Mitochondrial dysfunction activates the AMPK signaling and autophagy to promote cell survival

Genes and Diseases

Volumn 3, Issue 1, 2016, Pages 82-87

  Zhao, Baozhong ^a   Qiang, Lei ^a   Joseph, Joy ^b   Kalyanaraman, Balaraman ^b   Viollet, Benoit ^c   He, Yu Ying ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b FREE RADICAL RESEARCH CENTER   (United States)

^c INSERM   (France)

Author keywords

AMPK; Apoptosis; Autophagy; DNA repair; Mitochondria; Ultraviolet radiation; UV

Indexed keywords

ADENYLATE KINASE; CYTOCHROME B; GENOMIC DNA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; UBIQUINOL CYTOCHROME C REDUCTASE;

APOPTOSIS; ARTICLE; AUTOPHAGY; CELL SURVIVAL; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA DAMAGE; ENZYME ACTIVATION; HUMAN; HUMAN CELL; KERATINOCYTE; SIGNAL TRANSDUCTION; ULTRAVIOLET RADIATION; WESTERN BLOTTING;

EID: 84978154338     PISSN: None     EISSN: 23523042     Source Type: Journal    
DOI: 10.1016/j.gendis.2015.12.002     Document Type: Article

References (37)

1. Klionsky D.J. Autophagy: from phenomenology to molecular understanding in less than a decade. Nat Rev Mol Cell Biol 2007, 8:931-937.
2. Mizushima N., Levine B., Cuervo A.M., et al. Autophagy fights disease through cellular self-digestion. Nature 2008, 451:1069-1075.
3. Choi A.M., Ryter S.W., Levine B. Autophagy in human health and disease. N Engl J Med 2013, 368:1845-1846.
4. White E. Deconvoluting the context-dependent role for autophagy in cancer. Nat Rev Cancer 2012, 12:401-410.
5. Kroemer G., Marino G., Levine B. Autophagy and the integrated stress response. Mol Cell 2010, 40:280-293.
6. Bossy-Wetzel E., Barsoum M.J., Godzik A., et al. Mitochondrial fission in apoptosis, neurodegeneration and aging. Curr Opin Cell Biol 2003, 15:706-716.
7. Lin M.T., Beal M.F. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 2006, 443:787-795.
8. Lowell B.B., Shulman G.I. Mitochondrial dysfunction and type 2 diabetes. Science 2005, 307:384-387.
9. Brandon M., Baldi P., Wallace D.C. Mitochondrial mutations in cancer. Oncogene 2006, 25:4647-4662.
10. Youle R.J., Narendra D.P. Mechanisms of mitophagy. Nat Rev Mol Cell Biol 2011, 12:9-14.
11. Bess A.S., Crocker T.L., Ryde I.T., et al. Mitochondrial dynamics and autophagy aid in removal of persistent mitochondrial DNA damage in Caenorhabditis elegans. Nucleic Acids Res 2012, 40:7916-7931.
12. Laderoute K.R., Amin K., Calaoagan J.M., et al. 5'-AMP-activated protein kinase (AMPK) is induced by low-oxygen and glucose deprivation conditions found in solid-tumor microenvironments. Mol Cell Biol 2006, 26:5336-5347.
13. Weinberg F., Hamanaka R., Wheaton W.W., et al. Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity. Proc Natl Acad Sci U. S. A 2010, 107:8788-8793.
14. Mullen A.R., Wheaton W.W., Jin E.S., et al. Reductive carboxylation supports growth in tumour cells with defective mitochondria. Nature 2012, 481:385-388.
15. Ming M., Han W., Maddox J., et al. UVB-induced ERK/AKT-dependent PTEN suppression promotes survival of epidermal keratinocytes. Oncogene 2010, 29:492-502.
16. Ming M., Shea C.R., Guo X., et al. Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C. Proc Natl Acad Sci U. S. A 2010, 107:22623-22628.
17. Qiang L., Zhao B.Z., Ming M., et al. Regulation of cell proliferation and migration by p62 through stabilization of Twist1. Proc Natl Acad Sci U. S. A 2014, 111:9241-9246.
18. Ming M., Soltani K., Shea C.R., et al. Dual role of SIRT1 in UVB-induced skin tumorigenesis. Oncogene 2015, 34:357-363.
19. Cheng G., Lopez M., Zielonka J., et al. Mitochondria-targeted nitroxides exacerbate fluvastatin-mediated cytostatic and cytotoxic effects in breast cancer cells. Cancer Biol Ther 2011, 12:707-717.
20. Cheng G., Zielonka J., Dranka B.P., et al. Mitochondria-targeted drugs synergize with 2-deoxyglucose to trigger breast cancer cell death. Cancer Res 2012, 72:2634-2644.
21. Cheng G., Zielonka J., McAllister D., et al. Antiproliferative effects of mitochondria-targeted cationic antioxidants and analogs: role of mitochondrial bioenergetics and energy-sensing mechanism. Cancer Lett 2015, 365:96-106.
22. Qiang L., Wu C., Ming M., et al. Autophagy controls p38 activation to promote cell survival under genotoxic stress. J Biol Chem 2013, 288:1603-1611.
23. Chen L.H., Chu P.M., Lee Y.J., et al. Targeting protective autophagy exacerbates UV-triggered apoptotic cell death. Int J Mol Sci 2012, 13:1209-1224.
24. Kabeya Y., Mizushima N., Ueno T., et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 2000, 19:5720-5728.
25. Klionsky D.J., Abeliovich H., Agostinis P., et al. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy 2008, 4:151-175.
26. Wu C.L., Qiang L., Han W., et al. Role of AMPK in UVB-induced DNA damage repair and growth control. Oncogene 2013, 32:2682-2689.
27. Qiang L., Zhao B., Shah P., et al. Autophagy positively regulates DNA damage recognition by nucleotide excision repair. Autophagy 2015 Nov 13, 0. [Epub ahead of print]. 10.1080/15548627.2015.1110667.
28. Maiuri M.C., Zalckvar E., Kimchi A., et al. Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol 2007, 8:741-752.
29. Nunnari J., Suomalainen A. Mitochondria: in sickness and in health. Cell 2012, 148:1145-1159.
30. Mihaylova M.M., Shaw R.J. The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Nat Cell Biol 2011, 13:1016-1023.
31. Komatsu M., Waguri S., Chiba T., et al. Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature 2006, 441:880-884.
32. Nixon R.A. The role of autophagy in neurodegenerative disease. Nat Med 2013, 19:983-997.
33. Kimmelman A.C. The dynamic nature of autophagy in cancer. Genes Dev 2011, 25:1999-2010.
34. Galluzzi L., Pietrocola F., Bravo-San Pedro J.M., et al. Autophagy in malignant transformation and cancer progression. EMBO J 2015, 34:856-880.
35. Zhi X., Zhong Q. Autophagy in cancer. F1000Prime Rep 2015, 7:18.
36. Rao V.A., Klein S.R., Bonar S.J., et al. The antioxidant transcription factor Nrf2 negatively regulates autophagy and growth arrest induced by the anticancer redox agent mitoquinone. J Biol Chem 2010, 285:34447-34459.
37. Dhanasekaran A., Kotamraju S., Karunakaran C., et al. Mitochondria superoxide dismutase mimetic inhibits peroxide-induced oxidative damage and apoptosis: role of mitochondrial superoxide. Free Radic Biol Med 2005, 39:567-583.