Rapamycin regulates macrophage activation by inhibiting NLRP3 inflammasome-p38 MAPK-NFκB pathways in autophagy- and p62-dependent manners

Oncotarget

Volumn 8, Issue 25, 2017, Pages 40817-40831

  Ko, Jung Hwa ^a   Yoon, Sun Ok ^b   Lee, Hyun Ju ^a   Oh, Joo Youn ^a  

^a Seoul National University Hospital   (South Korea)

^b Eutilex Co Ltd   (South Korea)

Author keywords

Autophagy; Macrophage; NLRP3 inflammasome; P62 SQSTM1; Rapamycin

Indexed keywords

ADENOSINE TRIPHOSPHATE; CRYOPYRIN; I KAPPA B KINASE ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 1; RAPAMYCIN; REACTIVE OXYGEN METABOLITE; SEQUESTOSOME 1; TRANSCRIPTION FACTOR NRF2; INFLAMMASOME; P62 PROTEIN, HUMAN; RNA BINDING PROTEIN; SIROLIMUS;

ARTICLE; AUTOPHAGY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DOWN REGULATION; HUMAN; HUMAN CELL; MACROPHAGE ACTIVATION; MITOCHONDRION; UPREGULATION; DRUG EFFECT; GENETIC TRANSFECTION; MACROPHAGE; MAPK SIGNALING; METABOLISM; PHYSIOLOGY; THP-1 CELL LINE;

AUTOPHAGY; HUMANS; INFLAMMASOMES; MACROPHAGES; MAP KINASE SIGNALING SYSTEM; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RNA-BINDING PROTEINS; SIROLIMUS; THP-1 CELLS; TRANSFECTION;

EID: 85020871195     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.17256     Document Type: Article

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