Adverse effects of AMP-activated protein kinase α2-subunit deletion and high-fat diet on heart function and ischemic tolerance in aged female mice

Physiological Research

Volumn 65, Issue 1, 2016, Pages 33-42

  Slamova K ^a   Papousek F ^a   Janovska P ^a   Kopecky J ^a   Kolar F ^a  

^a INSTITUTE OF PHYSIOLOGY   (Czech Republic)

Author keywords

Aging; AMP kinase; High fat diet; Ischemia reperfusion; Myocardial infarction

Indexed keywords

AMPK ALPHA2 SUBUNIT, MOUSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE;

ADVERSE EFFECTS; AGING; ANIMAL; C57BL MOUSE; DEFICIENCY; FEMALE; GENE DELETION; GENETICS; HEART MUSCLE ISCHEMIA; KNOCKOUT MOUSE; LIPID DIET; METABOLISM; MOUSE;

AGING; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; DIET, HIGH-FAT; FEMALE; GENE DELETION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYOCARDIAL ISCHEMIA;

EID: 84963815042     PISSN: 08628408     EISSN: 18029973     Source Type: Journal    
DOI: None     Document Type: Article

References (51)

1. ABBOTT MJ, CONSTANTINESCU S, TURCOTTE LP: AMP-activated protein kinase a2 is an essential signal in the regulation of insulin-stimulated fatty acid uptake in control-fed and high-fat-fed mice. Exp Physiol 97: 603-617, 2012
2. ASHTON KJ, WILLEMS L, HOLMGREN K, FERREIRA L, HEADRICK JP: Age associated shifts in cardiac gene transcription and transcriptional responses to ischemic stress. Exp Gerontol 41: 189-204, 2006
3. AURICH AC, NIEMANN B, PAN R, GRUENLER S, ISSA H, SILBER RE, ROHRBACH S: Age-dependent effects of high fat-diet on murine left ventricles: role of palmitate. Basic Res Cardiol 108: 369, 2013
4. AZHAR G, GAO W, LIU L, WEI JY: Ischemia-reperfusion in the adult mouse heart influence of age. Exp Gerontol 34: 699-714, 1999
5. BOENGLER K, KONIETZKA I, BUECHERT A, HEINEN Y, GARCIE-DORADO D, HEUSCH G, SCHULZ R: Loss of ischemic preconditioning's cardioprotection in aged mouse hearts is associated with reduced gap junctional and mitochondrial levels of connexin 43. Am J Physiol Heart Circ Physiol 292: H1764-H1769, 2007
6. BOENNGLER K, SCHULZ R, HEUSCH G: Loss of cardioprotection with ageing. Cardiovasc Res 83: 247-261, 2009
7. BRAINARD RE, WATSON LJ, DEMARTINO AM, BRITTIAN KR, READNOWER RD, BOAKYE AA, ZHANG D, HOETKER JD, BHATNAGAR A, BABA SP, JONES SP: High fat feeding in mice is insufficient to induce cardiac dysfunction and does not exacerbate heart failure. PloS One 8: e83174, 2013
8. DYCK JR, LOPASCHUK GD: AMPK alterations in cardiac physiology and pathology: enemy or ally?. J Physiol 574: 95-112, 2006
9. EDWARDS AG, DONATO AJ, LESNIEWSKI LA, GIOSCIA RA, SEALS DR, MOORE RL: Life-long caloric restriction elicits pronounced protection of the aged myocardium: a role for AMPK. Mech Ageing Dev 131: 739-742, 2010
10. FELICIO LS, NELSON JF, FINCH CE: Longitudinal studies of estrous cyclicity in aging C57BL/6J mice: II. Cessation of cyclicity and the duration of persistent vaginal cornification. Biol Reprod 31: 446-453, 1984
11. FERRARI AU, RADAELLI A, CENTOLA M: Aging and the cardiovascular system. J Appl Physiol 95: 2591-2597, 2003
12. FOLMES CD, WAGG CS, SHEN M, CLANACHAN AS, TIAN R, LOPASCHUK GD: Suppression of 5'-AMPactivated protein kinase activity does not impair recovery of contractile function during reperfusion of ischemic hearts. Am J Physiol Heart Circ Physiol 297: H313-H321, 2009
13. FUJII N, HO RC, MANABE Y, JESSEN N, TOYODA T, HOLLAND WL, SUMMERS SA, HIRSHMAN MF, GOODYEAR LJ: Ablation of AMP-activated protein kinase alpha2 activity exacerbates insulin resistance induced by high-fat feeding of mice. Diabetes 57: 2958-2966, 2008
14. GONZALEZ AA, KUMAR R, MULLIGAN JD, DAVIS AJ, SAUPE KW: Effects of aging on cardiac and skeletal muscle AMPK activity: basal activity, allosteric activation, and response to in vivo hypoxemia in mice. Am J Physiol Regul Integr Comp Physiol 287: R1270-R1275, 2004
15. GOULD KE, TAFFAT GE, MICHAEL LH, CHRISTIE RM, KONKOL DL, POCIUS JS, ZACHARIAH JP, CHAUPIN DF, DANIEL SL, SANDUSKY GE JR, HARTLEY CJ, ENTMAN ML: Heart failure and greater infarct expansion in middle-aged mice: a relevant model for postinfarction failure. Am J Physiol Heart Circ Physiol 282: H615-H621, 2002
16. GUO R, ZHANG Y, TURDI S, REN J: Adiponectin knockout accentuates high fat diet-induced obesity and cardiac dysfunction: role of autophagy. Biochim Biophys Acta 1832: 1136-1148, 2013
17. HARDIE DG: Minireview: the AMP-activated protein kinase cascade: the key sensor of cellular energy status. Endocrinology 144: 5179-5183, 2003
18. HARDIE DG, CARLING D: The AMP-activated protein kinase-fuel gauge of the mammalian cell?. Eur J Biochem 246: 259-273, 1997
19. JELENíK T, ROSSMEISL M, KUDA O, JíLKOVá ZM, MEDRíKOVá D, KUS V, HENSLER M, JANOVSKá P, MIKŠíK I, BARANOWSKI M, GORSKI J, HEBRARD S, JENSEN TE, FLACHS P, HAWLEY S, VIOLLET B, KOPECKỲ J: AMP-activated protein kinase a2 subunit is required for the preservation of hepatic insulin sensitivity by n-3 polyunsaturated fatty acids. Diabetes 59: 2737-2746, 2010
20. KUDA O, JELENíK T, JíLKOVá Z, FLACHS P, ROSSMEISL M, HENSLER M, KAZDOVá L, OGSTON N, BARANOWSKI M, GORSKI J, JANOVSKá P, KUS V, POLAK J, MOHAMED-ALI V, BURCELIN R, CINTI S, BRYHN M, KOPECKỲ J: n-3 fatty acids and rosiglitazone improve insulin sensitivity through additive stimulatory effects on muscle glycogen synthesis in mice fed high-fat diet. Diabetologia 52: 941-951, 2009
21. KUDO N, BARR AJ, BARR RL, DESAI S, LOPASCHUK GD: High rates of fatty acid oxidation during reperfusion of ischemic hearts are associated with a decrease in malonyl-CoA levels due to an increase in 5'-AMP-activated protein kinase inhibition of acetyl-CoA carboxylase. J Biol Chem 270: 17513-17520, 1995
22. KUS V, PRAŽáK T, BRAUNER P, HENSLER M, KUDA O, FLACHS P, JANOVSKá P, MEDRíKOVá D, ROSSMEISL M, JíLKOVá Z, ŠTEFL B, PASTALKOVA E, DRAHOTA Z, HOUŠTEK J, KOPECKỲ J: Induction of muscle thermogenesis by high-fat diet in mice: association with obesity-resistance. Am J Physiol Endocrinol Metab 295: E356-E367, 2008
23. LAKKATTA EG, SOLLOTT SJ: The "heartbreak" of older age. Mol Interv 2: 431-446, 2002
24. LI J, COVEN DL, MILLER EJ, HU X, YOUNG ME, CARLING D, SINUSAS AJ, YOUNG LH: Activation of AMPK alpha-and gamma-isoform complexes in the intact ischemic rat heart. Am J Physiol Heart Circ Physiol 291: H1927-H1934, 2006
25. LINDHOLM CR, ERTEL RL, BAUWENS JD, SCHMUCK EG, MULLIGAN JD, SAUPE KW: A high-fat diet decreases AMPK activity in multiple tissues in the absence of hyperglycemia or systemic inflammation in rats. J Physiol Biochem 69: 165-175, 2013
26. LIU Q, DOCHERTY JC, RENDELL JC, CLANACHAN AS, LOPASHUK GD: High levels of fatty acids delay the recovery of intracellular pH and cardiac efficiency in post-ischemic hearts by inhibiting glucose oxidation. J Am Coll Cardiol 39: 718-725, 2002
27. LOPASCHUK GD, FOLMES CD, STANLEY WC: Cardiac energy metabolism in obesity. Circ Res 101: 335-347, 2007
28. MATEJKOVá O, MUSTARD KJ, ŠPONAROVá J, FLACHS P, ROSSMEISL M, MIKŠíK I, THOMASONHUGHES M, GRAHAME HARDIE D, KOPECKỲ J: Possible involvement of AMP-activated protein kinase in obesity resistance induced by respiratory uncoupling in white fat. FEBS Lett 569: 245-248, 2004
29. MCCARTY MF: Chronic activation of AMP-activated kinase as a strategy for slowing aging. Med Hypotheses 63: 334-339, 2004
30. MULLIGAN JD, GONZALEZ AA, KUMAR R, DAVIS AJ, SAUPE KW: Aging elevates basal adenosine monophosphate-activated protein kinase (AMPK) activity and eliminates hypoxic activation of AMPK in mouse liver. J Gerontol A Biol Sci Med Sci 60: 21-27, 2005
31. NASCIMENTO AF, LUVIZOTTO RA, LEOPOLDO AS, LIMA-LEOPOLDO AP, SEIVA FR, JUSTULIN LA JR, SILVA MD, OKOSHI K, WANG XD, CICOGNA AC: Long-term high-fat diet-induced obesity decreases the cardiac leptin receptor without apparent lipotoxicity. Life Sci 88: 1031-1038, 2011
32. NIEMANN B, PAN R, TESCHNER M, BOENING A, SILBER RE, ROHRBACH S: Age and obesity-associated changes in the expression and activation of components of the AMPK signaling pathway in human right atrial tissue. Exp Gerontol 48: 55-63, 2013
33. OUWENS DM, BOER C, FODOR M, DE GALAN P, HEINE RJ, MAASSEN JA, DIAMANT M: Cardiac dysfunction induced by high-fat diet is associated with altered myocardial insulin signalling in rats. Diabetologia 48: 1229-1237, 2005
34. PEART JN, GROSS ER, HEADRICK JP, GROSS GJ: Impaired p38 MAPK/HSP27 signaling underlies aging-related failure in opioid-mediated cardioprotection. J Mol Cell Cardiol 42: 972-980, 2007
35. PRZYKLENK K, MAYNARD M, DARLING CE, WHITTAKER P: Aging mouse hearts are refractory to infarct size reduction with post-conditioning. J Am Coll Cardiol 51: 1393-1398, 2008
36. QIANG W, WEIQIANG K, QING Z, PENGJU Z, YI L: Aging impairs insulin-stimulated glucose uptake in rat skeletal muscle via suppressing AMPK-alpha. Exp Mol Med 39: 535-543, 2007
37. RELLING DP, ESBERG LB, FANG CX, JOHNSON WT, MURPHY EJ, CARLSON EC, SAARI JT, REN J: High-fat diet-induced juvenile obesity leads to cardiomyocyte dysfunction and upregulation of Foxo3a transcription factor independent of lipotoxicity and apoptosis. J Hypertens 24: 549-561, 2006
38. REZNICK RM, ZONG H, LI J, MORINO K, MOORE IK, YU HJ, LIU ZX, DONG J, MUSTARD KJ, HAWLEY SA, BEFROY D, PYPAERT M, HARDIE DG, YOUNG LH, SHULMAN GI: Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis. Cell Metab 5: 151-156, 2007
39. 2+ loading and improved functional recovery after ischemia-reperfusion injury in old vs. young guinea pig hearts. Eur J Clin Microbiol Infect Dis 31: 1551-1559, 2012
40. SALMINEN A, KAARNIRANTA K: AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network. J Mol Med 89: 667-676, 2012
41. SLáMOVá K, JANOVSKá P, PAPOUŠEK F, KOPECKỲ J, KOLáR F: Influence of aging and high-fat diet on myocardial ischemic tolerance in mice with AMP-activated protein kinase a2-subunit deficiency. Act Nerv Super Rediviva 54: 100, 2012
42. SNIECINSKI R, LIU H: Reduced efficacy of volatile anesthetic preconditioning with advanced age in isolated rat myocardium. Anesthesiology 100: 589-597, 2004
43. STEINBERG GR, KEMP BE: AMPK in health and disease. Physiol Rev 89: 1025-1078, 2009
44. THAKKER GD, FRANGOGIANNIS NG, ZYMEK PT, SHARMA S, RAYA JL, BARGER PM, TAEGTMEYER H, ENTMAN ML, BALLANTYNE CM: Increased myocardial susceptibility to repetitive ischemia with high-fat diet-induced obesity. Obesity 16: 2593-2600, 2008
45. TURDI S, FAN X, LI J, ZHAO J, HUFF AF, DU M, REN J: AMP-activated protein kinase deficiency exacerbates aging-induced myocardial contractile dysfunction. Aging Cell 9: 592-606, 2010
46. TURDI S, KANDADI MR, ZHAO J, HUFF AF, DU M, REN J: Deficiency in AMP-activated protein kinase exaggerates high fat diet-induced cardiac hypertrophy and contractile dysfunction. J Mol Cell Cardiol 50: 712-722, 2011
47. VIOLLET B, ANDREELLI F, JØRGENSEN SB, PERRIN C, GELOEN A, FLAMEZ D, MU J, LENZNER C, BAUD O, BENNOUN M, GOMAS E, NICOLAS G, WOJTASZEWSKI JF, KAHN A, CARLING D, SCHUIT FC, BIRNBAUM MJ, RICHTER EA, BURCELIN R, VAULONT S: The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity. J Clin Invest 111: 91-98, 2003
48. WANG W, YANG X, LóPEZ DE SILANES I, CARLING D, GOROSPE M: Increased AMP:ATP ratio and AMPactivated protein kinase activity during cellular senescence linked to reduced HuR function. J Biol Chem 278: 27016-27023, 2003
49. WANG S, SONG P, ZOU MH: AMP-activated protein kinase, stress responses and cardiovascular diseases. Clin Sci 122: 555-573, 2012
50. WILLEMS L, ZATTA A, HOLMGREN K, ASHTON KJ, HEADRICK JP: Age-related changes in ischemic tolerance in male and female mouse hearts. J Mol Cell Cardiol 38: 245-256, 2005
51. ZAHA VG, YOUNG LH: AMP-activated protein kinase regulation and biological actions in the heart. Circ Res 111: 800-814, 2012