메뉴 건너뛰기




Volumn 29, Issue 1, 2018, Pages 8-17

AMP-Activated Protein Kinase Regulation of the NLRP3 Inflammasome during Aging

Author keywords

aging; AMPK; autophagy; NLRP3 inflammasome

Indexed keywords

CRYOPYRIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INFLAMMASOME; PATHOGEN ASSOCIATED MOLECULAR PATTERN; SIRTUIN 1; NLRP3 PROTEIN, HUMAN;

EID: 85035129593     PISSN: 10432760     EISSN: 18793061     Source Type: Journal    
DOI: 10.1016/j.tem.2017.10.009     Document Type: Review
Times cited : (118)

References (80)
  • 1
    • 84878864199 scopus 로고    scopus 로고
    • The hallmarks of aging
    • López-Otín, C., et al. The hallmarks of aging. Cell 153 (2013), 1194–1217.
    • (2013) Cell , vol.153 , pp. 1194-1217
    • López-Otín, C.1
  • 2
    • 84949550661 scopus 로고    scopus 로고
    • The metabolic regulation of aging
    • Finkel, T., The metabolic regulation of aging. Nat. Med. 21 (2015), 1416–1423.
    • (2015) Nat. Med. , vol.21 , pp. 1416-1423
    • Finkel, T.1
  • 3
    • 85021056480 scopus 로고    scopus 로고
    • AMPK as a therapeutic target for treating metabolic diseases
    • Day, E.A., et al. AMPK as a therapeutic target for treating metabolic diseases. Trends Endocrinol. Metab. 28 (2017), 545–560.
    • (2017) Trends Endocrinol. Metab. , vol.28 , pp. 545-560
    • Day, E.A.1
  • 4
    • 85021851489 scopus 로고    scopus 로고
    • AMPK as a pro-longevity target
    • Burkewitz, K., et al. AMPK as a pro-longevity target. EXS 107 (2016), 227–256.
    • (2016) EXS , vol.107 , pp. 227-256
    • Burkewitz, K.1
  • 5
    • 84962878621 scopus 로고    scopus 로고
    • Age-related changes in AMPK activation: role for AMPK phosphatases and inhibitory phosphorylation by upstream signaling pathways
    • Salminen, A., Age-related changes in AMPK activation: role for AMPK phosphatases and inhibitory phosphorylation by upstream signaling pathways. Ageing Res. Rev. 28 (2016), 15–26.
    • (2016) Ageing Res. Rev. , vol.28 , pp. 15-26
    • Salminen, A.1
  • 6
    • 85019703527 scopus 로고    scopus 로고
    • AMPK in cardiovascular diseases
    • Daskalopoulos, E.P., et al. AMPK in cardiovascular diseases. EXS 107 (2016), 179–201.
    • (2016) EXS , vol.107 , pp. 179-201
    • Daskalopoulos, E.P.1
  • 7
    • 85011083358 scopus 로고    scopus 로고
    • AMPK in neurodegenerative diseases
    • Domise, M., Vingtdeux, V., AMPK in neurodegenerative diseases. EXS 107 (2016), 153–177.
    • (2016) EXS , vol.107 , pp. 153-177
    • Domise, M.1    Vingtdeux, V.2
  • 8
    • 85018524807 scopus 로고    scopus 로고
    • AMPK and cancer
    • Wang, Z., et al. AMPK and cancer. EXS 107 (2016), 203–226.
    • (2016) EXS , vol.107 , pp. 203-226
    • Wang, Z.1
  • 9
    • 85021850349 scopus 로고    scopus 로고
    • AMPK/mitochondria in metabolic diseases
    • Bullon, P., et al. AMPK/mitochondria in metabolic diseases. EXS 107 (2016), 129–152.
    • (2016) EXS , vol.107 , pp. 129-152
    • Bullon, P.1
  • 10
    • 84872576236 scopus 로고    scopus 로고
    • Metabolism of inflammation limited by AMPK and pseudo-starvation
    • O'Neill, L.A., Hardie, D.G., Metabolism of inflammation limited by AMPK and pseudo-starvation. Nature 493 (2013), 346–355.
    • (2013) Nature , vol.493 , pp. 346-355
    • O'Neill, L.A.1    Hardie, D.G.2
  • 11
    • 85013951365 scopus 로고    scopus 로고
    • AMPK deficiency in chondrocytes accelerated the progression of instability-induced and ageing-associated osteoarthritis in adult mice
    • Zhou, S., et al. AMPK deficiency in chondrocytes accelerated the progression of instability-induced and ageing-associated osteoarthritis in adult mice. Sci. Rep., 7, 2017, 43245.
    • (2017) Sci. Rep. , vol.7 , pp. 43245
    • Zhou, S.1
  • 12
    • 84880369307 scopus 로고    scopus 로고
    • Linked decreases in liver kinase B1 and AMP-activated protein kinase activity modulate matrix catabolic responses to biomechanical injury in chondrocytes
    • Petursson, F., et al. Linked decreases in liver kinase B1 and AMP-activated protein kinase activity modulate matrix catabolic responses to biomechanical injury in chondrocytes. Arthritis Res. Ther., 15, 2013, R77.
    • (2013) Arthritis Res. Ther. , vol.15 , pp. R77
    • Petursson, F.1
  • 13
    • 84930589100 scopus 로고    scopus 로고
    • AMPK activation of muscle autophagy prevents fasting-induced hypoglycemia and myopathy during aging
    • Bujak, A.L., et al. AMPK activation of muscle autophagy prevents fasting-induced hypoglycemia and myopathy during aging. Cell Metab. 21 (2015), 883–890.
    • (2015) Cell Metab. , vol.21 , pp. 883-890
    • Bujak, A.L.1
  • 14
    • 84904799195 scopus 로고    scopus 로고
    • Reduced skeletal muscle AMPK and mitochondrial markers do not promote age-induced insulin resistance
    • Bujak, A.L., et al. Reduced skeletal muscle AMPK and mitochondrial markers do not promote age-induced insulin resistance. J. Appl. Physiol., 117, 2014, 171179.
    • (2014) J. Appl. Physiol. , vol.117
    • Bujak, A.L.1
  • 15
    • 84928348920 scopus 로고    scopus 로고
    • Exercise-stimulated interleukin-15 is controlled by AMPK and regulates skin metabolism and aging
    • Crane, J.D., et al. Exercise-stimulated interleukin-15 is controlled by AMPK and regulates skin metabolism and aging. Aging Cell 14 (2015), 625–634.
    • (2015) Aging Cell , vol.14 , pp. 625-634
    • Crane, J.D.1
  • 16
    • 84951980059 scopus 로고    scopus 로고
    • Absence of AMPKα2 accelerates cellular senescence via p16 induction in mouse embryonic fibroblasts
    • Ding, Y., et al. Absence of AMPKα2 accelerates cellular senescence via p16 induction in mouse embryonic fibroblasts. Int. J. Biochem. Cell Biol. 71 (2016), 72–80.
    • (2016) Int. J. Biochem. Cell Biol. , vol.71 , pp. 72-80
    • Ding, Y.1
  • 17
    • 78049438321 scopus 로고    scopus 로고
    • AMP-activated protein kinase deficiency exacerbates aging-induced myocardial contractile dysfunction
    • Turdi, S., et al. AMP-activated protein kinase deficiency exacerbates aging-induced myocardial contractile dysfunction. Aging Cell 9 (2010), 592–606.
    • (2010) Aging Cell , vol.9 , pp. 592-606
    • Turdi, S.1
  • 18
    • 84963815042 scopus 로고    scopus 로고
    • Adverse effects of AMP-activated protein kinase α2-subunit deletion and high-fat diet on heart function and ischemic tolerance in aged female mice
    • Slámová, K., et al. Adverse effects of AMP-activated protein kinase α2-subunit deletion and high-fat diet on heart function and ischemic tolerance in aged female mice. Physiol. Res. 65 (2016), 33–42.
    • (2016) Physiol. Res. , vol.65 , pp. 33-42
    • Slámová, K.1
  • 19
    • 84901310586 scopus 로고    scopus 로고
    • Mechanisms and functions of inflammasomes
    • Lamkanfi, M., Dixit, V.M., Mechanisms and functions of inflammasomes. Cell 157 (2014), 1013–1022.
    • (2014) Cell , vol.157 , pp. 1013-1022
    • Lamkanfi, M.1    Dixit, V.M.2
  • 20
    • 85025653655 scopus 로고    scopus 로고
    • Mitochondrial function is required for extracellular ATP-induced NLRP3 inflammasome activation
    • Sadatomi, D., et al. Mitochondrial function is required for extracellular ATP-induced NLRP3 inflammasome activation. J. Biochem. 161 (2017), 503–512.
    • (2017) J. Biochem. , vol.161 , pp. 503-512
    • Sadatomi, D.1
  • 21
    • 85009502184 scopus 로고    scopus 로고
    • Soluble uric acid activates the NLRP3 inflammasome
    • Braga, T.T., et al. Soluble uric acid activates the NLRP3 inflammasome. Sci. Rep., 7, 2017, 39884.
    • (2017) Sci. Rep. , vol.7
    • Braga, T.T.1
  • 22
    • 84873087532 scopus 로고    scopus 로고
    • NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice
    • Heneka, M.T., et al. NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice. Nature 493 (2013), 674–678.
    • (2013) Nature , vol.493 , pp. 674-678
    • Heneka, M.T.1
  • 23
    • 77951800951 scopus 로고    scopus 로고
    • NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
    • Duewell, P., et al. NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature 464 (2010), 1357–1361.
    • (2010) Nature , vol.464 , pp. 1357-1361
    • Duewell, P.1
  • 24
    • 84925047701 scopus 로고    scopus 로고
    • NLRP3 inflammasome: from a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases
    • Abderrazak, A., et al. NLRP3 inflammasome: from a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases. Redox Biol. 4 (2015), 296–307.
    • (2015) Redox Biol. , vol.4 , pp. 296-307
    • Abderrazak, A.1
  • 25
    • 84861164794 scopus 로고    scopus 로고
    • The Nlrp3 inflammasome promotes age-related thymic demise and immunosenescence
    • Youm, Y.H., et al. The Nlrp3 inflammasome promotes age-related thymic demise and immunosenescence. Cell Rep. 1 (2012), 56–68.
    • (2012) Cell Rep. , vol.1 , pp. 56-68
    • Youm, Y.H.1
  • 26
    • 84885167222 scopus 로고    scopus 로고
    • Canonical Nlrp3 inflammasome links systemic low-grade inflammation to functional decline in aging
    • Youm, Y.H., et al. Canonical Nlrp3 inflammasome links systemic low-grade inflammation to functional decline in aging. Cell Metab. 18 (2013), 519–532.
    • (2013) Cell Metab. , vol.18 , pp. 519-532
    • Youm, Y.H.1
  • 27
    • 85027019757 scopus 로고    scopus 로고
    • The NLRP3 inflammasome contributes to sarcopenia and lower muscle glycolytic potential in old mice
    • McBride, M.J., et al. The NLRP3 inflammasome contributes to sarcopenia and lower muscle glycolytic potential in old mice. Am. J. Physiol. Endocrinol. Metab. 313 (2017), E222–E232.
    • (2017) Am. J. Physiol. Endocrinol. Metab. , vol.313 , pp. E222-E232
    • McBride, M.J.1
  • 28
    • 84988945057 scopus 로고    scopus 로고
    • Age-dependent susceptibility to pulmonary fibrosis is associated with NLRP3 inflammasome activation
    • Stout-Delgado, H.W., et al. Age-dependent susceptibility to pulmonary fibrosis is associated with NLRP3 inflammasome activation. Am. J. Respir. Cell Mol. Biol. 55 (2016), 252–263.
    • (2016) Am. J. Respir. Cell Mol. Biol. , vol.55 , pp. 252-263
    • Stout-Delgado, H.W.1
  • 29
    • 84959088069 scopus 로고    scopus 로고
    • Growth hormone receptor deficiency protects against age-related NLRP3 inflammasome activation and immune senescence
    • Spadaro, O., et al. Growth hormone receptor deficiency protects against age-related NLRP3 inflammasome activation and immune senescence. Cell Rep. 14 (2016), 1571–1580.
    • (2016) Cell Rep. , vol.14 , pp. 1571-1580
    • Spadaro, O.1
  • 30
    • 84927748959 scopus 로고    scopus 로고
    • Drivers of age-related inflammation and strategies for healthspan extension
    • Goldberg, E.L., Dixit, V.D., Drivers of age-related inflammation and strategies for healthspan extension. Immunol. Rev. 265 (2015), 63–74.
    • (2015) Immunol. Rev. , vol.265 , pp. 63-74
    • Goldberg, E.L.1    Dixit, V.D.2
  • 31
    • 84989962589 scopus 로고    scopus 로고
    • Aging-associated TNF production primes inflammasome activation and NLRP3-related metabolic disturbances
    • Bauernfeind, F., et al. Aging-associated TNF production primes inflammasome activation and NLRP3-related metabolic disturbances. J. Immunol. 197 (2016), 2900–2908.
    • (2016) J. Immunol. , vol.197 , pp. 2900-2908
    • Bauernfeind, F.1
  • 32
    • 15244348518 scopus 로고    scopus 로고
    • The origins of age-related proinflammatory state
    • Ferrucci, L., et al. The origins of age-related proinflammatory state. Blood 105 (2005), 2294–2299.
    • (2005) Blood , vol.105 , pp. 2294-2299
    • Ferrucci, L.1
  • 33
    • 84943377812 scopus 로고    scopus 로고
    • Gene expression of inflammasome components in peripheral blood mononuclear cells (PBMC) of vascular patients increases with age
    • Wu, X., et al. Gene expression of inflammasome components in peripheral blood mononuclear cells (PBMC) of vascular patients increases with age. Immun. Ageing, 12, 2015, 15.
    • (2015) Immun. Ageing , vol.12 , pp. 15
    • Wu, X.1
  • 34
    • 77951800951 scopus 로고    scopus 로고
    • NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
    • Duewell, P., et al. NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature 464 (2010), 1357–1361.
    • (2010) Nature , vol.464 , pp. 1357-1361
    • Duewell, P.1
  • 35
    • 85007417755 scopus 로고    scopus 로고
    • The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer's disease
    • Saresella, M., et al. The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer's disease. Mol. Neurodegener., 11, 2016, 23.
    • (2016) Mol. Neurodegener. , vol.11 , pp. 23
    • Saresella, M.1
  • 36
    • 79960920271 scopus 로고    scopus 로고
    • NLRP3 inflammasomes link inflammation and metabolic disease
    • De Nardo, D., Latz, E., NLRP3 inflammasomes link inflammation and metabolic disease. Trends Immunol. 32 (2011), 373–379.
    • (2011) Trends Immunol. , vol.32 , pp. 373-379
    • De Nardo, D.1    Latz, E.2
  • 37
    • 85013763791 scopus 로고    scopus 로고
    • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
    • Klionsky, D.J., et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12 (2016), 1–222.
    • (2016) Autophagy , vol.12 , pp. 1-222
    • Klionsky, D.J.1
  • 38
    • 84883114523 scopus 로고    scopus 로고
    • Overexpression of Atg5 in mice activates autophagy and extends lifespan
    • Pyo, J.O., et al. Overexpression of Atg5 in mice activates autophagy and extends lifespan. Nat. Commun., 4, 2013, 2300.
    • (2013) Nat. Commun. , vol.4 , pp. 2300
    • Pyo, J.O.1
  • 39
    • 84993949487 scopus 로고    scopus 로고
    • Sex-specific autophagy modulation in osteoblastic lineage: a critical function to counteract bone loss in female
    • Camuzard, O., et al. Sex-specific autophagy modulation in osteoblastic lineage: a critical function to counteract bone loss in female. Oncotarget 7 (2016), 66416–66428.
    • (2016) Oncotarget , vol.7 , pp. 66416-66428
    • Camuzard, O.1
  • 40
    • 84968719073 scopus 로고    scopus 로고
    • Aging and autophagy in the heart
    • Shirakabe, A., et al. Aging and autophagy in the heart. Circ. Res. 118 (2016), 1563–1576.
    • (2016) Circ. Res. , vol.118 , pp. 1563-1576
    • Shirakabe, A.1
  • 41
    • 84857195479 scopus 로고    scopus 로고
    • Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction
    • Shi, C.S., et al. Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction. Nat. Immunol. 13 (2012), 255–263.
    • (2012) Nat. Immunol. , vol.13 , pp. 255-263
    • Shi, C.S.1
  • 42
    • 84986556228 scopus 로고    scopus 로고
    • Autophagy deficiency in macrophages enhances NLRP3 inflammasome activity and chronic lung disease following silica exposure
    • Jessop, F., et al. Autophagy deficiency in macrophages enhances NLRP3 inflammasome activity and chronic lung disease following silica exposure. Toxicol. Appl. Pharmacol. 309 (2016), 101–110.
    • (2016) Toxicol. Appl. Pharmacol. , vol.309 , pp. 101-110
    • Jessop, F.1
  • 43
    • 85019837334 scopus 로고    scopus 로고
    • Foxo3a-dependent Bim transcription protects mice from a high fat diet via inhibition of activation of the NLRP3 inflammasome by facilitating autophagy flux in Kupffer cells
    • Liu, Y., et al. Foxo3a-dependent Bim transcription protects mice from a high fat diet via inhibition of activation of the NLRP3 inflammasome by facilitating autophagy flux in Kupffer cells. Oncotarget 8 (2017), 34258–34267.
    • (2017) Oncotarget , vol.8 , pp. 34258-34267
    • Liu, Y.1
  • 44
    • 84959420149 scopus 로고    scopus 로고
    • NF-κB restricts inflammasome activation via elimination of damaged mitochondria
    • Zhong, Z., et al. NF-κB restricts inflammasome activation via elimination of damaged mitochondria. Cell 164 (2016), 896–910.
    • (2016) Cell , vol.164 , pp. 896-910
    • Zhong, Z.1
  • 45
    • 85020871195 scopus 로고    scopus 로고
    • Rapamycin regulates macrophage activation by inhibiting NLRP3 inflammasome–p38 MAPK–NFκB pathways in autophagy- and p62-dependent manners
    • Ko, J.H., et al. Rapamycin regulates macrophage activation by inhibiting NLRP3 inflammasome–p38 MAPK–NFκB pathways in autophagy- and p62-dependent manners. Oncotarget 8 (2017), 40817–40831.
    • (2017) Oncotarget , vol.8 , pp. 40817-40831
    • Ko, J.H.1
  • 46
    • 84949649953 scopus 로고    scopus 로고
    • Genipin inhibits NLRP3 and NLRC4 inflammasome activation via autophagy suppression
    • Yu, S.X., et al. Genipin inhibits NLRP3 and NLRC4 inflammasome activation via autophagy suppression. Sci. Rep., 5, 2015, 17935.
    • (2015) Sci. Rep. , vol.5 , pp. 17935
    • Yu, S.X.1
  • 47
    • 84929515613 scopus 로고    scopus 로고
    • Anti-inflammatory and antiatherogenic effects of the NLRP3 inflammasome inhibitor arglabin in ApoE2. Ki mice fed a high-fat diet
    • Abderrazak, A., et al. Anti-inflammatory and antiatherogenic effects of the NLRP3 inflammasome inhibitor arglabin in ApoE2. Ki mice fed a high-fat diet. Circulation 131 (2015), 1061–1070.
    • (2015) Circulation , vol.131 , pp. 1061-1070
    • Abderrazak, A.1
  • 48
    • 84925584516 scopus 로고    scopus 로고
    • Resveratrol inhibits NLRP3 inflammasome activation by preserving mitochondrial integrity and augmenting autophagy
    • Chang, Y.P., et al. Resveratrol inhibits NLRP3 inflammasome activation by preserving mitochondrial integrity and augmenting autophagy. J. Cell. Physiol. 230 (2015), 1567–1579.
    • (2015) J. Cell. Physiol. , vol.230 , pp. 1567-1579
    • Chang, Y.P.1
  • 49
    • 85018736108 scopus 로고    scopus 로고
    • Antidepressants induce autophagy dependent-NLRP3-inflammasome inhibition in major depressive disorder
    • Alcocer-Gómez, E., et al. Antidepressants induce autophagy dependent-NLRP3-inflammasome inhibition in major depressive disorder. Pharmacol. Res. 121 (2017), 114–121.
    • (2017) Pharmacol. Res. , vol.121 , pp. 114-121
    • Alcocer-Gómez, E.1
  • 50
    • 85029716483 scopus 로고    scopus 로고
    • Molecular mechanisms determining lifespan in short- and long-lived species
    • Tian, X., et al. Molecular mechanisms determining lifespan in short- and long-lived species. Trends Endocrinol. Metab. 28 (2017), 722–734.
    • (2017) Trends Endocrinol. Metab. , vol.28 , pp. 722-734
    • Tian, X.1
  • 51
    • 85009128688 scopus 로고    scopus 로고
    • Resveratrol and lifespan in model organisms
    • Pallauf, K., et al. Resveratrol and lifespan in model organisms. Curr. Med. Chem. 23 (2016), 4639–4680.
    • (2016) Curr. Med. Chem. , vol.23 , pp. 4639-4680
    • Pallauf, K.1
  • 52
    • 84978154338 scopus 로고    scopus 로고
    • Mitochondrial dysfunction activates the AMPK signaling and autophagy to promote cell survival
    • Zhao, B., et al. Mitochondrial dysfunction activates the AMPK signaling and autophagy to promote cell survival. Genes Dis. 3 (2016), 82–87.
    • (2016) Genes Dis. , vol.3 , pp. 82-87
    • Zhao, B.1
  • 53
    • 84941687152 scopus 로고    scopus 로고
    • Critical role of AMP-activated protein kinase in the balance between mitophagy and mitochondrial biogenesis in MELAS disease
    • Garrido-Maraver, J., et al. Critical role of AMP-activated protein kinase in the balance between mitophagy and mitochondrial biogenesis in MELAS disease. Biochim. Biophys. Acta 1852 (2015), 2535–2553.
    • (2015) Biochim. Biophys. Acta , vol.1852 , pp. 2535-2553
    • Garrido-Maraver, J.1
  • 54
    • 84862777872 scopus 로고    scopus 로고
    • Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis
    • Shimada, K., et al. Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. Immunity 36 (2012), 401–414.
    • (2012) Immunity , vol.36 , pp. 401-414
    • Shimada, K.1
  • 55
    • 84955243435 scopus 로고    scopus 로고
    • AMPK phosphorylation modulates pain by activation of NLRP3 inflammasome
    • Bullón, P., et al. AMPK phosphorylation modulates pain by activation of NLRP3 inflammasome. Antioxid. Redox Signal. 24 (2016), 157–170.
    • (2016) Antioxid. Redox Signal. , vol.24 , pp. 157-170
    • Bullón, P.1
  • 56
    • 84957309462 scopus 로고    scopus 로고
    • Suppression of NLRP3 inflammasome by γ-tocotrienol ameliorates type 2 diabetes
    • Kim, Y., et al. Suppression of NLRP3 inflammasome by γ-tocotrienol ameliorates type 2 diabetes. J. Lipid Res. 57 (2016), 66–76.
    • (2016) J. Lipid Res. , vol.57 , pp. 66-76
    • Kim, Y.1
  • 57
    • 84945556096 scopus 로고    scopus 로고
    • A mitochondrion-targeted antioxidant ameliorates isoflurane-induced cognitive deficits in aging mice
    • Wu, J., et al. A mitochondrion-targeted antioxidant ameliorates isoflurane-induced cognitive deficits in aging mice. PLoS One, 10, 2015, e0138256.
    • (2015) PLoS One , vol.10
    • Wu, J.1
  • 58
    • 85020055389 scopus 로고    scopus 로고
    • Melatonin supplementation, a strategy to prevent neurological diseases through maintaining integrity of blood brain barrier in old people
    • Liu, W.C., et al. Melatonin supplementation, a strategy to prevent neurological diseases through maintaining integrity of blood brain barrier in old people. Front. Aging Neurosci., 9, 2017, 165.
    • (2017) Front. Aging Neurosci. , vol.9 , pp. 165
    • Liu, W.C.1
  • 59
    • 84956884053 scopus 로고    scopus 로고
    • Same molecule but different expression: aging and sepsis trigger NLRP3 inflammasome activation, a target of melatonin
    • Volt, H., et al. Same molecule but different expression: aging and sepsis trigger NLRP3 inflammasome activation, a target of melatonin. J. Pineal Res. 60 (2016), 193–205.
    • (2016) J. Pineal Res. , vol.60 , pp. 193-205
    • Volt, H.1
  • 60
    • 85011798964 scopus 로고    scopus 로고
    • Melatonin alleviates lipopolysaccharide-compromised integrity of blood–brain barrier through activating AMP-activated protein kinase in old mice
    • Wang, X., et al. Melatonin alleviates lipopolysaccharide-compromised integrity of blood–brain barrier through activating AMP-activated protein kinase in old mice. Aging Cell 16 (2017), 414–421.
    • (2017) Aging Cell , vol.16 , pp. 414-421
    • Wang, X.1
  • 61
    • 85018635685 scopus 로고    scopus 로고
    • Endoplasmic reticulum proteostasis impairment in aging
    • Martínez, G., et al. Endoplasmic reticulum proteostasis impairment in aging. Aging Cell 16 (2017), 615–623.
    • (2017) Aging Cell , vol.16 , pp. 615-623
    • Martínez, G.1
  • 62
    • 84856857478 scopus 로고    scopus 로고
    • ER stress activates the NLRP3 inflammasome via an UPR-independent pathway
    • Menu, P., et al. ER stress activates the NLRP3 inflammasome via an UPR-independent pathway. Cell Death Dis., 3, 2012, e261.
    • (2012) Cell Death Dis. , vol.3 , pp. e261
    • Menu, P.1
  • 63
    • 84994031834 scopus 로고    scopus 로고
    • β-Hydroxybutyrate suppresses inflammasome formation by ameliorating endoplasmic reticulum stress via AMPK activation
    • Bae, H.R., et al. β-Hydroxybutyrate suppresses inflammasome formation by ameliorating endoplasmic reticulum stress via AMPK activation. Oncotarget 7 (2016), 66444–66454.
    • (2016) Oncotarget , vol.7 , pp. 66444-66454
    • Bae, H.R.1
  • 64
    • 84974851800 scopus 로고    scopus 로고
    • Metformin and resveratrol inhibit Drp1-mediated mitochondrial fission and prevent ER stress-associated NLRP3 inflammasome activation in the adipose tissue of diabetic mice
    • Li, A., et al. Metformin and resveratrol inhibit Drp1-mediated mitochondrial fission and prevent ER stress-associated NLRP3 inflammasome activation in the adipose tissue of diabetic mice. Mol. Cell. Endocrinol. 434 (2016), 36–47.
    • (2016) Mol. Cell. Endocrinol. , vol.434 , pp. 36-47
    • Li, A.1
  • 65
    • 84955242874 scopus 로고    scopus 로고
    • Pharmacological activation of AMPK prevents Drp1-mediated mitochondrial fission and alleviates endoplasmic reticulum stress-associated endothelial dysfunction
    • Li, J., et al. Pharmacological activation of AMPK prevents Drp1-mediated mitochondrial fission and alleviates endoplasmic reticulum stress-associated endothelial dysfunction. J. Mol. Cell. Cardiol. 86 (2015), 62–74.
    • (2015) J. Mol. Cell. Cardiol. , vol.86 , pp. 62-74
    • Li, J.1
  • 66
    • 84860477354 scopus 로고    scopus 로고
    • SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function
    • Price, N.L., et al. SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell Metab. 15 (2012), 675–690.
    • (2012) Cell Metab. , vol.15 , pp. 675-690
    • Price, N.L.1
  • 67
    • 84930757246 scopus 로고    scopus 로고
    • Metformin improves putative longevity effectors in peripheral mononuclear cells from subjects with prediabetes. A randomized controlled trial
    • de Kreutzenberg, S.V., et al. Metformin improves putative longevity effectors in peripheral mononuclear cells from subjects with prediabetes. A randomized controlled trial. Nutr. Metab. Cardiovasc. Dis. 25 (2015), 686–693.
    • (2015) Nutr. Metab. Cardiovasc. Dis. , vol.25 , pp. 686-693
    • de Kreutzenberg, S.V.1
  • 68
    • 84927722620 scopus 로고    scopus 로고
    • Sirt1 restrains lung inflammasome activation in a murine model of sepsis
    • Gao, R., et al. Sirt1 restrains lung inflammasome activation in a murine model of sepsis. Am. J. Physiol. Lung Cell. Mol. Physiol. 308 (2015), L847–L853.
    • (2015) Am. J. Physiol. Lung Cell. Mol. Physiol. , vol.308 , pp. L847-L853
    • Gao, R.1
  • 69
    • 84982803563 scopus 로고    scopus 로고
    • SIRT1 inhibits inflammatory response partly through regulation of NLRP3 inflammasome in vascular endothelial cells
    • Li, Y., et al. SIRT1 inhibits inflammatory response partly through regulation of NLRP3 inflammasome in vascular endothelial cells. Mol. Immunol. 77 (2016), 148–156.
    • (2016) Mol. Immunol. , vol.77 , pp. 148-156
    • Li, Y.1
  • 70
    • 84978864140 scopus 로고    scopus 로고
    • + deficiency as a therapeutic target for non-alcoholic fatty liver disease in ageing
    • + deficiency as a therapeutic target for non-alcoholic fatty liver disease in ageing. Br. J. Pharmacol. 173 (2016), 2352–2368.
    • (2016) Br. J. Pharmacol. , vol.173 , pp. 2352-2368
    • Zhou, C.C.1
  • 71
    • 85007406692 scopus 로고    scopus 로고
    • Negative regulation of NLRP3 inflammasome by SIRT1 in vascular endothelial cells
    • Li, Y., et al. Negative regulation of NLRP3 inflammasome by SIRT1 in vascular endothelial cells. Immunobiology 222 (2017), 552–561.
    • (2017) Immunobiology , vol.222 , pp. 552-561
    • Li, Y.1
  • 73
    • 84981312038 scopus 로고    scopus 로고
    • Metabolic control of longevity
    • López-Otín, C., et al. Metabolic control of longevity. Cell 166 (2016), 802–821.
    • (2016) Cell , vol.166 , pp. 802-821
    • López-Otín, C.1
  • 74
    • 85011662390 scopus 로고    scopus 로고
    • Metabolic effects of fasting on human and mouse blood in vivo
    • Pietrocola, F., et al. Metabolic effects of fasting on human and mouse blood in vivo. Autophagy 13 (2017), 567–578.
    • (2017) Autophagy , vol.13 , pp. 567-578
    • Pietrocola, F.1
  • 75
    • 84948807305 scopus 로고    scopus 로고
    • Fasting and refeeding differentially regulate NLRP3 inflammasome activation in human subjects
    • Traba, J., et al. Fasting and refeeding differentially regulate NLRP3 inflammasome activation in human subjects. J. Clin. Invest. 125 (2015), 4592–4600.
    • (2015) J. Clin. Invest. , vol.125 , pp. 4592-4600
    • Traba, J.1
  • 76
    • 84881347302 scopus 로고    scopus 로고
    • Metformin improves healthspan and lifespan in mice
    • Martin-Montalvo, A., et al. Metformin improves healthspan and lifespan in mice. Nat. Commun., 4, 2013, 2192.
    • (2013) Nat. Commun. , vol.4 , pp. 2192
    • Martin-Montalvo, A.1
  • 77
    • 84995467810 scopus 로고    scopus 로고
    • Cardioprotection and lifespan extension by the natural polyamine spermidine
    • Eisenberg, T., et al. Cardioprotection and lifespan extension by the natural polyamine spermidine. Nat. Med. 22 (2016), 1428–1438.
    • (2016) Nat. Med. , vol.22 , pp. 1428-1438
    • Eisenberg, T.1
  • 78
    • 84924415042 scopus 로고    scopus 로고
    • A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
    • Coll, R.C., et al. A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nat. Med. 21 (2015), 248–255.
    • (2015) Nat. Med. , vol.21 , pp. 248-255
    • Coll, R.C.1
  • 79
    • 84924356420 scopus 로고    scopus 로고
    • The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease
    • Youm, Y.H., et al. The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease. Nat. Med. 21 (2015), 263–269.
    • (2015) Nat. Med. , vol.21 , pp. 263-269
    • Youm, Y.H.1
  • 80
    • 85021761128 scopus 로고    scopus 로고
    • Pressor response to angiotensin II is enhanced in aged mice and associated with inflammation, vasoconstriction and oxidative stress
    • Dinh, Q.N., et al. Pressor response to angiotensin II is enhanced in aged mice and associated with inflammation, vasoconstriction and oxidative stress. Aging (Albany NY) 9 (2017), 1595–1606.
    • (2017) Aging (Albany NY) , vol.9 , pp. 1595-1606
    • Dinh, Q.N.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.