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Volumn 17, Issue 4, 2016, Pages 451-460

The heterogeneity of human CD127+ innate lymphoid cells revealed by single-cell RNA sequencing

Author keywords

[No Author keywords available]

Indexed keywords

CD27 ANTIGEN; CD28 ANTIGEN; CD4 ANTIGEN; CD5 ANTIGEN; CD6 ANTIGEN; CELL SURFACE PROTEIN; CHEMOKINE RECEPTOR CCR7; CHEMOKINE RECEPTOR CXCR3; COMPLEMENTARY RNA; GAMMA INTERFERON; IL17RB PROTEIN; IL1RL1 PROTEIN; INTERLEUKIN 18 BINDING PROTEIN; INTERLEUKIN 22; INTERLEUKIN 6; INTERLEUKIN 7 RECEPTOR; JANUS KINASE; KLRG1 PROTEIN; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 2; PLZF PROTEIN; PROTEIN; PTGDR2 PROTEIN; RETINOIC ACID; STAT PROTEIN; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR T BET; TRANSCRIPTOME; UNCLASSIFIED DRUG; UNINDEXED DRUG; INTERLEUKIN 7 RECEPTOR ALPHA;

EID: 84958078627     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.3368     Document Type: Article
Times cited : (396)

References (58)
  • 1
    • 0346496018 scopus 로고    scopus 로고
    • An essential function for the nuclear receptor RORγ(t) in the generation of fetal lymphoid tissue inducer cells
    • Eberl, G., et al. An essential function for the nuclear receptor RORγ(t) in the generation of fetal lymphoid tissue inducer cells. Nat. Immunol. 5, 64-73 (2004
    • (2004) Nat. Immunol , vol.5 , pp. 64-73
    • Eberl, G.1
  • 2
    • 0030710079 scopus 로고    scopus 로고
    • Developing lymph nodes collect CD4+CD3?LT?+ cells that can differentiate to APC NK cells, and follicular cells but not T or B cells
    • Mebius, R.E., Rennert, P. & Weissman, I.L. Developing lymph nodes collect CD4+CD3?LT?+ cells that can differentiate to APC, NK cells, and follicular cells but not T or B cells. Immunity 7, 493-504 (1997
    • (1997) Immunity , vol.7 , pp. 493-504
    • Mebius, R.E.1    Rennert, P.2    Weissman, I.L.3
  • 3
    • 57849131584 scopus 로고    scopus 로고
    • Human fetal lymphoid tissue-inducer cells are interleukin 17-producing precursors to RORC+CD127+ natural killer-like cells
    • Cupedo, T., et al. Human fetal lymphoid tissue-inducer cells are interleukin 17-producing precursors to RORC+CD127+ natural killer-like cells. Nat. Immunol. 10, 66-74 (2009
    • (2009) Nat. Immunol , vol.10 , pp. 66-74
    • Cupedo, T.1
  • 4
    • 84922607138 scopus 로고    scopus 로고
    • The biology of innate lymphoid cells
    • Artis, D. & Spits, H. The biology of innate lymphoid cells. Nature 517, 293-301 (2015
    • (2015) Nature , vol.517 , pp. 293-301
    • Artis, D.1    Spits, H.2
  • 5
    • 85027945857 scopus 로고    scopus 로고
    • Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues
    • Bernink, J.H., et al. Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues. Nat. Immunol. 14, 221-229 (2013
    • (2013) Nat. Immunol , vol.14 , pp. 221-229
    • Bernink, J.H.1
  • 6
    • 77149135298 scopus 로고    scopus 로고
    • Human NKp44+IL-22+ cells and LTi-like cells constitute a stable RORC+ lineage distinct from conventional natural killer cells
    • Crellin, N.K., Trifari, S., Kaplan, C.D., Cupedo, T. & Spits, H. Human NKp44+IL-22+ cells and LTi-like cells constitute a stable RORC+ lineage distinct from conventional natural killer cells. J. Exp. Med. 207, 281-290 (2010
    • (2010) J. Exp. Med , vol.207 , pp. 281-290
    • Crellin, N.K.1    Trifari, S.2    Kaplan, C.D.3    Cupedo, T.4    Spits, H.5
  • 7
    • 80054889051 scopus 로고    scopus 로고
    • Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161
    • Mjösberg, J.M., et al. Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161. Nat. Immunol. 12, 1055-1062 (2011
    • (2011) Nat. Immunol , vol.12 , pp. 1055-1062
    • Mjösberg, J.M.1
  • 8
    • 84872977452 scopus 로고    scopus 로고
    • Innate lymphoid cells-A proposal for uniform nomenclature
    • Spits, H., et al. Innate lymphoid cells-A proposal for uniform nomenclature. Nat. Rev. Immunol. 13, 145-149 (2013
    • (2013) Nat. Rev. Immunol , vol.13 , pp. 145-149
    • Spits, H.1
  • 9
    • 84937707458 scopus 로고    scopus 로고
    • Interleukin-12 and -23 control plasticity of cd127+ group 1 and group 3 innate lymphoid cells in the intestinal lamina propria
    • Bernink, J.H., et al. Interleukin-12 and -23 control plasticity of cd127+ group 1 and group 3 innate lymphoid cells in the intestinal lamina propria. Immunity 43, 146-160 (2015
    • (2015) Immunity , vol.43 , pp. 146-160
    • Bernink, J.H.1
  • 10
    • 84898640432 scopus 로고    scopus 로고
    • Differentiation of type 1 ILCs from a common progenitor to all helper-like innate lymphoid cell lineages
    • Klose, C.S., et al. Differentiation of type 1 ILCs from a common progenitor to all helper-like innate lymphoid cell lineages. Cell 157, 340-356 (2014
    • (2014) Cell , vol.157 , pp. 340-356
    • Klose, C.S.1
  • 12
    • 84879602800 scopus 로고    scopus 로고
    • RORγt+ innate lymphoid cells acquire a proinflammatory program upon engagement of the activating receptor NKp44
    • Glatzer, T., et al. RORγt+ innate lymphoid cells acquire a proinflammatory program upon engagement of the activating receptor NKp44. Immunity 38, 1223-1235 (2013
    • (2013) Immunity , vol.38 , pp. 1223-1235
    • Glatzer, T.1
  • 13
    • 84907462339 scopus 로고    scopus 로고
    • Human CD117 (cKit)+ innate lymphoid cells have a discrete transcriptional profile at homeostasis and are expanded during filarial infection
    • Boyd, A., Ribeiro, J.M. & Nutman, T.B. Human CD117 (cKit)+ innate lymphoid cells have a discrete transcriptional profile at homeostasis and are expanded during filarial infection. PLoS ONE 9, e108649 (2014
    • (2014) PLoS ONE , vol.9 , pp. e108649
    • Boyd, A.1    Ribeiro, J.M.2    Nutman, T.B.3
  • 14
    • 84887101406 scopus 로고    scopus 로고
    • Smart-seq2 for sensitive full-length transcriptome profiling in single cells
    • Picelli, S., et al. Smart-seq2 for sensitive full-length transcriptome profiling in single cells. Nat. Methods 10, 1096-1098 (2013
    • (2013) Nat. Methods , vol.10 , pp. 1096-1098
    • Picelli, S.1
  • 15
    • 84891677425 scopus 로고    scopus 로고
    • Full-length RNA-seq from single cells using Smart-seq2
    • Picelli, S., et al. Full-length RNA-seq from single cells using Smart-seq2. Nat. Protoc. 9, 171-181 (2014
    • (2014) Nat. Protoc , vol.9 , pp. 171-181
    • Picelli, S.1
  • 16
    • 84924565530 scopus 로고    scopus 로고
    • Brain structure Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq
    • Zeisel, A., et al. Brain structure. Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq. Science 347, 1138-1142 (2015
    • (2015) Science , vol.347 , pp. 1138-1142
    • Zeisel, A.1
  • 17
    • 84892179132 scopus 로고    scopus 로고
    • Single-cell RNA-seq reveals dynamic random monoallelic gene expression in mammalian cells
    • Deng, Q., Ramskold, D., Reinius, B. & Sandberg, R. Single-cell RNA-seq reveals dynamic, random monoallelic gene expression in mammalian cells. Science 343, 193-196 (2014
    • (2014) Science , vol.343 , pp. 193-196
    • Deng, Q.1    Ramskold, D.2    Reinius, B.3    Sandberg, R.4
  • 18
    • 84900529199 scopus 로고    scopus 로고
    • Reconstructing lineage hierarchies of the distal lung epithelium using single-cell RNA-seq
    • Treutlein, B., et al. Reconstructing lineage hierarchies of the distal lung epithelium using single-cell RNA-seq. Nature 509, 371-375 (2014
    • (2014) Nature , vol.509 , pp. 371-375
    • Treutlein, B.1
  • 19
    • 84902668801 scopus 로고    scopus 로고
    • Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma
    • Patel, A.P., et al. Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma. Science 344, 1396-1401 (2014
    • (2014) Science , vol.344 , pp. 1396-1401
    • Patel, A.P.1
  • 20
    • 84878997106 scopus 로고    scopus 로고
    • Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells
    • Shalek, A.K., et al. Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells. Nature 498, 236-240 (2013
    • (2013) Nature , vol.498 , pp. 236-240
    • Shalek, A.K.1
  • 21
    • 84901188210 scopus 로고    scopus 로고
    • Single-cell RNA sequencing reveals T helper cells synthesizing steroids de novo to contribute to immune homeostasis
    • Mahata, B., et al. Single-cell RNA sequencing reveals T helper cells synthesizing steroids de novo to contribute to immune homeostasis. Cell Rep. 7, 1130-1142 (2014
    • (2014) Cell Rep , vol.7 , pp. 1130-1142
    • Mahata, B.1
  • 22
    • 84887109584 scopus 로고    scopus 로고
    • Accounting for technical noise in single-cell RNA-seq experiments
    • Brennecke, P., et al. Accounting for technical noise in single-cell RNA-seq experiments. Nat. Methods 10, 1093-1095 (2013
    • (2013) Nat. Methods , vol.10 , pp. 1093-1095
    • Brennecke, P.1
  • 24
    • 77955102352 scopus 로고    scopus 로고
    • Quantifying E coli proteome and transcriptome with single-molecule sensitivity in single cells
    • Taniguchi, Y., et al. Quantifying E. coli proteome and transcriptome with single-molecule sensitivity in single cells. Science 329, 533-538 (2010
    • (2010) Science , vol.329 , pp. 533-538
    • Taniguchi, Y.1
  • 25
    • 79956322553 scopus 로고    scopus 로고
    • Global quantification of mammalian gene expression control
    • Schwanhäusser, B., et al. Global quantification of mammalian gene expression control. Nature 473, 337-342 (2011
    • (2011) Nature , vol.473 , pp. 337-342
    • Schwanhäusser, B.1
  • 26
    • 84923436228 scopus 로고    scopus 로고
    • Transcriptional programs define molecular characteristics of innate lymphoid cell classes and subsets
    • Robinette, M.L., et al. Transcriptional programs define molecular characteristics of innate lymphoid cell classes and subsets. Nat. Immunol. 16, 306-317 (2015
    • (2015) Nat. Immunol , vol.16 , pp. 306-317
    • Robinette, M.L.1
  • 27
    • 84897480560 scopus 로고    scopus 로고
    • Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity
    • van de Pavert, S.A., et al. Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity. Nature 508, 123-127 (2014
    • (2014) Nature , vol.508 , pp. 123-127
    • Van De Pavert, S.A.1
  • 28
    • 84866537220 scopus 로고    scopus 로고
    • Molecular definition of the identity and activation of natural killer cells
    • Bezman, N.A., et al. Molecular definition of the identity and activation of natural killer cells. Nat. Immunol. 13, 1000-1009 (2012
    • (2012) Nat. Immunol , vol.13 , pp. 1000-1009
    • Bezman, N.A.1
  • 29
    • 84924626927 scopus 로고    scopus 로고
    • Genomic Expression Profiling of NK Cells in Health and Disease
    • Wang, F., Tian, Z. & Wei, H. Genomic expression profiling of NK cells in health and disease. Eur. J. Immunol. 45, 661-678 (2015
    • (2015) Eur. J. Immunol , vol.45 , pp. 661-678
    • Wang, F.1    Tian, Z.2    Wei, H.3
  • 30
    • 84911392339 scopus 로고    scopus 로고
    • Peripheral natural killer cell maturation depends on the transcription factor Aiolos
    • Holmes, M.L., et al. Peripheral natural killer cell maturation depends on the transcription factor Aiolos. EMBO J. 33, 2721-2734 (2014
    • (2014) EMBO J. , vol.33 , pp. 2721-2734
    • Holmes, M.L.1
  • 31
    • 84876008998 scopus 로고    scopus 로고
    • Lipoxin A4 regulates natural killer cell and type 2 innate lymphoid cell activation in asthma
    • Barnig, C., et al. Lipoxin A4 regulates natural killer cell and type 2 innate lymphoid cell activation in asthma. Sci. Transl. Med. 5, 174ra126 (2013
    • (2013) Sci. Transl. Med , vol.5 , pp. 174ra126
    • Barnig, C.1
  • 32
    • 84897402119 scopus 로고    scopus 로고
    • Prostaglandin D2 activates group 2 innate lymphoid cells through chemoattractant receptor-homologous molecule expressed on TH2 cells
    • Xue, L., et al. Prostaglandin D2 activates group 2 innate lymphoid cells through chemoattractant receptor-homologous molecule expressed on TH2 cells. J. Allergy Clin. Immunol. 133, 1184-1194 (2014
    • (2014) J. Allergy Clin. Immunol , vol.133 , pp. 1184-1194
    • Xue, L.1
  • 33
    • 84900818071 scopus 로고    scopus 로고
    • Modulation of signal strength switches Notch from an inducer of T Cells to an inducer of ILC2
    • Gentek, R., et al. Modulation of signal strength switches Notch from an inducer of T Cells to an inducer of ILC2. Front. Immunol. 4, 334 (2013
    • (2013) Front. Immunol , vol.4 , pp. 334
    • Gentek, R.1
  • 34
    • 84885439404 scopus 로고    scopus 로고
    • TCF-1 controls ILC2 and NKp46+RORγt+ innate lymphocyte differentiation and protection in intestinal inflammation
    • Mielke, L.A., et al. TCF-1 controls ILC2 and NKp46+RORγt+ innate lymphocyte differentiation and protection in intestinal inflammation. J. Immunol. 191, 4383-4391 (2013
    • (2013) J. Immunol , vol.191 , pp. 4383-4391
    • Mielke, L.A.1
  • 35
    • 84876762753 scopus 로고    scopus 로고
    • T cell factor 1 is required for group 2 innate lymphoid cell generation
    • Yang, Q., et al. T cell factor 1 is required for group 2 innate lymphoid cell generation. Immunity 38, 694-704 (2013
    • (2013) Immunity , vol.38 , pp. 694-704
    • Yang, Q.1
  • 36
    • 84881256774 scopus 로고    scopus 로고
    • Increased cAMP in monocytes augments Notch signaling mechanisms by elevating RBP-J and transducin-like enhancer of Split (TLE
    • Larabee, J.L., Shakir, S.M., Barua, S. & Ballard, J.D. Increased cAMP in monocytes augments Notch signaling mechanisms by elevating RBP-J and transducin-like enhancer of Split (TLE). J. Biol. Chem. 288, 21526-21536 (2013
    • (2013) J. Biol. Chem , vol.288 , pp. 21526-21536
    • Larabee, J.L.1    Shakir, S.M.2    Barua, S.3    Ballard, J.D.4
  • 37
    • 84891429267 scopus 로고    scopus 로고
    • Tle4 regulates epigenetic silencing of gamma interferon expression during effector T helper cell tolerance
    • Bandyopadhyay, S., Valdor, R. & Macian, F. Tle4 regulates epigenetic silencing of gamma interferon expression during effector T helper cell tolerance. Mol. Cell. Biol. 34, 233-245 (2014
    • (2014) Mol. Cell. Biol , vol.34 , pp. 233-245
    • Bandyopadhyay, S.1    Valdor, R.2    MacIan, F.3
  • 38
    • 84876780238 scopus 로고    scopus 로고
    • Intraepithelial type 1 innate lymphoid cells are a unique subset of IL-12- and IL-15-responsive IFN-γ-producing cells
    • Fuchs, A., et al. Intraepithelial type 1 innate lymphoid cells are a unique subset of IL-12- and IL-15-responsive IFN-γ-producing cells. Immunity 38, 769-781 (2013
    • (2013) Immunity , vol.38 , pp. 769-781
    • Fuchs, A.1
  • 39
    • 80052970974 scopus 로고    scopus 로고
    • Notch signaling is necessary for adult, but not fetal, development of RORγt+ innate lymphoid cells
    • Possot, C., et al. Notch signaling is necessary for adult, but not fetal, development of RORγt+ innate lymphoid cells. Nat. Immunol. 12, 949-958 (2011
    • (2011) Nat. Immunol , vol.12 , pp. 949-958
    • Possot, C.1
  • 40
    • 84855917402 scopus 로고    scopus 로고
    • AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch
    • Lee, J.S., et al. AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch. Nat. Immunol. 13, 144-151 (2012
    • (2012) Nat. Immunol , vol.13 , pp. 144-151
    • Lee, J.S.1
  • 41
    • 84867656028 scopus 로고    scopus 로고
    • Functional differences between human NKp44? and NKp44+ RORC+ innate lymphoid cells
    • Hoorweg, K., et al. Functional differences between human NKp44? and NKp44+ RORC+ innate lymphoid cells. Front. Immunol. 3, 72 (2012
    • (2012) Front. Immunol , vol.3 , pp. 72
    • Hoorweg, K.1
  • 42
    • 84930663466 scopus 로고    scopus 로고
    • Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4+ T cells
    • Hepworth, M.R., et al. Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4+ T cells. Science 348, 1031-1035 (2015
    • (2015) Science , vol.348 , pp. 1031-1035
    • Hepworth, M.R.1
  • 43
    • 84878737123 scopus 로고    scopus 로고
    • Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria
    • Hepworth, M.R., et al. Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria. Nature 498, 113-117 (2013
    • (2013) Nature , vol.498 , pp. 113-117
    • Hepworth, M.R.1
  • 44
    • 79251515158 scopus 로고    scopus 로고
    • Exploration and analysis of post-cytometric complex multivariate datasets
    • Roederer, M., Nozzi, J.L. & Nason, M.C. SPICE: exploration and analysis of post-cytometric complex multivariate datasets. Cytometry 79, 167-174 (2011
    • (2011) Cytometry , vol.79 , pp. 167-174
    • Roederer, M.1    Nozzi, J.L.2    Spice, C.N.M.3
  • 45
    • 34948883510 scopus 로고    scopus 로고
    • Notch signaling induces cytoplasmic CD3' expression in human differentiating NK cells
    • De Smedt, M., et al. Notch signaling induces cytoplasmic CD3? expression in human differentiating NK cells. Blood 110, 2696-2703 (2007
    • (2007) Blood , vol.110 , pp. 2696-2703
    • De Smedt, M.1
  • 46
    • 84922857734 scopus 로고    scopus 로고
    • IL-25-responsive, lineage-negative KLRG1hi cells are multipotential 'inflammatory' type 2 innate lymphoid cells
    • Huang, Y., et al. IL-25-responsive, lineage-negative KLRG1hi cells are multipotential 'inflammatory' type 2 innate lymphoid cells. Nat. Immunol. 16, 161-169 (2015
    • (2015) Nat. Immunol , vol.16 , pp. 161-169
    • Huang, Y.1
  • 47
    • 84860595791 scopus 로고    scopus 로고
    • High-throughput DNA sequencing libraries for multiplexed target capture
    • Rohland, N. & Reich, D. Cost-effective, high-throughput DNA sequencing libraries for multiplexed target capture. Genome Res. 22, 939-946 (2012
    • (2012) Genome Res , vol.22 , pp. 939-946
    • Rohland, N.1    Cost-Effective, R.D.2
  • 48
    • 84913593681 scopus 로고    scopus 로고
    • Tn5 transposase and tagmentation procedures for massively scaled sequencing projects
    • Picelli, S., et al. Tn5 transposase and tagmentation procedures for massively scaled sequencing projects. Genome Res. 24, 2033-2040 (2014
    • (2014) Genome Res , vol.24 , pp. 2033-2040
    • Picelli, S.1
  • 49
    • 84871809302 scopus 로고    scopus 로고
    • Ultrafast universal RNA-seq aligner
    • STAR:
    • Dobin, A., et al. STAR: ultrafast universal RNA-seq aligner. Bioinformatics 29, 15-21 (2013
    • (2013) Bioinformatics , vol.29 , pp. 15-21
    • Dobin, A.1
  • 50
    • 74549125753 scopus 로고    scopus 로고
    • An abundance of ubiquitously expressed genes revealed by tissue transcriptome sequence data
    • Ramsköld, D., Wang, E.T., Burge, C.B. & Sandberg, R. An abundance of ubiquitously expressed genes revealed by tissue transcriptome sequence data. PLoS Comput. Biol. 5, e1000598 (2009
    • (2009) PLoS Comput. Biol , vol.5 , pp. e1000598
    • Ramsköld, D.1    Wang, E.T.2    Burge, C.B.3    Sandberg, R.4
  • 51
    • 84865074382 scopus 로고    scopus 로고
    • RSeQC: Quality control of RNA-seq experiments
    • Wang, L., Wang, S. & Li, W. RSeQC: quality control of RNA-seq experiments. Bioinformatics 28, 2184-2185 (2012
    • (2012) Bioinformatics , vol.28 , pp. 2184-2185
    • Wang, L.1    Wang, S.2    Li, W.3
  • 52
    • 84859098571 scopus 로고    scopus 로고
    • The sva package for removing batch effects and other unwanted variation in high-throughput experiments
    • Leek, J.T., Johnson, W.E., Parker, H.S., Jaffe, A.E. & Storey, J.D. The sva package for removing batch effects and other unwanted variation in high-throughput experiments. Bioinformatics 28, 882-883 (2012
    • (2012) Bioinformatics , vol.28 , pp. 882-883
    • Leek, J.T.1    Johnson, W.E.2    Parker, H.S.3    Jaffe, A.E.4    Storey, J.D.5
  • 53
    • 33745612095 scopus 로고    scopus 로고
    • Pvclust: An R package for assessing the uncertainty in hierarchical clustering
    • Suzuki, R. & Shimodaira, H. Pvclust: an R package for assessing the uncertainty in hierarchical clustering. Bioinformatics 22, 1540-1542 (2006
    • (2006) Bioinformatics , vol.22 , pp. 1540-1542
    • Suzuki, R.1    Shimodaira, H.2
  • 54
    • 84903574951 scopus 로고    scopus 로고
    • Bayesian approach to single-cell differential expression analysis
    • Kharchenko, P.V., Silberstein, L. & Scadden, D.T. Bayesian approach to single-cell differential expression analysis. Nat. Methods 11, 740-742 (2014
    • (2014) Nat. Methods , vol.11 , pp. 740-742
    • Kharchenko, P.V.1    Silberstein, L.2    Scadden, D.T.3
  • 55
    • 79961232797 scopus 로고    scopus 로고
    • The split-Apply-combine strategy for data analysis
    • Wickham, H. The split-Apply-combine strategy for data analysis. J. Stat. Softw. 40, 1-29 (2011
    • (2011) J. Stat. Softw , vol.40 , pp. 1-29
    • Wickham, H.1


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