Single-cell 5hmC sequencing reveals chromosome-wide cell-to-cell variability and enables lineage reconstruction

Nature Biotechnology

Volumn 34, Issue 8, 2016, Pages 852-856

  Mooijman, Dylan ^a,b   Dey, Siddharth S ^a,b   Boisset, Jean Charles ^a,b   Crosetto, Nicola ^a,b,c   Van Oudenaarden, Alexander ^a,b  

^a ROYAL NETHERLANDS ACADEMY OF ARTS AND SCIENCES   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMOSOMES; CYTOLOGY; DNA; FORECASTING; GENE ENCODING; GLYCOSYLATION;

5-HYDROXYMETHYLCYTOSINE; CELL-TO-CELL VARIABILITY; DNA MODIFICATION; DNA STRANDS; GLUCOSYLATION; MOUSE EMBRYOS; SINGLE CELLS; SINGLE-CELL LEVEL;

CELLS;

5 HYDROXYMETHYLCYTOSINE; DNA; 5 METHYLCYTOSINE; 5-HYDROXYMETHYLCYTOSINE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CHROMOSOME; CONTROLLED STUDY; DNA STRAND; EMBRYO; GENE SEQUENCE; GENOME; GLYCOSYLATION; MATHEMATICAL MODEL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SINGLE CELL ANALYSIS; ANALOGS AND DERIVATIVES; ANIMAL; BIOLOGICAL MODEL; CELL DIFFERENTIATION; CELL LINEAGE; CHEMICAL MODEL; CHEMISTRY; CHROMOSOMAL MAPPING; COMPUTER SIMULATION; DNA SEQUENCE; EMBRYO DEVELOPMENT; GENETIC EPIGENESIS; GENETIC VARIATION; GENETICS; MALE; PROCEDURES;

5-METHYLCYTOSINE; ANIMALS; CELL DIFFERENTIATION; CELL LINEAGE; CHROMOSOME MAPPING; CHROMOSOMES; COMPUTER SIMULATION; EMBRYONIC DEVELOPMENT; EPIGENESIS, GENETIC; GENETIC VARIATION; MALE; MICE; MODELS, CHEMICAL; MODELS, GENETIC; SEQUENCE ANALYSIS, DNA;

EID: 84981312051     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt.3598     Document Type: Article

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