Melatonin alleviates lipopolysaccharide-compromised integrity of blood–brain barrier through activating AMP-activated protein kinase in old mice

Aging Cell

Volumn 16, Issue 2, 2017, Pages 414-421

  Wang, Xiaona ^a   Xue, Gai Xiu ^b   Liu, Wen Cao ^c   Shu, Hui ^a   Wang, Mengwei ^a   Sun, Yanyun ^a   Liu, Xiaojing ^d   Sun, Yi Eve ^d,e   Liu, Chun Feng ^a   Liu, Jie ^d   Liu, Wenlan ^f   Jin, Xinchun ^a  

^a THE SECOND AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

^b SUZHOU MUNICIPAL HOSPITAL   (China)

^c SHAANXI PROVINCIAL PEOPLE S HOSPITAL   (China)

^d TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f THE FIRST AFFILIATED HOSPITAL OF SHENZHEN UNIVERSITY   (China)

Author keywords

AMPK; blood brain barrier; lipopolysaccharide; Melatonin; old mice; tight junction protein

Indexed keywords

CASPASE 3; CLAUDIN 5; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; IMMUNOGLOBULIN G; LIPOPOLYSACCHARIDE; MELATONIN; METFORMIN; OCCLUDIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; TIGHT JUNCTION PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CAPILLARY ENDOTHELIAL CELL; CELL DISRUPTION; CONTROLLED STUDY; DOWN REGULATION; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME INHIBITION; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SEPSIS; UPREGULATION; WESTERN BLOTTING; AGING; ANIMAL; C57BL MOUSE; CELL LINE; DRUG EFFECTS; METABOLISM;

AGING; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; BLOOD-BRAIN BARRIER; CELL LINE; ENZYME ACTIVATION; LIPOPOLYSACCHARIDES; MELATONIN; MICE, INBRED C57BL; NADPH OXIDASE; PROTEOLYSIS; TIGHT JUNCTION PROTEINS; UP-REGULATION;

EID: 85011798964     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12572     Document Type: Article

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