cDC1- and cDC2-committed DC progenitors reveals early lineage priming at the common DC progenitor stage in the bone marrow. Nat. Immunol 16 (2015), 718–728.
    • (2015) Nat. Immunol , vol.16 , pp. 718-728
    • Schlitzer, A.1    Sivakamasundari, V.2    Chen, J.3    Sumatoh, H.R.4    Schreuder, J.5    Lum, J.6    Malleret, B.7    Zhang, S.8    Larbi, A.9    Zolezzi, F.10
  • 69
    • 84899929564 scopus 로고    scopus 로고
    • Heterogeneity in immune responses: from populations to single cells
    • Satija, R., Shalek, A.K., Heterogeneity in immune responses: from populations to single cells. Trends Immunol. 35 (2014), 219–229.
    • (2014) Trends Immunol. , vol.35 , pp. 219-229
    • Satija, R.1    Shalek, A.K.2
  • 70
    • 77449093887 scopus 로고    scopus 로고
    • Hematopoietic stem cell heterogeneity: subtypes, not unpredictable behavior
    • Schroeder, T., Hematopoietic stem cell heterogeneity: subtypes, not unpredictable behavior. Cell Stem Cell 6 (2010), 203–207.
    • (2010) Cell Stem Cell , vol.6 , pp. 203-207
    • Schroeder, T.1
  • 71
    • 84887093048 scopus 로고    scopus 로고
    • How do immune cells support and shape the brain in health, disease, and aging?
    • Schwartz, M., Kipnis, J., Rivest, S., Prat, A., How do immune cells support and shape the brain in health, disease, and aging?. J. Neurosci. 33 (2013), 17587–17596.
    • (2013) J. Neurosci. , vol.33 , pp. 17587-17596
    • Schwartz, M.1    Kipnis, J.2    Rivest, S.3    Prat, A.4
  • 73
    • 84992437479 scopus 로고    scopus 로고
    • In Situ Transcription Profiling of Single Cells Reveals Spatial Organization of Cells in the Mouse Hippocampus
    • Shah, S., Lubeck, E., Zhou, W., Cai, L., In Situ Transcription Profiling of Single Cells Reveals Spatial Organization of Cells in the Mouse Hippocampus. Neuron 92 (2016), 342–357.
    • (2016) Neuron , vol.92 , pp. 342-357
    • Shah, S.1    Lubeck, E.2    Zhou, W.3    Cai, L.4
  • 76
    • 84927130807 scopus 로고    scopus 로고
    • Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential
    • Sharma, P., Allison, J.P., Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential. Cell 161 (2015), 205–214.
    • (2015) Cell , vol.161 , pp. 205-214
    • Sharma, P.1    Allison, J.P.2
  • 79
    • 84923647450 scopus 로고    scopus 로고
    • Computational and analytical challenges in single-cell transcriptomics
    • Stegle, O., Teichmann, S.A., Marioni, J.C., Computational and analytical challenges in single-cell transcriptomics. Nat. Rev. Genet. 16 (2015), 133–145.
    • (2015) Nat. Rev. Genet. , vol.16 , pp. 133-145
    • Stegle, O.1    Teichmann, S.A.2    Marioni, J.C.3
  • 80
    • 0015619335 scopus 로고
    • Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution
    • Steinman, R.M., Cohn, Z.A., Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution. J. Exp. Med. 137 (1973), 1142–1162.
    • (1973) J. Exp. Med. , vol.137 , pp. 1142-1162
    • Steinman, R.M.1    Cohn, Z.A.2
  • 81
    • 0037036114 scopus 로고    scopus 로고
    • Dynamic imaging of T cell-dendritic cell interactions in lymph nodes
    • Stoll, S., Delon, J., Brotz, T.M., Germain, R.N., Dynamic imaging of T cell-dendritic cell interactions in lymph nodes. Science 296 (2002), 1873–1876.
    • (2002) Science , vol.296 , pp. 1873-1876
    • Stoll, S.1    Delon, J.2    Brotz, T.M.3    Germain, R.N.4
  • 83
    • 85017360311 scopus 로고    scopus 로고
    • Scaling single-cell genomics from phenomenology to mechanism
    • Tanay, A., Regev, A., Scaling single-cell genomics from phenomenology to mechanism. Nature 541 (2017), 331–338.
    • (2017) Nature , vol.541 , pp. 331-338
    • Tanay, A.1    Regev, A.2
  • 84
    • 0242551508 scopus 로고    scopus 로고
    • Metchnikoff and the phagocytosis theory
    • Tauber, A.I., Metchnikoff and the phagocytosis theory. Nat. Rev. Mol. Cell Biol. 4 (2003), 897–901.
    • (2003) Nat. Rev. Mol. Cell Biol. , vol.4 , pp. 897-901
    • Tauber, A.I.1
  • 90
    • 0031570952 scopus 로고    scopus 로고
    • Dendritic cell subtypes in mouse lymphoid organs: cross-correlation of surface markers, changes with incubation, and differences among thymus, spleen, and lymph nodes
    • Vremec, D., Shortman, K., Dendritic cell subtypes in mouse lymphoid organs: cross-correlation of surface markers, changes with incubation, and differences among thymus, spleen, and lymph nodes. J. Immunol. 159 (1997), 565–573.
    • (1997) J. Immunol. , vol.159 , pp. 565-573
    • Vremec, D.1    Shortman, K.2
  • 91
    • 84994860357 scopus 로고    scopus 로고
    • Revealing the vectors of cellular identity with single-cell genomics
    • Wagner, A., Regev, A., Yosef, N., Revealing the vectors of cellular identity with single-cell genomics. Nat. Biotechnol. 34 (2016), 1145–1160.
    • (2016) Nat. Biotechnol. , vol.34 , pp. 1145-1160
    • Wagner, A.1    Regev, A.2    Yosef, N.3
  • 92
    • 84876800337 scopus 로고    scopus 로고
    • Macrophage biology in development, homeostasis and disease
    • Wynn, T.A., Chawla, A., Pollard, J.W., Macrophage biology in development, homeostasis and disease. Nature 496 (2013), 445–455.
    • (2013) Nature , vol.496 , pp. 445-455
    • Wynn, T.A.1    Chawla, A.2    Pollard, J.W.3
  • 94
    • 85028931659 scopus 로고    scopus 로고
    • Distinct Mesenchymal Lineages and Niches Promote Epithelial Self-Renewal and Myofibrogenesis in the Lung
    • Zepp, J.A., Zacharias, W.J., Frank, D.B., Cavanaugh, C.A., Zhou, S., Morley, M.P., Morrisey, E.E., Distinct Mesenchymal Lineages and Niches Promote Epithelial Self-Renewal and Myofibrogenesis in the Lung. Cell 170 (2017), 1134–1148.e10.
    • (2017) Cell , vol.170 , pp. 1134-1148.e10
    • Zepp, J.A.1    Zacharias, W.J.2    Frank, D.B.3    Cavanaugh, C.A.4    Zhou, S.5    Morley, M.P.6    Morrisey, E.E.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.