Identification of cDC1- and cDC2-committed DC progenitors reveals early lineage priming at the common DC progenitor stage in the bone marrow

Nature Immunology

Volumn 16, Issue 7, 2015, Pages 718-728

  Schlitzer, Andreas ^a   Sivakamasundari, V ^b   Chen, Jinmiao ^a   Sumatoh, Hermi Rizal Bin ^a   Schreuder, Jaring ^a   Lum, Josephine ^c   Malleret, Benoit ^a   Zhang, Sanqian ^a,d   Larbi, Anis ^a   Zolezzi, Francesca ^a   Renia, Laurent ^a   Poidinger, Michael ^a   Naik, Shalin ^c,e   Newell, Evan W ^a   Robson, Paul ^b   Ginhoux, Florent ^a  

^a AGENCY FOR SCIENCE   (Singapore)

^b GENOME INSTITUTE OF SINGAPORE   (Singapore)

^c WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^d NATIONAL UNIVERSITY HEALTH SYSTEM   (Singapore)

^e UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; LY6C PROTEIN; SIALIC ACID BINDING IMMUNOGLOBULIN LIKE LECTIN; SIGLEC H; TRANSCRIPTOME; UNCLASSIFIED DRUG; ALPHA E INTEGRINS; ALPHA INTEGRIN; CD11B ANTIGEN; CD8 ANTIGEN; CD8ALPHA ANTIGEN; CELL SURFACE RECEPTOR; LECTIN; LEUKOCYTE ANTIGEN; LY ANTIGEN; LY-6C ANTIGEN, MOUSE; SIGLECH PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL HETEROGENEITY; CELL LEVEL; CELL LINEAGE; CELL MATURATION; CELL SUBPOPULATION; CONVENTIONAL DENDRITIC CELL 1; CONVENTIONAL DENDRITIC CELL 2; DENDRITIC CELL; FLOW CYTOMETRY; HEMATOPOIETIC STEM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ANIMAL; BONE MARROW CELL; C57BL MOUSE; CELL CULTURE; CLUSTER ANALYSIS; DNA MICROARRAY; GENETICS; IMMUNOLOGY; METABOLISM; PROCEDURES; SCANNING ELECTRON MICROSCOPY; SINGLE CELL ANALYSIS; STEM CELL; TRANSGENIC MOUSE; ULTRASTRUCTURE;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD11B; ANTIGENS, CD8; ANTIGENS, LY; BONE MARROW CELLS; CELL LINEAGE; CELLS, CULTURED; CLUSTER ANALYSIS; DENDRITIC CELLS; FLOW CYTOMETRY; INTEGRIN ALPHA CHAINS; LECTINS; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROSCOPY, ELECTRON, SCANNING; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RECEPTORS, CELL SURFACE; SINGLE-CELL ANALYSIS; STEM CELLS; TRANSCRIPTOME;

EID: 84931394611     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.3200     Document Type: Article

References (53)

1. Schlitzer, A. & Ginhoux, F. Organization of the mouse and human DC network. Curr. Opin. Immunol. 26, 90-99 (2014).
2. Merad, M., Sathe, P., Helft, J., Miller, J. & Mortha, A. The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting. Annu. Rev. Immunol. 31, 563-604 (2013).
3. Schlitzer, A., McGovern, N. & Ginhoux, F. Dendritic cells and monocyte-derived cells: Two complementary and integrated functional systems. Semin. Cell Dev. Biol. doi:10.1016/j.semcdb.2015.03.011 (2015).
4. Karsunky, H., Merad, M. & Cozzio, A. Flt3 ligand regulates dendritic cell development from Flt3+ lymphoid and myeloid-committed progenitors to Flt3+ dendritic cells in vivo. J. Exp. Med. 198, 305-313 (2003).
5. Fogg, D.K. et al. A clonogenic bone marrow progenitor specific for macrophages and dendritic cells. Science 311, 83-87 (2006).
6. Naik, S.H. et al. Development of plasmacytoid and conventional dendritic cell subtypes from single precursor cells derived in vitro and in vivo. Nat. Immunol. 8, 1217-1226 (2007).
7. Onai, N. et al. Identification of clonogenic common Flt3+M-CSFR+ plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow. Nat. Immunol. 8, 1207-1216 (2007).
8. Sathe, P. et al. Lymphoid tissue and plasmacytoid dendritic cells and macrophages do not share a common macrophage-dendritic cell-Restricted progenitor. Immunity 41, 104-115 (2014).
9. Liu, K. & Nussenzweig, M.C. Development and homeostasis of dendritic cells. Eur. J. Immunol. 40, 2099-2102 (2010).
10. Ginhoux, F. et al. The origin and development of nonlymphoid tissue CD103+ DCs. J. Exp. Med. 206, 3115-3130 (2009).
11. Onai, N. et al. A clonogenic progenitor with prominent plasmacytoid dendritic cell developmental potential. Immunity 38, 943-957 (2013).
12. Swiecki, M. et al. Cell depletion in mice that express diphtheria toxin receptor under the control of SiglecH encompasses more than plasmacytoid dendritic cells. J. Immunol. 192, 4409-4416 (2014).
13. Kucharczak, J., Simmons, M.J., Fan, Y. & Gélinas, C. To be, or not to be: NF-κB is the answer-role of Rel/NF-κB in the regulation of apoptosis. Oncogene 22, 8961-8982 (2003).
14. LeibundGut-Landmann, S. et al. Mini-review: Specificity and expression of CIITA, the master regulator of MHC class II genes. Eur. J. Immunol. 34, 1513-1525 (2004).
15. Miller, J.C. et al. Deciphering the transcriptional network of the dendritic cell lineage. Nat. Immunol. 13, 888-899 (2012).
16. Gautier, E.L. et al. Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages. Nat. Immunol. 13, 1118-1128 (2012).
17. Lamb, J. et al. The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease. Science 313, 1929-1935 (2006).
18. Liu, K. et al. In vivo analysis of dendritic cell development and homeostasis. Science 324, 392-397 (2009).
19. Schlitzer, A. et al. Tissue-specific differentiation of a circulating CCR9-pDC-like common dendritic cell precursor. Blood 119, 6063-6071 (2012).
20. Satpathy, A.T. et al. Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages. J. Exp. Med. 209, 1135-1152 (2012).
21. Schlitzer, A. et al. IRF4 transcription factor-dependent CD11b+ dendritic cells in human and mouse control mucosal IL-17 cytokine responses. Immunity 38, 970-983 (2013).
22. Persson, E.K. et al. IRF4 transcription-factor-dependent CD103+CD11b+ dendritic cells drive mucosal T helper 17 cell differentiation. Immunity 38, 958-969 (2013).
23. Cisse, B. et al. Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development. Cell 135, 37-48 (2008).
24. Sakaue-Sawano, A. et al. Visualizing spatiotemporal dynamics of multicellular cell-cycle progression. Cell 132, 487-498 (2008).
25. Tenenbaum, J.B., de Silva, V. & Langford, J.C. A global geometric framework for nonlinear dimensionality reduction. Science 290, 2319-2323 (2000).
26. Naik, S.H. et al. Diverse and heritable lineage imprinting of early haematopoietic progenitors. Nature 496, 229-232 (2013).
27. Lara-Astiaso, D. et al. Immunogenetics. Chromatin state dynamics during blood formation. Science 345, 943-949 (2014).
28. Besson, A., Dowdy, S.F. & Roberts, J.M. CDK inhibitors: cell cycle regulators and beyond. Dev. Cell 14, 159-169 (2008).
29. Meister, P., Mango, S.E. & Gasser, S.M. Locking the genome: nuclear organization and cell fate. Curr. Opin. Genet. Dev. 21, 167-174 (2011).
30. Hildner, K. et al. Batf3 deficiency reveals a critical role for CD8α+ dendritic cells in cytotoxic T cell immunity. Science 322, 1097-1100 (2008).
31. Kashiwada, M., Pham, N.-L.L., Pewe, L.L., Harty, J.T. & Rothman, P.B. NFIL3/E4BP4 is a key transcription factor for CD8α+ dendritic cell development. Blood 117, 6193-6197 (2011).
32. Mendelson, A. & Frenette, P.S. Hematopoietic stem cell niche maintenance during homeostasis and regeneration. Nat. Med. 20, 833-846 (2014).
33. Prendergast, A.M. & Essers, M.A.G. Hematopoietic stem cells, infection, and the niche. Ann. NY Acad. Sci. 1310, 51-57 (2014).
34. Essers, M.A.G. et al. IFNalpha activates dormant haematopoietic stem cells in vivo. Nature 458, 904-908 (2009).
35. Baldridge, M.T., King, K.Y., Boles, N.C., Weksberg, D.C. & Goodell, M.A. Quiescent haematopoietic stem cells are activated by IFN-γ in response to chronic infection. Nature 465, 793-797 (2010).
36. Challen, G.A., Boles, N.C., Chambers, S.M. & Goodell, M.A. Distinct hematopoietic stem cell subtypes are differentially regulated by TGF-β1. Cell Stem Cell 6, 265-278 (2010).
37. Mercher, T. et al. Notch signaling specifies megakaryocyte development from hematopoietic stem cells. Cell Stem Cell 3, 314-326 (2008).
38. Lewis, K.L. et al. Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine. Immunity 35, 780-791 (2011).
39. Wu, L. et al. RelB is essential for the development of myeloid-related CD8α-dendritic cells but not of lymphoid-related CD8α+ dendritic cells. Immunity 9, 839-847 (1998).
40. Kabashima, K. et al. Intrinsic lymphotoxin-β receptor requirement for homeostasis of lymphoid tissue dendritic cells. Immunity 22, 439-450 (2005).
41. Satpathy, A.T. et al. Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens. Nat. Immunol. 14, 937-948 (2013).
42. Gatto, D. et al. The chemotactic receptor EBI2 regulates the homeostasis, localization and immunological function of splenic dendritic cells. Nat. Immunol. 14, 446-453 (2013).
43. Yi, T. & Cyster, J.G. EBI2-mediated bridging channel positioning supports splenic dendritic cell homeostasis and particulate antigen capture. eLife 2, e00757 (2013).
44. Gentleman, R., Carey, V., Huber, W., Irizarry, R. & Dudoit, S. Bioinformatics and computational biology solutions using R and Bioconductor. Brief. Bioinformatics 8, 136-137 (2006).
45. Dobin, A. et al. STAR: ultrafast universal RNA-seq aligner. Bioinformatics 29, 15-21 (2013).
46. Adiconis, X. et al. Comparative analysis of RNA sequencing methods for degraded or low-input samples. Nat. Methods 10, 623-629 (2013).
47. Mortazavi, A., Williams, B.A., McCue, K., Schaeffer, L. & Wold, B. Mapping and quantifying mammalian transcriptomes by RNA-Seq. Nat. Methods 5, 621-628 (2008).
48. Pollen, A.A. et al. Low-coverage single-cell mRNA sequencing reveals cellular heterogeneity and activated signaling pathways in developing cerebral cortex. Nat. Biotechnol. 32, 1053-1058 (2014).
49. Usoskin, D. et al. Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing. Nat. Neurosci. 18, 145-153 (2015).
50. Shalek, A.K. et al. Single-cell RNA-seq reveals dynamic paracrine control of cellular variation. Nature 510, 1-22 (2014).
51. Shalek, A.K. et al. Single-cell transcriptomics reveals bimodality inexpression and splicing in immune cells. Nature 498, 236-240 (2014).
52. Trapnell, C. et al. The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells. Nat. Biotechnol. 32, 381-386 (2014).
53. Ward, J.T.J. Hierarchical grouping to optimize an objective function. J. Am. Stat. Assoc. 58, 236-244 (1963).