AMPK deficiency in chondrocytes accelerated the progression of instability-induced and ageing-associated osteoarthritis in adult mice

Scientific Reports

Volumn 7, Issue , 2017, Pages

  Zhou, Sheng ^a   Lu, Wanli ^a   Chen, Liang ^a   Ge, Qiting ^a   Chen, Dongyang ^a   Xu, Zhihong ^a   Shi, Dongquan ^a   Dai, Jin ^a   Li, Jianxin ^a   Ju, Huangxian ^a   Cao, Yi ^a   Qin, Jinzhong ^a   Chen, Shuai ^a   Teng, Huajian ^a   Jiang, Qing ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMP-ACTIVATED PROTEIN KINASE KINASE; PROTEIN KINASE;

AGING; ANIMAL; CHONDROCYTE; DEFICIENCY; ENZYMOLOGY; FEMALE; KNOCKOUT MOUSE; MALE; MOUSE; OSTEOARTHRITIS; PATHOLOGY;

AGING; ANIMALS; CHONDROCYTES; FEMALE; MALE; MICE; MICE, KNOCKOUT; OSTEOARTHRITIS; PROTEIN KINASES;

EID: 85013951365     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep43245     Document Type: Article

References (45)

1. Aigner, T., Sachse, A., Gebhard, P. M. & Roach, H. I. Osteoarthritis: pathobiology-targets and ways for therapeutic intervention. Adv. Drug Deliv. Re. 58, 128-149 (2006).
2. Loeser, R. F., Goldring, S. R., Scanzello, C. R. & Goldring, M. B. Osteoarthritis: A disease of the joint as an organ. Arthritis Rheum. 64, 1697-1707 (2012).
3. Witczak, C. A., Sharoff, C. G. & Goodyear, L. J. AMP-activated protein kinase in skeletal muscle: from structure and localization to its role as a master regulator of cellular metabolism. Cell Mol. Life. Sci. 65, 3737-3755 (2008).
4. Steinberg, G. R. & Kemp, B. E. AMPK in Health and Disease. Physiol. Rev. 89, 1025-1078 (2009).
5. Salminen, A. & Kaarniranta, K. AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network. Ageing Res. Rev. 11, 230-241 (2012).
6. Bujak, A. L. et al. AMPK activation of muscle autophagy prevents fasting-induced hypoglycemia and myopathy during aging. Cell Metab. 21, 883-890 (2015).
7. Wang, S., Dale, G. L., Song, P., Viollet, B. & Zou, M. H. AMPKalpha1 deletion shortens erythrocyte life span in mice: role of oxidative stress. J. Biol. Chem. 285, 19976-19985 (2010).
8. Terkeltaub, R., Yang, B., Lotz, M. & Liu-Bryan, R. Chondrocyte AMP-activated protein kinase activity suppresses matrix degradation responses to proinflammatory cytokines interleukin-1beta and tumor necrosis factor alpha. Arthritis Rheum. 63, 1928-1937 (2011).
9. Petursson, F. et al. Linked decreases in liver kinase B1 and AMP-activated protein kinase activity modulate matrix catabolic responses to biomechanical injury in chondrocytes. Arthritis Res. Ther. 15, R77 (2013).
10. Zhao, X. et al. Peroxisome proliferator-activated receptor gamma coactivator 1alpha and FoxO3A mediate chondroprotection by AMP-activated protein kinase. Arthritis Rheumatol. 66, 3073-3082 (2014).
11. Zhou, Y. et al. Berberine prevents nitric oxide-induced rat chondrocyte apoptosis and cartilage degeneration in a rat osteoarthritis model via AMPK and p38 MAPK signaling. Apoptosis 20, 1187-1199 (2015).
12. Hu, P. F., Chen, W. P., Tang, J. L., Bao, J. P. & Wu, L. D. Protective effects of berberine in an experimental rat osteoarthritis model. Phytother. Res. 25, 878-885 (2011).
13. Zhao, H. et al. Berberine ameliorates cartilage degeneration in interleukin-1beta-stimulated rat chondrocytes and in a rat model of osteoarthritis via Akt signalling. J. Cell Mol. Med. 18, 283-292 (2014).
14. Liu-Bryan, R. Inflammation and intracellular metabolism: new targets in OA. Osteoarthritis Cartilage 23, 1835-1842 (2015).
15. Liu-Bryan, R. & Terkeltaub, R. Emerging regulators of the inflammatory process in osteoarthritis. Nat. Rev. Rheumatol. 11, 35-44 (2015).
16. Loeser, R. F., Collins, J. A. & Diekman, B. O. Ageing and the pathogenesis of osteoarthritis. Nat. Rev. Rheumatol. 12, 412-420 (2016).
17. Yang, C., Li, Z., Lai, P., Bai, X. & Jin, D. Chondrocyte-Specific Ablation of AMPKalpha1 Does Not Affect Bone Development or Pathogenesis of Osteoarthritis in Mice. DNA Cell Biol. 35, 156-162 (2016).
18. Glasson, S. S., Blanchet, T. J. & Morris, E. A. The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129/SvEv mouse. Osteoarthritis Cartilage 15, 1061-1069 (2007).
19. Lauder, S. N. et al. Interleukin-1beta induced activation of nuclear factor-kappab can be inhibited by novel pharmacological agents in osteoarthritis. Rheumatology 46, 752-758 (2007).
20. Mengshol, J. A., Vincenti, M. P., Coon, C. I., Barchowsky, A. & Brinckerhoff, C. E. Interleukin-1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c-Jun N-terminal kinase, and nuclear factor kappaB: differential regulation of collagenase 1 and collagenase 3. Arthritis Rheum. 43, 801-811 (2000).
21. Viollet, B. et al. AMPK: Lessons from transgenic and knockout animals. Front Biosci. (Landmark Ed.) 14, 19-44 (2009).
22. Munasinghe, J. P. et al. Magnetic resonance imaging, histology, and x-ray of three stages of damage to the knees of STR/ORT mice. Invest. Radiol. 31, 630-638 (1996).
23. Srikanth, V. K. et al. A meta-analysis of sex differences prevalence, incidence and severity of osteoarthritis. Osteoarthritis Cartilage 13, 769-781 (2005).
24. Lawrence, R. C. et al. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II. Arthritis Rheum. 58, 26-35 (2008).
25. Husa, M., Petursson, F., Lotz, M., Terkeltaub, R. & Liu-Bryan, R. C/EBP homologous protein drives pro-catabolic responses in chondrocytes. Arthritis Res. Ther. 15, R218 (2013).
26. Sondergaard, B. C. et al. Relative contribution of matrix metalloprotease and cysteine protease activities to cytokine-stimulated articular cartilage degradation. Osteoarthritis Cartilage 14, 738-748 (2006).
27. Minond, D. et al. The roles of substrate thermal stability and P2 and P1 subsite identity on matrix metalloproteinase triple-helical peptidase activity and collagen specificity. J. Biol. Chem. 281, 38302-38313 (2006).
28. Ryu, J. H. et al. Hypoxia-inducible factor-2alpha regulates Fas-mediated chondrocyte apoptosis during osteoarthritic cartilage destruction. Cell Death. Differ. 19, 440-450 (2012).
29. Mistry, D., Oue, Y., Chambers, M. G., Kayser, M. V. & Mason, R. M. Chondrocyte death during murine osteoarthritis. Osteoarthritis Cartilage 12, 131-141 (2004).
30. Kok, S. H. et al. Simvastatin inhibits cysteine-rich protein 61 expression in rheumatoid arthritis synovial fibroblasts through the regulation of sirtuin-1/FoxO3a signaling. Arthritis Rheum. 65, 639-649 (2013).
31. Hardie, D. G., Ross, F. A. & Hawley, S. A. AMP-activated protein kinase: A target for drugs both ancient and modern. Chem. Biol. 19, 1222-1236 (2012).
32. Hwang, J. T., Kwon, D. Y. & Yoon, S. H. AMP-activated protein kinase: A potential target for the diseases prevention by natural occurring polyphenols. N. Biotechnol. 26, 17-22 (2009).
33. Richter, E. A. & Ruderman, N. B. AMPK and the biochemistry of exercise: implications for human health and disease. Biochem. J. 418, 261-275 (2009).
34. Friedrichsen, M., Mortensen, B., Pehmoller, C., Birk, J. B. & Wojtaszewski, J. F. Exercise-induced AMPK activity in skeletal muscle: role in glucose uptake and insulin sensitivity. Mol. Cell Endocrino. 366, 204-214 (2013).
35. Chen, M. et al. Generation of a transgenic mouse model with chondrocyte-specific and tamoxifen-inducible expression of Cre recombinase. Genesis 45, 44-50 (2007).
36. Weng, T. et al. Genetic inhibition of fibroblast growth factor receptor 1 in knee cartilage attenuates the degeneration of articular cartilage in adult mice. Arthritis Rheum. 64, 3982-3992 (2012).
37. Tang, J. et al. Fibroblast growth factor receptor 3 inhibits osteoarthritis progression in knee joints of adult mice. Arthritis Rheumatol. (2016).
38. Gardiner M. D. et al. Transcriptional analysis of micro-dissected articular cartilage in post-traumatic murine osteoarthritis. Osteoarthritis Cartilage 23, 616-628 (2015).
39. Ma, H. L. et al. Osteoarthritis severity is sex dependent in a surgical mouse model. Osteoarthritis Cartilage 15, 695-700 (2007).
40. Glasson, S. S., Chambers, M. G., Van Den Berg, W. B. & Little, C. B. The OARSI histopathology initiative-recommendations for histological assessments of osteoarthritis in the mouse. Osteoarthritis Cartilage Suppl 3, S17-23 (2010).
41. Kim, J. H. et al. Regulation of the catabolic cascade in osteoarthritis by the zinc-ZIP8-MTF1 axis. Cell 156, 730-743 (2014).
42. Oh, H., Chun, C. H. & Chun, J. S. Dkk-1 expression in chondrocytes inhibits experimental osteoarthritic cartilage destruction in mice. Arthritis Rheum. 64, 2568-2578 (2012).
43. Gosset, M., Berenbaum, F., Thirion, S. & Jacques, C. Primary culture and phenotyping of murine chondrocytes. Nat. Protoc. 3, 1253-1260 (2008).
44. Cheng, S. et al. Minocycline reduces neuroinflammation but does not ameliorate neuron loss in a mouse model of neurodegeneration. Sci. Rep. 5, 10535 (2015).
45. Cai, D., Yin, S., Yang, J., Jiang, Q. & Cao, W. Histone deacetylase inhibition activates Nrf2 and protects against osteoarthritis. Arthritis Res. Ther. 17, 269 (2015).